{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T18:32:44Z","timestamp":1780425164840,"version":"3.54.1"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100005188","name":"Tobacco-Related Disease Research Program","doi-asserted-by":"publisher","award":["T29DT0485"],"award-info":[{"award-number":["T29DT0485"]}],"id":[{"id":"10.13039\/100005188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005188","name":"Tobacco-Related Disease Research Program","doi-asserted-by":"publisher","award":["24RT-0033H"],"award-info":[{"award-number":["24RT-0033H"]}],"id":[{"id":"10.13039\/100005188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03CA252788"],"award-info":[{"award-number":["R03CA252788"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Maternal tobacco smoking in the perinatal period increases the risk for adverse outcomes in offspring.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>To better understand the biological pathways through which maternal tobacco use may have long-term impacts on child metabolism, we performed a high-resolution metabolomics (HRM) analysis in newborns, following an untargeted metabolome-wide association study workflow.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The study population included 899 children without cancer diagnosis before age 6 and born between 1983 and 2011 in California. Newborn dried blood spots were collected by the California Genetic Disease Screening Program between 12 and 48\u00a0h after birth and stored for later research use. Based on HRM, we considered mothers to be active smokers if they were self- or provider-reported smokers on birth certificates or if we detected any cotinine or high hydroxycotinine intensities in newborn blood. We used partial least squares discriminant analysis and Mummichog pathway analysis to identify metabolites and metabolic pathways associated with maternal tobacco smoking.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 26,183 features were detected with HRM, including 1003 that were found to be associated with maternal smoking late in pregnancy and early postpartum (Variable Importance in Projection (VIP) scores\u2009&gt; =\u20092). Smoking affected metabolites and metabolic pathways in neonatal blood including vitamin A (retinol) metabolism, the kynurenine pathway, and tryptophan and arachidonic acid metabolism.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The smoking-associated metabolites and pathway perturbations that we identified suggested inflammatory responses and have also been implicated in chronic diseases of the central nervous system and the lung. Our results suggest that infant metabolism in the early postnatal period reflects smoking specific physiologic responses to maternal smoking with strong biologic plausibility.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11306-025-02225-3","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T17:31:04Z","timestamp":1740072664000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An untargeted metabolome-wide association study of maternal perinatal tobacco smoking in newborn blood spots"],"prefix":"10.1007","volume":"21","author":[{"given":"Di","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Uppal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas I.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean P.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Ritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8713-8413","authenticated-orcid":false,"given":"Julia E.","family":"Heck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"2225_CR2","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1111\/j.1471-0528.1993.tb14262.x","volume":"100","author":"AH Bardy","year":"1993","unstructured":"Bardy, A. H., Sepp\u00e4l\u00e4, T., Lillsunde, P., Kataja, J. M., Koskela, P., Pikkarainen, J., & Hiilesmaa, V. K. (1993). Objectively measured tobacco exposure during pregnancy: Neonatal effects and relation to maternal smoking. BJOG: an International Journal of Obstetrics & Gynaecology, 100, 721\u2013726.","journal-title":"BJOG: an International Journal of Obstetrics & Gynaecology"},{"key":"2225_CR3","doi-asserted-by":"publisher","first-page":"e64433","DOI":"10.1371\/journal.pone.0064433","volume":"8","author":"N Bonvallot","year":"2013","unstructured":"Bonvallot, N., Tremblay-Franco, M., Chevrier, C., Canlet, C., Warembourg, C., Cravedi, J.