{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:14:58Z","timestamp":1791252898087,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF2013M3A9C4078145"],"award-info":[{"award-number":["NRF2013M3A9C4078145"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"crossref","award":["2E30480"],"award-info":[{"award-number":["2E30480"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HC15C1322"],"award-info":[{"award-number":["HC15C1322"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s11306-021-01826-y","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T16:03:45Z","timestamp":1628179425000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Short-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass"],"prefix":"10.1007","volume":"17","author":[{"given":"Gakyung","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Suk","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chamlee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunbeom","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyoung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Joong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk-Joon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Kyung","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Wan","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Moon","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon-Won","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungsoo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Uk","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonseok","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7504-7132","authenticated-orcid":false,"given":"Byung Hwa","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"issue":"24","key":"1826_CR1","doi-asserted-by":"publisher","first-page":"7529","DOI":"10.3748\/wjg.v21.i24.7529","volume":"21","author":"N Calvo","year":"2015","unstructured":"Calvo, N., Beltran-Debon, R., Rodriguez-Gallego, E., Hernandez-Aguilera, A., Guirro, M., Marine-Casado, R., et al. (2015). Liver fat deposition and mitochondrial dysfunction in morbid obesity: An approach combining metabolomics with liver imaging and histology. World Journal of Gastroenterology, 21(24), 7529\u20137544.","journal-title":"World Journal of Gastroenterology"},{"issue":"3","key":"1826_CR2","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1161\/01.ATV.0000151874.81059.ad","volume":"25","author":"HC Chen","year":"2005","unstructured":"Chen, H. C., & Farese, R. V., Jr. (2005). Inhibition of triglyceride synthesis as a treatment strategy for obesity: Lessons from DGAT1-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology., 25(3), 482\u2013486.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology."},{"issue":"13","key":"1826_CR3","doi-asserted-by":"publisher","first-page":"e126925","DOI":"10.1172\/jci.insight.126925","volume":"4","author":"WS Chew","year":"2019","unstructured":"Chew, W. S., Torta, F., Ji, S., Choi, H., Begum, H., Sim, X., et al. (2019). Large-scale lipidomics identifies associations between plasma sphingolipids and T2DM incidence. JCI Insight, 4(13), e126925.","journal-title":"JCI Insight"},{"key":"1826_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003641.pub3\/abstract","author":"JL Colquitt","year":"2009","unstructured":"Colquitt, J. L., Picot, J., Loveman, E., & Clegg, A. J. (2009). Surgery for obesity. Cochrane Database of Systematic Reviews. https:\/\/doi.org\/10.1002\/14651858.CD003641.pub3\/abstract","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"1826_CR5","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/srep00139","volume":"1","author":"M Dashti","year":"2011","unstructured":"Dashti, M., Kulik, W., Hoek, F., Veerman, E. C., Peppelenbosch, M. P., & Rezaee, F. (2011). A phospholipidomic analysis of all defined human plasma lipoproteins. Scientific Reports, 1, 139.","journal-title":"Scientific Reports"},{"issue":"8","key":"1826_CR6","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1016\/j.soard.2016.05.010","volume":"12","author":"T Debs","year":"2016","unstructured":"Debs, T., Petrucciani, N., Kassir, R., Iannelli, A., Amor, I. B., & Gugenheim, J. (2016). Trends of bariatric surgery in France during the last 10 years: Analysis of 267,466 procedures from 2005\u20132014. Surgery Obesity Related Diseases, 12(8), 1602\u20131609.","journal-title":"Surgery Obesity Related Diseases"},{"key":"1826_CR7","doi-asserted-by":"publisher","first-page":"7715","DOI":"10.1038\/ncomms8715","volume":"6","author":"CR Flynn","year":"2015","unstructured":"Flynn, C. R., Albaugh, V. L., Cai, S., Cheung-Flynn, J., Williams, P. E., Brucker, R. M., et al. (2015). Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery. Nature Communications, 6, 7715.","journal-title":"Nature Communications"},{"issue":"4","key":"1826_CR8","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3390\/ijms17040479","volume":"17","author":"R Gambino","year":"2016","unstructured":"Gambino, R., Bugianesi, E., Rosso, C., Mezzabotta, L., Pinach, S., Alemanno, N., et al. (2016). Different serum free fatty acid profiles in NAFLD subjects and healthy controls after oral fat load. International Journal of Molecular Sciences., 17(4), 479.","journal-title":"International Journal of Molecular Sciences."},{"key":"1826_CR9","doi-asserted-by":"publisher","first-page":"e141","DOI":"10.1038\/nutd.2014.38","volume":"4","author":"H Hanamatsu","year":"2014","unstructured":"Hanamatsu, H., Ohnishi, S., Sakai, S., Yuyama, K., Mitsutake, S., Takeda, H., et al. (2014). Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults. Nutrition Diabetes, 4, e141.","journal-title":"Nutrition Diabetes"},{"issue":"9","key":"1826_CR10","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1007\/s11695-017-2660-3","volume":"27","author":"Z Hao","year":"2017","unstructured":"Hao, Z., Townsend, R. L., Mumphrey, M. B., Morrison, C. D., Munzberg, H., & Berthoud, H. R. (2017). RYGB produces more sustained body weight loss and improvement of glycemic control compared with VSG in the diet-induced obese mouse model. Surgery Obesity, 27(9), 2424\u20132433.","journal-title":"Surgery Obesity"},{"key":"1826_CR11","doi-asserted-by":"publisher","first-page":"135698","DOI":"10.1155\/2013\/135698","volume":"2013","author":"A Hernandez-Aguilera","year":"2013","unstructured":"Hernandez-Aguilera, A., Rull, A., Rodriguez-Gallego, E., Riera-Borrull, M., Luciano-Mateo, F., Camps, J., et al. (2013). Mitochondrial dysfunction: A basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities. Mediators of Inflammation, 2013, 135698.","journal-title":"Mediators of Inflammation"},{"issue":"12","key":"1826_CR12","doi-asserted-by":"publisher","first-page":"2614","DOI":"10.1161\/01.ATV.20.12.2614","volume":"20","author":"XC Jiang","year":"2000","unstructured":"Jiang, X. C., Paultre, F., Pearson, T. A., Reed, R. G., Francis, C. K., Lin, M., et al. (2000). Plasma sphingomyelin level as a risk factor for coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology., 20(12), 2614\u20132618.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology."},{"issue":"10","key":"1826_CR13","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1111\/j.1464-5491.1990.tb01321.x","volume":"7","author":"P Johnston","year":"1990","unstructured":"Johnston, P., Hollenbeck, C., Sheu, W., Chen, Y. D., & Reaven, G. M. (1990). Acute changes in plasma non-esterified fatty acid concentration do not change hepatic glucose production in people with type 2 diabetes. Diabetic Medicine, 7(10), 871\u2013875.","journal-title":"Diabetic Medicine"},{"issue":"3","key":"1826_CR14","doi-asserted-by":"publisher","first-page":"G652","DOI":"10.1152\/ajpgi.00221.2010","volume":"299","author":"R Kohli","year":"2010","unstructured":"Kohli, R., Kirby, M., Setchell, K. D., Jha, P., Klustaitis, K., Woollett, L. A., et al. (2010). Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. American Journal of Physiology. Gastrointestinal and Liver Physiology, 299(3), G652\u2013G660.","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"issue":"1","key":"1826_CR15","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3945\/ajcn.113.058743","volume":"98","author":"LC Kong","year":"2013","unstructured":"Kong, L. C., Tap, J., Aron-Wisnewsky, J., Pelloux, V., Basdevant, A., Bouillot, J. L., et al. (2013). Gut microbiota after gastric bypass in human obesity: Increased richness and associations of bacterial genera with adipose tissue genes. The American Journal of Clinical Nutrition., 98(1), 16\u201324.","journal-title":"The American Journal of Clinical Nutrition."