{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:17:36Z","timestamp":1790727456892,"version":"4.1.0"},"reference-count":142,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"DOI":"10.1007\/s11306-025-02273-9","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T12:51:14Z","timestamp":1748868674000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Metabolomics of ocular immune diseases"],"prefix":"10.1007","volume":"21","author":[{"given":"Runchuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Guo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"2273_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112309","author":"JK Ahn","year":"2017","unstructured":"Ahn, J. K., Kim, J., Hwang, J., Song, J., Kim, K. H., & Cha, H. S. (2017). Urinary metabolomic profiling to identify potential biomarkers for the diagnosis of Behcet\u2019s disease by gas Chromatography\/Time-of-Flight-Mass spectrometry. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms18112309","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"2273_CR2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jbspin.2017.05.019","volume":"85","author":"JK Ahn","year":"2018","unstructured":"Ahn, J. K., Kim, J., Hwang, J., Song, J., Kim, K. H., & Cha, H. S. (2018). Potential metabolomic biomarkers for reliable diagnosis of Behcet\u2019s disease using gas chromatography\/time-of-flight-mass spectrometry. Joint, Bone, Spine: Revue Du Rhumatisme, 85(3), 337\u2013343. https:\/\/doi.org\/10.1016\/j.jbspin.2017.05.019","journal-title":"Joint, Bone, Spine: Revue Du Rhumatisme"},{"issue":"1","key":"2273_CR3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/ijd.15101","volume":"60","author":"LS Al Akrash","year":"2021","unstructured":"Al Akrash, L. S., Semari, A., M. A., & Al Harithy, R. (2021). Ocular manifestations of dermatological diseases part I: Infectious and inflammatory disorders. International Journal of Dermatology, 60(1), 5\u201311. https:\/\/doi.org\/10.1111\/ijd.15101","journal-title":"International Journal of Dermatology"},{"key":"2273_CR4","doi-asserted-by":"publisher","unstructured":"Astley, R., Miller, F. C., Mursalin, M. H., Coburn, P. S., & Callegan, M. C. (2019). An Eye on Staphylococcus aureus Toxins: Roles in Ocular Damage and Inflammation. Toxins (Basel). https:\/\/doi.org\/10.3390\/toxins11060356","DOI":"10.3390\/toxins11060356"},{"issue":"16","key":"2273_CR5","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1001\/jama.2013.280318","volume":"310","author":"AA Azari","year":"2013","unstructured":"Azari, A. A., & Barney, N. P. (2013). Conjunctivitis: A systematic review of diagnosis and treatment. Jama, 310(16), 1721\u20131729. https:\/\/doi.org\/10.1001\/jama.2013.280318","journal-title":"Jama"},{"issue":"8","key":"2273_CR6","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1056\/NEJMra0905750","volume":"362","author":"RS Bahn","year":"2010","unstructured":"Bahn, R. S. (2010). Graves\u2019 ophthalmopathy. New England Journal of Medicine, 362(8), 726\u2013738. https:\/\/doi.org\/10.1056\/NEJMra0905750","journal-title":"New England Journal of Medicine"},{"key":"2273_CR7","doi-asserted-by":"publisher","first-page":"108268","DOI":"10.1016\/j.exer.2020.108268","volume":"201","author":"J Barbosa Breda","year":"2020","unstructured":"Barbosa Breda, J., Croitor Sava, A., Himmelreich, U., Somers, A., Matthys, C., Rocha Sousa, A., Vandewalle, E., & Stalmans, I. (2020). Metabolomic profiling of aqueous humor from glaucoma patients - The metabolomics in surgical ophthalmological patients (MISO) study. Experimental Eye Research, 201, 108268. https:\/\/doi.org\/10.1016\/j.exer.2020.108268","journal-title":"Experimental Eye Research"},{"issue":"2","key":"2273_CR8","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/ceo.13847","volume":"49","author":"BK Betzler","year":"2021","unstructured":"Betzler, B. K., Gupta, V., & Agrawal, R. (2021). Clinics of ocular tuberculosis: A review. Clinical & Experimental Ophthalmology, 49(2), 146\u2013160. https:\/\/doi.org\/10.1111\/ceo.13847","journal-title":"Clinical & Experimental Ophthalmology"},{"key":"2273_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11020404","author":"B Billiet","year":"2022","unstructured":"Billiet, B., de la Barca, C., Ferr\u00e9, J. M., Muller, M., Vautier, J., Assad, A., Blanchet, S., Tessier, O., Wetterwald, L., Faure, C., Urbanski, J., Simard, G., Mirebeau-Prunier, G., Rodien, D., Gohier, P., P., & Reynier, P. (2022). A tear metabolomic profile showing increased ornithine decarboxylase activity and spermine synthesis in Thyroid-Associated orbitopathy. J Clin Med. https:\/\/doi.org\/10.3390\/jcm11020404","journal-title":"J Clin Med"},{"issue":"8","key":"2273_CR10","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1210\/clinem\/dgad030","volume":"108","author":"F Biscarini","year":"2023","unstructured":"Biscarini, F., Masetti, G., Muller, I., Verhasselt, H. L., Covelli, D., Colucci, G., Zhang, L., Draman, M. S., Okosieme, O., Taylor, P., Daumerie, C., Burlacu, M. C., Marin\u00f2, M., Ezra, D. G., Perros, P., Plummer, S., Eckstein, A., Salvi, M., Marchesi, J. R., & Ludgate, M. (2023). Gut Microbiome associated with graves disease and graves orbitopathy: The INDIGO multicenter European study. Journal of Clinical Endocrinology and Metabolism, 108(8), 2065\u20132077. https:\/\/doi.org\/10.1210\/clinem\/dgad030","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"2","key":"2273_CR11","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.survophthal.2019.10.004","volume":"65","author":"O Bjordal","year":"2020","unstructured":"Bjordal, O., Norheim, K. B., R\u00f8dahl, E., Jonsson, R., & Omdal, R. (2020). Primary Sj\u00f6gren\u2019s syndrome and the eye. Survey of Ophthalmology, 65(2), 119\u2013132. https:\/\/doi.org\/10.1016\/j.survophthal.2019.10.004","journal-title":"Survey of Ophthalmology"},{"key":"2273_CR12","doi-asserted-by":"publisher","first-page":"358","DOI":"10.3389\/fimmu.2020.00358","volume":"11","author":"M Bonacini","year":"2020","unstructured":"Bonacini, M., Soriano, A., Cimino, L., De Simone, L., Bolletta, E., Gozzi, F., Muratore, F., Nicastro, M., Belloni, L., Zerbini, A., Fontana, L., Salvarani, C., & Croci, S. (2020). Cytokine profiling in aqueous humor samples from patients with Non-Infectious uveitis associated with systemic inflammatory diseases. Frontiers in Immunology, 11, 358. https:\/\/doi.org\/10.3389\/fimmu.2020.00358","journal-title":"Frontiers in Immunology"},{"issue":"10","key":"2273_CR13","doi-asserted-by":"publisher","first-page":"5633","DOI":"10.1021\/acs.chemrev.0c00901","volume":"121","author":"RM Borges","year":"2021","unstructured":"Borges, R. M., Colby, S. M., Das, S., Edison, A. S., Fiehn, O., Kind, T., Lee, J., Merrill, A. T., Merz, K. M. Jr., Metz, T. O., Nunez, J. R., Tantillo, D. J., Wang, L. P., Wang, S., & Renslow, R. S. (2021). Quantum chemistry calculations for metabolomics. Chemical Reviews, 121(10), 5633\u20135670. https:\/\/doi.org\/10.1021\/acs.chemrev.0c00901","journal-title":"Chemical Reviews"},{"key":"2273_CR14","doi-asserted-by":"publisher","first-page":"m4979","DOI":"10.1136\/bmj.m4979","volume":"372","author":"BM Burkholder","year":"2021","unstructured":"Burkholder, B. M., & Jabs, D. A. (2021). Uveitis for the non-ophthalmologist. Bmj, 372, m4979. https:\/\/doi.org\/10.1136\/bmj.m4979","journal-title":"Bmj"},{"issue":"27","key":"2273_CR15","doi-asserted-by":"publisher","first-page":"7121","DOI":"10.1007\/s00216-018-1313-2","volume":"410","author":"SK Byeon","year":"2018","unstructured":"Byeon, S. K., Park, S. H., Lee, J. C., Hwang, S., Ku, C. R., Shin, D. Y., Yoon, J. S., Lee, E. J., & Moon, M. H. (2018). Lipidomic differentiation of graves\u2019 ophthalmopathy in plasma and urine from graves\u2019 disease patients. Analytical and Bioanalytical Chemistry, 410(27), 7121\u20137133. https:\/\/doi.org\/10.1007\/s00216-018-1313-2","journal-title":"Analytical and Bioanalytical Chemistry"},{"key":"2273_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713338","author":"LIM Campagnoli","year":"2023","unstructured":"Campagnoli, L. I. M., Varesi, A., Barbieri, A., Marchesi, N., & Pascale, A. (2023). Targeting the Gut-Eye axis: An emerging strategy to face ocular diseases. