{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:36:31Z","timestamp":1780367791165,"version":"3.54.1"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>The chromosome 22q11.2 deletion syndrome (22q11.2DS) is characterized by a well-defined microdeletion and is associated with a wide range of brain-related phenotypes including schizophrenia spectrum disorders (SCZ), autism spectrum disorders (ASD), anxiety disorders and attention deficit disorders (ADHD). The typically deleted region in 22q11.2DS contains multiple genes which haploinsufficiency has the potential of altering the protein and the metabolic profiles.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p> Alteration in metabolic processes and downstream protein pathways during the early brain development may help to explain the increased prevalence of the observed neurodevelopmental phenotypes in 22q11.2DS. However, relatively little is known about the correlation of dysregulated protein\/metabolite expression and neurobehavioral impairments in individuals who developed them over time.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p> In this study, we performed untargeted metabolic and proteomic analysis in plasma samples derived from 30 subjects including 16 participants with 22q11.2DS and 14 healthy controls (TD) enrolled in a longitudinal study, aiming to identify a metabolic and protein signature informing about the underlying mechanisms involved in disease development and progression. The metabolic and proteomic profiles were also compared between the participants with 22q11.2DS with and without various comorbidities, such as medical involvement, psychiatric conditions, and autism spectrum disorder (ASD) to detect potential changes among multiple specimens, collected overtime, with the aim to understand the basic underlying mechanisms involved in disease development and progression.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We observed a large number of statistically significant differences in metabolites between the two groups. Among them, the levels of taurine and arachidonic acid were significantly lower in 22q11.2DS compared to the TD group. In addition, we identified 16 proteins that showed significant changes in expression levels (adjusted P\u2009&lt;\u20090.05) in 22q11.2DS as compared to TD, including those involved in 70 pathways such as gene expression, the PI3K-Akt signaling pathway and the complement system. Within participants with 22q11.2DS, no significant changes in those with and without medical or psychiatric conditions were observed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>To our knowledge, this is the first report on plasma metabolic and proteomic profiling and on the identification of unique biomarkers in 22q11.2DS. These findings may suggest the potential role of the identified metabolites and proteins as biomarkers for the onset of comorbid conditions in 22q11.2DS. Ultimately, the altered protein pathways in 22q11.2DS may provide insights of the biological mechanisms underlying the neurodevelopmental phenotype and may provide missing molecular outcome measures in future clinical trials to assess early-diagnosis treatment and the efficacy of response to targeted treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11306-024-02088-0","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T12:02:29Z","timestamp":1709121749000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Untargeted metabolomic, and proteomic analysis identifies metabolic biomarkers and pathway alterations in individuals with 22q11.2 deletion syndrome"],"prefix":"10.1007","volume":"20","author":[{"given":"Marwa","family":"Zafarullah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Angkustsiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Quach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungjun","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blythe P.","family":"Durbin-Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Bowling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Tassone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"issue":"4","key":"2088_CR1","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1159\/000102157","volume":"16","author":"NA Akar","year":"2007","unstructured":"Akar, N. A., & Adekile, A. D. (2007). Chromosome 22q11.2 deletion presenting with immune-mediated cytopenias, macrothrombocytopenia and platelet dysfunction. Medical Principles and Practice: International Journal of tHe Kuwait University, Health Science Centre, 16(4), 318. https:\/\/doi.org\/10.1159\/000102157","journal-title":"Medical Principles and Practice: International Journal of tHe Kuwait University, Health Science Centre"},{"key":"2088_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13246224","author":"N Almeida","year":"2021","unstructured":"Almeida, N., Rodriguez, J., Parada, I. P., Perez-Riverol, Y., Woldmar, N., Kim, Y., Oskolas, H., Betancourt, L., Vald\u00e9s, J. G., Barbara Sahlin, K., Luciana Pizzatti, A., Szasz, M., K\u00e1rp\u00e1ti, S., Appelqvist, R., Malm, J., Domont, G. B., Nogueira, F. C. S., Marko-Varga, G., & Sanchez, A. (2021). Mapping the melanoma plasma proteome (MPP) using single-shot proteomics interfaced with the WiMT database. Cancers. https:\/\/doi.org\/10.3390\/cancers13246224","journal-title":"Cancers"},{"key":"2088_CR3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12937-015-0091-3","volume":"14","author":"A Alshweki","year":"2015","unstructured":"Alshweki, A., Mu\u00f1uzuri, A. P., Ba\u00f1a, A. M., Jos\u00e9 de Castro, M., Andrade, F., Aldamiz-Echevarr\u00eda, L., S\u00e1enz, M., de Pipa\u00f3n, J. M., Fraga, M. L., & Couce,. (2015). Effects of different arachidonic acid supplementation on psychomotor development in very preterm infants; a randomized controlled trial. Nutrition Journal, 14, 101.","journal-title":"Nutrition Journal"},{"issue":"4","key":"2088_CR4","first-page":"833","volume":"43","author":"KM Antshel","year":"2016","unstructured":"Antshel, K. M., Fremont, W., Ramanathan, S., & Kates, W. R. (2016). Predicting cognition and psychosis in young adults with 22q11.2 deletion syndrome. Schizophrenia Bulletin, 43(4), 833\u2013842.","journal-title":"Schizophrenia Bulletin"},{"issue":"1","key":"2088_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/09297040590911185","volume":"11","author":"KM Antshel","year":"2005","unstructured":"Antshel, K. M., Kates, W. R., Roizen, N., Fremont, W., & Shprintzen, R. J. (2005). 