{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:50:34Z","timestamp":1786981834929,"version":"build-2736575974"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2020JM-691"],"award-info":[{"award-number":["2020JM-691"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Projects of Xi\u2019an","award":["2019115013YX005SF038(10)"],"award-info":[{"award-number":["2019115013YX005SF038(10)"]}]},{"name":"Project of Honghui Hospital, Xi\u2019an Jiaotong University","award":["YJ2017017"],"award-info":[{"award-number":["YJ2017017"]}]},{"name":"Fundamental Research Funds for the Central Universities of Northwestern Polytechnical University","award":["G2020KY0516"],"award-info":[{"award-number":["G2020KY0516"]}]},{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","award":["2020GXLH-Y-027"],"award-info":[{"award-number":["2020GXLH-Y-027"]}],"id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013278","name":"National Innovation Talent Promotion Program","doi-asserted-by":"publisher","award":["2020KJXX-023"],"award-info":[{"award-number":["2020KJXX-023"]}],"id":[{"id":"10.13039\/501100013278","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of Xi'an Municipal Health Commission","award":["2020qn16"],"award-info":[{"award-number":["2020qn16"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s11306-022-01872-0","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T07:02:38Z","timestamp":1644562958000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Plasma lipidomics analysis reveals altered lipids signature in patients with osteonecrosis of the femoral head"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6496-1706","authenticated-orcid":false,"given":"Yuzhu","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dageng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"1872_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13578-019-0324-9","volume":"9","author":"A Ando","year":"2019","unstructured":"Ando, A., Oka, M., & Satomi, Y. (2019). Deoxysphingolipids and ether-linked diacylglycerols accumulate in the tissues of aged mice. Cell & Bioscience, 9, 61. https:\/\/doi.org\/10.1186\/s13578-019-0324-9","journal-title":"Cell & Bioscience"},{"key":"1872_CR2","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1111\/j.1476-5381.2011.01474.x","volume":"163","author":"I Bab","year":"2011","unstructured":"Bab, I., Smoum, R., Bradshaw, H., & Mechoulam, R. (2011). Skeletal lipidomics: Regulation of bone metabolism by fatty acid amide family. British Journal of Pharmacology, 163, 1441\u20131446. https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01474.x","journal-title":"British Journal of Pharmacology"},{"key":"1872_CR3","doi-asserted-by":"publisher","first-page":"605979","DOI":"10.3389\/fcell.2020.605979","volume":"8","author":"X Bai","year":"2020","unstructured":"Bai, X., et al. (2020). Integrated metabolomics and lipidomics analysis reveal remodeling of lipid metabolism and amino acid metabolism in glucagon receptor-deficient zebrafish. Frontiers Cell and Developmental Biology, 8, 605979. https:\/\/doi.org\/10.3389\/fcell.2020.605979","journal-title":"Frontiers Cell and Developmental Biology"},{"key":"1872_CR4","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","volume":"41","author":"T Barrett","year":"2013","unstructured":"Barrett, T., et al. (2013). NCBI GEO: Archive for functional genomics data sets\u2013update. Nucleic Acids Research, 41, D991\u2013D995. https:\/\/doi.org\/10.1093\/nar\/gks1193","journal-title":"Nucleic Acids Research"},{"key":"1872_CR5","doi-asserted-by":"publisher","first-page":"102460","DOI":"10.1016\/j.jaut.2020.102460","volume":"110","author":"C