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms241713338","journal-title":"International Journal of Molecular Sciences"},{"key":"2273_CR17","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.preteyeres.2016.07.001","volume":"55","author":"G Carracedo","year":"2016","unstructured":"Carracedo, G., Crooke, A., Guzman-Aranguez, A., P\u00e9rez de Lara, M. J., Martin-Gil, A., & Pintor, J. (2016). The role of Dinucleoside polyphosphates on the ocular surface and other eye structures. Progress in Retinal and Eye Research, 55, 182\u2013205. https:\/\/doi.org\/10.1016\/j.preteyeres.2016.07.001","journal-title":"Progress in Retinal and Eye Research"},{"key":"2273_CR18","doi-asserted-by":"publisher","first-page":"108070","DOI":"10.1016\/j.exer.2020.108070","volume":"196","author":"L Chen","year":"2020","unstructured":"Chen, L., Chang, R., Pan, S., Xu, J., Cao, Q., Su, G., Zhou, C., Kijlstra, A., & Yang, P. (2020). Plasma metabolomics study of Vogt-Koyanagi-Harada disease identifies potential diagnostic biomarkers. Experimental Eye Research, 196, 108070. https:\/\/doi.org\/10.1016\/j.exer.2020.108070","journal-title":"Experimental Eye Research"},{"issue":"9","key":"2273_CR19","doi-asserted-by":"publisher","first-page":"3982","DOI":"10.1021\/acs.jproteome.5b00443","volume":"14","author":"L Chen","year":"2015","unstructured":"Chen, L., Li, J., Guo, T., Ghosh, S., Koh, S. K., Tian, D., Zhang, L., Jia, D., Beuerman, R. W., Aebersold, R., Chan, E. C., & Zhou, L. (2015). Global metabonomic and proteomic analysis of human conjunctival epithelial cells (IOBA-NHC) in response to hyperosmotic stress. Journal of Proteome Research, 14(9), 3982\u20133995. https:\/\/doi.org\/10.1021\/acs.jproteome.5b00443","journal-title":"Journal of Proteome Research"},{"issue":"11","key":"2273_CR20","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1038\/s41592-021-01303-3","volume":"18","author":"L Chen","year":"2021","unstructured":"Chen, L., Lu, W., Wang, L., Xing, X., Chen, Z., Teng, X., Zeng, X., Muscarella, A. D., Shen, Y., Cowan, A., McReynolds, M. R., Kennedy, B. J., Lato, A. M., Campagna, S. R., Singh, M., & Rabinowitz, J. D. (2021). Metabolite discovery through global annotation of untargeted metabolomics data. Nature Methods, 18(11), 1377\u20131385. https:\/\/doi.org\/10.1038\/s41592-021-01303-3","journal-title":"Nature Methods"},{"issue":"5","key":"2273_CR21","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1021\/acs.jproteome.9b00149","volume":"18","author":"X Chen","year":"2019","unstructured":"Chen, X., Rao, J., Zheng, Z., Yu, Y., Lou, S., Liu, L., He, Q., Wu, L., & Sun, X. (2019). Integrated tear proteome and metabolome reveal panels of Inflammatory-Related molecules via key regulatory pathways in dry eye syndrome. Journal of Proteome Research, 18(5), 2321\u20132330. https:\/\/doi.org\/10.1021\/acs.jproteome.9b00149","journal-title":"Journal of Proteome Research"},{"issue":"1","key":"2273_CR22","doi-asserted-by":"publisher","first-page":"16936","DOI":"10.1038\/s41598-018-35096-x","volume":"8","author":"CL Chng","year":"2018","unstructured":"Chng, C. L., Seah, L. L., Yang, M., Shen, S. Y., Koh, S. K., Gao, Y., Deng, L., Tong, L., Beuerman, R. W., & Zhou, L. (2018). Tear proteins calcium binding protein A4 (S100A4) and prolactin induced protein (PIP) are potential biomarkers for thyroid eye disease. Scientific Reports, 8(1), 16936. https:\/\/doi.org\/10.1038\/s41598-018-35096-x","journal-title":"Scientific Reports"},{"issue":"6","key":"2273_CR23","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1002\/mas.21562","volume":"37","author":"L Cui","year":"2018","unstructured":"Cui, L., Lu, H., & Lee, Y. H. (2018). Challenges and emergent solutions for LC-MS\/MS based untargeted metabolomics in diseases. Mass Spectrometry Reviews, 37(6), 772\u2013792. https:\/\/doi.org\/10.1002\/mas.21562","journal-title":"Mass Spectrometry Reviews"},{"issue":"3","key":"2273_CR24","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/cei.13435","volume":"200","author":"X Cui","year":"2020","unstructured":"Cui, X., Su, G., Zhang, L., Yi, S., Cao, Q., Zhou, C., Kijlstra, A., & Yang, P. (2020). Integrated omics analysis of sweat reveals an aberrant amino acid metabolism pathway in Vogt-Koyanagi-Harada disease. Clinical and Experimental Immunology, 200(3), 250\u2013259. https:\/\/doi.org\/10.1111\/cei.13435","journal-title":"Clinical and Experimental Immunology"},{"key":"2273_CR25","doi-asserted-by":"publisher","first-page":"107812","DOI":"10.1016\/j.intimp.2021.107812","volume":"97","author":"X Cui","year":"2021","unstructured":"Cui, X., Zhang, L., Su, G., Kijlstra, A., & Yang, P. (2021). Specific sweat metabolite profile in ocular Behcet\u2019s disease. International Immunopharmacology, 97, 107812. https:\/\/doi.org\/10.1016\/j.intimp.2021.107812","journal-title":"International Immunopharmacology"},{"key":"2273_CR26","doi-asserted-by":"publisher","first-page":"108734","DOI":"10.1016\/j.exer.2021.108734","volume":"211","author":"AL Daphne Teh","year":"2021","unstructured":"Daphne Teh, A. L., Jayapalan, J. J., Loke, M. F., Abdul Kadir, W., A. J., & Subrayan, V. (2021). Identification of potential serum metabolic biomarkers for patient with keratoconus using untargeted metabolomics approach. Experimental Eye Research, 211, 108734. https:\/\/doi.org\/10.1016\/j.exer.2021.108734","journal-title":"Experimental Eye Research"},{"issue":"1","key":"2273_CR27","doi-asserted-by":"publisher","first-page":"163","DOI":"10.18240\/ijo.2020.01.23","volume":"13","author":"UN Das","year":"2020","unstructured":"Das, U. N. (2020). Molecular pathobiology of scleritis and its therapeutic implications. Int J Ophthalmol, 13(1), 163\u2013175. https:\/\/doi.org\/10.18240\/ijo.2020.01.23","journal-title":"Int J Ophthalmol"},{"issue":"5","key":"2273_CR28","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s00109-020-01907-w","volume":"98","author":"A Di Zazzo","year":"2020","unstructured":"Di Zazzo, A., Yang, W., Coassin, M., Micera, A., Antonini, M., Piccinni, F., De Piano, M., Kohler, I., Harms, A. C., Hankemeier, T., Boinini, S., & Mashaghi, A. (2020). Signaling lipids as diagnostic biomarkers for ocular surface cicatrizing conjunctivitis. J Mol Med (Berl), 98(5), 751\u2013760. https:\/\/doi.org\/10.1007\/s00109-020-01907-w","journal-title":"J Mol Med (Berl)"},{"issue":"4","key":"2273_CR29","doi-asserted-by":"publisher","first-page":"103036","DOI":"10.1016\/j.autrev.2022.103036","volume":"21","author":"G Du","year":"2022","unstructured":"Du, G., Patzelt, S., van Beek, N., & Schmidt, E. (2022a). Mucous membrane pemphigoid. Autoimmun Rev, 21(4), 103036. https:\/\/doi.org\/10.1016\/j.autrev.2022.103036","journal-title":"Autoimmun Rev"},{"key":"2273_CR30","doi-asserted-by":"publisher","first-page":"1151757","DOI":"10.3389\/fendo.2023.1151757","volume":"14","author":"R Du","year":"2023","unstructured":"Du, R., Wang, F., Yang, C., Hu, J., Liu, J., Jian, Q., Wang, R., Zhang, J., Chen, H., Wang, Y., & Zhang, F. (2023). Metabolic features of orbital adipose tissue in patients with thyroid eye disease. Front Endocrinol (Lausanne), 14, 1151757. https:\/\/doi.org\/10.3389\/fendo.2023.1151757","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2273_CR31","doi-asserted-by":"publisher","first-page":"1037164","DOI":"10.3389\/fendo.2022.1037164","volume":"13","author":"X Du","year":"2022","unstructured":"Du, X., Yang, L., Kong, L., Sun, Y., Shen, K., Cai, Y., Sun, H., Zhang, B., Guo, S., Zhang, A., & Wang, X. (2022b). Metabolomics of various samples advancing biomarker discovery and pathogenesis Elucidation for diabetic retinopathy. Front Endocrinol (Lausanne), 13, 1037164. https:\/\/doi.org\/10.3389\/fendo.2022.1037164","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2273_CR33","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1039\/b906712b","volume":"40","author":"WB Dunn","year":"2011","unstructured":"Dunn, W. B., Broadhurst, D. I., Atherton, H. J., Goodacre, R., & Griffin, J. L. (2011b). Systems level studies of mammalian metabolomes: The roles of mass spectrometry and nuclear magnetic resonance spectroscopy. Chemical Society Reviews, 40(1), 387\u2013426. https:\/\/doi.org\/10.1039\/b906712b","journal-title":"Chemical Society Reviews"},{"issue":"7","key":"2273_CR32","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1038\/nprot.2011.335","volume":"6","author":"WB Dunn","year":"2011","unstructured":"Dunn, W. B., Broadhurst, D., Begley, P., Zelena, E., Francis-McIntyre, S., Anderson, N., Brown, M., Knowles, J. D., Halsall, A., Haselden, J. N., Nicholls, A. W., Wilson, I. D., Kell, D. B., & Goodacre, R. (2011a). Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nature Protocols, 6(7), 1060\u20131083. https:\/\/doi.org\/10.1038\/nprot.2011.335","journal-title":"Nature Protocols"},{"key":"2273_CR34","doi-asserted-by":"publisher","first-page":"623725","DOI":"10.3389\/fimmu.2021.623725","volume":"12","author":"CE Egwuagu","year":"2021","unstructured":"Egwuagu, C. E., Alhakeem, S. A., & Mbanefo, E. C. (2021). Uveitis: Molecular pathogenesis and emerging therapies. Frontiers in Immunology, 12, 623725. https:\/\/doi.org\/10.3389\/fimmu.2021.623725","journal-title":"Frontiers in Immunology"},{"issue":"4","key":"2273_CR35","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1021\/acssensors.2c02422","volume":"8","author":"R Einoch Amor","year":"2023","unstructured":"Einoch Amor, R., Levy, J., Broza, Y. Y., Vangravs, R., Rapoport, S., Zhang, M., Wu, W., Leja, M., Behar, J. A., & Haick, H. (2023). Liquid Biopsy-Based volatile organic compounds from blood and urine and their combined data sets for highly accurate detection of Cancer. ACS Sens, 8(4), 1450\u20131461. https:\/\/doi.org\/10.1021\/acssensors.2c02422","journal-title":"ACS Sens"},{"issue":"1","key":"2273_CR36","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/art.42658","volume":"76","author":"M Essex","year":"2024","unstructured":"Essex, M., Rodriguez, R., Rademacher, V., Proft, J., L\u00f6ber, F., Mark\u00f3, U., Pleyer, L., Strowig, U., Marchand, T., Kirwan, J., Siegmund, J. A., Forslund, B., S. K., & Poddubnyy, D. (2024). Shared and distinct gut microbiota in spondyloarthritis, acute anterior uveitis, and Crohn\u2019s disease. Arthritis Rheumatol, 76(1), 48\u201358. https:\/\/doi.org\/10.1002\/art.42658","journal-title":"Arthritis Rheumatol"},{"issue":"7","key":"2273_CR37","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1021\/acs.jproteome.3c00007","volume":"22","author":"J Fang","year":"2023","unstructured":"Fang, J., Wang, H., Niu, T., Shi, X., Xing, X., Qu, Y., Liu, Y., Liu, X., Xiao, Y., Dou, T., Shen, Y., & Liu, K. (2023). Integration of vitreous lipidomics and metabolomics for comprehensive Understanding of the pathogenesis of proliferative diabetic retinopathy. Journal of Proteome Research, 22(7), 2293\u20132306. https:\/\/doi.org\/10.1021\/acs.jproteome.3c00007","journal-title":"Journal of Proteome Research"},{"key":"2273_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13111125","author":"FA Fineide","year":"2023","unstructured":"Fineide, F. A., Tashbayev, B., Elgst\u00f8en, K. B. P., Sand\u00e5s, E. M., Rootwelt, H., Hynne, H., Chen, X., R\u00e6der, S., Vehof, J., Dartt, D., Jensen, J. L., & Utheim, T. P. (2023). Tear and saliva metabolomics in evaporative dry eye disease in females. Metabolites. https:\/\/doi.org\/10.3390\/metabo13111125","journal-title":"Metabolites"},{"issue":"5","key":"2273_CR39","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1002\/acr.24963","volume":"75","author":"I Foeldvari","year":"2023","unstructured":"Foeldvari, I., Maccora, I., Petrushkin, H., Rahman, N., Anton, J., de Boer, J., Calzada-Hern\u00e1ndez, J., Carreras, E., Diaz, J., Edelsten, C., Angeles-Han, S. T., Heiligenhaus, A., Miserocchi, E., Nielsen, S., Saurenmann, R. K., Stuebiger, N., Baquet-Walscheid, K., Furst, D., & Simonini, G. (2023). New and updated recommendations for the treatment of juvenile idiopathic Arthritis-Associated uveitis and idiopathic chronic anterior uveitis. Arthritis Care Res (Hoboken), 75(5), 975\u2013982. https:\/\/doi.org\/10.1002\/acr.24963","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2273_CR40","doi-asserted-by":"publisher","unstructured":"Galbis-Estrada, C., Martinez-Castillo, S., Morales, J. M., Vivar-Llopis, B., Monle\u00f3n, D., D\u00edaz-Llopis, M., & Pinazo-Dur\u00e1n, M. D. (2014). Differential effects of dry eye disorders on metabolomic profile by 1H nuclear magnetic resonance spectroscopy. Biomed Res Int, 2014, 542549. https:\/\/doi.org\/10.1155\/2014\/542549","DOI":"10.1155\/2014\/542549"},{"key":"2273_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25094782","author":"J Garcia-Queiruga","year":"2024","unstructured":"Garcia-Queiruga, J., Pena-Verdeal, H., Sabucedo-Villamarin, B., Paz-Tarrio, M., Guitian-Fernandez, E., Garcia-Resua, C., Yebra-Pimentel, E., & Giraldez, M. J. (2024). Meibum lipidomic analysis in evaporative dry eye subjects. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms25094782","journal-title":"International Journal of Molecular Sciences"},{"key":"2273_CR42","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2022-001091","author":"N Ghadiri","year":"2023","unstructured":"Ghadiri, N., Reekie, I. R., Gordon, I., Safi, S., Lingham, G., Evans, J. R., & Keel, S. (2023). Systematic review of clinical practice guidelines for uveitis. BMJ Open Ophthalmol. https:\/\/doi.org\/10.1136\/bmjophth-2022-001091","journal-title":"BMJ Open Ophthalmol"},{"issue":"9","key":"2273_CR43","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1177\/1352458518790396","volume":"25","author":"J Gong","year":"2019","unstructured":"Gong, J., Qiu, W., Zeng, Q., Liu, X., Sun, X., Li, H., Yang, Y., Wu, A., Bao, J., Wang, Y., Shu, Y., Hu, X., Bellanti, J. A., Zheng, S. G., Lu, Y., & Lu, Z. (2019). Lack of short-chain fatty acids and overgrowth of opportunistic pathogens define dysbiosis of neuromyelitis Optica spectrum disorders: A Chinese pilot study. Multiple Sclerosis (Houndmills, Basingstoke, England), 25(9), 1316\u20131325. https:\/\/doi.org\/10.1177\/1352458518790396","journal-title":"Multiple Sclerosis (Houndmills, Basingstoke, England)"},{"issue":"1","key":"2273_CR44","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1021\/acs.jproteome.1c00777","volume":"21","author":"S Guan","year":"2022","unstructured":"Guan, S., Liu, K., Liu, Z., Zhou, L., Jia, B., Wang, Z., Nie, Y., & Zhang, X. (2022). UPLC-Q-TOF\/MS-Based plasma and urine metabolomics contribute to the diagnosis of Sepsis. Journal of Proteome Research, 21(1), 209\u2013219. https:\/\/doi.org\/10.1021\/acs.jproteome.1c00777","journal-title":"Journal of Proteome Research"},{"issue":"6","key":"2273_CR45","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s00417-014-2619-1","volume":"252","author":"J Guo","year":"2014","unstructured":"Guo, J., Yan, T., Bi, H., Xie, X., Wang, X., Guo, D., & Jiang, H. (2014). Plasma metabonomics study of the patients with acute anterior uveitis based on ultra-performance liquid chromatography-mass spectrometry. Graefes Archive for Clinical and Experimental Ophthalmology, 252(6), 925\u2013934. https:\/\/doi.org\/10.1007\/s00417-014-2619-1","journal-title":"Graefes Archive for Clinical and Experimental Ophthalmology"},{"issue":"6","key":"2273_CR46","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1007\/s00436-011-2439-8","volume":"109","author":"S Hauber","year":"2011","unstructured":"Hauber, S., Parkes, H., Siddiqui, R., & Khan, N. A. (2011). The use of high-resolution \u00b9H nuclear magnetic resonance (NMR) spectroscopy in the clinical diagnosis of Acanthamoeba. Parasitology Research, 109(6), 1661\u20131669. https:\/\/doi.org\/10.1007\/s00436-011-2439-8","journal-title":"Parasitology Research"},{"issue":"13","key":"2273_CR47","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1038\/s41433-023-02416-z","volume":"37","author":"SS Hayreh","year":"2023","unstructured":"Hayreh, S. S., & Hayreh, S. B. (2023). Uveal vascular bed in health and disease: Uveal vascular bed anatomy. Paper 1 of 2. Eye (Lond), 37(13), 2590\u20132616. https:\/\/doi.org\/10.1038\/s41433-023-02416-z","journal-title":"Eye (Lond)"},{"issue":"3","key":"2273_CR48","doi-asserted-by":"publisher","first-page":"3392","DOI":"10.1096\/fj.201801805R","volume":"33","author":"T Hirakata","year":"2019","unstructured":"Hirakata, T., Lee, H. C., Ohba, M., Saeki, K., Okuno, T., Murakami, A., Matsuda, A., & Yokomizo, T. (2019a). Dietary \u03c9-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating T(h)2 immune responses. Faseb J, 33(3), 3392\u20133403. https:\/\/doi.org\/10.1096\/fj.201801805R","journal-title":"Faseb J"},{"issue":"5","key":"2273_CR49","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1097\/aci.0000000000000561","volume":"19","author":"T Hirakata","year":"2019","unstructured":"Hirakata, T., Yokomizo, T., & Matsuda, A. (2019b). The roles of omega-3 fatty acids and resolvins in allergic conjunctivitis. Current Opinion in Allergy and Clinical Immunology, 19(5), 517\u2013525. https:\/\/doi.org\/10.1097\/aci.0000000000000561","journal-title":"Current Opinion in Allergy and Clinical Immunology"},{"key":"2273_CR50","doi-asserted-by":"publisher","first-page":"1001349","DOI":"10.3389\/fendo.2022.1001349","volume":"13","author":"J Huang","year":"2022","unstructured":"Huang, J., Chen, M., Liang, Y., Hu, Y., Xia, W., Zhang, Y., Zhao, C., & Wu, L. (2022). Integrative metabolic analysis of orbital adipose\/connective tissue in patients with thyroid-associated ophthalmopathy. Front Endocrinol (Lausanne), 13, 1001349. https:\/\/doi.org\/10.3389\/fendo.2022.1001349","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"2273_CR51","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1167\/iovs.17-22677","volume":"59","author":"X Huang","year":"2018","unstructured":"Huang, X., Ye, Z., Cao, Q., Su, G., Wang, Q., Deng, J., Zhou, C., Kijlstra, A., & Yang, P. (2018). Gut microbiota composition and fecal metabolic phenotype in patients with acute anterior uveitis. Invest Ophthalmol Vis Sci, 59(3), 1523\u20131531. https:\/\/doi.org\/10.1167\/iovs.17-22677","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2273_CR52","doi-asserted-by":"publisher","unstructured":"Jabs, D. A., Nussenblatt, R. B., & Rosenbaum, J. T. (2005). Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol, 140(3), 509\u2013516. https:\/\/doi.org\/10.1016\/j.ajo.2005.03.057","DOI":"10.1016\/j.ajo.2005.03.057"},{"issue":"1","key":"2273_CR53","doi-asserted-by":"publisher","first-page":"9262","DOI":"10.1038\/s41598-018-27600-0","volume":"8","author":"DY Ji","year":"2018","unstructured":"Ji, D. Y., Park, S. H., Park, S. J., Kim, K. H., Ku, C. R., Shin, D. Y., Yoon, J. S., Lee, D. Y., & Lee, E. J. (2018). Comparative assessment of graves\u2019 disease and main extrathyroidal manifestation, graves\u2019 ophthalmopathy, by non-targeted metabolite profiling of blood and orbital tissue. Scientific Reports, 8(1), 9262. https:\/\/doi.org\/10.1038\/s41598-018-27600-0","journal-title":"Scientific Reports"},{"issue":"8","key":"2273_CR54","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1007\/s13238-014-0082-8","volume":"5","author":"P Jiang","year":"2014","unstructured":"Jiang, P., Du, W., & Wu, M. (2014). Regulation of the Pentose phosphate pathway in cancer. Protein and Cell, 5(8), 592\u2013602. https:\/\/doi.org\/10.1007\/s13238-014-0082-8","journal-title":"Protein and Cell"},{"key":"2273_CR55","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010207","author":"Q Jin","year":"2019","unstructured":"Jin, Q., Black, A., Kales, S. N., Vattem, D., Ruiz-Canela, M., & Sotos-Prieto, M. (2019). Metabolomics and microbiomes as potential tools to evaluate the effects of the mediterranean diet. Nutrients. https:\/\/doi.org\/10.3390\/nu11010207","journal-title":"Nutrients"},{"issue":"7","key":"2273_CR56","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nrm.2016.25","volume":"17","author":"CH Johnson","year":"2016","unstructured":"Johnson, C. H., Ivanisevic, J., & Siuzdak, G. (2016). Metabolomics: Beyond biomarkers and towards mechanisms. Nature Reviews Molecular Cell Biology, 17(7), 451\u2013459. https:\/\/doi.org\/10.1038\/nrm.2016.25","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"6","key":"2273_CR57","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1097\/icu.0000000000000809","volume":"32","author":"A Joye","year":"2021","unstructured":"Joye, A., & Suhler, E. (2021). Vogt-Koyanagi-Harada disease. Current Opinion in Ophthalmology, 32(6), 574\u2013582. https:\/\/doi.org\/10.1097\/icu.0000000000000809","journal-title":"Current Opinion in Ophthalmology"},{"issue":"1","key":"2273_CR58","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.tics.2022.09.011","volume":"27","author":"F Kano","year":"2023","unstructured":"Kano, F. (2023). Evolution of the uniformly white sclera in humans: Critical updates. Trends in Cognitive Sciences, 27(1), 10\u201312. https:\/\/doi.org\/10.1016\/j.tics.2022.09.011","journal-title":"Trends in Cognitive Sciences"},{"issue":"Suppl 3","key":"2273_CR59","doi-asserted-by":"publisher","first-page":"iii108","DOI":"10.1093\/rheumatology\/keaa086","volume":"59","author":"O Karadag","year":"2020","unstructured":"Karadag, O., & Bolek, E. C. (2020). Management of Behcet\u2019s syndrome. Rheumatology (Oxford), 59(Suppl 3), iii108\u2013iii117. https:\/\/doi.org\/10.1093\/rheumatology\/keaa086","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"2273_CR60","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.survophthal.2022.01.010","volume":"67","author":"RK Khanna","year":"2022","unstructured":"Khanna, R. K., Catanese, S., Emond, P., Corcia, P., Blasco, H., & Pisella, P. J. (2022). Metabolomics and lipidomics approaches in human tears: A systematic review. Survey of Ophthalmology, 67(4), 1229\u20131243. https:\/\/doi.org\/10.1016\/j.survophthal.2022.01.010","journal-title":"Survey of Ophthalmology"},{"key":"2273_CR61","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1159\/000099252","volume":"92","author":"E Knop","year":"2007","unstructured":"Knop, E., & Knop, N. (2007). Anatomy and immunology of the ocular surface. Chemical Immunology and Allergy, 92, 36\u201349. https:\/\/doi.org\/10.1159\/000099252","journal-title":"Chemical Immunology and Allergy"},{"issue":"1","key":"2273_CR62","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13321-023-00724-w","volume":"15","author":"EE Kontou","year":"2023","unstructured":"Kontou, E. E., Walter, A., Alka, O., Pfeuffer, J., Sachsenberg, T., Mohite, O. S., Nuhamunada, M., Kohlbacher, O., & Weber, T. (2023). UmetaFlow: An untargeted metabolomics workflow for high-throughput data processing And Analysis. Journal of Cheminformatics, 15(1), 52. https:\/\/doi.org\/10.1186\/s13321-023-00724-w","journal-title":"Journal of Cheminformatics"},{"issue":"6","key":"2273_CR63","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1210\/jc.2016-1315","volume":"101","author":"CC Krieger","year":"2016","unstructured":"Krieger, C. C., Place, R. F., Bevilacqua, C., Marcus-Samuels, B., Abel, B. S., Skarulis, M. C., Kahaly, G. J., Neumann, S., & Gershengorn, M. C. (2016). TSH\/IGF-1 receptor cross talk in graves\u2019 ophthalmopathy pathogenesis. Journal of Clinical Endocrinology and Metabolism, 101(6), 2340\u20132347. https:\/\/doi.org\/10.1210\/jc.2016-1315","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"2","key":"2273_CR64","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1210\/jc.2003-031427","volume":"89","author":"S Kumar","year":"2004","unstructured":"Kumar, S., Coenen, M. J., Scherer, P. E., & Bahn, R. S. (2004). Evidence for enhanced adipogenesis in the orbits of patients with graves\u2019 ophthalmopathy. Journal of Clinical Endocrinology and Metabolism, 89(2), 930\u2013935. https:\/\/doi.org\/10.1210\/jc.2003-031427","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"2","key":"2273_CR65","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.survophthal.2021.05.009","volume":"67","author":"S Lahoti","year":"2022","unstructured":"Lahoti, S., Weiss, M., Johnson, D. A., & Kheirkhah, A. (2022). Superior limbic keratoconjunctivitis: A comprehensive review. Survey of Ophthalmology, 67(2), 331\u2013341. https:\/\/doi.org\/10.1016\/j.survophthal.2021.05.009","journal-title":"Survey of Ophthalmology"},{"issue":"4","key":"2273_CR66","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.survophthal.2016.12.008","volume":"62","author":"JH Lee","year":"2017","unstructured":"Lee, J. H., Agarwal, A., Mahendradas, P., Lee, C. S., Gupta, V., Pavesio, C. E., & Agrawal, R. (2017). Viral posterior uveitis. Survey of Ophthalmology, 62(4), 404\u2013445. https:\/\/doi.org\/10.1016\/j.survophthal.2016.12.008","journal-title":"Survey of Ophthalmology"},{"issue":"6","key":"2273_CR67","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.preteyeres.2011.07.001","volume":"30","author":"BK Leung","year":"2011","unstructured":"Leung, B. K., Bonanno, J. A., & Radke, C. J. (2011). Oxygen-deficient metabolism and corneal edema. Progress in Retinal and Eye Research, 30(6), 471\u2013492. https:\/\/doi.org\/10.1016\/j.preteyeres.2011.07.001","journal-title":"Progress in Retinal and Eye Research"},{"key":"2273_CR68","doi-asserted-by":"publisher","first-page":"1124443","DOI":"10.3389\/fimmu.2023.1124443","volume":"14","author":"H Li","year":"2023","unstructured":"Li, H., Zhan, H., Cheng, L., Huang, Y., Li, X., Yan, S., Liu, Y., Wang, L., & Li, Y. (2023). Plasma lipidomics of primary biliary cholangitis and its comparison with Sj\u00f6gren\u2019s syndrome. Frontiers in