{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T11:07:03Z","timestamp":1772881623181,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:00:00Z","timestamp":1681516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:00:00Z","timestamp":1681516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"DOI":"10.1007\/s11306-023-01988-x","type":"journal-article","created":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T08:02:16Z","timestamp":1681545736000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fetal effects of mild maternal COVID-19 infection: metabolomic profiling of cord blood"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4286-7481","authenticated-orcid":false,"given":"Onur","family":"Turkoglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Alhousseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Sajja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Idler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Stuart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Ashrafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Wharton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stewart F.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray O.","family":"Bahado-Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,4,15]]},"reference":[{"key":"1988_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/sj.mp.4001748","volume":"11","author":"H Ashdown","year":"2006","unstructured":"Ashdown, H., Dumont, Y., Ng, M., Poole, S., Boksa, P., & Luheshi, G. N. (2006). The role of cytokines in mediating effects of prenatal infection on the fetus: Implications for schizophrenia. Molecular Psychiatry, 11, 47\u201355.","journal-title":"Molecular Psychiatry"},{"key":"1988_CR2","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1159\/000513545","volume":"30","author":"H Ashrafian","year":"2021","unstructured":"Ashrafian, H., Sounderajah, V., Glen, R., Ebbels, T., Blaise, B. J., Kalra, D., Kultima, K., Spjuth, O., Tenori, L., Salek, R. M., Kale, N., Haug, K., Schober, D., Rocca-Serra, P., O\u2019Donovan, C., Steinbeck, C., Cano, I., de Atauri, P., & Cascante, M. (2021). Metabolomics: The stethoscope for the twenty-first century. Medical Principles and Practice, 30, 301\u2013310.","journal-title":"Medical Principles and Practice"},{"key":"1988_CR3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.15585\/mmwr.mm7102e2","volume":"71","author":"CE Barrett","year":"2022","unstructured":"Barrett, C. E., Koyama, A. K., Alvarez, P., Chow, W., Lundeen, E. A., Perrine, C. G., Pavkov, M. E., Rolka, D. B., Wiltz, J. L., Bull-Otterson, L., Gray, S., Boehmer, T. K., Gundlapalli, A. V., Siegel, D. A., Kompaniyets, L., Goodman, A. B., Mahon, B. E., Tauxe, R. V., Remley, K., & Saydah, S. (2022). Risk for newly diagnosed diabetes >30 days after SARS-CoV-2 infection among persons aged <18 years\u2014United States, March 1, 2020\u2013June 28, 2021. MMWR. Morbidity and Mortality Weekly Report, 71, 59\u201365.","journal-title":"MMWR. Morbidity and Mortality Weekly Report"},{"key":"1988_CR4","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1210\/er.2013-1012","volume":"34","author":"T Braun","year":"2013","unstructured":"Braun, T., Challis, J. R., Newnham, J. P., & Sloboda, D. M. (2013). Early-life glucocorticoid exposure: The hypothalamic-pituitary-adrenal axis, placental function, and long-term disease risk. Endocrine Reviews, 34, 885\u2013916.","journal-title":"Endocrine Reviews"},{"key":"1988_CR5","doi-asserted-by":"publisher","first-page":"e0186656","DOI":"10.1371\/journal.pone.0186656","volume":"12","author":"AG Brown","year":"2017","unstructured":"Brown, A. G., Tulina, N. M., Barila, G. O., Hester, M. S., & Elovitz, M. A. (2017). Exposure to intrauterine inflammation alters metabolomic profiles in the amniotic fluid, fetal and neonatal brain in the mouse. PLoS ONE, 12, e0186656.","journal-title":"PLoS ONE"},{"key":"1988_CR6","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1038\/s41467-020-16754-z","volume":"11","author":"Q