-P., & Cordier, S. (2013). Metabolomics tools for describing complex pesticide exposure in pregnant women in Brittany (France). PLoS ONE, 8, e64433.","journal-title":"PLoS ONE"},{"issue":"21","key":"2225_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182111545","volume":"18","author":"M Broekhuizen","year":"2021","unstructured":"Broekhuizen, M., Danser, A. H. J., Reiss, I. K. M., & Merkus, D. (2021). The Function of the Kynurenine Pathway in the Placenta: A Novel Pharmacotherapeutic Target? International Journal of Environmental Research and Public Health, 18(21), 11545.","journal-title":"International Journal of Environmental Research and Public Health"},{"key":"2225_CR5","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.3390\/metabo12111101","volume":"12","author":"KN Cajachagua-Torres","year":"2022","unstructured":"Cajachagua-Torres, K. N., Blaauwendraad, S. M., El Marroun, H., Demmelmair, H., Koletzko, B., Gaillard, R., & Jaddoe, V. W. V. (2022). Fetal exposure to maternal smoking and neonatal metabolite profiles. Metabolites, 12, 1101.","journal-title":"Metabolites"},{"key":"2225_CR6","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s11306-019-1587-1","volume":"15","author":"RA Carter","year":"2019","unstructured":"Carter, R. A., Pan, K., Harville, E. W., McRitchie, S., & Sumner, S. (2019). Metabolomics to reveal biomarkers and pathways of preterm birth: A systematic review and epidemiologic perspective. Metabolomics, 15, 124.","journal-title":"Metabolomics"},{"key":"2225_CR7","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.mrrev.2008.04.002","volume":"659","author":"A Catassi","year":"2008","unstructured":"Catassi, A., Servent, D., Paleari, L., Cesario, A., & Russo, P. (2008). Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: Implications on lung carcinogenesis. Mutation Research\/reviews in Mutation Research, 659, 221\u2013231.","journal-title":"Mutation Research\/reviews in Mutation Research"},{"key":"2225_CR1","unstructured":"California Department of Public Health, California Tobacco Control Program. Smoking prevalence among California and U.S. minus California adults, 1984\u20132010. (2014)."},{"key":"2225_CR8","unstructured":"California Department of Public Health. Newborn Screening Program. (2023). Available at: https:\/\/www.cdph.ca.gov\/Programs\/CFH\/DGDS\/Pages\/nbs\/default.aspx"},{"key":"2225_CR43","unstructured":"Centers for Disease Control and Prevention. Smoking is down, but almost 38 million American adults still smoke. (2018). Available at: https:\/\/archive.cdc.gov\/#\/details?url=https:\/\/www.cdc.gov\/media\/releases\/2018\/p0118-smoking-rates-declining.html"},{"key":"2225_CR9","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1586\/14737175.2015.1049999","volume":"15","author":"I Davis","year":"2015","unstructured":"Davis, I., & Liu, A. (2015). What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics? Expert Review of Neurotherapeutics, 15, 719\u2013721.","journal-title":"Expert Review of Neurotherapeutics"},{"key":"2225_CR10","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1067\/mcp.2000.106129","volume":"67","author":"D Dempsey","year":"2000","unstructured":"Dempsey, D., Jacob, P., III., & Benowitz, N. L. (2000). Nicotine metabolism and elimination kinetics in newborns. Clinical Pharmacology & Therapeutics, 67, 458\u2013465.","journal-title":"Clinical Pharmacology & Therapeutics"},{"key":"2225_CR11","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.aca.2019.02.010","volume":"1061","author":"K Deng","year":"2019","unstructured":"Deng, K., Zhang, F., Tan, Q., Huang, Y., Song, W., Rong, Z., Zhu, Z.-J., Li, Z., & Li, K. (2019). WaveICA: A novel algorithm to remove batch effects for large-scale untargeted metabolomics data based on wavelet analysis. Analytica Chimica Acta, 1061, 60\u201369.","journal-title":"Analytica Chimica Acta"},{"key":"2225_CR12","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.it.2016.12.006","volume":"38","author":"MN Erkelens","year":"2017","unstructured":"Erkelens, M. N., & Mebius, R. E. (2017). Retinoic acid and immune homeostasis: A balancing act. Trends in Immunology, 38, 168\u2013180.","journal-title":"Trends in Immunology"},{"key":"2225_CR13","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.envint.2017.07.019","volume":"107","author":"ST Fischer","year":"2017","unstructured":"Fischer, S. T., Lili, L. N., Li, S., Tran, V. T., Stewart, K. B., Schwartz, C. E., Jones, D. P., Sherman, S. L., & Fridovich-Keil, J. L. (2017). Low-level maternal exposure to nicotine associates with significant metabolic perturbations in second-trimester amniotic fluid. Environment International, 107, 227\u2013234.","journal-title":"Environment International"},{"key":"2225_CR14","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1093\/toxsci\/kfv198","volume":"148","author":"Y-M Go","year":"2015","unstructured":"Go, Y.