Immunology, 14, 1124443. https:\/\/doi.org\/10.3389\/fimmu.2023.1124443","journal-title":"Frontiers in Immunology"},{"key":"2273_CR69","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jtos.2023.12.005","volume":"31","author":"H Ma","year":"2024","unstructured":"Ma, H., Chen, T., Li, C., Xu, H., Feng, Q., Su, Y., Cai, J., Zhu, Q., Liu, F., & Hu, L. (2024). Metabolic signatures of tear extracellular vesicles caused by herpes simplex keratitis. The Ocular Surface, 31, 21\u201330. https:\/\/doi.org\/10.1016\/j.jtos.2023.12.005","journal-title":"The Ocular Surface"},{"key":"2273_CR70","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/978-3-030-77252-9_11","volume":"1336","author":"AN Macedo","year":"2021","unstructured":"Macedo, A. N., Faccio, A. T., Fukuji, T. S., Canuto, G. A. B., & Tavares, M. F. M. (2021). Analytical platforms for mass Spectrometry-Based metabolomics of Polar and ionizable metabolites. Advances in Experimental Medicine and Biology, 1336, 215\u2013242. https:\/\/doi.org\/10.1007\/978-3-030-77252-9_11","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"4","key":"2273_CR71","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.immuni.2017.03.019","volume":"46","author":"TW Mak","year":"2017","unstructured":"Mak, T. W., Grusdat, M., Duncan, G. S., Dostert, C., Nonnenmacher, Y., Cox, M., Binsfeld, C., Hao, Z., Br\u00fcstle, A., Itsumi, M., J\u00e4ger, C., Chen, Y., Pinkenburg, O., Camara, B., Ollert, M., Bindslev-Jensen, C., Vasiliou, V., Gorrini, C., Lang, P. A., & Brenner, D. (2017). Glutathione primes T cell metabolism for inflammation. Immunity, 46(4), 675\u2013689. https:\/\/doi.org\/10.1016\/j.immuni.2017.03.019","journal-title":"Immunity"},{"issue":"2","key":"2273_CR72","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.survophthal.2021.06.006","volume":"67","author":"A Maleki","year":"2022","unstructured":"Maleki, A., Anesi, S. D., Look-Why, S., Manhapra, A., & Foster, C. S. (2022). Pediatric uveitis: A comprehensive review. Survey of Ophthalmology, 67(2), 510\u2013529. https:\/\/doi.org\/10.1016\/j.survophthal.2021.06.006","journal-title":"Survey of Ophthalmology"},{"issue":"5","key":"2273_CR73","doi-asserted-by":"publisher","first-page":"314","DOI":"10.3390\/separations10050314","volume":"10","author":"CF Marques","year":"2023","unstructured":"Marques, C. F., & Justino, G. C. (2023). An optimised MS-Based versatile untargeted metabolomics protocol. Separations, 10(5), 314.","journal-title":"Separations"},{"issue":"20","key":"2273_CR74","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1039\/d1ay00173f","volume":"13","author":"BB Misra","year":"2021","unstructured":"Misra, B. B. (2021). Advances in high resolution GC-MS technology: A focus on the application of GC-Orbitrap-MS in metabolomics and exposomics for FAIR practices. Analytical Methods, 13(20), 2265\u20132282. https:\/\/doi.org\/10.1039\/d1ay00173f","journal-title":"Analytical Methods"},{"issue":"1","key":"2273_CR75","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1001\/jamaophthalmol.2023.5750","volume":"142","author":"NR Morales-Mancillas","year":"2024","unstructured":"Morales-Mancillas, N. R., Velazquez-Valenzuela, F., Kinoshita, S., Suzuki, T., Dahlmann-Noor, A. H., Dart, J. K. G., Hingorani, M., Ali, A., Fung, S., Akova, Y. A., Doan, S., Gupta, N., Hammersmith, K. M., Tan, D. T. H., Paez-Garza, J. H., & Rodriguez-Garcia, A. (2024). Definition and diagnostic criteria for pediatric blepharokeratoconjunctivitis. JAMA Ophthalmol, 142(1), 39\u201347. https:\/\/doi.org\/10.1001\/jamaophthalmol.2023.5750","journal-title":"JAMA Ophthalmol"},{"issue":"4","key":"2273_CR76","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11306-022-01881-z","volume":"18","author":"SL Nam","year":"2022","unstructured":"Nam, S. L., Carrillo, T., de la Mata, K., de Bruin, A. P., Doukhanine, O. M., E., & Harynuk, J. (2022). Evaluation of fresh, frozen, and lyophilized fecal samples by SPME and derivatization methods using GC\u00d7GC-TOFMS. Metabolomics, 18(4), 25. https:\/\/doi.org\/10.1007\/s11306-022-01881-z","journal-title":"Metabolomics"},{"issue":"3","key":"2273_CR77","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1167\/tvst.9.3.16","volume":"9","author":"J N\u00e4ttinen","year":"2020","unstructured":"N\u00e4ttinen, J., Aapola, U., Jylh\u00e4, A., Vaajanen, A., & Uusitalo, H. (2020). Comparison of capillary and schirmer strip tear fluid sampling methods using SWATH-MS proteomics approach. Transl Vis Sci Technol, 9(3), 16. https:\/\/doi.org\/10.1167\/tvst.9.3.16","journal-title":"Transl Vis Sci Technol"},{"issue":"4","key":"2273_CR78","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11926-020-0885-y","volume":"22","author":"A Nevares","year":"2020","unstructured":"Nevares, A., Raut, R., Libman, B., & Hajj-Ali, R. (2020). Noninfectious autoimmune scleritis: Recognition, systemic associations, and therapy. Current Rheumatology Reports, 22(4), 11. https:\/\/doi.org\/10.1007\/s11926-020-0885-y","journal-title":"Current Rheumatology Reports"},{"issue":"5","key":"2273_CR79","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1080\/09273940600977241","volume":"14","author":"S Onal","year":"2006","unstructured":"Onal, S., Kazokoglu, H., Incili, B., Demiralp, E. E., & Yavuz, S. (2006). Prevalence and levels of serum antibodies to gram negative microorganisms in Turkish patients with HLA-B27 positive acute anterior uveitis and controls. Ocular Immunology and Inflammation, 14(5), 293\u2013299. https:\/\/doi.org\/10.1080\/09273940600977241","journal-title":"Ocular Immunology and Inflammation"},{"issue":"1","key":"2273_CR80","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13075-022-02986-5","volume":"25","author":"SJ Park","year":"2023","unstructured":"Park, S. J., Park, M. J., Park, S., Lee, E. S., & Lee, D. Y. (2023). Integrative metabolomics of plasma and PBMCs identifies distinctive metabolic signatures in Beh\u00e7et\u2019s disease. Arthritis Res Ther, 25(1), 5. https:\/\/doi.org\/10.1186\/s13075-022-02986-5","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"2273_CR81","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s40168-022-01243-w","volume":"10","author":"A Parker","year":"2022","unstructured":"Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E., Vauzour, D., Rudder, S., Blackshaw, L. A., Jeffery, G., & Carding, S. R. (2022). Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain. Microbiome, 10(1), 68. https:\/\/doi.org\/10.1186\/s40168-022-01243-w","journal-title":"Microbiome"},{"issue":"9","key":"2273_CR82","doi-asserted-by":"publisher","first-page":"4053","DOI":"10.1167\/iovs.05-0980","volume":"47","author":"A Peral","year":"2006","unstructured":"Peral, A., Carracedo, G., Acosta, M. C., Gallar, J., & Pintor, J. (2006). Increased levels of diadenosine polyphosphates in dry eye. Invest Ophthalmol Vis Sci, 47(9), 4053\u20134058. https:\/\/doi.org\/10.1167\/iovs.05-0980","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"2273_CR83","doi-asserted-by":"publisher","first-page":"R63","DOI":"10.1186\/gb-2009-10-6-r63","volume":"10","author":"JM Peregr\u00edn-Alvarez","year":"2009","unstructured":"Peregr\u00edn-Alvarez, J. M., Sanford, C., & Parkinson, J. (2009). The conservation and evolutionary modularity of metabolism. Genome Biology, 10(6), R63. https:\/\/doi.org\/10.1186\/gb-2009-10-6-r63","journal-title":"Genome Biology"},{"issue":"2","key":"2273_CR84","doi-asserted-by":"publisher","first-page":"E132","DOI":"10.1097\/OPX.0b013e318194e767","volume":"86","author":"N Pescosolido","year":"2009","unstructured":"Pescosolido, N., Imperatrice, B., Koverech, A., & Messano, M. (2009). L-carnitine and short chain ester in tears from patients with dry eye. Optometry and Vision Science, 86(2), E132\u2013138. https:\/\/doi.org\/10.1097\/OPX.0b013e318194e767","journal-title":"Optometry and Vision Science"},{"issue":"5","key":"2273_CR85","doi-asserted-by":"publisher","first-page":"3093","DOI":"10.1167\/iovs.13-13844","volume":"55","author":"PM Pinsky","year":"2014","unstructured":"Pinsky, P. M. (2014). Three-dimensional modeling of metabolic species transport in the cornea with a hydrogel intrastromal inlay. Invest Ophthalmol Vis Sci, 55(5), 3093\u20133106. https:\/\/doi.org\/10.1167\/iovs.13-13844","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2273_CR86","doi-asserted-by":"publisher","first-page":"102362","DOI":"10.1016\/j.cbpa.2023.102362","volume":"76","author":"M