{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:38:43Z","timestamp":1778798323409,"version":"3.51.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The Performance Incentive Guidance for Scientific Research Institution of Chongqing","award":["No. cstc2020jxjl130013"],"award-info":[{"award-number":["No. cstc2020jxjl130013"]}]},{"name":"The Fundamental Research Funds for the Central University","award":["No. 2019CDYGZD002"],"award-info":[{"award-number":["No. 2019CDYGZD002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"DOI":"10.1007\/s11306-023-02023-9","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T08:01:41Z","timestamp":1686211301000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Mitochondrial damage-induced abnormal glucose metabolism with ageing in the hippocampus of APP\/PS1 mice"],"prefix":"10.1007","volume":"19","author":[{"given":"Shijie","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanlin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoju","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"2023_CR2","doi-asserted-by":"publisher","first-page":"100940","DOI":"10.1016\/j.arr.2019.100940","volume":"54","author":"M Akbari","year":"2019","unstructured":"Akbari, M., Kirkwood, T. B. L., & Bohr, V. A. (2019). Mitochondria in the signaling pathways that control longevity and health span. Ageing Research Reviews, 54, 100940. https:\/\/doi.org\/10.1016\/j.arr.2019.100940.","journal-title":"Ageing Research Reviews"},{"key":"2023_CR3","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.jalz.2017.09.011","volume":"14","author":"Y An","year":"2018","unstructured":"An, Y., et al. (2018). Evidence for brain glucose dysregulation in Alzheimer\u2019s disease. Alzheimers Dement, 14, 318\u2013329. https:\/\/doi.org\/10.1016\/j.jalz.2017.09.011.","journal-title":"Alzheimers Dement"},{"key":"2023_CR4","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.stemcr.2021.01.019","volume":"16","author":"KR Babcock","year":"2021","unstructured":"Babcock, K. R., Page, J. S., Fallon, J. R., & Webb, A. E. (2021). Adult hippocampal neurogenesis in aging and Alzheimer\u2019s Disease. Stem Cell Reports, 16, 681\u2013693. https:\/\/doi.org\/10.1016\/j.stemcr.2021.01.019.","journal-title":"Stem Cell Reports"},{"key":"2023_CR5","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/s41591-020-0781-z","volume":"26","author":"NR Barthelemy","year":"2020","unstructured":"Barthelemy, N. R., et al. (2020). A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer\u2019s disease. Nature Medicine, 26, 398\u2013407. https:\/\/doi.org\/10.1038\/s41591-020-0781-z.","journal-title":"Nature Medicine"},{"key":"2023_CR6","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1080\/15548627.2020.1728095","volume":"17","author":"I Benito-Cuesta","year":"2021","unstructured":"Benito-Cuesta, I., Ordonez-Gutierrez, L., & Wandosell, F. (2021). AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: Different impact on beta-amyloid clearance. Autophagy, 17, 656\u2013671. https:\/\/doi.org\/10.1080\/15548627.2020.1728095.","journal-title":"Autophagy"},{"key":"2023_CR7","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1002\/mds.28194","volume":"35","author":"V Bharat","year":"2020","unstructured":"Bharat, V., & Wang, X. (2020). Precision Neurology for Parkinson\u2019s Disease: Coupling Miro1-Based diagnosis with Drug Discovery. Movement Disorders, 35, 1502\u20131508. https:\/\/doi.org\/10.1002\/mds.28194.","journal-title":"Movement Disorders"},{"key":"2023_CR8","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","volume":"20","author":"DA Butterfield","year":"2019","unstructured":"Butterfield, D. A., & Halliwell, B. (2019). Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nature Reviews Neuroscience, 20, 148\u2013160. https:\/\/doi.org\/10.1038\/s41583-019-0132-6.","journal-title":"Nature Reviews Neuroscience"},{"key":"2023_CR9","doi-asserted-by":"publisher","unstructured":"Cai, Q., & Jeong, Y. Y. (2020). Mitophagy in Alzheimer\u2019s Disease and other Age-Related neurodegenerative Diseases. Cells, 9, https:\/\/doi.org\/10.3390\/cells9010150.","DOI":"10.3390\/cells9010150"},{"key":"2023_CR10","doi-asserted-by":"publisher","first-page":"5731","DOI":"10.1038\/s41467-020-19547-6","volume":"11","author":"X Cen","year":"2020","unstructured":"Cen, X., et al. (2020). Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer\u2019s disease mouse model. Nature Communications, 11, 5731. https:\/\/doi.org\/10.1038\/s41467-020-19547-6.","journal-title":"Nature Communications"},{"key":"2023_CR11","doi-asserted-by":"publisher","first-page":"793","DOI":"10.3233\/JAD-170613","volume":"61","author":"YL Chai","year":"2018","unstructured":"Chai, Y. L., et al. (2018). Mitochondrial translocase of the outer membrane alterations may underlie dysfunctional oxidative phosphorylation in Alzheimer\u2019s Disease. Journal Of Alzheimer\u2019S Disease, 61, 793\u2013801. https:\/\/doi.org\/10.3233\/JAD-170613.","journal-title":"Journal Of Alzheimer\u2019S Disease"},{"key":"2023_CR12","doi-asserted-by":"publisher","first-page":"551","DOI":"10.3233\/JAD-180202","volume":"64","author":"E Croteau","year":"2018","unstructured":"Croteau, E., et al. (2018). Ketogenic medium chain triglycerides increase Brain Energy Metabolism in Alzheimer\u2019s Disease. Journal Of Alzheimer\u2019S Disease, 64, 551\u2013561. https:\/\/doi.org\/10.3233\/JAD-180202.","journal-title":"Journal Of Alzheimer\u2019S Disease"},{"key":"2023_CR13","doi-asserted-by":"publisher","unstructured":"Eysert, F., Kinoshita, P. F., Mary, A., Vaillant-Beuchot, L., Checler, F., & Chami, M. (2020). Molecular Dysfunctions of Mitochondria-Associated membranes (MAMs) in Alzheimer\u2019s Disease. International Journal Of Molecular Sciences, 21, https:\/\/doi.org\/10.3390\/ijms21249521.","DOI":"10.3390\/ijms21249521"},{"key":"2023_CR14","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","volume":"22","author":"EF Fang","year":"2019","unstructured":"Fang, E. F., et al. (2019). Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease. Nature Neuroscience, 22, 401\u2013412. https:\/\/doi.org\/10.1038\/s41593-018-0332-9.","journal-title":"Nature Neuroscience"},{"key":"2023_CR15","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1152\/physrev.00015.2020","volume":"101","author":"C Ferrari","year":"2021","unstructured":"Ferrari, C., & Sorbi, S. (2021). The complexity of Alzheimer\u2019s disease: An evolving puzzle. Physiological Reviews, 101, 1047\u20131081. https:\/\/doi.org\/10.1152\/physrev.00015.2020.","journal-title":"Physiological Reviews"},{"key":"2023_CR16","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jchromb.2017.12.021","volume":"1077\u20131078","author":"H Gao","year":"2018","unstructured":"Gao, H., et al. (2018). Quantitative GC-MS assay of citric acid from humans and db\/db mice blood serum to assist the diagnosis of diabetic nephropathy. Journal Of Chromatography. B, Analytical Technologies In The Biomedical And Life Sciences, 1077\u20131078, 28\u201334. https:\/\/doi.org\/10.1016\/j.jchromb.2017.12.021.","journal-title":"Journal Of Chromatography. B, Analytical Technologies In The Biomedical And Life Sciences"},{"key":"2023_CR17","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","volume":"15","author":"Y Hou","year":"2019","unstructured":"Hou, Y., et al. (2019). Ageing as a risk factor for neurodegenerative disease. Nat Rev Neurol, 15, 565\u2013581. https:\/\/doi.org\/10.1038\/s41582-019-0244-7.","journal-title":"Nat Rev