-M., Walker, D. I., Liang, Y., Uppal, K., Soltow, Q. A., Tran, V., Strobel, F., Quyyumi, A. A., Ziegler, T. R., Pennell, K. D., Miller, G. W., & Jones, D. P. (2015a). Reference standardization for mass spectrometry and high-resolution metabolomics applications to exposome research. Toxicological Sciences, 148, 531\u2013543.","journal-title":"Toxicological Sciences"},{"key":"2225_CR15","first-page":"490","volume":"32","author":"JL Gonzales","year":"2011","unstructured":"Gonzales, J. L. (2011). Ethics for the pediatrician. Genetic Testing and Newborn Screening, 32, 490\u2013493.","journal-title":"Genetic Testing and Newborn Screening"},{"key":"2225_CR16","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.aca.2015.02.012","volume":"879","author":"PS Gromski","year":"2015","unstructured":"Gromski, P. S., Muhamadali, H., Ellis, D. I., Xu, Y., Correa, E., Turner, M. L., & Goodacre, R. (2015). A tutorial review: Metabolomics and partial least squares-discriminant analysis\u2014A marriage of convenience or a shotgun wedding. Analytica Chimica Acta, 879, 10\u201323.","journal-title":"Analytica Chimica Acta"},{"key":"2225_CR17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/B978-0-12-802147-7.00007-3","volume-title":"Nutraceuticals","author":"SM Gwaltney-Brant","year":"2016","unstructured":"Gwaltney-Brant, S. M. (2016). Chapter 7\u2014Nutraceuticals in hepatic diseases. In R. C. Gupta (Ed.), Nutraceuticals (pp. 87\u201399). Academic Press."},{"key":"2225_CR18","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1093\/humupd\/dmr022","volume":"17","author":"A Hackshaw","year":"2011","unstructured":"Hackshaw, A., Rodeck, C., & Boniface, S. (2011). Maternal smoking in pregnancy and birth defects: A systematic review based on 173 687 malformed cases and 11.7 million controls. Human Reproduction Update, 17, 589\u2013604.","journal-title":"Human Reproduction Update"},{"key":"2225_CR19","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1097\/IAE.0000000000003678","volume":"43","author":"D He","year":"2023","unstructured":"He, D., Huang, X., Uppal, K., Coleman, A. L., Walker, D. D., Ritz, B., Jones, D. P., & Heck, J. E. (2023a). Biomarkers of maternal smoking and the risk of retinoblastoma in offspring. Retina, 43, 481\u2013489.","journal-title":"Retina"},{"key":"2225_CR20","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1093\/aje\/kwad122","volume":"192","author":"D He","year":"2023","unstructured":"He, D., Yan, Q., Uppal, K., Walker, D. I., Jones, D. P., Ritz, B., & Heck, J. E. (2023b). Metabolite stability in archived neonatal dried blood spots used for epidemiological research. American Journal of Epidemiology, 192, 1720\u20131730.","journal-title":"American Journal of Epidemiology"},{"key":"2225_CR22","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1002\/ijc.30111","volume":"139","author":"JE Heck","year":"2016","unstructured":"Heck, J. E., Contreras, Z. A., Park, A. S., Davidson, T. B., Cockburn, M., & Ritz, B. (2016). Smoking in pregnancy and risk of cancer among young children: A population-based study. International Journal of Cancer, 139, 613\u2013616.","journal-title":"International Journal of Cancer"},{"key":"2225_CR23","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1007\/s10552-012-0034-7","volume":"23","author":"JE Heck","year":"2012","unstructured":"Heck, J. E., Lombardi, C. A., Meyers, T. J., Cockburn, M., Wilhelm, M., & Ritz, B. (2012). Perinatal characteristics and retinoblastoma. Cancer Causes & Control, 23, 1567\u20131575.","journal-title":"Cancer Causes & Control"},{"key":"2225_CR24","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1007\/s10903-011-9556-4","volume":"14","author":"KJ Hoggatt","year":"2012","unstructured":"Hoggatt, K. J., Flores, M., Solorio, R., Wilhelm, M., & Ritz, B. (2012). The \u201cLatina Epidemiologic Paradox\u201d revisited: the role of birthplace and acculturation in predicting infant low birth weight for Latinas in Los Angeles, CA. Journal of Immigrant and Minority Health, 14, 875\u2013884.","journal-title":"Journal of Immigrant and Minority