Planque","year":"2023","unstructured":"Planque, M., Igelmann, S., Ferreira Campos, A. M., & Fendt, S. M. (2023). Spatial metabolomics principles and application to cancer research. Current Opinion in Chemical Biology, 76, 102362. https:\/\/doi.org\/10.1016\/j.cbpa.2023.102362","journal-title":"Current Opinion in Chemical Biology"},{"issue":"1","key":"2273_CR87","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/s41392-023-01399-3","volume":"8","author":"S Qiu","year":"2023","unstructured":"Qiu, S., Cai, Y., Yao, H., Lin, C., Xie, Y., Tang, S., & Zhang, A. (2023). Small molecule metabolites: Discovery of biomarkers and therapeutic targets. Signal Transduct Target Ther, 8(1), 132. https:\/\/doi.org\/10.1038\/s41392-023-01399-3","journal-title":"Signal Transduct Target Ther"},{"issue":"7418","key":"2273_CR88","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1136\/bmj.327.7418.789","volume":"327","author":"RP Rietveld","year":"2003","unstructured":"Rietveld, R. P., van Weert, H. C., ter Riet, G., & Bindels, P. J. (2003). Diagnostic impact of signs and symptoms in acute infectious conjunctivitis: Systematic literature search. Bmj, 327(7418), 789. https:\/\/doi.org\/10.1136\/bmj.327.7418.789","journal-title":"Bmj"},{"issue":"3","key":"2273_CR89","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.semarthrit.2019.06.004","volume":"49","author":"JT Rosenbaum","year":"2019","unstructured":"Rosenbaum, J. T., Bodaghi, B., Couto, C., Zierhut, M., Acharya, N., Pavesio, C., Tay-Kearney, M. L., Neri, P., Douglas, K., Pathai, S., Song, A. P., Kron, M., & Foster, C. S. (2019). New observations and emerging ideas in diagnosis and management of non-infectious uveitis: A review. Seminars in Arthritis and Rheumatism, 49(3), 438\u2013445. https:\/\/doi.org\/10.1016\/j.semarthrit.2019.06.004","journal-title":"Seminars in Arthritis and Rheumatism"},{"issue":"1","key":"2273_CR90","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ophtha.2011.07.043","volume":"119","author":"M Sainz de la Maza","year":"2012","unstructured":"Sainz de la Maza, M., Molina, N., Gonzalez-Gonzalez, L. A., Doctor, P. P., Tauber, J., & Foster, C. S. (2012). Scleritis therapy. Ophthalmology, 119(1), 51\u201358. https:\/\/doi.org\/10.1016\/j.ophtha.2011.07.043","journal-title":"Ophthalmology"},{"issue":"4","key":"2273_CR91","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/s41596-022-00801-8","volume":"18","author":"S Sarmad","year":"2023","unstructured":"Sarmad, S., Viant, M. R., Dunn, W. B., Goodacre, R., Wilson, I. D., Chappell, K. E., Griffin, J. L., O\u2019Donnell, V. B., Naicker, B., Lewis, M. R., & Suzuki, T. (2023). A proposed framework to evaluate the quality and reliability of targeted metabolomics assays from the UK consortium on metabolic phenotyping (MAP\/UK). Nature Protocols, 18(4), 1017\u20131027. https:\/\/doi.org\/10.1038\/s41596-022-00801-8","journal-title":"Nature Protocols"},{"issue":"12","key":"2273_CR92","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1007\/s13361-016-1469-y","volume":"27","author":"AC Schrimpe-Rutledge","year":"2016","unstructured":"Schrimpe-Rutledge, A. C., Codreanu, S. G., Sherrod, S. D., & McLean, J. A. (2016). Untargeted metabolomics Strategies-Challenges and emerging directions. Journal of the American Society for Mass Spectrometry, 27(12), 1897\u20131905. https:\/\/doi.org\/10.1007\/s13361-016-1469-y","journal-title":"Journal of the American Society for Mass Spectrometry"},{"issue":"1","key":"2273_CR93","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12987-023-00494-5","volume":"20","author":"J Serrano-Mar\u00edn","year":"2023","unstructured":"Serrano-Mar\u00edn, J., Marin, S., Bernal-Casas, D., Lillo, A., Gonz\u00e1lez-Sub\u00edas, M., Navarro, G., Cascante, M., S\u00e1nchez-Nav\u00e9s, J., & Franco, R. (2023). A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson\u2019s disease. Fluids Barriers CNS, 20(1), 90. https:\/\/doi.org\/10.1186\/s12987-023-00494-5","journal-title":"Fluids Barriers CNS"},{"issue":"9","key":"2273_CR94","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.2174\/1871530323666230221120711","volume":"23","author":"TT Shi","year":"2023","unstructured":"Shi, T. T., Liu, H. Y., Zhu, X. R., Xin, Z., Hua, L., Xie, R. R., Sun, R., Cao, X., & Yang, J. K. (2023). Integrated proteomics and metabolomics analyses of serum in Chinese patients with severe and active graves\u2019 orbitopathy: A Cross-sectional study. Endocrine, Metabolic & Immune Disorders: Drug Targets, 23(9), 1151\u20131161. https:\/\/doi.org\/10.2174\/1871530323666230221120711","journal-title":"Endocrine, Metabolic & Immune Disorders: Drug Targets"},{"issue":"11","key":"2273_CR95","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1016\/j.ophtha.2012.05.038","volume":"119","author":"J Shim","year":"2012","unstructured":"Shim, J., Park, C., Lee, H. S., Park, M. S., Lim, H. T., Chauhan, S., Dana, R., Lee, H., & Lee, H. K. (2012). Change in prostaglandin expression levels and synthesizing activities in dry eye disease. Ophthalmology, 119(11), 2211\u20132219. https:\/\/doi.org\/10.1016\/j.ophtha.2012.05.038","journal-title":"Ophthalmology"},{"key":"2273_CR96","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9123955","author":"H Shimizu","year":"2020","unstructured":"Shimizu, H., Usui, Y., Asakage, M., Nezu, N., Wakita, R., Tsubota, K., Sugimoto, M., & Goto, H. (2020). Serum metabolomic profiling of patients with Non-Infectious uveitis. J Clin Med. https:\/\/doi.org\/10.3390\/jcm9123955","journal-title":"J Clin Med"},{"key":"2273_CR97","doi-asserted-by":"publisher","first-page":"109409","DOI":"10.1016\/j.exer.2023.109409","volume":"228","author":"GS Shrestha","year":"2023","unstructured":"Shrestha, G. S., Vijay, A. K., Stapleton, F., White, A., Pickford, R., & Carnt, N. (2023). Human tear metabolites associated with nucleoside-signalling pathways in bacterial keratitis. Experimental Eye Research, 228, 109409. https:\/\/doi.org\/10.1016\/j.exer.2023.109409","journal-title":"Experimental Eye Research"},{"issue":"1","key":"2273_CR98","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41572-022-00359-5","volume":"8","author":"AW Solomon","year":"2022","unstructured":"Solomon, A. W., Burton, M. J., Gower, E. W., Harding-Esch, E. M., Oldenburg, C. E., Taylor, H. R., & Traor\u00e9, L. (2022). Trachoma. Nat Rev Dis Primers, 8(1), 32. https:\/\/doi.org\/10.1038\/s41572-022-00359-5","journal-title":"Nat Rev Dis Primers"},{"issue":"2","key":"2273_CR99","doi-asserted-by":"publisher","first-page":"020503","DOI":"10.7189\/jogh.08.020503","volume":"8","author":"P Song","year":"2018","unstructured":"Song, P., Xia, W., Wang, M., Chang, X., Wang, J., Jin, S., Wang, J., Wei, W., & Rudan, I. (2018). Variations of dry eye disease prevalence by age, sex and geographic characteristics in China: A systematic review and meta-analysis. J Glob Health, 8(2), 020503. https:\/\/doi.org\/10.7189\/jogh.08.020503","journal-title":"J Glob Health"},{"issue":"3","key":"2273_CR100","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","volume":"15","author":"F Stapleton","year":"2017","unstructured":"Stapleton, F., Alves, M., Bunya, V. Y., Jalbert, I., Lekhanont, K., Malet, F., Na, K. S., Schaumberg, D., Uchino, M., Vehof, J., Viso, E., Vitale, S., & Jones, L. (2017). TFOS DEWS II epidemiology report. The Ocular Surface, 15(3), 334\u2013365. https:\/\/doi.org\/10.1016\/j.jtos.2017.05.003","journal-title":"The Ocular Surface"},{"issue":"7","key":"2273_CR101","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1093\/clinchem\/hvaa118","volume":"66","author":"FG Strathmann","year":"2020","unstructured":"Strathmann, F. G., Lynch, K. L., Krotulski, A., Negri, P., Cichelli, J., & Meyer, M. R. (2020). Challenges of High-Resolution mass spectrometry for detecting designer drugs. Clinical Chemistry, 66(7), 868\u2013874. https:\/\/doi.org\/10.1093\/clinchem\/hvaa118","journal-title":"Clinical Chemistry"},{"issue":"2","key":"2273_CR102","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.jaci.2014.12.1926","volume":"136","author":"W Su","year":"2015","unstructured":"Su, W., Wan, Q., Huang, J., Han, L., Chen, X., Chen, G., Olsen, N., Zheng, S. G., & Liang, D. (2015). Culture medium from TNF-\u03b1-stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms. The Journal of Allergy and Clinical Immunology, 136(2), 423\u2013432e428. https:\/\/doi.org\/10.1016\/j.jaci.2014.12.1926","journal-title":"The Journal of Allergy and Clinical