Neurol"},{"key":"2023_CR18","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.neures.2020.01.016","volume":"159","author":"Y Imai","year":"2020","unstructured":"Imai, Y. (2020). PINK1-Parkin signaling in Parkinson\u2019s disease: Lessons from Drosophila. Neuroscience Research, 159, 40\u201346. https:\/\/doi.org\/10.1016\/j.neures.2020.01.016.","journal-title":"Neuroscience Research"},{"key":"2023_CR19","doi-asserted-by":"publisher","first-page":"3885","DOI":"10.1038\/s41467-019-11813-6","volume":"10","author":"P Jadiya","year":"2019","unstructured":"Jadiya, P., et al. (2019). Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer\u2019s disease. Nature Communications, 10, 3885. https:\/\/doi.org\/10.1038\/s41467-019-11813-6.","journal-title":"Nature Communications"},{"key":"2023_CR20","doi-asserted-by":"publisher","first-page":"613","DOI":"10.14348\/molcells.2017.0096","volume":"40","author":"S Jeong","year":"2017","unstructured":"Jeong, S. (2017). Molecular and Cellular basis of Neurodegeneration in Alzheimer\u2019s Disease. Molecules And Cells, 40, 613\u2013620. https:\/\/doi.org\/10.14348\/molcells.2017.0096.","journal-title":"Molecules And Cells"},{"key":"2023_CR21","doi-asserted-by":"publisher","first-page":"101208","DOI":"10.1016\/j.arr.2020.101208","volume":"65","author":"A John","year":"2021","unstructured":"John, A., & Reddy, P. H. (2021). Synaptic basis of Alzheimer\u2019s disease: Focus on synaptic amyloid beta, P-tau and mitochondria. Ageing Research Reviews, 65, 101208. https:\/\/doi.org\/10.1016\/j.arr.2020.101208.","journal-title":"Ageing Research Reviews"},{"key":"2023_CR22","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.cell.2011.10.028","volume":"147","author":"LA Kane","year":"2011","unstructured":"Kane, L. A., & Youle, R. J. (2011). PINK1 and parkin flag miro to direct mitochondrial traffic. Cell, 147, 721\u2013723. https:\/\/doi.org\/10.1016\/j.cell.2011.10.028.","journal-title":"Cell"},{"key":"2023_CR23","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10571-016-0386-8","volume":"37","author":"Q Li","year":"2017","unstructured":"Li, Q., Liu, Y., & Sun, M. (2017). Autophagy and Alzheimer\u2019s Disease. Cellular And Molecular Neurobiology, 37, 377\u2013388. https:\/\/doi.org\/10.1007\/s10571-016-0386-8.","journal-title":"Cellular And Molecular Neurobiology"},{"key":"2023_CR24","doi-asserted-by":"publisher","first-page":"e1002537","DOI":"10.1371\/journal.pgen.1002537","volume":"8","author":"S Liu","year":"2012","unstructured":"Liu, S., et al. (2012). Parkinson\u2019s disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. Plos Genetics, 8, e1002537. https:\/\/doi.org\/10.1371\/journal.pgen.1002537.","journal-title":"Plos Genetics"},{"key":"2023_CR25","doi-asserted-by":"publisher","first-page":"32145","DOI":"10.1073\/pnas.2009680117","volume":"117","author":"N Lonnemann","year":"2020","unstructured":"Lonnemann, N., et al. (2020). The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer\u2019s disease. Proc Natl Acad Sci U S A, 117, 32145\u201332154. https:\/\/doi.org\/10.1073\/pnas.2009680117.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023_CR26","doi-asserted-by":"publisher","first-page":"321","DOI":"10.15252\/embj.201696380","volume":"37","author":"G Lopez-Domenech","year":"2018","unstructured":"Lopez-Domenech, G., et al. (2018). Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution. Embo Journal, 37, 321\u2013336. https:\/\/doi.org\/10.15252\/embj.201696380.","journal-title":"Embo Journal"},{"key":"2023_CR27","doi-asserted-by":"publisher","first-page":"e100715","DOI":"10.15252\/embj.2018100715","volume":"40","author":"G Lopez-Domenech","year":"2021","unstructured":"Lopez-Domenech, G., et al. (2021). Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response. Embo Journal, 40, e100715. https:\/\/doi.org\/10.15252\/embj.2018100715.","journal-title":"Embo Journal"},{"key":"2023_CR28","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1080\/15548627.2019.1596488","volume":"16","author":"R Luo","year":"2020","unstructured":"Luo, R., et al. (2020). Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model. Autophagy, 16, 52\u201369. https:\/\/doi.org\/10.1080\/15548627.2019.1596488.","journal-title":"Autophagy"},{"key":"2023_CR29","doi-asserted-by":"publisher","first-page":"e1003012","DOI":"10.1371\/journal.pmed.1003012","volume":"17","author":"UV Mahajan","year":"2020","unstructured":"Mahajan, U. V., et al. (2020). Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study. Plos Medicine, 17, e1003012. https:\/\/doi.org\/10.1371\/journal.pmed.1003012.","journal-title":"Plos Medicine"},{"key":"2023_CR30","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","volume":"11","author":"I Martinez-Reyes","year":"2020","unstructured":"Martinez-Reyes, I., & Chandel, N. S. (2020). Mitochondrial TCA cycle metabolites control physiology and disease. Nature Communications, 11, 102. https:\/\/doi.org\/10.1038\/s41467-019-13668-3.","journal-title":"Nature Communications"},{"key":"2023_CR31","doi-asserted-by":"publisher","unstructured":"Nikolac Perkovic, M., et al. (2021). Epigenetics of Alzheimer\u2019s Disease. Biomolecules, 11, https:\/\/doi.org\/10.3390\/biom11020195.","DOI":"10.3390\/biom11020195"},{"key":"2023_CR32","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.mito.2020.10.005","volume":"56","author":"K Panchal","year":"2021","unstructured":"Panchal, K., & Tiwari, A. K. (2021). Miro (mitochondrial rho GTPase), a key player of mitochondrial axonal transport and mitochondrial dynamics in neurodegenerative diseases. Mitochondrion, 56, 118\u2013135. https:\/\/doi.org\/10.1016\/j.mito.2020.10.005.","journal-title":"Mitochondrion"},{"key":"2023_CR33","doi-asserted-by":"publisher","first-page":"101947","DOI":"10.1016\/j.redox.2021.101947","volume":"41","author":"MW Park","year":"2021","unstructured":"Park, M. W., et al. (2021). NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer\u2019s diseases. Redox Biology, 41, 101947. https:\/\/doi.org\/10.1016\/j.redox.2021.101947.","journal-title":"Redox Biology"},{"key":"2023_CR34","doi-asserted-by":"publisher","unstructured":"Patro, S., et al. (2021). ATP synthase and mitochondrial bioenergetics dysfunction in Alzheimer\u2019s Disease. International Journal Of Molecular Sciences, 22, https:\/\/doi.org\/10.3390\/ijms222011185.","DOI":"10.3390\/ijms222011185"},{"key":"2023_CR35","doi-asserted-by":"publisher","first-page":"3489","DOI":"10.1111\/bph.14585","volume":"176","author":"JM Perez Ortiz","year":"2019","unstructured":"Perez Ortiz, J. M., & Swerdlow, R. H. (2019). Mitochondrial dysfunction in Alzheimer\u2019s disease: Role in pathogenesis and novel therapeutic opportunities. British Journal Of Pharmacology, 176, 3489\u20133507. https:\/\/doi.org\/10.1111\/bph.14585.","journal-title":"British Journal Of Pharmacology"},{"key":"2023_CR36","doi-asserted-by":"publisher","first-page":"101191","DOI":"10.1016\/j.arr.2020.101191","volume":"64","author":"JA Pradeepkiran","year":"2020","unstructured":"Pradeepkiran, J. A., & Reddy, P. H. (2020). Defective mitophagy in Alzheimer\u2019s disease. Ageing Research Reviews, 64, 101191. https:\/\/doi.org\/10.1016\/j.arr.2020.101191.","journal-title":"Ageing Research Reviews"},{"key":"2023_CR37","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s40478-020-01062-w","volume":"8","author":"PMJ Quinn","year":"2020","unstructured":"Quinn, P. M. J., Moreira, P. I., Ambrosio, A. F., & Alves, C. H. (2020). PINK1\/PARKIN signalling in neurodegeneration and