Chen","year":"2020","unstructured":"Chen, Q., Gouilly, J., Ferrat, Y. J., Espino, A., Glaziou, Q., Cartron, G., El Costa, H., Al-Daccak, R., & Jabrane-Ferrat, N. (2020). Metabolic reprogramming by Zika virus provokes inflammation in human placenta. Nature Communications, 11, 2967.","journal-title":"Nature Communications"},{"key":"1988_CR7","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.3390\/ijms21031019","volume":"21","author":"I Del Gaudio","year":"2020","unstructured":"Del Gaudio, I., Sasset, L., Lorenzo, A. D., & Wadsack, C. (2020). Sphingolipid signature of human feto-placental vasculature in preeclampsia. International Journal of Molecular Science, 21, 1019.","journal-title":"International Journal of Molecular Science"},{"key":"1988_CR8","doi-asserted-by":"publisher","first-page":"769","DOI":"10.15585\/mmwr.mm6925a1","volume":"69","author":"S Ellington","year":"2020","unstructured":"Ellington, S., Strid, P., Tong, V. T., Woodworth, K., Galang, R. R., Zambrano, L. D., Nahabedian, J., Anderson, K., & Gilboa, S. M. (2020). Characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status\u2014United States, January 22\u2013June 7, 2020. MMWR. Morbidity and Mortality Weekly Report, 69, 769\u2013775.","journal-title":"MMWR. Morbidity and Mortality Weekly Report"},{"key":"1988_CR9","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1183\/09031936.00089807","volume":"31","author":"CR Esther Jr","year":"2008","unstructured":"Esther, C. R., Jr., Alexis, N. E., Clas, M. L., Lazarowski, E. R., Donaldson, S. H., Ribeiro, C. M., Moore, C. G., Davis, S. D., & Boucher, R. C. (2008). Extracellular purines are biomarkers of neutrophilic airway inflammation. European Respiratory Journal, 31, 949\u2013956.","journal-title":"European Respiratory Journal"},{"key":"1988_CR10","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/aja.1001570304","volume":"157","author":"AG Farr","year":"1980","unstructured":"Farr, A. G., Cho, Y., & De Bruyn, P. P. (1980). The structure of the sinus wall of the lymph node relative to its endocytic properties and transmural cell passage. The American Journal of Anatomy, 157, 265\u2013284.","journal-title":"The American Journal of Anatomy"},{"key":"1988_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s11306-005-1102-8","volume":"1","author":"JB German","year":"2005","unstructured":"German, J. B., Hammock, B. D., & Watkins, S. M. (2005). Metabolomics: Building on a century of biochemistry to guide human health. Metabolomics, 1, 3\u20139.","journal-title":"Metabolomics"},{"key":"1988_CR12","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1067\/mob.2000.106180","volume":"182","author":"MG Gravett","year":"2000","unstructured":"Gravett, M. G., Hitti, J., Hess, D. L., & Eschenbach, D. A. (2000). Intrauterine infection and preterm delivery: Evidence for activation of the fetal hypothalamic-pituitary-adrenal axis. American Journal of Obstetrics and Gynecology, 182, 1404\u20131413.","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"144\u2013149","key":"1988_CR13","first-page":"e1","volume":"203","author":"R Kadakia","year":"2018","unstructured":"Kadakia, R., Scholtens, D. M., Rouleau, G. W., Talbot, O., Ilkayeva, O. R., George, T., & Josefson, J. L. (2018). Cord blood metabolites associated with newborn adiposity and hyperinsulinemia. Journal of Pediatrics, 203(144\u2013149), e1.","journal-title":"Journal of Pediatrics"},{"key":"1988_CR14","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/bioinformatics\/btr661","volume":"28","author":"A Karnovsky","year":"2012","unstructured":"Karnovsky, A., Weymouth, T., Hull, T., Tarcea, V. G., Scardoni, G., Laudanna, C., Sartor, M. A., Stringer, K. A., Jagadish, H. V., & Burant, C. (2012). Metscape 2 bioinformatics tool for the analysis and visualization of metabolomics and gene expression data. Bioinformatics, 28, 373\u2013380.","journal-title":"Bioinformatics"},{"key":"1988_CR15","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1042\/cs1010739","volume":"101","author":"S