Chang","year":"2020","unstructured":"Chang, C., Greenspan, A., & Gershwin, M. E. (2020). The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis. Journal of Autoimmunity, 110, 102460. https:\/\/doi.org\/10.1016\/j.jaut.2020.102460","journal-title":"Journal of Autoimmunity"},{"key":"1872_CR6","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1210\/jc.2016-1366","volume":"101","author":"PY Chang","year":"2016","unstructured":"Chang, P. Y., et al. (2016). Triglyceride levels and fracture risk in midlife women: Study of Women\u2019s Health Across the Nation (SWAN). Journal of Clinical Endocrinology and Metabolism, 101, 3297\u20133305. https:\/\/doi.org\/10.1210\/jc.2016-1366","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"1872_CR7","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1007\/s00264-018-3979-7","volume":"42","author":"XJ Chen","year":"2018","unstructured":"Chen, X. J., et al. (2018). Association of reduced sclerostin expression with collapse process in patients with osteonecrosis of the femoral head. International Orthopaedics, 42, 1675\u20131682. https:\/\/doi.org\/10.1007\/s00264-018-3979-7","journal-title":"International Orthopaedics"},{"key":"1872_CR8","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1093\/bioinformatics\/bty679","volume":"35","author":"E Fahy","year":"2019","unstructured":"Fahy, E., et al. (2019). LipidFinder on LIPID MAPS: Peak filtering, MS searching and statistical analysis for lipidomics. Bioinformatics, 35, 685\u2013687. https:\/\/doi.org\/10.1093\/bioinformatics\/bty679","journal-title":"Bioinformatics"},{"key":"1872_CR9","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s12967-019-1898-z","volume":"17","author":"D Gao","year":"2019","unstructured":"Gao, D., et al. (2019). Values of integration between lipidomics and clinical phenomes in patients with acute lung infection, pulmonary embolism, or acute exacerbation of chronic pulmonary diseases: A preliminary study. Journal of Translational Medicine, 17, 162. https:\/\/doi.org\/10.1186\/s12967-019-1898-z","journal-title":"Journal of Translational Medicine"},{"key":"1872_CR10","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1530\/JOE-16-0513","volume":"234","author":"CE Geisler","year":"2017","unstructured":"Geisler, C. E., & Renquist, B. J. (2017). Hepatic lipid accumulation: Cause and consequence of dysregulated glucoregulatory hormones. Journal of Endocrinology, 234, R1\u2013R21. https:\/\/doi.org\/10.1530\/JOE-16-0513","journal-title":"Journal of Endocrinology"},{"key":"1872_CR11","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1080\/07435800.2019.1625057","volume":"44","author":"S Ghorabi","year":"2019","unstructured":"Ghorabi, S., Shab-Bidar, S., Sadeghi, O., Nasiri, M., Khatibi, S. R., & Djafarian, K. (2019). Lipid profile and risk of bone fracture: A systematic review and meta-analysis of observational studies. Endocrine Research, 44, 168\u2013184. https:\/\/doi.org\/10.1080\/07435800.2019.1625057","journal-title":"Endocrine Research"},{"key":"1872_CR12","doi-asserted-by":"crossref","unstructured":"Gosling-Gardeniers, A., Rijnen, W., & Gardeniers, J. (2014). The prevalence of osteonecrosis in different parts of the world. (pp. 35\u201337).","DOI":"10.1007\/978-3-642-35767-1_4"},{"key":"1872_CR13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.taap.2012.02.009","volume":"260","author":"M Goutet","year":"2012","unstructured":"Goutet, M., Pepin, E., Langonne, I., Huguet, N., & Ban, M. (2012). Identification of contact and respiratory sensitizers according to IL-4 receptor alpha expression and IL-2 production. Toxicology and Applied Pharmacology, 260, 95\u2013104. https:\/\/doi.org\/10.1016\/j.taap.2012.02.009","journal-title":"Toxicology and Applied