Health"},{"key":"2225_CR25","doi-asserted-by":"publisher","first-page":"R70","DOI":"10.1186\/gb-2003-4-10-r70","volume":"4","author":"DA Hosack","year":"2003","unstructured":"Hosack, D. A., Dennis, G., Sherman, B. T., Lane, H. C., & Lempicki, R. A. (2003). Identifying biological themes within lists of genes with EASE. Genome Biology, 4, R70.","journal-title":"Genome Biology"},{"key":"2225_CR26","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1002\/ijc.32555","volume":"146","author":"JY Huang","year":"2020","unstructured":"Huang, J. Y., Larose, T. L., Luu, H. N., Wang, R., Fanidi, A., Alcala, K., Stevens, V. L., Weinstein, S. J., Albanes, D., Caporaso, N. E., Purdue, M. P., Ziegler, R. G., Freedman, N. D., Lan, Q., Prentice, R. L., Pettinger, M., Thomson, C. A., Cai, Q., & Yuan, J.-M. (2020). Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3). International Journal of Cancer, 146, 2394\u20132405.","journal-title":"International Journal of Cancer"},{"key":"2225_CR27","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1124\/pr.57.1.3","volume":"57","author":"J Hukkanen","year":"2005","unstructured":"Hukkanen, J., Jacob, P., & Benowitz, N. L. (2005). Metabolism and disposition kinetics of nicotine. Pharmacological Reviews, 57, 79\u2013115.","journal-title":"Pharmacological Reviews"},{"key":"2225_CR28","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.jchromb.2010.12.012","volume":"879","author":"P Jacob","year":"2011","unstructured":"Jacob, P., Yu, L., Duan, M., Ramos, L., Yturralde, O., & Benowitz, N. L. (2011). Determination of the nicotine metabolites cotinine and trans-3\u2032-hydroxycotinine in biologic fluids of smokers and non-smokers using liquid chromatography\u2013tandem mass spectrometry: Biomarkers for tobacco smoke exposure and for phenotyping cytochrome P450 2A6 activity. Journal of Chromatography B, 879, 267\u2013276.","journal-title":"Journal of Chromatography B"},{"key":"2225_CR29","doi-asserted-by":"publisher","first-page":"S111","DOI":"10.1097\/JOM.0000000000000763","volume":"58","author":"DP Jones","year":"2016","unstructured":"Jones, D. P., Walker, D. I., Uppal, K., Rohrbeck, P., Mallon, T. M., & Go, Y.-M. (2016). Metabolic pathways and networks associated with tobacco use in military personnel. Journal of Occupational and Environmental Medicine\/American College of Occupational and Environmental Medicine, 58, S111.","journal-title":"Journal of Occupational and Environmental Medicine\/American College of Occupational and Environmental Medicine"},{"key":"2225_CR30","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.socscimed.2012.10.011","volume":"76","author":"KM Keyes","year":"2013","unstructured":"Keyes, K. M., March, D., Link, B. G., Chilcoat, H. D., & Susser, E. (2013). Do socio-economic gradients in smoking emerge differently across time by gender? Implications for the tobacco epidemic from a pregnancy cohort in California, USA. Social Science & Medicine, 76, 101\u2013106.","journal-title":"Social Science & Medicine"},{"key":"2225_CR31","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/(SICI)1097-0215(20000101)85:1<35::AID-IJC6>3.0.CO;2-A","volume":"85","author":"P Koskela","year":"2000","unstructured":"Koskela, P., Anttila, T., Bj\u00f8rge, T., Brunsvig, A., Dillner, J., Hakama, M., Hakulinen, T., Jellum, E., Lehtinen, M., & Lenner, P. (2000). Chlamydia trachomatis infection as a risk factor for invasive cervical cancer. International Journal of Cancer, 85, 35\u201339.","journal-title":"International Journal of Cancer"},{"key":"2225_CR32","doi-asserted-by":"publisher","first-page":"e1003123","DOI":"10.1371\/journal.pcbi.1003123","volume":"9","author":"S Li","year":"2013","unstructured":"Li, S., Park, Y., Duraisingham, S., Strobel, F. H., Khan, N., Soltow, Q. A., Jones, D. P., & Pulendran, B. (2013). Predicting network activity from high throughput metabolomics. PLoS Computational Biology, 9, e1003123.","journal-title":"PLoS Computational Biology"},{"key":"2225_CR33","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.envint.2018.07.044","volume":"120","author":"D Liang","year":"2018","unstructured":"Liang, D., Moutinho, J. L., Golan, R., Yu, T., Ladva, C. N., Niedzwiecki, M., Walker, D. I., Sarnat, S. E., Chang, H. H., Greenwald, R., Jones, D. P., Russell, A. G., & Sarnat, J. A. (2018). Use of high-resolution metabolomics for the identification of metabolic signals associated with traffic-related air pollution. Environment International, 120, 145\u2013154.","journal-title":"Environment