{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:55:08Z","timestamp":1780451708119,"version":"3.54.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medizinische Hochschule Hannover (MHH)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Biliary atresia (BA) is a rare progressive neonatal cholangiopathy with unknown pathophysiology and time of onset. Newborn Screening (NBS) in Germany is routinely performed in the first days of life to identify rare congenital diseases utilizing dried blood spot (DBS) card analyses. Infants with biliary atresia (BA) are known to have altered amino acid profiles (AAP) at the time point of diagnosis, but it is unclear whether these alterations are present at the time point of NBS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>We aimed to analyze amino acid profiles in NBS\u2013DBS of infants with Biliary Atresia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Original NBS-DBS cards of 41 infants who were later on diagnosed with BA were retrospectively obtained. NBS\u2013DBS cards from healthy newborns (<jats:italic>n<\/jats:italic>\u2009=\u200940) served as controls. In some BA infants (<jats:italic>n<\/jats:italic>\u2009=\u200914) a second DBS card was obtained at time of Kasai surgery. AAP in DBS cards were analyzed by targeted metabolomics.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>DBS metabolomics in the NBS of at that time point seemingly healthy infants later diagnosed with BA revealed significantly higher levels of Methionine (14.6\u2009\u00b1\u20098.6\u00a0\u03bcmol\/l), Histidine (23.5\u2009\u00b1\u200950.3\u00a0\u03bcmol\/l), Threonine (123.9\u2009\u00b1\u200972.8\u00a0\u03bcmol\/l) and Arginine (14.1\u2009\u00b1\u200911.8\u00a0\u03bcmol\/l) compared to healthy controls (Met: 8.1\u2009\u00b1\u20092.6\u00a0\u03bcmol\/l, His: 18.6\u2009\u00b1\u200910.1\u00a0\u03bcmol\/l, Thr: 98.1\u2009\u00b1\u200934.3\u00a0\u03bcmol\/l, Arg: 9.3\u2009\u00b1\u20096.6\u00a0\u03bcmol\/l). Methionine, Arginine and Histidine showed a further increase at time point of Kasai procedure. No correlation between amino acid levels and clinical course was observed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our data demonstrate that BA patients exhibit an altered AAP within 72\u00a0h after birth, long before the infants become symptomatic. This supports the theory of a prenatal onset of the disease and, thus, the possibility of developing a sensitive and specific NBS. Methionine might be particularly relevant due to its involvement in glutathione metabolism. Further investigation of AAP in BA may help in understanding the underlying pathophysiology.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11306-024-02175-2","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T17:01:38Z","timestamp":1728147698000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Infants with biliary atresia exhibit an altered amino acid profile in their newborn screening"],"prefix":"10.1007","volume":"20","author":[{"given":"Marie","family":"Uecker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Prehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-3311","authenticated-orcid":false,"given":"Nils","family":"Janzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9259-0199","authenticated-orcid":false,"given":"Jerzy","family":"Adamski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-4664","authenticated-orcid":false,"given":"Gertrud","family":"Vieten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim F.","family":"Kuebler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7239-8973","authenticated-orcid":false,"given":"Omid","family":"Madadi-Sanjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5639-8690","authenticated-orcid":false,"given":"Christian","family":"Klemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,5]]},"reference":[{"issue":"1","key":"2175_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/s1386-6346(01)00079-1","volume":"21","author":"D Abukawa","year":"2001","unstructured":"Abukawa, D., Ohura, T., Iinuma, K., & Tazawa, Y. 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