Pharmacology"},{"key":"1872_CR14","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/s12944-018-0827-0","volume":"17","author":"Y Hao","year":"2018","unstructured":"Hao, Y., et al. (2018). The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: A meta-analysis. Lipids in Health and Disease, 17, 192. https:\/\/doi.org\/10.1186\/s12944-018-0827-0","journal-title":"Lipids in Health and Disease"},{"key":"1872_CR15","doi-asserted-by":"publisher","first-page":"D440","DOI":"10.1093\/nar\/gkz1019","volume":"48","author":"K Haug","year":"2020","unstructured":"Haug, K., et al. (2020). MetaboLights: A resource evolving in response to the needs of its scientific community. Nucleic Acids Research, 48, D440\u2013D444. https:\/\/doi.org\/10.1093\/nar\/gkz1019","journal-title":"Nucleic Acids Research"},{"key":"1872_CR16","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.cbpb.2019.02.001","volume":"232","author":"X Hu","year":"2019","unstructured":"Hu, X., et al. (2019). Effects of glucocorticoids on lipid metabolism and AMPK in broiler chickens\u2019 liver. Comparative Biochemistry and Physiology Part b: Biochemistry and Molecular Biology, 232, 23\u201330. https:\/\/doi.org\/10.1016\/j.cbpb.2019.02.001","journal-title":"Comparative Biochemistry and Physiology Part b: Biochemistry and Molecular Biology"},{"key":"1872_CR17","doi-asserted-by":"publisher","first-page":"7280342","DOI":"10.1155\/2018\/7280342","volume":"2018","author":"SA Jang","year":"2018","unstructured":"Jang, S. A., et al. (2018). Protocatechuic acid attenuates trabecular bone loss in ovariectomized mice. Oxidative Medicine and Cellular Longevity, 2018, 7280342. https:\/\/doi.org\/10.1155\/2018\/7280342","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"1872_CR18","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/toxsci\/kfn216","volume":"107","author":"FA Jefferson","year":"2009","unstructured":"Jefferson, F. A., Xiao, G. H., & Hein, D. W. (2009). 4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats. Toxicological Sciences, 107, 293\u2013297. https:\/\/doi.org\/10.1093\/toxsci\/kfn216","journal-title":"Toxicological Sciences"},{"key":"1872_CR19","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1093\/rheumatology\/keh721","volume":"44","author":"T Kabata","year":"2005","unstructured":"Kabata, T., et al. (2005). Onset of steroid-induced osteonecrosis in rabbits and its relationship to hyperlipaemia and increased free fatty acids. Rheumatology, 44, 1233\u20131237. https:\/\/doi.org\/10.1093\/rheumatology\/keh721","journal-title":"Rheumatology"},{"key":"1872_CR20","doi-asserted-by":"publisher","first-page":"952943","DOI":"10.1155\/2014\/952943","volume":"2014","author":"S Kakkar","year":"2014","unstructured":"Kakkar, S., & Bais, S. (2014). A review on protocatechuic Acid and its pharmacological potential. ISRN Pharmacology, 2014, 952943. https:\/\/doi.org\/10.1155\/2014\/952943","journal-title":"ISRN Pharmacology"},{"key":"1872_CR21","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1186\/s13287-019-1408-5","volume":"10","author":"J Kim","year":"2019","unstructured":"Kim, J., et al. (2019). Metabolomic profiles of induced pluripotent stem cells derived from patients with rheumatoid arthritis and osteoarthritis. Stem Cell Research & Therapy, 10, 319. https:\/\/doi.org\/10.1186\/s13287-019-1408-5","journal-title":"Stem Cell Research & Therapy"},{"key":"1872_CR22","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/nmeth.2551","volume":"10","author":"T Kind","year":"2013","unstructured":"Kind, T., Liu, K. H., Lee, D. Y., DeFelice, B., Meissen, J. K., & Fiehn, O. (2013). LipidBlast in silico tandem mass spectrometry database for lipid identification. Nature Methods, 10, 755\u2013758. https:\/\/doi.org\/10.1038\/nmeth.2551","journal-title":"Nature