International"},{"key":"2225_CR34","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.trac.2011.02.007","volume":"30","author":"KH Liland","year":"2011","unstructured":"Liland, K. H. (2011). Multivariate methods in metabolomics\u2014from pre-processing to dimension reduction and statistical analysis. TrAC Trends in Analytical Chemistry, 30, 827\u2013841.","journal-title":"TrAC Trends in Analytical Chemistry"},{"key":"2225_CR35","doi-asserted-by":"publisher","first-page":"8836","DOI":"10.1021\/acs.analchem.0c00338","volume":"92","author":"KH Liu","year":"2020","unstructured":"Liu, K. H., Nellis, M., Uppal, K., Ma, C., Tran, V., Liang, Y., Walker, D. I., & Jones, D. P. (2020a). Reference standardization for quantification and harmonization of large-scale metabolomics. Analytical Chemistry, 92, 8836\u20138844.","journal-title":"Analytical Chemistry"},{"key":"2225_CR36","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.neuropharm.2016.03.024","volume":"112","author":"MD Lovelace","year":"2017","unstructured":"Lovelace, M. D., Varney, B., Sundaram, G., Lennon, M. J., Lim, C. K., Jacobs, K., Guillemin, G. J., & Brew, B. J. (2017). Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases. Neuropharmacology, 112, 373\u2013388.","journal-title":"Neuropharmacology"},{"key":"2225_CR37","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1053\/j.gastro.2007.07.019","volume":"133","author":"U Mahadevan","year":"2007","unstructured":"Mahadevan, U., Sandborn, W. J., Li, D. K., Hakimian, S., Kane, S., & Corley, D. A. (2007). Pregnancy outcomes in women with inflammatory bowel disease: A large community-based study from Northern California. Gastroenterology, 133, 1106\u20131112.","journal-title":"Gastroenterology"},{"key":"2225_CR38","doi-asserted-by":"crossref","unstructured":"Masvosva, W., Voutilainen, T., Lehtonen, M., Haikonen, R., Auriola, S., Keski-Nisula, L., Rys\u00e4, J., & K\u00e4rkk\u00e4inen, O. (2024) Alterations in the plasma metabolome associated with maternal smoking during the first trimester. medRxiv, 2024.11. 28.24318123.","DOI":"10.1101\/2024.11.28.24318123"},{"key":"2225_CR39","first-page":"140","volume-title":"Alcohol","author":"H Mernitz","year":"2006","unstructured":"Mernitz, H., & Wang, X.-D. (2006). Alcohol and tobacco smoke in retinoid metabolism and signaling: Implications for carcinogenesis. Alcohol, Tobacco and Cancer, (pp. 140\u2013159). Basel: Karger Publishers."},{"key":"2225_CR40","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/jes.2013.7","volume":"23","author":"SE Murphy","year":"2013","unstructured":"Murphy, S. E., Wickham, K. M., Lindgren, B. R., Spector, L. G., & Joseph, A. (2013). Cotinine and trans 3\u2032-hydroxycotinine in dried blood spots as biomarkers of tobacco exposure and nicotine metabolism. Journal of Exposure Science & Environmental Epidemiology, 23, 513\u2013518.","journal-title":"Journal of Exposure Science & Environmental Epidemiology"},{"key":"2225_CR21","unstructured":"National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. The Health Consequences of Smoking\u201450 Years of Progress: A Report of the Surgeon General. Atlanta (GA): Centers for Disease Control and Prevention (US); (2014). Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK179276\/"},{"key":"2225_CR41","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3390\/metabo9100212","volume":"9","author":"S Naz","year":"2019","unstructured":"Naz, S., Bhat, M., St\u00e5hl, S., Forsslund, H., Sk\u00f6ld, C. M., Wheelock, \u00c5. M., & Wheelock, C. E. (2019). Dysregulation of the tryptophan pathway evidences gender differences in COPD. Metabolites, 9, 212.","journal-title":"Metabolites"},{"key":"2225_CR42","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41598-017-14943-3","volume":"8","author":"TM Nelson","year":"2018","unstructured":"Nelson, T. M., Borgogna, J. C., Michalek, R. D., Roberts, D. W., Rath, J. M., Glover, E. D., Ravel, J., Shardell, M. D., Yeoman, C. J., & Brotman, R. M. (2018). Cigarette smoking is associated with an altered vaginal tract metabolomic profile. Scientific Reports, 8, 852.","journal-title":"Scientific Reports"},{"key":"2225_CR44","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1194\/jlr.R037648","volume":"54","author":"SM O\u2019Byrne","year":"2013","unstructured":"O\u2019Byrne, S. M., & Blaner, W. S. (2013). Retinol and retinyl esters: Biochemistry and physiology. Journal of Lipid Research, 54, 1731\u20131743.","journal-title":"Journal of