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All other authors have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"De-identified serum samples were obtained from patients enrolled in one of two consecutive clinical trials conducted by the Dana-Farber Cancer Institute (DFCI) ALL Consortium; these trials were the DFCI 05\u2013001 and DFCI 11\u2013001. The protocols were approved by the Institutional Review Boards of each participating institution.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval:"}},{"value":"Written informed consent from each participant's parent\/legal guardian, as well as patient assent when appropriate, was obtained prior to enrollment and initiation of therapy. 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