Methods"},{"key":"1872_CR23","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1097\/MOL.0b013e3283606845","volume":"24","author":"B Klop","year":"2013","unstructured":"Klop, B., do Rego, A. T., & Cabezas, M. C. (2013). Alcohol and plasma triglycerides. Current Opinion in Lipidology, 24, 321\u2013326. https:\/\/doi.org\/10.1097\/MOL.0b013e3283606845","journal-title":"Current Opinion in Lipidology"},{"key":"1872_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.toxlet.2010.04.003","volume":"196","author":"N Lambrechts","year":"2010","unstructured":"Lambrechts, N., et al. (2010). Gene markers in dendritic cells unravel pieces of the skin sensitization puzzle. Toxicology Letters, 196, 95\u2013103. https:\/\/doi.org\/10.1016\/j.toxlet.2010.04.003","journal-title":"Toxicology Letters"},{"key":"1872_CR25","doi-asserted-by":"publisher","first-page":"196702","DOI":"10.1155\/2015\/196702","volume":"2015","author":"JK Li","year":"2015","unstructured":"Li, J. K., et al. (2015). ADAMTS-7 exhibits elevated expression in cartilage of osteonecrosis of femoral head and has a positive correlation with TNF- alpha and NF- kappa B P65. Mediators of Inflammation, 2015, 196702. https:\/\/doi.org\/10.1155\/2015\/196702","journal-title":"Mediators of Inflammation"},{"key":"1872_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4103\/1735-1995.200273","volume":"22","author":"F Liu","year":"2017","unstructured":"Liu, F., et al. (2017). An epidemiological study of etiology and clinical characteristics in patients with nontraumatic osteonecrosis of the femoral head. Journal of Research in Medical Sciences: THe Official Journal of Isfahan University of Medical Sciences, 22, 15. https:\/\/doi.org\/10.4103\/1735-1995.200273","journal-title":"Journal of Research in Medical Sciences: THe Official Journal of Isfahan University of Medical Sciences"},{"key":"1872_CR27","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1002\/jor.23129","volume":"34","author":"X Liu","year":"2016","unstructured":"Liu, X., et al. (2016). Unique plasma metabolomic signature of osteonecrosis of the femoral head. Journal of Orthopaedic Research, 34, 1158\u20131167. https:\/\/doi.org\/10.1002\/jor.23129","journal-title":"Journal of Orthopaedic Research"},{"key":"1872_CR28","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.abb.2018.07.021","volume":"654","author":"W Luczaj","year":"2018","unstructured":"Luczaj, W., Moniuszko-Malinowska, A., Domingues, P., Domingues, M. R., Gindzienska-Sieskiewicz, E., & Skrzydlewska, E. (2018). Plasma lipidomic profile signature of rheumatoid arthritis versus Lyme arthritis patients. Archives of Biochemistry and Biophysics, 654, 105\u2013114. https:\/\/doi.org\/10.1016\/j.abb.2018.07.021","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"1872_CR29","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1016\/j.clnu.2017.10.008","volume":"37","author":"C Martin-Gonzalez","year":"2018","unstructured":"Martin-Gonzalez, C., et al. (2018). Lipid profile and bone mineral density in heavy alcoholics. Clinical Nutrition, 37, 2137\u20132143. https:\/\/doi.org\/10.1016\/j.clnu.2017.10.008","journal-title":"Clinical Nutrition"},{"key":"1872_CR30","doi-asserted-by":"publisher","first-page":"4561","DOI":"10.4049\/jimmunol.173.7.4561","volume":"173","author":"JM Mason","year":"2004","unstructured":"Mason, J. M., Naidu, M. D., Barcia, M., Porti, D., Chavan, S. S., & Chu, C. C. (2004). IL-4-induced gene-1 is a leukocyte L-amino acid oxidase with an unusual acidic pH preference and lysosomal localization. The Journal of Immunology, 173, 4561\u20134567. https:\/\/doi.org\/10.4049\/jimmunol.173.7.4561","journal-title":"The Journal of