Lipid Research"},{"key":"2225_CR45","doi-asserted-by":"publisher","first-page":"395","DOI":"10.2105\/AJPH.90.3.395","volume":"90","author":"H Pollack","year":"2000","unstructured":"Pollack, H., Lantz, P. M., & Frohna, J. G. (2000). Maternal smoking and adverse birth outcomes among singletons and twins. American Journal of Public Health, 90, 395\u2013400.","journal-title":"American Journal of Public Health"},{"key":"2225_CR46","doi-asserted-by":"publisher","first-page":"111907","DOI":"10.1016\/j.envres.2021.111907","volume":"203","author":"B Ritz","year":"2022","unstructured":"Ritz, B., Yan, Q., He, D., Wu, J., Walker, D. I., Uppal, K., Jones, D. P., & Heck, J. E. (2022). Child serum metabolome and traffic-related air pollution exposure in pregnancy. Environmental Research, 203, 111907.","journal-title":"Environmental Research"},{"key":"2225_CR47","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s11306-016-0983-z","volume":"12","author":"UE Rolle-Kampczyk","year":"2016","unstructured":"Rolle-Kampczyk, U. E., Krumsiek, J., Otto, W., R\u00f6der, S. W., Kohajda, T., Borte, M., Theis, F., Lehmann, I., & von Bergen, M. (2016). Metabolomics reveals effects of maternal smoking on endogenous metabolites from lipid metabolism in cord blood of newborns. Metabolomics, 12, 76.","journal-title":"Metabolomics"},{"key":"2225_CR48","first-page":"303826","volume":"114","author":"D Saleheen","year":"2014","unstructured":"Saleheen, D., Zhao, W., & Rasheed, A. (2014). Epidemiology and public health policy of tobacco use and cardiovascular disorders in low-and middle-income countries. Arteriosclerosis, Thrombosis, and Vascular Biology, ATVBAHA, 114, 303826.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology, ATVBAHA"},{"key":"2225_CR49","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.cca.2005.06.013","volume":"364","author":"K Schr\u00f6cksnadel","year":"2006","unstructured":"Schr\u00f6cksnadel, K., Wirleitner, B., Winkler, C., & Fuchs, D. (2006). Monitoring tryptophan metabolism in chronic immune activation. Clinica Chimica Acta, 364, 82\u201390.","journal-title":"Clinica Chimica Acta"},{"key":"2225_CR50","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1164\/ajrccm.163.5.2007135","volume":"163","author":"HJ Sch\u00fcnemann","year":"2001","unstructured":"Sch\u00fcnemann, H. J., Grant, B. J., Freudenheim, J. L., Muti, P., Browne, R. W., Drake, J. A., Klocke, R. A., & Trevisan, M. (2001). The relation of serum levels of antioxidant vitamins C and E, retinol and carotenoids with pulmonary function in the general population. American Journal of Respiratory and Critical Care Medicine, 163, 1246\u20131255.","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"2225_CR51","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1021\/es5002105","volume":"48","author":"EL Schymanski","year":"2014","unstructured":"Schymanski, E. L., Jeon, J., Gulde, R., Fenner, K., Ruff, M., Singer, H. P., & Hollender, J. (2014). Identifying small molecules via high resolution mass spectrometry: Communicating confidence. Environmental Science & Technology,\u00a048,\u00a02097\u20132098.","journal-title":"Environmental Science & Technology"},{"key":"2225_CR52","doi-asserted-by":"publisher","first-page":"11725","DOI":"10.1021\/ac402503m","volume":"85","author":"Y Simon-Manso","year":"2013","unstructured":"Simon-Manso, Y., Lowenthal, M. S., Kilpatrick, L. E., Sampson, M. L., Telu, K. H., Rudnick, P. A., Mallard, W. G., Bearden, D. W., Schock, T. B., Tchekhovskoi, D. V., Blonder, N., Yan, X., Liang, Y., Zheng, Y., Wallace, W. E., Neta, P., Phinney, K. W., Remaley, A. T., & Stein, S. E. (2013). Metabolite profiling of a NIST Standard Reference Material for human plasma (SRM 1950): GC-MS, LC-MS, NMR, and clinical laboratory analyses, libraries, and web-based resources. Analytical Chemistry, 85, 11725\u201311731.","journal-title":"Analytical Chemistry"},{"key":"2225_CR53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02565","author":"FJH Sorgdrager","year":"2019","unstructured":"Sorgdrager, F. J. H., Naud\u00e9, P. J. W., Kema, I. P., Nollen, E. A., & Deyn, P. P. D. (2019a). Tryptophan metabolism in inflammaging: From biomarker to therapeutic target. Frontiers in Immunology. https:\/\/doi.org\/10.3389\/fimmu.2019.02565","journal-title":"Frontiers in Immunology"},{"key":"2225_CR54","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1111\/jnc.14843","volume":"151","author":"FJH Sorgdrager","year":"2019","unstructured":"Sorgdrager, F. J. H., Vermeiren, Y., Van Faassen, M., van der Ley, C., Nollen, E. A. A., Kema, I. P., & De Deyn, P. P. (2019b). Age- and disease-specific changes of the kynurenine pathway in Parkinson\u2019s and Alzheimer\u2019s disease. Journal of Neurochemistry, 151, 656\u2013668.","journal-title":"Journal of Neurochemistry"},{"key":"2225_CR55","doi-asserted-by":"publisher","first-page":"106888","DOI":"10.1016\/j.envint.2021.106888","volume":"158","author":"Y Sun","year":"2022","unstructured":"Sun, Y., Li, X., Benmarhnia, T., Chen, J.