neuroinflammation. Acta Neuropathol Commun, 8, 189. https:\/\/doi.org\/10.1186\/s40478-020-01062-w.","journal-title":"Acta Neuropathol Commun"},{"key":"2023_CR38","doi-asserted-by":"publisher","unstructured":"Reddy, P. H., & Oliver, D. M. (2019). Amyloid Beta and phosphorylated Tau-Induced defective autophagy and Mitophagy in Alzheimer\u2019s Disease. Cells, 8, https:\/\/doi.org\/10.3390\/cells8050488.","DOI":"10.3390\/cells8050488"},{"key":"2023_CR39","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1093\/hmg\/ddy154","volume":"27","author":"PH Reddy","year":"2018","unstructured":"Reddy, P. H., et al. (2018). Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer\u2019s disease. Human Molecular Genetics, 27, 2502\u20132516. https:\/\/doi.org\/10.1093\/hmg\/ddy154.","journal-title":"Human Molecular Genetics"},{"key":"2023_CR40","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","volume":"397","author":"P Scheltens","year":"2021","unstructured":"Scheltens, P., et al. (2021). Alzheimer\u2019s disease. Lancet, 397, 1577\u20131590. https:\/\/doi.org\/10.1016\/S0140-6736(20)32205-4.","journal-title":"Lancet"},{"key":"2023_CR41","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.phrs.2018.03.010","volume":"131","author":"V Shoshan-Barmatz","year":"2018","unstructured":"Shoshan-Barmatz, V., Nahon-Crystal, E., Shteinfer-Kuzmine, A., & Gupta, R. (2018). VDAC1, mitochondrial dysfunction, and Alzheimer\u2019s disease. Pharmacological Research, 131, 87\u2013101. https:\/\/doi.org\/10.1016\/j.phrs.2018.03.010.","journal-title":"Pharmacological Research"},{"key":"2023_CR42","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1080\/15548627.2020.1822097","volume":"17","author":"K Sun","year":"2021","unstructured":"Sun, K., Jing, X., Guo, J., Yao, X., & Guo, F. (2021). Mitophagy in degenerative joint diseases. Autophagy, 17, 2082\u20132092. https:\/\/doi.org\/10.1080\/15548627.2020.1822097.","journal-title":"Autophagy"},{"key":"2023_CR43","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3233\/JAD-170585","volume":"62","author":"RH Swerdlow","year":"2018","unstructured":"Swerdlow, R. H. (2018). Mitochondria and mitochondrial cascades in Alzheimer\u2019s Disease. Journal Of Alzheimer\u2019S Disease, 62, 1403\u20131416. https:\/\/doi.org\/10.3233\/JAD-170585.","journal-title":"Journal Of Alzheimer\u2019S Disease"},{"key":"2023_CR44","doi-asserted-by":"publisher","first-page":"7653","DOI":"10.1002\/jcp.29682","volume":"235","author":"BL Tang","year":"2020","unstructured":"Tang, B. L. (2020). Glucose, glycolysis, and neurodegenerative diseases. Journal Of Cellular Physiology, 235, 7653\u20137662. https:\/\/doi.org\/10.1002\/jcp.29682.","journal-title":"Journal Of Cellular Physiology"},{"key":"2023_CR45","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1016\/j.jalz.2019.09.075","volume":"16","author":"M Tolar","year":"2020","unstructured":"Tolar, M., Abushakra, S., & Sabbagh, M. (2020). The path forward in Alzheimer\u2019s disease therapeutics: Reevaluating the amyloid cascade hypothesis. Alzheimers Dement, 16, 1553\u20131560. https:\/\/doi.org\/10.1016\/j.jalz.2019.09.075.","journal-title":"Alzheimers Dement"},{"key":"2023_CR46","doi-asserted-by":"publisher","first-page":"e13037","DOI":"10.1111\/acel.13037","volume":"18","author":"R Velazquez","year":"2019","unstructured":"Velazquez, R., et al. (2019). Lifelong choline supplementation ameliorates Alzheimer\u2019s disease pathology and associated cognitive deficits by attenuating microglia activation. Aging Cell, 18, e13037. https:\/\/doi.org\/10.1111\/acel.13037.","journal-title":"Aging Cell"},{"key":"2023_CR47","doi-asserted-by":"publisher","first-page":"118247","DOI":"10.1016\/j.lfs.2020.118247","volume":"259","author":"N Wang","year":"2020","unstructured":"Wang, N., et al. (2020a). PINK1: The guard of mitochondria. Life Sciences, 259, 118247. 