Immunology"},{"key":"1872_CR31","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/os.12302","volume":"9","author":"Microsurgery Department of the Orthopedics Branch of the Chinese Medical Doctor, A., O. Group from the, R. Bone Defect Branch of the Chinese Association of, S. Reconstructive, Microsurgery, A. Reconstructive Surgery Group of the Orthopedics Branch of the Chinese Medical","year":"2017","unstructured":"Microsurgery Department of the Orthopedics Branch of the Chinese Medical Doctor, A., O. Group from the, R. Bone Defect Branch of the Chinese Association of, S. Reconstructive, Microsurgery, A. Reconstructive Surgery Group of the Orthopedics Branch of the Chinese Medical. (2017). Chinese guideline for the diagnosis and treatment of osteonecrosis of the femoral head in adults. Orthopaedic Surgery, 9, 3\u201312. https:\/\/doi.org\/10.1111\/os.12302","journal-title":"Orthopaedic Surgery"},{"key":"1872_CR32","doi-asserted-by":"publisher","first-page":"115160","DOI":"10.1016\/j.bone.2019.115160","volume":"131","author":"BH Mishra","year":"2020","unstructured":"Mishra, B. H., et al. (2020). Lipidomic architecture shared by subclinical markers of osteoporosis and atherosclerosis: The Cardiovascular Risk in Young Finns Study. Bone, 131, 115160. https:\/\/doi.org\/10.1016\/j.bone.2019.115160","journal-title":"Bone"},{"key":"1872_CR33","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/s41582-020-0350-6","volume":"16","author":"J Montaner","year":"2020","unstructured":"Montaner, J., et al. (2020). Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke. Nature Reviews Neurology, 16, 247\u2013264. https:\/\/doi.org\/10.1038\/s41582-020-0350-6","journal-title":"Nature Reviews Neurology"},{"key":"1872_CR34","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1002\/ptr.5565","volume":"30","author":"SH Park","year":"2016","unstructured":"Park, S. H., et al. (2016). Protocatechuic acid attenuates osteoclastogenesis by downregulating JNK\/c-Fos\/NFATc1 signaling and prevents inflammatory bone loss in mice. Phytotherapy Research, 30, 604\u2013612. https:\/\/doi.org\/10.1002\/ptr.5565","journal-title":"Phytotherapy Research"},{"key":"1872_CR35","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41580-019-0108-4","volume":"20","author":"MM Rinschen","year":"2019","unstructured":"Rinschen, M. M., Ivanisevic, J., Giera, M., & Siuzdak, G. (2019). Identification of bioactive metabolites using activity metabolomics. Nature Reviews Molecular Cell Biology, 20, 353\u2013367. https:\/\/doi.org\/10.1038\/s41580-019-0108-4","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"1872_CR36","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1194\/jlr.M088559","volume":"60","author":"J Roy","year":"2019","unstructured":"Roy, J., Dibaeinia, P., Fan, T. M., Sinha, S., & Das, A. (2019). Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells. Journal of Lipid Research, 60, 375\u2013387. https:\/\/doi.org\/10.1194\/jlr.M088559","journal-title":"Journal of Lipid Research"},{"key":"1872_CR37","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s00204-017-2082-y","volume":"92","author":"RA Salazar-Gonzalez","year":"2018","unstructured":"Salazar-Gonzalez, R. A., et al. (2018). Arylamine N-acetyltransferase 1 in situ N-acetylation on CD3+ peripheral blood mononuclear cells correlate with NATb mRNA and NAT1 haplotype. Archives of Toxicology, 92, 661\u2013668. https:\/\/doi.org\/10.1007\/s00204-017-2082-y","journal-title":"Archives of Toxicology"},{"key":"1872_CR38","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1136\/annrheumdis-2019-216374","volume":"79","author":"M Souto-Carneiro","year":"2020","unstructured":"Souto-Carneiro, M., et al. (2020). Differences in the serum metabolome and lipidome identify potential biomarkers for seronegative