-C., Avila, C., Sacks, D. A., Chiu, V., Slezak, J., Molitor, J., Getahun, D., & Wu, J. (2022). Exposure to air pollutant mixture and gestational diabetes mellitus in Southern California: Results from electronic health record data of a large pregnancy cohort. Environment International, 158, 106888.","journal-title":"Environment International"},{"key":"2225_CR56","doi-asserted-by":"publisher","first-page":"118361","DOI":"10.1016\/j.envpol.2021.118361","volume":"292","author":"Y Tan","year":"2022","unstructured":"Tan, Y., Barr, D. B., Ryan, P. B., Fedirko, V., Sarnat, J. A., Gaskins, A. J., Chang, C.-J., Tang, Z., Marsit, C. J., Corwin, E. J., Jones, D. P., Dunlop, A. L., & Liang, D. (2022). High-resolution metabolomics of exposure to tobacco smoke during pregnancy and adverse birth outcomes in the Atlanta African American maternal-child cohort. Environmental Pollution, 292, 118361.","journal-title":"Environmental Pollution"},{"key":"2225_CR57","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/all.12376","volume":"69","author":"NC Thomson","year":"2014","unstructured":"Thomson, N. C., Chaudhuri, R., Spears, M., Messow, C. M., Jelinsky, S., Miele, G., Nocka, K., Takahashi, E., Hilmi, O. J., Shepherd, M. C., Miller, D. K., & McSharry, C. (2014). Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking. Allergy, 69, 527\u2013536.","journal-title":"Allergy"},{"key":"2225_CR58","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.csbj.2020.04.011","volume":"18","author":"B Titz","year":"2020","unstructured":"Titz, B., Szostak, J., Sewer, A., Phillips, B., Nury, C., Schneider, T., Dijon, S., Lavrynenko, O., Elamin, A., Guedj, E., Tsin Wong, E., Lebrun, S., Vuillaume, G., Kondylis, A., Gubian, S., Cano, S., Leroy, P., Keppler, B., Ivanov, N. V., \u2026 Hoeng, J. (2020). Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke. Computational and Structural Biotechnology Journal, 18, 1056\u20131073.","journal-title":"Computational and Structural Biotechnology Journal"},{"key":"2225_CR59","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1093\/bioinformatics\/17.6.520","volume":"17","author":"O Troyanskaya","year":"2001","unstructured":"Troyanskaya, O., Cantor, M., Sherlock, G., Brown, P., Hastie, T., Tibshirani, R., Botstein, D., & Altman, R. B. (2001). Missing value estimation methods for DNA microarrays. Bioinformatics, 17, 520\u2013525.","journal-title":"Bioinformatics"},{"key":"2225_CR60","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3389\/fbioe.2015.00087","volume":"3","author":"K Uppal","year":"2015","unstructured":"Uppal, K., Soltow, Q. A., Promislow, D. E., Wachtman, L. M., Quyyumi, A. A., & Jones, D. P. (2015). MetabNet: An R package for metabolic association analysis of high-resolution metabolomics data. Frontiers in Bioengineering and Biotechnology, 3, 87.","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"key":"2225_CR61","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1471-2105-14-15","volume":"14","author":"K Uppal","year":"2013","unstructured":"Uppal, K., Soltow, Q. A., Strobel, F. H., Pittard, W. S., Gernert, K. M., Yu, T., & Jones, D. P. (2013). xMSanalyzer: Automated pipeline for improved feature detection and downstream analysis of large-scale, non-targeted metabolomics data. BMC Bioinformatics, 14, 15.","journal-title":"BMC Bioinformatics"},{"key":"2225_CR62","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1021\/acs.analchem.6b01214","volume":"89","author":"K Uppal","year":"2017","unstructured":"Uppal, K., Walker, D. I., & Jones, D. P. (2017). xMSannotator: An R package for network-based annotation of high-resolution metabolomics data. Analytical Chemistry, 89, 1063\u20131067.","journal-title":"Analytical Chemistry"},{"key":"2225_CR63","doi-asserted-by":"publisher","first-page":"699","DOI":"10.2105\/AJPH.78.6.699","volume":"78","author":"MA Wall","year":"1988","unstructured":"Wall, M. A., Johnson, J., Jacob, P., & Benowitz, N. L. (1988). Cotinine in the serum, saliva, and urine of nonsmokers, passive smokers, and active smokers. American Journal of Public Health, 78, 699\u2013701.","journal-title":"American Journal of Public Health"},{"key":"2225_CR64","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1001\/archinte.162.7.811","volume":"162","author":"C-S Wang","year":"2002","unstructured":"Wang, C.