Khani","year":"2001","unstructured":"Khani, S., & Tayek, J. A. (2001). Cortisol increases gluconeogenesis in humans: Its role in the metabolic syndrome. Clinical Science (london, England), 101, 739\u2013747.","journal-title":"Clinical Science (london, England)"},{"key":"1988_CR16","doi-asserted-by":"publisher","first-page":"20866","DOI":"10.1038\/s41598-021-00286-7","volume":"11","author":"MM Khodadoust","year":"2021","unstructured":"Khodadoust, M. M. (2021). Inferring a causal relationship between ceramide levels and COVID-19 respiratory distress. Science and Reports, 11, 20866.","journal-title":"Science and Reports"},{"key":"1988_CR17","doi-asserted-by":"publisher","first-page":"4442","DOI":"10.1021\/acs.jproteome.0c00519","volume":"19","author":"T Kimhofer","year":"2020","unstructured":"Kimhofer, T., Lodge, S., Whiley, L., Gray, N., Loo, R. L., Lawler, N. G., Nitschke, P., Bong, S. H., Morrison, D. L., Begum, S., Richards, T., Yeap, B. B., Smith, C., Smith, K. G. C., Holmes, E., & Nicholson, J. K. (2020). Integrative modeling of quantitative plasma lipoprotein, metabolic, and amino acid data reveals a multiorgan pathological signature of SARS-CoV-2 infection. Journal of Proteome Research, 19, 4442\u20134454.","journal-title":"Journal of Proteome Research"},{"key":"1988_CR18","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41380-021-01309-5","volume":"27","author":"J Kornhuber","year":"2021","unstructured":"Kornhuber, J., Hoertel, N., & Gulbins, E. (2021). The acid sphingomyelinase\/ceramide system in COVID-19. Molecular Psychiatry, 27, 307.","journal-title":"Molecular Psychiatry"},{"key":"1988_CR19","doi-asserted-by":"publisher","first-page":"E282","DOI":"10.1152\/ajpendo.00328.2005","volume":"290","author":"I Kossintseva","year":"2006","unstructured":"Kossintseva, I., Wong, S., Johnstone, E., Guilbert, L., Olson, D. M., & Mitchell, B. F. (2006). Proinflammatory cytokines inhibit human placental 11beta-hydroxysteroid dehydrogenase type 2 activity through Ca2+ and cAMP pathways. American Journal of Physiology. Endocrinology and Metabolism, 290, E282\u2013E288.","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"key":"1988_CR20","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftx093","author":"M Leon-Juarez","year":"2017","unstructured":"Leon-Juarez, M., Martinez-Castillo, M., Gonzalez-Garcia, L. D., Helguera-Repetto, A. C., Zaga-Clavellina, V., Garcia-Cordero, J., Flores-Pliego, A., Herrera-Salazar, A., Vazquez-Martinez, E. R., & Reyes-Munoz, E. (2017). Cellular and molecular mechanisms of viral infection in the human placenta. Pathogens and Disease. https:\/\/doi.org\/10.1093\/femspd\/ftx093","journal-title":"Pathogens and Disease"},{"key":"1988_CR21","doi-asserted-by":"publisher","first-page":"77.e1","DOI":"10.1016\/j.ajog.2020.12.1221","volume":"225","author":"EM Lokken","year":"2021","unstructured":"Lokken, E. M., Huebner, E. M., Taylor, G. G., Hendrickson, S., Vanderhoeven, J., Kachikis, A., Coler, B., Walker, C. L., Sheng, J. S., Al-Haddad, B. J. S., McCartney, S. A., Kretzer, N. M., Resnick, R., Barnhart, N., Schulte, V., Bergam, B., Ma, K. K., Albright, C., Larios, V., \u2026 Adams Waldorf, K. M. (2021). Disease severity, pregnancy outcomes, and maternal deaths among pregnant patients with severe acute respiratory syndrome coronavirus 2 infection in Washington State. American Journal of Obstetrics and Gynecology, 225, 77.e1-77.e14.","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"1988_CR22","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/j.1442-200x.2004.02002.x","volume":"47","author":"M Manabe","year":"2005","unstructured":"Manabe, M., Nishida, T., Imai, T., Kusaka, T., Kawada, K., Okada, H., Okubo, K., Isobe, K., & Itoh, S. (2005). Cortisol levels in umbilical vein and umbilical artery with or without antenatal corticosteroids. Pediatrics International, 47, 60\u201363.","journal-title":"Pediatrics International"},{"key":"1988_CR23","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1515\/cclm-2021-0414","volume":"59","author":"M