Immunology"},{"key":"2273_CR103","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.exer.2015.10.015","volume":"143","author":"SO Tamara","year":"2016","unstructured":"Tamara, S. O., Yanshole, L. V., Yanshole, V. V., Fursova, A., Stepakov, D. A., Novoselov, V. P., & Tsentalovich, Y. P. (2016). Spatial distribution of metabolites in the human lens. Experimental Eye Research, 143, 68\u201374. https:\/\/doi.org\/10.1016\/j.exer.2015.10.015","journal-title":"Experimental Eye Research"},{"issue":"1","key":"2273_CR104","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s13020-024-00995-x","volume":"19","author":"P Tan","year":"2024","unstructured":"Tan, P., Wei, X., Huang, H., Wang, F., Wang, Z., Xie, J., Wang, L., Liu, D., & Hu, Z. (2024). Application of omics technologies in studies on antitumor effects of traditional Chinese medicine. Chinese Medicine, 19(1), 123. https:\/\/doi.org\/10.1186\/s13020-024-00995-x","journal-title":"Chinese Medicine"},{"key":"2273_CR105","doi-asserted-by":"publisher","DOI":"10.3390\/life14060650","author":"F Tariq","year":"2024","unstructured":"Tariq, F. (2024). Allergic conjunctivitis: Review of current types, treatments, and trends. Life (Basel). https:\/\/doi.org\/10.3390\/life14060650","journal-title":"Life (Basel)"},{"key":"2273_CR106","doi-asserted-by":"publisher","first-page":"114869","DOI":"10.1016\/j.addr.2023.114869","volume":"198","author":"S Teabagy","year":"2023","unstructured":"Teabagy, S., Wood, E., Bilsbury, E., Doherty, S., Janardhana, P., & Lee, D. J. (2023). Ocular immunosuppressive microenvironment and novel drug delivery for control of uveitis. Advanced Drug Delivery Reviews, 198, 114869. https:\/\/doi.org\/10.1016\/j.addr.2023.114869","journal-title":"Advanced Drug Delivery Reviews"},{"key":"2273_CR107","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.ajo.2021.03.020","volume":"227","author":"Y Terada","year":"2021","unstructured":"Terada, Y., Kaburaki, T., Takase, H., Goto, H., Nakano, S., Inoue, Y., Maruyama, K., Miyata, K., Namba, K., Sonoda, K. H., Kaneko, Y., Numaga, J., Fukushima, M., Horiguchi, N., Ide, M., Ehara, F., Miyazaki, D., Hasegawa, E., & Mochizuki, M. (2021). Distinguishing features of anterior uveitis caused by herpes simplex virus, Varicella-Zoster virus, and cytomegalovirus. American Journal of Ophthalmology, 227, 191\u2013200. https:\/\/doi.org\/10.1016\/j.ajo.2021.03.020","journal-title":"American Journal of Ophthalmology"},{"issue":"8","key":"2273_CR108","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1038\/s42255-023-00863-2","volume":"5","author":"T TeSlaa","year":"2023","unstructured":"TeSlaa, T., Ralser, M., Fan, J., & Rabinowitz, J. D. (2023). The Pentose phosphate pathway in health and disease. Nat Metab, 5(8), 1275\u20131289. https:\/\/doi.org\/10.1038\/s42255-023-00863-2","journal-title":"Nat Metab"},{"issue":"3","key":"2273_CR109","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/1469-0691.12126","volume":"19","author":"PA Thomas","year":"2013","unstructured":"Thomas, P. A., & Kaliamurthy, J. (2013). Mycotic keratitis: Epidemiology, diagnosis and management. Clinical Microbiology & Infection, 19(3), 210\u2013220. https:\/\/doi.org\/10.1111\/1469-0691.12126","journal-title":"Clinical Microbiology & Infection"},{"issue":"1","key":"2273_CR110","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s00125-020-05309-y","volume":"64","author":"Y Tomita","year":"2021","unstructured":"Tomita, Y., Cagnone, G., Fu, Z., Cakir, B., Kotoda, Y., Asakage, M., Wakabayashi, Y., Hellstr\u00f6m, A., Joyal, J. S., Talukdar, S., Smith, L. E. H., & Usui, Y. (2021). Vitreous metabolomics profiling of proliferative diabetic retinopathy. Diabetologia, 64(1), 70\u201382. https:\/\/doi.org\/10.1007\/s00125-020-05309-y","journal-title":"Diabetologia"},{"issue":"1","key":"2273_CR111","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/09273948.2016.1196713","volume":"26","author":"T Tsirouki","year":"2018","unstructured":"Tsirouki, T., Dastiridou, A., Symeonidis, C., Tounakaki, O., Brazitikou, I., Kalogeropoulos, C., & Androudi, S. (2018). A focus on the epidemiology of uveitis. Ocular Immunology and Inflammation, 26(1), 2\u201316. https:\/\/doi.org\/10.1080\/09273948.2016.1196713","journal-title":"Ocular Immunology and Inflammation"},{"issue":"6","key":"2273_CR112","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1210\/clinem\/dgad004","volume":"108","author":"HO Ueland","year":"2023","unstructured":"Ueland, H. O., Ulvik, A., L\u00f8v\u00e5s, K., Wolff, A. S. B., Breivik, L. E., Stokland, A. M., R\u00f8dahl, E., Nilsen, R. M., Husebye, E., & Ueland, G. (2023). Systemic activation of the kynurenine pathway in graves disease with and without ophthalmopathy. Journal of Clinical Endocrinology and Metabolism, 108(6), 1290\u20131297. https:\/\/doi.org\/10.1210\/clinem\/dgad004","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2273_CR113","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1146\/annurev-physchem-061020-053416","volume":"72","author":"D Unsihuay","year":"2021","unstructured":"Unsihuay, D., Sanchez, M., D., & Laskin, J. (2021). Quantitative mass spectrometry imaging of biological systems. Annual Review of Physical Chemistry, 72, 307\u2013329. https:\/\/doi.org\/10.1146\/annurev-physchem-061020-053416","journal-title":"Annual Review of Physical Chemistry"},{"key":"2273_CR114","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jtos.2021.07.006","volume":"22","author":"G Urbanski","year":"2021","unstructured":"Urbanski, G., Assad, S., Chabrun, F., de la Chao, J. M., Blanchet, O., Simard, G., Lenaers, G., Prunier-Mirebeau, D., Gohier, P., Lavigne, C., & Reynier, P. (2021). Tear metabolomics highlights new potential biomarkers for differentiating between Sj\u00f6gren\u2019s syndrome and other causes of dry eye. The Ocular Surface, 22, 110\u2013116. https:\/\/doi.org\/10.1016\/j.jtos.2021.07.006","journal-title":"The Ocular Surface"},{"issue":"4","key":"2273_CR115","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.ophtha.2016.12.011","volume":"124","author":"J Vehof","year":"2017","unstructured":"Vehof, J., Hysi, P. G., & Hammond, C. J. (2017). A Metabolome-Wide study of dry eye disease reveals serum androgens as biomarkers. Ophthalmology, 124(4), 505\u2013511. https:\/\/doi.org\/10.1016\/j.ophtha.2016.12.011","journal-title":"Ophthalmology"},{"key":"2273_CR116","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.ajo.2018.10.004","volume":"198","author":"FH Verhagen","year":"2019","unstructured":"Verhagen, F. H., Stigter, E. C. A., Pras-Raves, M. L., Burgering, B. M. T., Imhof, S. M., Radstake, T., de Boer, J. H., & Kuiper, J. J. W. (2019). Aqueous humor analysis identifies higher branched chain amino acid metabolism as a marker for human leukocyte Antigen-B27 acute anterior uveitis and disease activity. American Journal of Ophthalmology, 198, 97\u2013110. https:\/\/doi.org\/10.1016\/j.ajo.2018.10.004","journal-title":"American Journal of Ophthalmology"},{"key":"2273_CR117","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.preteyeres.2013.02.004","volume":"35","author":"D Wakefield","year":"2013","unstructured":"Wakefield, D., Di Girolamo, N., Thurau, S., Wildner, G., & McCluskey, P. (2013). Scleritis: Immunopathogenesis and molecular basis for therapy. Progress in Retinal and Eye Research, 35, 44\u201362. https:\/\/doi.org\/10.1016\/j.preteyeres.2013.02.004","journal-title":"Progress in Retinal and Eye Research"},{"issue":"6","key":"2273_CR118","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.clae.2020.06.005","volume":"43","author":"MK Walker","year":"2020","unstructured":"Walker, M. K., Schornack, M. M., & Vincent, S. J. (2020). Anatomical and physiological considerations in scleral lens wear: Conjunctiva and sclera. Cont Lens Anterior Eye, 43(6), 517\u2013528. https:\/\/doi.org\/10.1016\/j.clae.2020.06.005","journal-title":"Cont Lens Anterior Eye"},{"issue":"20","key":"2273_CR119","doi-asserted-by":"publisher","first-page":"11201","DOI":"10.18632\/aging.205122","volume":"15","author":"J Wang","year":"2023","unstructured":"Wang, J., Zhao, T., Li, B., & Wei, W. (2023). Tryptophan metabolism-related gene expression patterns: Unveiling prognostic insights and immune landscapes in uveal melanoma. Aging (Albany NY), 15(20), 11201\u201311216. https:\/\/doi.org\/10.18632\/aging.205122","journal-title":"Aging (Albany NY)"},{"issue":"6","key":"2273_CR120","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11306-022-01895-7","volume":"18","author":"S