-S., Wang, S.-T., Chang, T.-T., Yao, W.-J., & Chou, P. (2002). Smoking and alanine aminotransferase levels in hepatitis C virus infection: Implications for prevention of hepatitis C virus progression. Archives of Internal Medicine, 162, 811\u2013815.","journal-title":"Archives of Internal Medicine"},{"key":"2225_CR65","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1741-7015-11-60","volume":"11","author":"T Xu","year":"2013","unstructured":"Xu, T., Holzapfel, C., Dong, X., Bader, E., Yu, Z., Prehn, C., Perstorfer, K., Jaremek, M., Roemisch-Margl, W., Rathmann, W., Li, Y., Wichmann, H. E., Wallaschofski, H., Ladwig, K. H., Theis, F., Suhre, K., Adamski, J., Illig, T., Peters, A., & Wang-Sattler, R. (2013). Effects of smoking and smoking cessation on human serum metabolite profile: Results from the KORA cohort study. BMC Medicine, 11, 60.","journal-title":"BMC Medicine"},{"key":"2225_CR70","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s12929-015-0189-0","volume":"22","author":"Y Xue","year":"2015","unstructured":"Xue, Y., Harris, E., Wang, W., & Baybutt, R. C. (2015). Vitamin A depletion induced by cigarette smoke is associated with an increase in lung cancer-related markers in rats. Journal of Biomedical Science, 22, 84\u201384.","journal-title":"Journal of Biomedical Science"},{"key":"2225_CR66","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1093\/aje\/kwt182","volume":"178","author":"J Yang","year":"2013","unstructured":"Yang, J., Pearl, M., Jacob, P., 3rd., DeLorenze, G. N., Benowitz, N. L., Yu, L., Havel, C., & Kharrazi, M. (2013). Levels of cotinine in dried blood specimens from newborns as a biomarker of maternal smoking close to the time of delivery. American Journal of Epidemiology, 178, 1648\u20131654.","journal-title":"American Journal of Epidemiology"},{"key":"2225_CR67","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1023\/A:1011240019516","volume":"12","author":"K Yost","year":"2001","unstructured":"Yost, K., Perkins, C., Cohen, R., Morris, C., & Wright, W. (2001). Socioeconomic status and breast cancer incidence in California for different race\/ethnic groups. Cancer Causes and Control, 12, 703\u2013711.","journal-title":"Cancer Causes and Control"},{"key":"2225_CR68","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1093\/bioinformatics\/btp291","volume":"25","author":"T Yu","year":"2009","unstructured":"Yu, T., Park, Y., Johnson, J. M., & Jones, D. P. (2009). apLCMS\u2013adaptive processing of high-resolution LC\/MS data. Bioinformatics, 25, 1930\u20131936.","journal-title":"Bioinformatics"},{"key":"2225_CR69","doi-asserted-by":"publisher","first-page":"710","DOI":"10.3390\/ijerph18020710","volume":"18","author":"H Zhu","year":"2021","unstructured":"Zhu, H., Abdullah, A. S., He, J., Xi, J., Mao, Y., Feng, Y., Xiao, Q., & Zheng, P. (2021). Untargeted urinary metabolomics and children\u2019s exposure to secondhand smoke: the influence of individual differences. International Journal of Environmental Research and Public Health, 18, 710.","journal-title":"International Journal of Environmental Research and Public Health"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-025-02225-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-025-02225-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-025-02225-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T06:01:37Z","timestamp":1745042497000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-025-02225-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,20]]},"references-count":70,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["2225"],"URL":"https:\/\/doi.org\/10.1007\/s11306-025-02225-3","relation":{},"ISSN":["1573-3890"],"issn-type":[{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,20]]},"assertion":[{"value":"15 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Human subject permissions were obtained from the California Committee for the Protection of Human Subjects, the University of California, Los Angeles, and the University of North Texas.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"30"}}