10.1016\/j.lfs.2020a.118247.","journal-title":"Life Sciences"},{"key":"2023_CR48","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13024-020-00376-6","volume":"15","author":"W Wang","year":"2020","unstructured":"Wang, W., Zhao, F., Ma, X., Perry, G., & Zhu, X. (2020b). Mitochondria dysfunction in the pathogenesis of Alzheimer\u2019s disease: Recent advances. Mol Neurodegener, 15, 30. 10.1186\/s13024-020-00376-6.","journal-title":"Mol Neurodegener"},{"key":"2023_CR49","doi-asserted-by":"publisher","first-page":"113321","DOI":"10.1016\/j.expneurol.2020.113321","volume":"330","author":"IW Weidling","year":"2020","unstructured":"Weidling, I. W., & Swerdlow, R. H. (2020). Mitochondria in Alzheimer\u2019s disease and their potential role in Alzheimer\u2019s proteostasis. Experimental Neurology, 330, 113321. https:\/\/doi.org\/10.1016\/j.expneurol.2020.113321.","journal-title":"Experimental Neurology"},{"key":"2023_CR50","doi-asserted-by":"publisher","first-page":"112266","DOI":"10.1016\/j.yexcr.2020.112266","volume":"396","author":"X Xiong","year":"2020","unstructured":"Xiong, X., et al. (2020). Study of mitophagy and ATP-related metabolomics based on beta-amyloid levels in Alzheimer\u2019s disease. Experimental Cell Research, 396, 112266. https:\/\/doi.org\/10.1016\/j.yexcr.2020.112266.","journal-title":"Experimental Cell Research"},{"key":"2023_CR51","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1089\/ars.2012.4774","volume":"20","author":"F Yin","year":"2014","unstructured":"Yin, F., Boveris, A., & Cadenas, E. (2014). Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration. Antioxidants & Redox Signaling, 20, 353\u2013371. https:\/\/doi.org\/10.1089\/ars.2012.4774.","journal-title":"Antioxidants & Redox Signaling"},{"key":"2023_CR52","doi-asserted-by":"publisher","unstructured":"Zhao, Y., Zeng, C. Y., Li, X. H., Yang, T. T., Kuang, X., & Du, J. R. (2020). Klotho overexpression improves amyloid-beta clearance and cognition in the APP\/PS1 mouse model of Alzheimer\u2019s disease. Aging Cell, e13239. https:\/\/doi.org\/10.1111\/acel.13239.","DOI":"10.1111\/acel.13239"},{"key":"2023_CR53","doi-asserted-by":"publisher","first-page":"12142","DOI":"10.18632\/aging.103382","volume":"12","author":"F Zhou","year":"2020","unstructured":"Zhou, F., et al. (2020). Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Abeta clearance and cognitive function in APP\/PS1 double transgenic mice. Aging (Albany NY), 12, 12142\u201312159. https:\/\/doi.org\/10.18632\/aging.103382.","journal-title":"Aging (Albany NY)"},{"key":"2023_CR1","doi-asserted-by":"publisher","unstructured":"Alzheimer\u2019s disease facts and figures. Alzheimers Dement 18, 700\u2013789 doi:https:\/\/doi.org\/10.1002\/alz.12638","DOI":"10.1002\/alz.12638"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-023-02023-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-023-02023-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-023-02023-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T04:28:29Z","timestamp":1687321709000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-023-02023-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,8]]},"references-count":53,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["2023"],"URL":"https:\/\/doi.org\/10.1007\/s11306-023-02023-9","relation":{},"ISSN":["1573-3890"],"issn-type":[{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,8]]},"assertion":[{"value":"21 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Experiments in mice were performed under Ethical code: CZLS2022061-A of Chongqing University Cancer Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"56"}}