22q11.2 deletion syndrome: genetics, neuroanatomy and cognitive\/behavioral features keywords. Child Neuropsychology: A Journal on Normal and Abnormal Development in Childhood and Adolescence, 11(1), 5\u201319.","journal-title":"Child Neuropsychology: A Journal on Normal and Abnormal Development in Childhood and Adolescence"},{"issue":"2","key":"2088_CR6","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s11920-008-0026-1","volume":"10","author":"AS Bassett","year":"2008","unstructured":"Bassett, A. S., & Chow, E. W. C. (2008). Schizophrenia and 22q11.2 deletion syndrome. Current Psychiatry Reports, 10(2), 148.","journal-title":"Current Psychiatry Reports"},{"issue":"2","key":"2088_CR7","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jpeds.2011.02.039","volume":"159","author":"AS Bassett","year":"2011","unstructured":"Bassett, A. S., McDonald-McGinn, D. M., Devriendt, K., Digilio, M. C., Goldenberg, P., Habel, A., Marino, B., Oskarsdottir, S., Philip, N., Sullivan, K., & Swillen, A. (2011). Practical guidelines for managing patients with 22q11.2 deletion syndrome. The Journal of Pediatrics, 159(2), 332\u20139.e1.","journal-title":"The Journal of Pediatrics"},{"issue":"3","key":"2088_CR8","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/cei.13334","volume":"197","author":"FC Bennett","year":"2019","unstructured":"Bennett, F. C., & Molofsky, A. V. (2019). The immune system and psychiatric disease: A basic science perspective. Clinical and Experimental Immunology, 197(3), 294\u2013307.","journal-title":"Clinical and Experimental Immunology"},{"key":"2088_CR9","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20200294","author":"C Blagojevic","year":"2021","unstructured":"Blagojevic, C., Heung, T., Theriault, M., Tomita-Mitchell, A., Chakraborty, P., Kernohan, K., Bulman, D. E., & Bassett, A. S. (2021). Estimate of the contemporary live-birth prevalence of recurrent 22q11.2 deletions: A cross-sectional analysis from population-based newborn screening. CMAJ Open. https:\/\/doi.org\/10.9778\/cmajo.20200294","journal-title":"CMAJ Open"},{"issue":"3","key":"2088_CR10","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1207\/s15327655jchn2203_4","volume":"22","author":"D Callaghan","year":"2005","unstructured":"Callaghan, D. (2005). Healthy behaviors, self-efficacy, self-care, and basic conditioning factors in older adults. Journal of Community Health Nursing, 22(3), 169\u2013178.","journal-title":"Journal of Community Health Nursing"},{"key":"2088_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.rchipe.2015.06.019","author":"M Cascella","year":"2015","unstructured":"Cascella, M., & Muzio, M. R. (2015). Early onset intellectual disability in chromosome 22q11.2 deletion syndrome. Revista Chilena De Pediatria. https:\/\/doi.org\/10.1016\/j.rchipe.2015.06.019","journal-title":"Revista Chilena De Pediatria"},{"issue":"7","key":"2088_CR12","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1002\/cbin.10613","volume":"40","author":"G Chen","year":"2016","unstructured":"Chen, G., Zou, Y., Zhang, X., Lingfei, X., Qiaoyun, H., Li, T., Yao, C., Shali, Yu., Wang, X., & Wang, C. (2016). \u03b2-Actin protein expression differs in the submandibular glands of male and female mice. Cell Biology International, 40(7), 779\u2013786.","journal-title":"Cell Biology International"},{"issue":"10","key":"2088_CR13","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1002\/ajmg.a.40494","volume":"176","author":"JL Cohen","year":"2018","unstructured":"Cohen, J. L., Crowley, T. B., McGinn, D. E., McDougall, C., Unolt, M., Lambert, M. P., Emanuel, B. S., Zackai, E. H., & McDonald-McGinn, D. M. (2018). 22q and two: 22q11.2 deletion syndrome and coexisting conditions. American Journal of Medical Genetics. Part A, 176(10), 2203.","journal-title":"American Journal of Medical Genetics. Part A"},{"key":"2088_CR14","doi-asserted-by":"publisher","first-page":"102108","DOI":"10.1016\/j.nicl.2019.102108","volume":"26","author":"G Collin","year":"2020","unstructured":"Collin, G., Nieto-Castanon, A., Shenton, M. E., Pasternak, O., Kelly, S., Keshavan, M. S., Seidman, L. J., McCarley, R. W., Niznikiewicz, M. A., Li, H., & Zhang, T. (2020). Brain functional connectivity data enhance prediction of clinical outcome in youth at risk for psychosis. NeuroImage. Clinical, 26, 102108.","journal-title":"NeuroImage. Clinical"},{"issue":"10","key":"2088_CR15","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1002\/ajmg.a.38597","volume":"176","author":"B Crowley","year":"2018","unstructured":"Crowley, B., Ruffner, M., McDonald McGinn, D. M., & Sullivan, K. E. (2018). Variable immune deficiency related to deletion size in chromosome 22q11.2 deletion syndrome. American Journal of Medical Genetics. Part A, 176(10), 2082\u20132086.","journal-title":"American Journal of Medical Genetics. Part A"},{"issue":"5042","key":"2088_CR16","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1126\/science.1549777","volume":"255","author":"CC Cunningham","year":"1992","unstructured":"Cunningham, C. C., Gorlin, J. B., Kwiatkowski, D. J., Hartwig, J. H., Janmey, P. A., Byers, H. R., & Stossel, T. P. (1992). Actin-binding