Mussap","year":"2021","unstructured":"Mussap, M., & Fanos, V. (2021). Could metabolomics drive the fate of COVID-19 pandemic? A narrative review on lights and shadows. Clinical Chemistry and Laboratory Medicine, 59, 1891\u20131905.","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"key":"1988_CR24","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1001\/jama.2021.5775","volume":"325","author":"M Norman","year":"2021","unstructured":"Norman, M., Naver, L., Soderling, J., Ahlberg, M., Hervius Askling, H., Aronsson, B., Bystrom, E., Jonsson, J., Sengpiel, V., Ludvigsson, J. F., Hakansson, S., & Stephansson, O. (2021). Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes. JAMA, 325, 2076\u20132086.","journal-title":"JAMA"},{"key":"1988_CR25","doi-asserted-by":"publisher","first-page":"W388","DOI":"10.1093\/nar\/gkab382","volume":"49","author":"Z Pang","year":"2021","unstructured":"Pang, Z., Chong, J., Zhou, G., de Lima Morais, D. A., Chang, L., Barrette, M., Gauthier, C., Jacques, P. E., Li, S., & Xia, J. (2021). MetaboAnalyst 5.0: Narrowing the gap between raw spectra and functional insights. Nucleic Acids Research, 49, W388\u2013W396.","journal-title":"Nucleic Acids Research"},{"key":"1988_CR26","doi-asserted-by":"publisher","first-page":"e0124219","DOI":"10.1371\/journal.pone.0124219","volume":"10","author":"S Ravanbakhsh","year":"2015","unstructured":"Ravanbakhsh, S., Liu, P., Bjordahl, T. C., Mandal, R., Grant, J. R., Wilson, M., Eisner, R., Sinelnikov, I., Hu, X., Luchinat, C., Greiner, R., & Wishart, D. S. (2015). Accurate, fully-automated NMR spectral profiling for metabolomics. PLoS ONE, 10, e0124219.","journal-title":"PLoS ONE"},{"key":"1988_CR27","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0171-2985(99)80072-2","volume":"200","author":"P Reissland","year":"1999","unstructured":"Reissland, P., & Wandinger, K. P. (1999). Increased cortisol levels in human umbilical cord blood inhibit interferon alpha production of neonates. Immunobiology, 200, 227\u2013233.","journal-title":"Immunobiology"},{"key":"1988_CR28","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.ajog.2021.03.001","volume":"224","author":"JI Rosenbloom","year":"2021","unstructured":"Rosenbloom, J. I., Raghuraman, N., Carter, E. B., & Kelly, J. C. (2021). Coronavirus disease 2019 infection and hypertensive disorders of pregnancy. American Journal of Obstetrics and Gynecology, 224, 623\u2013624.","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"1988_CR29","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3390\/jpm11060483","volume":"11","author":"M Saadaoui","year":"2021","unstructured":"Saadaoui, M., Kumar, M., & Al Khodor, S. (2021). COVID-19 infection during pregnancy: Risk of vertical transmission, fetal, and neonatal outcomes. Journal of Personalized Medicine, 11, 483.","journal-title":"Journal of Personalized Medicine"},{"key":"1988_CR30","doi-asserted-by":"publisher","first-page":"103185","DOI":"10.1016\/j.jri.2020.103185","volume":"142","author":"PD Shallie","year":"2020","unstructured":"Shallie, P. D., Margolis, D., Shallie, O. F., & Naicker, T. (2020). Placental 11beta-HSD2 downregulated in HIV associated preeclampsia. Journal of Reproductive Immunology, 142, 103185.","journal-title":"Journal of Reproductive Immunology"},{"key":"1988_CR31","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12915-019-0678-9","volume":"17","author":"SK Thaker","year":"2019","unstructured":"Thaker, S. K., Ch\u2019ng, J., & Christofk, H. R. (2019). Viral hijacking of cellular metabolism. BMC Biology, 17, 59.","journal-title":"BMC Biology"},{"key":"1988_CR32","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1080\/21505594.2018.1504558","volume":"9","author":"I Trus","year":"2018","unstructured":"Trus, I., Darbellay, J., Huang, Y., Gilmour, M., Safronetz, D., Gerdts, V., & Karniychuk, U. (2018). Persistent Zika virus infection in porcine conceptuses is associated with elevated in utero cortisol levels. Virulence, 9, 1338\u20131343.","journal-title":"Virulence"},{"key":"1988_CR33","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1152\/physrev.00024.2020","volume":"101","author":"EAN Wastnedge","year":"2021","unstructured":"Wastnedge, E. A. N., Reynolds, R. M., van Boeckel, S. R., Stock, S. J., Denison, F. C., Maybin, J. A., & Critchley, H. O. D. (2021). Pregnancy and COVID-19. Physiological Reviews, 101, 303\u2013318.","journal-title":"Physiological Reviews"},{"key":"1988_CR34","volume-title":"WHO COVID-19 dashboard","author":"WHO","year":"2019","unstructured":"WHO. (2019). WHO COVID-19 dashboard. World Health Organization."