rheumatoid arthritis versus psoriatic arthritis. Annals of the Rheumatic Diseases, 79, 499\u2013506. https:\/\/doi.org\/10.1136\/annrheumdis-2019-216374","journal-title":"Annals of the Rheumatic Diseases"},{"key":"1872_CR39","doi-asserted-by":"publisher","first-page":"e7010016","DOI":"10.3390\/biom7010016","volume":"7","author":"JL Steiner","year":"2017","unstructured":"Steiner, J. L., & Lang, C. H. (2017). Alcohol, adipose tissue and lipid dysregulation. Biomolecules, 7, e7010016. https:\/\/doi.org\/10.3390\/biom7010016","journal-title":"Biomolecules"},{"key":"1872_CR40","doi-asserted-by":"publisher","first-page":"G509","DOI":"10.1152\/ajpgi.00376.2018","volume":"316","author":"PG Thomes","year":"2019","unstructured":"Thomes, P. G., et al. (2019). Ethanol withdrawal mitigates fatty liver by normalizing lipid catabolism. American Journal of Physiology, Gastrointestinal and Liver Physiology, 316, G509\u2013G518. https:\/\/doi.org\/10.1152\/ajpgi.00376.2018","journal-title":"American Journal of Physiology, Gastrointestinal and Liver Physiology"},{"key":"1872_CR41","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11306-017-1304-x","volume":"14","author":"J Tu","year":"2017","unstructured":"Tu, J., Yin, Y., Xu, M., Wang, R., & Zhu, Z. J. (2017). Absolute quantitative lipidomics reveals lipidome-wide alterations in aging brain. Metabolomics, 14, 5. https:\/\/doi.org\/10.1007\/s11306-017-1304-x","journal-title":"Metabolomics"},{"key":"1872_CR42","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1021\/acs.chemrestox.8b00236","volume":"31","author":"Y Uno","year":"2018","unstructured":"Uno, Y., Murayama, N., & Yamazaki, H. (2018). Molecular and functional characterization of N-acetyltransferases NAT1 and NAT2 in cynomolgus macaque. Chemical Research in Toxicology, 31, 1269\u20131276. https:\/\/doi.org\/10.1021\/acs.chemrestox.8b00236","journal-title":"Chemical Research in Toxicology"},{"key":"1872_CR43","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.3389\/fphar.2018.01051","volume":"9","author":"M Wang","year":"2018","unstructured":"Wang, M., et al. (2018). Treatment of rheumatoid arthritis using combination of methotrexate and tripterygium glycosides tablets\u2014A quantitative plasma pharmacochemical and pseudotargeted metabolomic approach. Frontiers in Pharmacology, 9, 1051. https:\/\/doi.org\/10.3389\/fphar.2018.01051","journal-title":"Frontiers in Pharmacology"},{"key":"1872_CR44","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/s13075-016-1139-2","volume":"18","author":"W Wang","year":"2016","unstructured":"Wang, W., et al. (2016). Plasma, urine and ligament tissue metabolite profiling reveals potential biomarkers of ankylosing spondylitis using NMR-based metabolic profiles. Arthritis Research & Therapy, 18, 244. https:\/\/doi.org\/10.1186\/s13075-016-1139-2","journal-title":"Arthritis Research & Therapy"},{"key":"1872_CR45","doi-asserted-by":"publisher","first-page":"e298","DOI":"10.1002\/ctm2.298","volume":"11","author":"XY Wang","year":"2021","unstructured":"Wang, X. Y., et al. (2021). Altered lipidomic profiles in patients with and without osteonecrosis of the femoral head after 1-month glucocorticoid treatment. Clinical and Translational Medicine, 11, e298. https:\/\/doi.org\/10.1002\/ctm2.298","journal-title":"Clinical and Translational Medicine"},{"key":"1872_CR46","first-page":"11332","volume":"8","author":"Y Wang","year":"2015","unstructured":"Wang, Y., et al. (2015). Genetic association of the ApoB and ApoA1 gene polymorphisms with the risk for alcohol-induced osteonecrosis of femoral head. International Journal of Clinical and Experimental Pathology, 8, 