protein requirement for cortical stability and efficient locomotion. Science, 255(5042), 325\u2013327.","journal-title":"Science"},{"key":"2088_CR17","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201600177","author":"P Devaraju","year":"2017","unstructured":"Devaraju, P., & Zakharenko, S. S. (2017). Mitochondria in complex psychiatric disorders: Lessons from mouse models of 22q11.2 deletion syndrome: Hemizygous deletion of several mitochondrial genes in the 22q11.2 genomic region can lead to symptoms associated with neuropsychiatric disease. BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology. https:\/\/doi.org\/10.1002\/bies.201600177","journal-title":"BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology"},{"issue":"2","key":"2088_CR18","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1080\/02699050500443822","volume":"20","author":"S Driver","year":"2006","unstructured":"Driver, S., Rees, K., O\u2019Connor, J., & Lox, C. (2006). Aquatics, health-promoting self-care behaviours and adults with brain injuries. Brain Injury: [BI], 20(2), 133\u2013141.","journal-title":"Brain Injury: [BI]"},{"key":"2088_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00573","author":"M Druart","year":"2019","unstructured":"Druart, M., & Le Magueresse, C. (2019). Emerging roles of complement in psychiatric disorders. Frontiers in Psychiatry. https:\/\/doi.org\/10.3389\/fpsyt.2019.00573","journal-title":"Frontiers in Psychiatry"},{"key":"2088_CR20","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.097139","author":"SN Duijff","year":"2012","unstructured":"Duijff, S. N., Klaassen, P. W., de Veye, H. F., Beemer, F. A., Sinnema, G., & Vorstman, J. A. (2012). Cognitive development in children with 22q11.2 deletion syndrome. The British Journal of Psychiatry: the Journal of Mental Science. https:\/\/doi.org\/10.1192\/bjp.bp.111.097139","journal-title":"The British Journal of Psychiatry: the Journal of Mental Science"},{"issue":"52","key":"2088_CR21","doi-asserted-by":"publisher","first-page":"19836","DOI":"10.1073\/pnas.0609628104","volume":"103","author":"Y Feng","year":"2006","unstructured":"Feng, Y., Chen, M. H., Moskowitz, I. P., Mendonza, A. M., Vidali, L., Nakamura, F., Kwiatkowski, D. J., & Walsh, C. A. (2006). Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proceedings of the National Academy of Sciences of the United States of America, 103(52), 19836\u201319841.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2088_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-00988-6","author":"AM Fiksinski","year":"2022","unstructured":"Fiksinski, A. M., Bearden, C. E., Bassett, A. S., Kahn, R. S., Zinkstok, J. R., Hooper, S. R., Tempelaar, W., McDonald-McGinn, D., Swillen, A., Emanuel, B., Morrow, B., Gur, R., Chow, E., van den Bree, M., Vermeesch, J., Warren, S., Owen, M., van Amelsvoort, T., Eliez, S., \u2026 Breetvelt, E. J. (2022). A normative chart for cognitive development in a genetically selected population. Neuropsychopharmacology Official Publication of the American College of Neuropsychopharmacology. https:\/\/doi.org\/10.1038\/s41386-021-00988-6","journal-title":"Neuropsychopharmacology Official Publication of the American College of Neuropsychopharmacology"},{"key":"2088_CR23","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3389\/fncel.2014.00088","volume":"8","author":"T Furukawa","year":"2014","unstructured":"Furukawa, T., Yamada, J., Akita, T., Matsushima, Y., Yanagawa, Y., & Fukuda, A. (2014). Roles of taurine-mediated tonic GABAA receptor activation in the radial migration of neurons in the fetal mouse cerebral cortex. Frontiers in Cellular Neuroscience, 8, 88.","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"2088_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2016.02.015","author":"PE Geyer","year":"2016","unstructured":"Geyer, P. E., Kulak, N. A., Pichler, G., Holdt, L. M., Teupser, D., & Mann, M. (2016). Plasma proteome profiling to assess human health and disease. Cell Systems. https:\/\/doi.org\/10.1016\/j.cels.2016.02.015","journal-title":"Cell Systems"},{"key":"2088_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.051","author":"M Giacomelli","year":"2016","unstructured":"Giacomelli, M., Kumar, R., Soresina, A., Tamassia, N., Lorenzini, T., Moratto, D., Gasperini, S., Cassatella, M., Plebani, A., Lougaris, V., & Badolato, R. (2016). Reduction of CRKL expression in patients with partial DiGeorge syndrome is associated with impairment of T-cell functions. The Journal of Allergy and Clinical Immunology. https:\/\/doi.org\/10.1016\/j.jaci.2015.10.051","journal-title":"The Journal of Allergy and Clinical Immunology"},{"issue":"3","key":"2088_CR26","doi-asserted-by":"publisher","first-page":"531","DOI":"10.3945\/ajcn.112.045781","volume":"97","author":"JF Gould","year":"2013","unstructured":"Gould, J. F., Smithers, L. G., & Makrides, M. (2013). The effect of maternal omega-3 (n-3) LCPUFA supplementation during pregnancy on early childhood cognitive and visual development: A systematic review and meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition, 97(3), 531\u2013544.","journal-title":"American Journal of Clinical Nutrition"},{"issue":"11","key":"2088_CR27","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1097\/CHI.0b013e3181b76683","volume":"48","author":"T Green","year":"2009","unstructured":"Green, T., Gothelf, D., Glaser, B., Debbane, M., Frisch, A., Kotler, M., Weizman, A., & Eliez, S. (2009). Psychiatric disorders and intellectual functioning throughout development in velocardiofacial (22q11.2 deletion) syndrome. Journal of the American Academy of Child and Adolescent Psychiatry, 48(11), 