},{"key":"1826_CR16","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.neuroscience.2019.07.029","volume":"416","author":"G Lee","year":"2019","unstructured":"Lee, G., Hasan, M., Kwon, O. S., & Jung, B. H. (2019). Identification of altered metabolic pathways during disease progression in EAE mice via metabolomics and lipidomics. Neuroscience, 416, 74\u201387.","journal-title":"Neuroscience"},{"issue":"7","key":"1826_CR17","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/nm.4358","volume":"23","author":"R Liu","year":"2017","unstructured":"Liu, R., Hong, J., Xu, X., Feng, Q., Zhang, D., Gu, Y., et al. (2017). Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nature Medicine, 23(7), 859\u2013868.","journal-title":"Nature Medicine"},{"issue":"6801","key":"1826_CR18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/35025203","volume":"407","author":"AJ Lusis","year":"2000","unstructured":"Lusis, A. J. (2000). Atherosclerosis. Nature, 407(6801), 233\u2013241.","journal-title":"Nature"},{"issue":"2","key":"1826_CR19","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.ygyno.2015.05.015","volume":"138","author":"SC Modesitt","year":"2015","unstructured":"Modesitt, S. C., Hallowell, P. T., Slack-Davis, J. K., Michalek, R. D., Atkins, K. A., Kelley, S. L., et al. (2015). Women at extreme risk for obesity-related carcinogenesis: Baseline endometrial pathology and impact of bariatric surgery on weight, metabolic profiles and quality of life. Gynecologic Oncology, 138(2), 238\u2013245.","journal-title":"Gynecologic Oncology"},{"issue":"4","key":"1826_CR20","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","volume":"9","author":"CB Newgard","year":"2009","unstructured":"Newgard, C. B., An, J., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Lien, L. F., et al. (2009). A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metabolism, 9(4), 311\u2013326.","journal-title":"Cell Metabolism"},{"issue":"10","key":"1826_CR21","doi-asserted-by":"publisher","first-page":"4769","DOI":"10.1021\/pr2005555","volume":"10","author":"A Oberbach","year":"2011","unstructured":"Oberbach, A., Bluher, M., Wirth, H., Till, H., Kovacs, P., Kullnick, Y., et al. (2011). Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes. Journal of Proteome Research, 10(10), 4769\u20134788.","journal-title":"Journal of Proteome Research"},{"issue":"7","key":"1826_CR22","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1161\/CIRCRESAHA.118.313320","volume":"124","author":"M Pareek","year":"2019","unstructured":"Pareek, M., Bhatt, D. L., Schiavon, C. A., & Schauer, P. R. (2019). Metabolic surgery for hypertension in patients with obesity. Circulation Research, 124(7), 1009\u20131024.","journal-title":"Circulation Research"},{"issue":"10","key":"1826_CR23","doi-asserted-by":"crossref","first-page":"e018044","DOI":"10.1136\/bmjopen-2017-018044","volume":"7","author":"YS Park","year":"2017","unstructured":"Park, Y. S., Park, D. J., Lee, J. H., Lee, H. J., Ha, T. K., Kim, Y. J., et al. (2017). Korean OBEsity Surgical Treatment Study (KOBESS): Protocol of a prospective multicentre cohort study on obese patients undergoing laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass. BMJ Open, 7(10), e018044.","journal-title":"BMJ Open"},{"issue":"2","key":"1826_CR24","doi-asserted-by":"publisher","first-page":"e218","DOI":"10.1371\/journal.pone.0000218","volume":"2","author":"KH Pietilainen","year":"2007","unstructured":"Pietilainen, K. H., Sysi-Aho, M., Rissanen, A., Seppanen-Laakso, T., Yki-Jarvinen, H., Kaprio, J., et al. (2007). Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects\u2014A monozygotic twin study. PLoS ONE, 2(2), e218.","journal-title":"PLoS ONE"},{"key":"1826_CR25","doi-asserted-by":"publisher","first-page":"6270875","DOI":"10.1155\/2018\/6270875","volume":"2018","author":"P Samczuk","year":"2018","unstructured":"Samczuk, P., Ciborowski, M., & Kretowski, A. (2018). Application of metabolomics to study effects of bariatric surgery. Journal of Diabetes Research, 2018, 6270875.","journal-title":"Journal of Diabetes Research"},{"issue":"7","key":"1826_CR26","doi-asserted-by":"publisher","first-page":"e2630","DOI":"10.1371\/journal.pone.0002630","volume":"3","author":"U Schwab","year":"2008","unstructured":"Schwab, U., Seppanen-Laakso, T., Yetukuri, L., Agren, J., Kolehmainen, M., Laaksonen, D. E., et al. (2008). Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism\u2013the GENOBIN study. PLoS ONE, 3(7), e2630.","journal-title":"PLoS ONE"},{"issue":"3 Suppl 1","key":"1826_CR27","doi-asserted-by":"publisher","first-page":"S142","DOI":"10.1053\/ajkd.2003.50104","volume":"41","author":"F Takayama","year":"2003","unstructured":"Takayama, F., Taki, K., & Niwa, T. (2003). Bifidobacterium in gastro-resistant seamless capsule reduces serum levels of indoxyl sulfate in patients on hemodialysis. American Journal of Kidney Diseases: The Official Journal of the National Kidney Foundation, 41(3 Suppl 1), S142\u2013S145.","journal-title":"American Journal of Kidney Diseases: The Official Journal of the National Kidney Foundation"},{"issue":"7415","key":"1826_CR28","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/nature11552","volume":"489","author":"V Tremaroli","year":"2012","unstructured":"Tremaroli, V., & Backhed, F. (2012). Functional interactions between the gut microbiota and host metabolism. Nature, 489(7415), 242\u2013249.","journal-title":"Nature"},{"key":"1826_CR29","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/1476-511X-10-234","volume":"10","author":"X Wang","year":"2011","unstructured":"Wang, X., Cao, Y., Fu, Y., Guo, G., & Zhang, X. (2011). Liver fatty acid composition in mice with or without nonalcoholic fatty liver disease. Lipids in Health and Disease, 10, 234.","journal-title":"Lipids in Health and Disease"},{"issue":"16","key":"1826_CR30","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1007\/s00018-017-2509-x","volume":"74","author":"GA Weiss","year":"2017","unstructured":"Weiss, G. A., & Hennet, T. (2017). Mechanisms and consequences of intestinal dysbiosis. Cellular and Molecular Life Sciences\u202f: CMLS., 74(16), 2959\u20132977.","journal-title":"Cellular and Molecular Life Sciences : CMLS."},{"issue":"4","key":"1826_CR31","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/ijo.2015.223","volume":"40","author":"JM Wentworth","year":"2016","unstructured":"Wentworth, J. M., Naselli, G., Ngui, K., Smyth, G. K., Liu, R., O\u2019Brien, P. E., et al. (2016). GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women. International Journal of Obesity., 40(4), 706\u2013713.","journal-title":"International Journal of Obesity."},{"issue":"10","key":"1826_CR32","doi-asserted-by":"publisher","first-page":"3698","DOI":"10.1073\/pnas.0812874106","volume":"106","author":"WR Wikoff","year":"2009","unstructured":"Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., et al. (2009). Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proceedings of the National Academy of Sciences of the United States of America, 106(10), 3698\u20133703.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"updated-by":[{"DOI":"10.1007\/s11306-021-01838-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000}}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-021-01826-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-021-01826-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-021-01826-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T17:43:47Z","timestamp":1673027027000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-021-01826-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["1826"],"URL":"https:\/\/doi.org\/10.1007\/s11306-021-01826-y","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s11306-021-01838-8","asserted-by":"object"}]},"ISSN":["1573-3882","1573-3890"],"issn-type":[{"value":"1573-3882","type":"print"},{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"24 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11306-021-01838-8","URL":"https:\/\/doi.org\/10.1007\/s11306-021-01838-8","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The trial was performed in accordance with the Declaration of Helsinki. The protocol was approved by the Institutional Review Board (IRB) (No. B-1608\/357\u2013005) and registered at clinicaltrials.gov (NCT03100292).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"71"}}