11332\u201311339.","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"1872_CR47","doi-asserted-by":"publisher","first-page":"D400","DOI":"10.1093\/nar\/gkr1132","volume":"40","author":"Y Wang","year":"2012","unstructured":"Wang, Y., et al. (2012). PubChem\u2019s BioAssay database. Nucleic Acids Research, 40, D400\u2013D412. https:\/\/doi.org\/10.1093\/nar\/gkr1132","journal-title":"Nucleic Acids Research"},{"key":"1872_CR48","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/s41587-019-0233-9","volume":"37","author":"T Wilmanski","year":"2019","unstructured":"Wilmanski, T., et al. (2019). Blood metabolome predicts gut microbiome alpha-diversity in humans. Nature Biotechnology, 37, 1217\u20131228. https:\/\/doi.org\/10.1038\/s41587-019-0233-9","journal-title":"Nature Biotechnology"},{"key":"1872_CR49","doi-asserted-by":"publisher","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","volume":"46","author":"DS Wishart","year":"2018","unstructured":"Wishart, D. S., et al. (2018). HMDB 4.0: The human metabolome database for 2018. Nucleic Acids Research, 46, D608\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkx1089","journal-title":"Nucleic Acids Research"},{"key":"1872_CR50","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.biopha.2016.05.008","volume":"82","author":"YX Wu","year":"2016","unstructured":"Wu, Y. X., et al. (2016). Protocatechuic acid inhibits osteoclast differentiation and stimulates apoptosis in mature osteoclasts. Biomedicine & Pharmacotherapy, 82, 399\u2013405. https:\/\/doi.org\/10.1016\/j.biopha.2016.05.008","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"1872_CR51","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s11306-019-1491-8","volume":"15","author":"G Yang","year":"2019","unstructured":"Yang, G., et al. (2019). Global urinary metabolic profiling of the osteonecrosis of the femoral head based on UPLC-QTOF\/MS. Metabolomics, 15, 26. https:\/\/doi.org\/10.1007\/s11306-019-1491-8","journal-title":"Metabolomics"},{"key":"1872_CR52","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.arth.2019.11.029","volume":"35","author":"BH Yoon","year":"2020","unstructured":"Yoon, B. H., et al. (2020). The 2019 revised version of association research circulation osseous staging system of osteonecrosis of the femoral head. Journal of Arthroplasty, 35, 933\u2013940. https:\/\/doi.org\/10.1016\/j.arth.2019.11.029","journal-title":"Journal of Arthroplasty"},{"key":"1872_CR53","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jhep.2018.10.037","volume":"70","author":"M You","year":"2019","unstructured":"You, M., & Arteel, G. E. (2019). Effect of ethanol on lipid metabolism. Journal of Hepatology, 70, 237\u2013248. https:\/\/doi.org\/10.1016\/j.jhep.2018.10.037","journal-title":"Journal of Hepatology"},{"key":"1872_CR54","doi-asserted-by":"publisher","first-page":"e5407","DOI":"10.1097\/MD.0000000000005407","volume":"95","author":"Y Yu","year":"2016","unstructured":"Yu, Y., et al. (2016). Single-nucleotide polymorphisms of MMP2 in MMP\/TIMP pathways associated with the risk of alcohol-induced osteonecrosis of the femoral head in Chinese males: A case-control study. Medicine, 95, e5407. https:\/\/doi.org\/10.1097\/MD.0000000000005407","journal-title":"Medicine"},{"key":"1872_CR55","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.2147\/JPR.S143036","volume":"10","author":"YB Yue","year":"2017","unstructured":"Yue, Y. B., Liu, X., & Wei, B. F. (2017). Attenuated serum adiponectin levels are associated with disease severity in patients with non-traumatic osteonecrosis of the femoral head. Journal of Pain Research, 10, 2387\u20132393. https:\/\/doi.org\/10.2147\/JPR.S143036","journal-title":"Journal of Pain Research"},{"key":"1872_CR56","doi-asserted-by":"publisher","first-page":"232","DOI":"10.3892\/etm.2019.8189","volume":"19","author":"J