1060\u20131068.","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"issue":"3","key":"2088_CR28","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s10875-020-00766-x","volume":"40","author":"D Grinde","year":"2020","unstructured":"Grinde, D., \u00d8verland, T., Lima, K., Schjalm, C., Mollnes, T. E., & Abrahamsen, T. G. (2020). Complement activation in 22q11.2 deletion syndrome. Journal of Clinical Immunology, 40(3), 515.","journal-title":"Journal of Clinical Immunology"},{"issue":"1","key":"2088_CR29","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/humu.20061","volume":"24","author":"B Hoogendoorn","year":"2004","unstructured":"Hoogendoorn, B., Coleman, S. L., Guy, C. A., Smith, S. K., O\u2019Donovan, M. C., & Buckland, P. R. (2004). Functional analysis of polymorphisms in the promoter regions of genes on 22q11. Human Mutation, 24(1), 35\u201342.","journal-title":"Human Mutation"},{"key":"2088_CR30","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s12881-014-0106-5","volume":"15","author":"VJ Hwang","year":"2014","unstructured":"Hwang, V. J., Maar, D., Regan, J., Angkustsiri, K., Simon, T. J., & Tassone, F. (2014). Mapping the deletion endpoints in individuals with 22q11.2 deletion syndrome by droplet digital PCR. BMC Medical Genetics, 15, 106.","journal-title":"BMC Medical Genetics"},{"issue":"2","key":"2088_CR31","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1159\/000236447","volume":"60","author":"Y Ishikura","year":"2009","unstructured":"Ishikura, Y., Ikeda, G., Akimoto, K., Hata, M., Kusumoto, A., Kidokoro, A., Kontani, M., Kawashima, H., Kiso, Y., & Koga, Y. (2009). Arachidonic acid supplementation decreases P300 latency and increases P300 amplitude of event-related potentials in healthy elderly men. Neuropsychobiology, 60(2), 73\u201379.","journal-title":"Neuropsychobiology"},{"key":"2088_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101223","volume":"24","author":"M Jakaria","year":"2019","unstructured":"Jakaria, M., Azam, S., Haque, M. E., Jo, S.-H., Uddin, M. S., Kim, I.-S., & Choi, D.-K. (2019). Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms. Redox Biology, 24, 101223.","journal-title":"Redox Biology"},{"key":"2088_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066282","author":"LT Jeker","year":"2013","unstructured":"Jeker, L. T., Zhou, X., Blelloch, R., & Bluestone, J. A. (2013). DGCR8-mediated production of canonical microRNAs is critical for regulatory T cell function and stability. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0066282","journal-title":"PLoS ONE"},{"key":"2088_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/85845","author":"LA Jerome","year":"2001","unstructured":"Jerome, L. A., & Papaioannou, V. E. (2001). DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nature Genetics. https:\/\/doi.org\/10.1038\/85845","journal-title":"Nature Genetics"},{"key":"2088_CR35","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-009-0016-y","author":"EM Jolin","year":"2009","unstructured":"Jolin, E. M., Weller, R. A., & Weller, E. B. (2009). Psychosis in children with velocardiofacial syndrome (22q11.2 deletion syndrome). Current Psychiatry Reports. https:\/\/doi.org\/10.1007\/s11920-009-0016-y","journal-title":"Current Psychiatry Reports"},{"issue":"5","key":"2088_CR36","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.biopsych.2013.07.019","volume":"75","author":"RK Jonas","year":"2014","unstructured":"Jonas, R. K., Montojo, C. A., & Bearden, C. E. (2014). The 22q11.2 deletion syndrome as a window into complex neuropsychiatric disorders over the lifespan. Biological Psychiatry, 75(5), 351\u2013360.","journal-title":"Biological Psychiatry"},{"issue":"3","key":"2088_CR37","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/S2215-0366(14)00122-9","volume":"2","author":"GM Khandaker","year":"2015","unstructured":"Khandaker, G. M., Cousins, L., Deakin, J., Lennox, B. R., Yolken, R., & Jones, P. B. (2015). Inflammation and immunity in schizophrenia: Implications for pathophysiology and treatment. Lancet Psychiatry, 2(3), 258\u2013270.","journal-title":"Lancet Psychiatry"},{"issue":"1","key":"2088_CR38","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/s41398-022-01859-4","volume":"12","author":"D Korteling","year":"2022","unstructured":"Korteling, D., Boks, M. P., Fiksinski, A. M., van Hoek, I. N., Vorstman, J. A. S., Verhoeven-Duif, N. M., Jans, J. J. M., & Zinkstok, J. R. (2022). Untargeted metabolic analysis in dried blood spots reveals metabolic signature in 22q11.2 deletion syndrome. Translational Psychiatry, 12(1), 97.","journal-title":"Translational Psychiatry"},{"issue":"2","key":"2088_CR39","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.neures.2006.06.010","volume":"56","author":"S Kotani","year":"2006","unstructured":"Kotani, S., Sakaguchi, E., Warashina, S., Matsukawa, N., Ishikura, Y., Kiso, Y., Sakakibara, M., Yoshimoto, T., Guo, J., & Yamashima, T. (2006). Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. Neuroscience Research, 56(2), 159\u2013164.","journal-title":"Neuroscience Research"},{"issue":"11","key":"2088_CR40","doi-asserted-by":"publisher","first-page":"4020","DOI":"10.1021\/acs.jproteome.9b00492","volume":"18","author":"MY Lim","year":"2019","unstructured":"Lim, M. Y., Paulo, J. A., & Gygi, S. P. (2019). Evaluating false transfer rates from the match-between-runs algorithm with a two-proteome model. Journal of Proteome Research, 18(11), 4020\u20134026.","journal-title":"Journal of Proteome Research"},{"key":"2088_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/s41397-021-00222-y","author":"C Liu","year":"2021","unstructured":"Liu, C., Tang, W., Zhao, H., Yang, S., Ren, Z., Li, J., Chen, Y., Zhao, X., Xu, D., Zhao, Y., & Shen, C. (2021). The variants at FLNA and FLNB contribute to the susceptibility of hypertension and stroke with differentially expressed mRNA. Pharmacogenomics