},{"key":"1988_CR35","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.4155\/bio.11.155","volume":"3","author":"DS Wishart","year":"2011","unstructured":"Wishart, D. S. (2011). Advances in metabolite identification. Bioanalysis, 3, 1769\u20131782.","journal-title":"Bioanalysis"},{"key":"1988_CR36","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3390\/diagnostics11010094","volume":"11","author":"YP Wong","year":"2021","unstructured":"Wong, Y. P., Khong, T. Y., & Tan, G. C. (2021). The effects of COVID-19 on placenta and pregnancy: What do we know so far? Diagnostics (basel), 11, 94.","journal-title":"Diagnostics (basel)"},{"key":"1988_CR37","doi-asserted-by":"publisher","first-page":"W127","DOI":"10.1093\/nar\/gks374","volume":"40","author":"J Xia","year":"2012","unstructured":"Xia, J., Mandal, R., Sinelnikov, I. V., Broadhurst, D., & Wishart, D. S. (2012). MetaboAnalyst 2.0\u2014a comprehensive server for metabolomic data analysis. Nucleic Acids Research, 40, W127\u2013W133.","journal-title":"Nucleic Acids Research"},{"key":"1988_CR38","doi-asserted-by":"publisher","first-page":"W652","DOI":"10.1093\/nar\/gkp356","volume":"37","author":"J Xia","year":"2009","unstructured":"Xia, J., Psychogios, N., Young, N., & Wishart, D. S. (2009). MetaboAnalyst: A web server for metabolomic data analysis and interpretation. Nucleic Acids Research, 37, W652\u2013W660.","journal-title":"Nucleic Acids Research"},{"key":"1988_CR39","doi-asserted-by":"publisher","first-page":"423","DOI":"10.21037\/tp-20-144","volume":"10","author":"J Yuan","year":"2021","unstructured":"Yuan, J., Qian, H., Cao, S., Dong, B., Yan, X., Luo, S., Zhou, M., Zhou, S., Ning, B., & Zhao, L. (2021). Is there possibility of vertical transmission of COVID-19: A systematic review. Translational Pediatrics, 10, 423\u2013434.","journal-title":"Translational Pediatrics"},{"key":"1988_CR40","doi-asserted-by":"publisher","first-page":"4948","DOI":"10.1111\/jcmm.13759","volume":"22","author":"O Zhenyukh","year":"2018","unstructured":"Zhenyukh, O., Gonzalez-Amor, M., Rodrigues-Diez, R. R., Esteban, V., Ruiz-Ortega, M., Salaices, M., Mas, S., Briones, A. M., & Egido, J. (2018). Branched-chain amino acids promote endothelial dysfunction through increased reactive oxygen species generation and inflammation. Journal of Cellular and Molecular Medicine, 22, 4948\u20134962.","journal-title":"Journal of Cellular and Molecular Medicine"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-023-01988-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-023-01988-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-023-01988-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T02:33:50Z","timestamp":1682044430000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-023-01988-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,15]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["1988"],"URL":"https:\/\/doi.org\/10.1007\/s11306-023-01988-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-1980228\/v1","asserted-by":"object"}]},"ISSN":["1573-3890"],"issn-type":[{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,15]]},"assertion":[{"value":"20 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"S.F.G. has received commercial support as a consultant from Biogen, Roche, Iollo and Coleman Research. The remaining authors report no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving in human and animal participants"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"41"}}