Zhang","year":"2020","unstructured":"Zhang, J., Fu, B., Chen, X., Chen, D., & Yang, H. (2020). Protocatechuic acid attenuates anterior cruciate ligament transection-induced osteoarthritis by suppressing osteoclastogenesis. Experimental and Therapeutic Medicine, 19, 232\u2013240. https:\/\/doi.org\/10.3892\/etm.2019.8189","journal-title":"Experimental and Therapeutic Medicine"},{"key":"1872_CR57","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1177\/0300060517700299","volume":"46","author":"Q Zhang","year":"2018","unstructured":"Zhang, Q., Lv, J., & Jin, L. (2018a). Role of coagulopathy in glucocorticoid-induced osteonecrosis of the femoral head. Journal of International Medical Research, 46, 2141\u20132148. https:\/\/doi.org\/10.1177\/0300060517700299","journal-title":"Journal of International Medical Research"},{"key":"1872_CR58","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.4103\/0366-6999.244111","volume":"131","author":"QY Zhang","year":"2018","unstructured":"Zhang, Q. Y., Li, Z. R., Gao, F. Q., & Sun, W. (2018b). Pericollapse stage of osteonecrosis of the femoral head: A last chance for joint preservation. Chinese Medical Journal, 131, 2589\u20132598. https:\/\/doi.org\/10.4103\/0366-6999.244111","journal-title":"Chinese Medical Journal"},{"key":"1872_CR59","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jot.2019.12.004","volume":"21","author":"D Zhao","year":"2020","unstructured":"Zhao, D., et al. (2020). Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version). Journal of Orthopaedic Translation, 21, 100\u2013110. https:\/\/doi.org\/10.1016\/j.jot.2019.12.004","journal-title":"Journal of Orthopaedic Translation"},{"key":"1872_CR60","doi-asserted-by":"publisher","first-page":"16456","DOI":"10.1038\/s41598-018-34574-6","volume":"8","author":"H Zhao","year":"2018","unstructured":"Zhao, H., et al. (2018). Integrative bone metabolomics-lipidomics strategy for pathological mechanism of postmenopausal osteoporosis mouse model. Science and Reports, 8, 16456. https:\/\/doi.org\/10.1038\/s41598-018-34574-6","journal-title":"Science and Reports"},{"key":"1872_CR61","doi-asserted-by":"publisher","first-page":"635","DOI":"10.2310\/JIM.0000000000000050","volume":"62","author":"L Zheng","year":"2014","unstructured":"Zheng, L., et al. (2014). Plasma interleukin 33 level in patients with osteonecrosis of femoral head: An alarmin for osteonecrosis of the femoral head? Journal of Investigative Medicine, 62, 635\u2013637. https:\/\/doi.org\/10.2310\/JIM.0000000000000050","journal-title":"Journal of Investigative Medicine"},{"key":"1872_CR62","doi-asserted-by":"publisher","first-page":"8928934","DOI":"10.1155\/2019\/8928934","volume":"2019","author":"T Zhou","year":"2019","unstructured":"Zhou, T., Yang, Y., Chen, Q., & Xie, L. (2019). Glutamine metabolism is essential for stemness of bone marrow mesenchymal stem cells and bone homeostasis. Stem Cells International, 2019, 8928934. https:\/\/doi.org\/10.1155\/2019\/8928934","journal-title":"Stem Cells International"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-022-01872-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-022-01872-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-022-01872-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T04:11:45Z","timestamp":1646021505000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-022-01872-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["1872"],"URL":"https:\/\/doi.org\/10.1007\/s11306-022-01872-0","relation":{},"ISSN":["1573-3882","1573-3890"],"issn-type":[{"value":"1573-3882","type":"print"},{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"31 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"14"}}