Journal. https:\/\/doi.org\/10.1038\/s41397-021-00222-y","journal-title":"Pharmacogenomics Journal"},{"key":"2088_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s13039-017-0308-6","author":"MK Maisenbacher","year":"2017","unstructured":"Maisenbacher, M. K., Merrion, K., Pettersen, B., Young, M., Paik, K., Iyengar, S., Kareht, S., Sigurjonsson, S., Demko, Z. P., & Martin, K. A. (2017). Incidence of the 22q11.2 deletion in a large cohort of miscarriage samples. Molecular Cytogenetics. https:\/\/doi.org\/10.1186\/s13039-017-0308-6","journal-title":"Molecular Cytogenetics"},{"issue":"1","key":"2088_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2015.71","volume":"1","author":"DM McDonald-McGinn","year":"2015","unstructured":"McDonald-McGinn, D. M., Sullivan, K. E., Marino, B., Philip, N., Swillen, A., Vorstman, J. A., Zackai, E. H., Emanuel, B. S., Vermeesch, J. R., Morrow, B. E., & Scambler, P. J. (2015). 22q11.2 deletion syndrome. Nature Reviews Disease Primers, 1(1), 1\u201319.","journal-title":"Nature Reviews Disease Primers"},{"key":"2088_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2015.03.004","volume":"130","author":"DW Meechan","year":"2015","unstructured":"Meechan, D. W., Maynard, T. M., Fernandez, A., Karpinski, B. A., Rothblat, L. A., & LaMantia, A. S. (2015). Modeling a model: Mouse genetics, 22q11.2 deletion syndrome, and disorders of cortical circuit development. Progress in Neurobiology, 130, 1.","journal-title":"Progress in Neurobiology"},{"issue":"13","key":"2088_CR45","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.clinbiochem.2008.05.013","volume":"41","author":"NA Meguid","year":"2008","unstructured":"Meguid, N. A., Atta, H. M., Gouda, A. S., & Khalil, R. O. (2008). Role of polyunsaturated fatty acids in the management of Egyptian children with autism. Clinical Biochemistry, 41(13), 1044\u20131048.","journal-title":"Clinical Biochemistry"},{"issue":"1","key":"2088_CR46","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/npp.2016.158","volume":"42","author":"A Meltzer","year":"2017","unstructured":"Meltzer, A., & Van de Water, J. (2017). The role of the immune system in autism spectrum disorder. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 42(1), 284\u2013298.","journal-title":"Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology"},{"issue":"7","key":"2088_CR47","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.biopsych.2011.04.013","volume":"70","author":"BJ Miller","year":"2011","unstructured":"Miller, B. J., Buckley, P., Seabolt, W., Mellor, A., & Kirkpatrick, B. (2011). Meta-analysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects. Biological Psychiatry, 70(7), 663\u2013671.","journal-title":"Biological Psychiatry"},{"key":"2088_CR48","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.40504","author":"BE Morrow","year":"2018","unstructured":"Morrow, B. E., McDonald-McGinn, D. M., Emanuel, B. S., Vermeesch, J. R., & Scambler, P. J. (2018). Molecular genetics of 22q11.2 deletion syndrome. American Journal of Medical Genetics. Part A. https:\/\/doi.org\/10.1002\/ajmg.a.40504","journal-title":"American Journal of Medical Genetics. Part A"},{"key":"2088_CR49","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38319","author":"M Morsheimer","year":"2017","unstructured":"Morsheimer, M., Tf, B. W., Heimall, J., & Sullivan, K. E. (2017). The immune deficiency of chromosome 22q11.2 deletion syndrome. American Journal of Medical Genetics. Part A. https:\/\/doi.org\/10.1002\/ajmg.a.38319","journal-title":"American Journal of Medical Genetics. Part A"},{"issue":"38","key":"2088_CR50","doi-asserted-by":"publisher","first-page":"23240","DOI":"10.1074\/jbc.M115.672360","volume":"290","author":"E Napoli","year":"2015","unstructured":"Napoli, E., Tassone, F., Wong, S., Angkustsiri, K., Simon, T. J., Song, G., & Giulivi, C. (2015). Mitochondrial citrate transporter-dependent metabolic signature in the 22q11.2 deletion syndrome. Journal of Biological Chemistry, 290(38), 23240\u201323253.","journal-title":"Journal of Biological Chemistry"},{"key":"2088_CR51","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-15126-7_33","author":"LS Neuwirth","year":"2015","unstructured":"Neuwirth, L. S., Volpe, N. P., Ng, S., Marsillo, A., Corwin, C., Madan, N., Ferraro, A. M., & El Idrissi, A. (2015). Taurine recovers mice emotional learning and memory disruptions associated with fragile x syndrome in context fear and auditory cued-conditioning. Advances in Experimental Medicine and Biology. https:\/\/doi.org\/10.1007\/978-3-319-15126-7_33","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"3","key":"2088_CR52","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1177\/107602960200800311","volume":"8","author":"A Noda","year":"2002","unstructured":"Noda, A., Wada, H., Kusiya, F., Sakakura, M., Onishi, K., Nakatani, K., Gabazza, E. C., Asahara, N., Tsukada, M., Nobori, T., & Shiku, H. (2002). Plasma levels of heparin cofactor II (HCII) and thrombin-HCII complex in patients with disseminated intravascular coagulation. Clinical and Applied Thrombosis\/hemostasis: Official Journal of the International Academy of Clinical and Applied Thrombosis\/hemostasis, 8(3), 265\u2013271.","journal-title":"Clinical and Applied Thrombosis\/hemostasis: Official Journal of the International Academy of Clinical and Applied Thrombosis\/hemostasis"},{"issue":"2","key":"2088_CR53","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1136\/adc.2003.026880","volume":"89","author":"S Oskarsd\u00f3ttir","year":"2004","unstructured":"Oskarsd\u00f3ttir, S., Vujic, M., & Fasth, A. (2004). Incidence and prevalence of the 22q11 deletion syndrome: A population-based study in Western Sweden. Archives of Disease in Childhood, 89(2), 148\u2013151.","journal-title":"Archives of Disease in Childhood"},{"issue":"7","key":"2088_CR54","first-page":"265","volume":"93","author":"L Palomera","year":"1989","unstructured":"Palomera, L., Garc\u00eda D\u00edez, I., & Mart\u00ednez, R. (1989). Beneficial effect of 1,25-dihydroxyvitamin D3 in the treatment of myelofibrosis. Medicina Clinica, 93(7), 265.","journal-title":"Medicina Clinica"},{"issue":"5","key":"2088_CR55","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.ejmg.2017.12.008","volume":"61","author":"O Palumbo","year":"2018","unstructured":"Palumbo, O., Accadia, M., Palumbo, P., Leone, M. P., Scorrano, A., Palladino, T., Stallone, R., Bonaglia, M. C., & Carella, M. (2018). Refinement of the critical 7p22.1 deletion region: Haploinsufficiency of ACTB is the cause of the 7p22.1 microdeletion-related developmental disorders. European Journal of Medical Genetics, 61(5), 248\u2013252.","journal-title":"European Journal of Medical Genetics"},{"issue":"3","key":"2088_CR56","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/jcpp.12657","volume":"58","author":"PD Radoeva","year":"2017","unstructured":"Radoeva, P. D., Bansal, R., Antshel, K. M., Fremont, W., Peterson, B. S., & Kates, W. R. (2017). Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 58(3), 305\u2013314.","journal-title":"Journal of Child Psychology and Psychiatry, and Allied Disciplines"},{"key":"2088_CR57","doi-asserted-by":"publisher","DOI":"10.3390\/nu14061292","author":"Z Rafiee","year":"2022","unstructured":"Rafiee, Z., Garc\u00eda-Serrano, A. M., & Duarte, J. M. N. (2022). Taurine supplementation as a neuroprotective strategy upon brain dysfunction in metabolic syndrome and diabetes. Nutrients. https:\/\/doi.org\/10.3390\/nu14061292","journal-title":"Nutrients"},{"key":"2088_CR58","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/B978-0-12-385950-1.00007-9","volume":"501","author":"CM Rein","year":"2011","unstructured":"Rein, C. M., Desai, U. R., & Church, F. C. (2011). Serpin-glycosaminoglycan interactions. Methods in Enzymology, 501, 105\u2013137.","journal-title":"Methods in Enzymology"},{"issue":"9","key":"2088_CR59","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s10072-015-2201-6","volume":"36","author":"L Ricciardi","year":"2015","unstructured":"Ricciardi, L., De Nigris, F., Specchia, A., & Fasano, A. (2015). Homotaurine in Parkinson\u2019s disease. Neurological Sciences: Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 36(9), 1581\u20131587.","journal-title":"Neurological Sciences: Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology"},{"issue":"2","key":"2088_CR60","doi-asserted-by":"publisher","first-page":"151","DOI":"10.5581\/1516-8484.20110037","volume":"33","author":"RFM Rosa","year":"2011","unstructured":"Rosa, R. F. M., Rosa, R. C. M., dos Santos, P. P. A., Zen, P. R. G., & Paskulin, G. A. (2011). Hematological abnormalities and 22q11.2 deletion syndrome. Revista Brasileira De Hematologia e Hemoterapia, 33(2), 151.","journal-title":"Revista Brasileira De Hematologia e Hemoterapia"},{"key":"2088_CR61","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2017.251","author":"S Schaffer","year":"2018","unstructured":"Schaffer, S., & Kim, H. W. (2018). Effects and mechanisms of taurine as a therapeutic agent. Biomolecules Therapeutics. https:\/\/doi.org\/10.4062\/biomolther.2017.251","journal-title":"Biomolecules Therapeutics"},{"key":"2088_CR62","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13070864","author":"M Schneider","year":"2014","unstructured":"Schneider, M., Debban\u00e9, M., Bassett, A. S., Chow, E. W. C., Fung, W. L. A., van den Bree, M. B. M., Owen, M., Murphy, K. C., Niarchou, M., Kates, W. R., Antshel, K. M., Fremont, W., McDonald-McGinn, D. M., Gur, R. E., Zackai, E. H., Vorstman, J., Duijff, S. N., Klaassen, P. W. J., Swillen, A., \u2026 Eliez, S. (2014). Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the International Consortium on Brain and Behavior in 22q11.2 deletion syndrome. American Journal of Psychiatry. https:\/\/doi.org\/10.1176\/appi.ajp.2013.13070864","journal-title":"American Journal of Psychiatry"},{"issue":"8","key":"2088_CR63","doi-asserted-by":"publisher","first-page":"e103884","DOI":"10.1371\/journal.pone.0103884","volume":"9","author":"C Sellier","year":"2014","unstructured":"Sellier, C., Hwang, V. J., Dandekar, R., Durbin-Johnson, B., Charlet-Berguerand, N., Ander, B. P., Sharp, F. R., Angkustsiri, K., Simon, T. J., & Tassone, F. (2014). Decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 deletion syndrome. PLoS ONE, 9(8), e103884.","journal-title":"PLoS ONE"},{"key":"2088_CR64","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000184465.73833.0b","author":"RJ Shprintzen","year":"2005","unstructured":"Shprintzen, R. J., Higgins, A. M., Antshel, K., Fremont, W., Roizen, N., & Kates, W. (2005). Velo-cardio-facial syndrome. Current Opinion in Pediatrics. https:\/\/doi.org\/10.1097\/01.mop.0000184465.73833.0b","journal-title":"Current Opinion in Pediatrics"},{"key":"2088_CR65","doi-asserted-by":"publisher","DOI":"10.3390\/ph11020056","author":"D Siniscalco","year":"2018","unstructured":"Siniscalco, D., Schultz, S., Brigida, A. L., & Antonucci, N. (2018). Inflammation and neuro-immune dysregulations in autism spectrum disorders. Pharmaceuticals. https:\/\/doi.org\/10.3390\/ph11020056","journal-title":"Pharmaceuticals"},{"key":"2088_CR66","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.bbr.2014.05.056","volume":"276","author":"DD Stephenson","year":"2015","unstructured":"Stephenson, D. D., Beaton, E. A., Weems, C. F., Angkustsiri, K., & Simon, T. J. (2015). Identifying patterns of anxiety and depression in children with chromosome 22q11.2 deletion syndrome: Comorbidity predicts behavioral difficulties and impaired functional communications. Behavioural Brain Research, 276, 190\u2013198.","journal-title":"Behavioural Brain Research"},{"issue":"7","key":"2088_CR67","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.apmr.2006.04.003","volume":"87","author":"AK Stuifbergen","year":"2006","unstructured":"Stuifbergen, A. K., Blozis, S. A., Harrison, T. C., & Becker, H. A. (2006). Exercise, functional limitations, and quality of life: A longitudinal study of persons with multiple sclerosis. Archives of Physical Medicine and Rehabilitation, 87(7), 935\u2013943.","journal-title":"Archives of Physical Medicine and Rehabilitation"},{"key":"2088_CR68","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12701","author":"KE Sullivan","year":"2019","unstructured":"Sullivan, K. E. (2019). Chromosome 22q11.2 deletion syndrome and DiGeorge syndrome. Immunological Reviews. https:\/\/doi.org\/10.1111\/imr.12701","journal-title":"Immunological Reviews"},{"key":"2088_CR69","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31435","author":"A Swillen","year":"2015","unstructured":"Swillen, A., & McDonald-McGinn, D. (2015). Developmental trajectories in 22q11.2 deletion. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. https:\/\/doi.org\/10.1002\/ajmg.c.31435","journal-title":"American Journal of Medical Genetics. Part C, Seminars in Medical Genetics"},{"issue":"10","key":"2088_CR70","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1002\/ajmg.a.38500","volume":"176","author":"SX Tang","year":"2018","unstructured":"Tang, S. X., & Gur, R. E. (2018). Longitudinal perspectives on the psychosis spectrum in 22q11.2 deletion syndrome. American Journal of Medical Genetics. Part A, 176(10), 2192\u20132202.","journal-title":"American Journal of Medical Genetics. Part A"},{"key":"2088_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.apnr.2005.07.006","author":"JL Thanavaro","year":"2006","unstructured":"Thanavaro, J. L., Moore, S. M., Anthony, M., Narsavage, G., & Delicath, T. (2006). Predictors of health promotion behavior in women without prior history of coronary heart disease. Applied Nursing Research. https:\/\/doi.org\/10.1016\/j.apnr.2005.07.006","journal-title":"Applied Nursing Research"},{"key":"2088_CR72","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.neures.2014.08.002","volume":"88","author":"H Tokuda","year":"2014","unstructured":"Tokuda, H., Kontani, M., Kawashima, H., Kiso, Y., Shibata, H., & Osumi, N. (2014). Differential effect of arachidonic acid and docosahexaenoic acid on age-related decreases in hippocampal neurogenesis. Neuroscience Research, 88, 58\u201366.","journal-title":"Neuroscience Research"},{"key":"2088_CR73","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/1752-1947-1-167","volume":"1","author":"AR Tonelli","year":"2007","unstructured":"Tonelli, A. R., Kosuri, K., Wei, S., & Chick, D. (2007). Seizures as the first manifestation of chromosome 22q11.2 deletion syndrome in a 40-year old man: a case report. Journal of Medical Case Reports, 1, 167.","journal-title":"Journal of Medical Case Reports"},{"key":"2088_CR74","doi-asserted-by":"publisher","DOI":"10.1542\/peds.83.3.406","author":"JE Tyson","year":"1989","unstructured":"Tyson, J. E., Lasky, R., Flood, D., Mize, C., Picone, T., & Paule, C. L. (1989). Randomized trial of taurine supplementation for infants \\g=le\\1,300-gram birth weight: Effect on auditory brainstem-evoked responses. Pediatrics. https:\/\/doi.org\/10.1542\/peds.83.3.406","journal-title":"Pediatrics"},{"key":"2088_CR75","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000324","author":"L Van","year":"2017","unstructured":"Van, L., Boot, E., & Bassett, A. S. (2017). Update on the 22q11.2 deletion syndrome and its relevance to schizophrenia. Current Opinion in Psychiatry. https:\/\/doi.org\/10.1097\/YCO.0000000000000324","journal-title":"Current Opinion in Psychiatry"},{"key":"2088_CR76","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.bbi.2018.03.022","volume":"70","author":"E Vergaelen","year":"2018","unstructured":"Vergaelen, E., Schiweck, C., Van Steeland, K., Counotte, J., Veling, W., Swillen, A., Drexhage, H., & Claes, S. (2018). A pilot study on immuno-psychiatry in the 22q11.2 deletion syndrome: A role for Th17 cells in psychosis? Brain, Behavior, and Immunity, 70, 88\u201395.","journal-title":"Brain, Behavior, and Immunity"},{"key":"2088_CR77","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-198703000-00002","author":"SN Walker","year":"1987","unstructured":"Walker, S. N., Sechrist, K. R., & Pender, N. J. (1987). The health-promoting lifestyle profile: development and psychometric characteristics. Nursing Research. https:\/\/doi.org\/10.1097\/00006199-198703000-00002","journal-title":"Nursing Research"},{"issue":"3","key":"2088_CR78","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/mp.2016.27","volume":"22","author":"H Wesseling","year":"2017","unstructured":"Wesseling, H., Xu, B., Want, E. J., Holmes, E., Guest, P. C., Karayiorgou, M., Gogos, J. A., & Bahn, S. (2017). System-based proteomic and metabonomic analysis of the Df(16)A mouse identifies potential miR-185 targets and molecular pathway alterations. Molecular Psychiatry, 22(3), 384\u2013395.","journal-title":"Molecular Psychiatry"},{"key":"2088_CR79","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.bbi.2021.09.005","volume":"99","author":"LJ Westacott","year":"2022","unstructured":"Westacott, L. J., Humby, T., Haan, N., Brain, S. A., Bush, E. L., Toneva, M., Baloc, A. I., Moon, A. L., Reddaway, J., Owen, M. J., Hall, J., Hughes, T. R., Paul Morgan, B., Gray, W. P., & Wilkinson, L. S. (2022). Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder. Brain, Behavior, and Immunity, 99, 70\u201382.","journal-title":"Brain, Behavior, and Immunity"},{"issue":"6","key":"2088_CR80","doi-asserted-by":"publisher","first-page":"F497","DOI":"10.1136\/adc.2003.048389","volume":"89","author":"BA Wharton","year":"2004","unstructured":"Wharton, B. A., Morley, R., Isaacs, E. B., Cole, T. J., & Lucas, A. (2004). Low plasma taurine and later neurodevelopment. Archives of Disease in Childhood. Fetal and Neonatal Edition, 89(6), F497\u2013F498.","journal-title":"Archives of Disease in Childhood. Fetal and Neonatal Edition"},{"key":"2088_CR81","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.507","author":"KJ Woodward","year":"2019","unstructured":"Woodward, K. J., Stampalia, J., Vanyai, H., Rijhumal, H., Potts, K., Taylor, F., Peverall, J., Grumball, T., Sivamoorthy, S., Alinejad-Rokny, H., Wray, J., Whitehouse, A., Nagarajan, L., Scurlock, J., Afchani, S., Edwards, M., Murch, A., Beilby, J., Baynam, G., \u2026 Heng, J. I. T. (2019). Atypical nested 22q11.2 duplications between LCR22B and LCR22D are associated with neurodevelopmental phenotypes including autism spectrum disorder with incomplete penetrance. Molecular Genetics Genomic Medicine. https:\/\/doi.org\/10.1002\/mgg3.507","journal-title":"Molecular Genetics Genomic Medicine"},{"key":"2088_CR82","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3389\/fpsyt.2018.00381","volume":"9","author":"X Yang","year":"2018","unstructured":"Yang, X., Tao, H., Xiao, L., Li, C., Tang, Y., & Liu, Y. (2018). Increased serum C3 and decreased UA in patients of bipolar disorder in Chinese han population. Frontiers in Psychiatry \/ Frontiers Research Foundation, 9, 381.","journal-title":"Frontiers in Psychiatry \/ Frontiers Research Foundation"},{"key":"2088_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2021.100077","volume":"20","author":"F Yu","year":"2021","unstructured":"Yu, F., Haynes, S. E., & Nesvizhskii, A. I. (2021). IonQuant enables accurate and sensitive label-free quantification with FDR-controlled match-between-runs. Molecular Cellular Proteomics: MCP, 20, 100077.","journal-title":"Molecular Cellular Proteomics: MCP"},{"issue":"2","key":"2088_CR84","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1097\/JCP.0b013e3182485791","volume":"32","author":"K Yui","year":"2012","unstructured":"Yui, K., Koshiba, M., Nakamura, S., & Kobayashi, Y. (2012). Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: A double-blind, placebo-controlled, randomized trial. Journal of Clinical Psychopharmacology, 32(2), 200\u2013206.","journal-title":"Journal of Clinical Psychopharmacology"},{"issue":"3","key":"2088_CR85","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.clim.2010.04.011","volume":"136","author":"R Zemble","year":"2010","unstructured":"Zemble, R., Luning Prak, E., McDonald, K., McDonald-McGinn, D., Zackai, E., & Sullivan, K. (2010). Secondary immunologic consequences in chromosome 22q11.2 deletion syndrome (DiGeorge syndrome\/velocardiofacial syndrome). Clinical Immunology, 136(3), 409\u2013418.","journal-title":"Clinical Immunology"},{"issue":"1","key":"2088_CR86","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ajhg.2019.11.010","volume":"106","author":"Y Zhao","year":"2020","unstructured":"Zhao, Y., Diacou, A., Johnston, H. R., Musfee, F. I., McDonald-McGinn, D. M., McGinn, D., Crowley, T. B., Repetto, G. M., Swillen, A., Breckpot, J., & Vermeesch, J. R. (2020). Complete sequence of the 22q11.2 allele in 1,053 subjects with 22q11.2 deletion syndrome reveals modifiers of conotruncal heart defects. American Journal of Human Genetics, 106(1), 26\u201340.","journal-title":"American Journal of Human Genetics"},{"issue":"5","key":"2088_CR87","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.jaci.2015.01.011","volume":"135","author":"P Zheng","year":"2015","unstructured":"Zheng, P., Noroski, L. M., Hanson, I. C., Chen, Y., Lee, M. E., Huang, Y., Zhu, M. X., Banerjee, P. P., Makedonas, G., Orange, J. S., Shearer, W. T., & Liu, D. (2015). Molecular mechanisms of functional natural killer deficiency in patients with partial DiGeorge syndrome. The Journal of Allergy and Clinical Immunology, 135(5), 1293\u20131302.","journal-title":"The Journal of Allergy and Clinical Immunology"},{"key":"2088_CR88","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30076-8","author":"JR Zinkstok","year":"2019","unstructured":"Zinkstok, J. R., Boot, E., Bassett, A. S., Hiroi, N., Butcher, N. J., Vingerhoets, C., Vorstman, J. A. S., & van Amelsvoort, T. A. M. J. (2019). Neurobiological perspective of 22q11.2 deletion syndrome. Lancet Psychiatry. https:\/\/doi.org\/10.1016\/S2215-0366(19)30076-8","journal-title":"Lancet Psychiatry"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-024-02088-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-024-02088-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-024-02088-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T22:05:20Z","timestamp":1713564320000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-024-02088-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,28]]},"references-count":88,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["2088"],"URL":"https:\/\/doi.org\/10.1007\/s11306-024-02088-0","relation":{},"ISSN":["1573-3890"],"issn-type":[{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,28]]},"assertion":[{"value":"10 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"M.Z.: No disclosures to report; K. A: No disclosures to report; A.Q. & S.Y.: AQ and SY are co-founders of, are employed by, and own stock in Dalton Bioanalytics Inc.; B.J.: No disclosures to report; H.B.: H. B. is an employee of Epistemic AI; F.T.: No disclosures to report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All samples were collected under approved Institutional Review Board (IRB) protocols and all methods were carried out in accordance with the relevant guidelines and regulations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"31"}}