Wei","year":"2022","unstructured":"Wei, S., Wei, Y., Gong, Y., Chen, Y., Cui, J., Li, L., Yan, H., Yu, Y., Lin, X., Li, G., & Yi, L. (2022). Metabolomics as a valid analytical technique in environmental exposure research: Application and progress. Metabolomics, 18(6), 35. https:\/\/doi.org\/10.1007\/s11306-022-01895-7","journal-title":"Metabolomics"},{"issue":"6","key":"2273_CR121","doi-asserted-by":"publisher","first-page":"3124","DOI":"10.1021\/acs.jproteome.1c00019","volume":"20","author":"Y Wei","year":"2021","unstructured":"Wei, Y., Jasbi, P., Shi, X., Turner, C., Hrovat, J., Liu, L., Rabena, Y., Porter, P., & Gu, H. (2021). Early breast Cancer detection using untargeted and targeted metabolomics. Journal of Proteome Research, 20(6), 3124\u20133133. https:\/\/doi.org\/10.1021\/acs.jproteome.1c00019","journal-title":"Journal of Proteome Research"},{"issue":"23","key":"2273_CR122","doi-asserted-by":"publisher","first-page":"7023","DOI":"10.1113\/jp273839","volume":"595","author":"DF Wilson","year":"2017","unstructured":"Wilson, D. F. (2017). Oxidative phosphorylation: Regulation and role in cellular and tissue metabolism. Journal of Physiology, 595(23), 7023\u20137038. https:\/\/doi.org\/10.1113\/jp273839","journal-title":"Journal of Physiology"},{"issue":"4","key":"2273_CR123","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1152\/physrev.00035.2018","volume":"99","author":"DS Wishart","year":"2019","unstructured":"Wishart, D. S. (2019). Metabolomics for investigating physiological and pathophysiological processes. Physiological Reviews, 99(4), 1819\u20131875. https:\/\/doi.org\/10.1152\/physrev.00035.2018","journal-title":"Physiological Reviews"},{"issue":"4","key":"2273_CR124","doi-asserted-by":"publisher","first-page":"552","DOI":"10.4269\/ajtmh.2008.79.552","volume":"79","author":"KY Won","year":"2008","unstructured":"Won, K. Y., Kruszon-Moran, D., Schantz, P. M., & Jones, J. L. (2008). National Seroprevalence and risk factors for zoonotic Toxocara spp. Infection. American Journal of Tropical Medicine and Hygeine, 79(4), 552\u2013557.","journal-title":"American Journal of Tropical Medicine and Hygeine"},{"issue":"4","key":"2273_CR125","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/s10238-022-00954-6","volume":"23","author":"X Wu","year":"2023","unstructured":"Wu, X., Tao, M., Zhu, L., Zhang, T., & Zhang, M. (2023). Pathogenesis and current therapies for non-infectious uveitis. Clin Exp Med, 23(4), 1089\u20131106. https:\/\/doi.org\/10.1007\/s10238-022-00954-6","journal-title":"Clin Exp Med"},{"issue":"5","key":"2273_CR126","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41422-022-00614-0","volume":"32","author":"Y Xiao","year":"2022","unstructured":"Xiao, Y., Ma, D., Yang, Y. S., Yang, F., Ding, J. H., Gong, Y., Jiang, L., Ge, L. P., Wu, S. Y., Yu, Q., Zhang, Q., Bertucci, F., Sun, Q., Hu, X., Li, D. Q., Shao, Z. M., & Jiang, Y. Z. (2022). Comprehensive metabolomics expands precision medicine for triple-negative breast cancer. Cell Research, 32(5), 477\u2013490. https:\/\/doi.org\/10.1038\/s41422-022-00614-0","journal-title":"Cell Research"},{"key":"2273_CR127","doi-asserted-by":"publisher","first-page":"587393","DOI":"10.3389\/fimmu.2021.587393","volume":"12","author":"J Xu","year":"2021","unstructured":"Xu, J., Su, G., Huang, X., Chang, R., Chen, Z., Ye, Z., Cao, Q., Kijlstra, A., & Yang, P. (2021). Metabolomic analysis of aqueous humor identifies aberrant amino acid and fatty acid metabolism in Vogt-Koyanagi-Harada and Behcet\u2019s disease. Frontiers in Immunology, 12, 587393. https:\/\/doi.org\/10.3389\/fimmu.2021.587393","journal-title":"Frontiers in Immunology"},{"key":"2273_CR128","doi-asserted-by":"publisher","first-page":"1098140","DOI":"10.3389\/fimmu.2023.1098140","volume":"14","author":"F Yan","year":"2023","unstructured":"Yan, F., Liu, Y., Zhang, T., & Shen, Y. (2023). Identifying TNF and IL6 as potential hub genes and targeted drugs associated with scleritis: A bio-informative report. Frontiers in Immunology, 14, 1098140. https:\/\/doi.org\/10.3389\/fimmu.2023.1098140","journal-title":"Frontiers in Immunology"},{"key":"2273_CR129","doi-asserted-by":"publisher","first-page":"874021","DOI":"10.3389\/fimmu.2022.874021","volume":"13","author":"L Yang","year":"2022","unstructured":"Yang, L., Xiang, Z., Zou, J., Zhang, Y., Ni, Y., & Yang, J. (2022). Comprehensive analysis of the relationships between the gut microbiota and fecal metabolome in individuals with primary Sjogren\u2019s syndrome by 16S rRNA sequencing and LC-MS-Based metabolomics. Frontiers in Immunology, 13, 874021. https:\/\/doi.org\/10.3389\/fimmu.2022.874021","journal-title":"Frontiers in Immunology"},{"key":"2273_CR130","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153755","author":"M Yazdani","year":"2019","unstructured":"Yazdani, M., Elgst\u00f8en, K. B. P., Rootwelt, H., Shahdadfar, A., Utheim, \u00d8., A., & Utheim, T. P. (2019). Tear metabolomics in dry eye disease: A review. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms20153755","journal-title":"International Journal of Molecular Sciences"},{"key":"2273_CR131","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cbpa.2016.12.006","volume":"36","author":"M Zampieri","year":"2017","unstructured":"Zampieri, M., Sekar, K., Zamboni, N., & Sauer, U. (2017). Frontiers of high-throughput metabolomics. Current Opinion in Chemical Biology, 36, 15\u201323. https:\/\/doi.org\/10.1016\/j.cbpa.2016.12.006","journal-title":"Current Opinion in Chemical Biology"},{"key":"2273_CR132","doi-asserted-by":"publisher","first-page":"104468","DOI":"10.1016\/j.neuint.2019.104468","volume":"129","author":"Q Zeng","year":"2019","unstructured":"Zeng, Q., Junli, G., Liu, X., Chen, C., Sun, X., Li, H., Zhou, Y., Cui, C., Wang, Y., Yang, Y., Wu, A., Shu, Y., Hu, X., Lu, Z., Zheng, S. G., Qiu, W., & Lu, Y. (2019). Gut dysbiosis and lack of short chain fatty acids in a Chinese cohort of patients with multiple sclerosis. Neurochemistry International, 129, 104468. https:\/\/doi.org\/10.1016\/j.neuint.2019.104468","journal-title":"Neurochemistry International"},{"issue":"4","key":"2273_CR133","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s13167-021-00265-y","volume":"12","author":"X Zhan","year":"2021","unstructured":"Zhan, X., Li, J., Guo, Y., & Golubnitschaja, O. (2021). Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine. Epma J, 12(4), 449\u2013475. https:\/\/doi.org\/10.1007\/s13167-021-00265-y","journal-title":"Epma J"},{"key":"2273_CR134","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.07.029","author":"C Zhang","year":"2024","unstructured":"Zhang, C., Liu, X., Gu, C., Su, Y., Lv, J., Liu, Y., Gao, Y., Chen, H., Xu, N., Xiao, J., Xu, Z., & Su, W. (2024a). Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6\/ID2 axis. Journal of Advanced Research. https:\/\/doi.org\/10.1016\/j.jare.2024.07.029","journal-title":"Journal of Advanced Research"},{"key":"2273_CR135","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239145","author":"L Zhang","year":"2020","unstructured":"Zhang, L., Evans, A., von Ruhland, C., Draman, M. S., Edkins, S., Vincent, A. E., Berlinguer-Palmini, R., Rees, D. A., Haridas, A. S., Morris, D., Tee, A. R., Ludgate, M., Turnbull, D. M., Karpe, F., & Dayan, C. M. (2020). Distinctive features of orbital adipose tissue (OAT) in graves\u2019 orbitopathy. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms21239145","journal-title":"International Journal of Molecular Sciences"},{"key":"2273_CR136","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab188","author":"L Zhang","year":"2021","unstructured":"Zhang, L., Rai, P., Miwa, S., Draman, M. S., Rees, D. A., Haridas, A. S., Morris, D. S., Tee, A. R., Ludgate, M., Turnbull, D. M., & Dayan, C. M. (2021). The role of Mitochondria-Linked Fatty-Acid Uptake-Driven adipogenesis in graves orbitopathy. Endocrinology. https:\/\/doi.org\/10.1210\/endocr\/bqab188","journal-title":"Endocrinology"},{"key":"2273_CR137","doi-asserted-by":"publisher","first-page":"1413890","DOI":"10.3389\/fendo.2024.1413890","volume":"15","author":"X Zhang","year":"2024","unstructured":"Zhang, X., Dong, K., Zhang, X., Kang, Z., & Sun, B. (2024b). Exploring gut microbiota and metabolite alterations in patients with thyroid-associated ophthalmopathy using high-throughput sequencing and untargeted metabolomics. Front Endocrinol (Lausanne), 15, 1413890. https:\/\/doi.org\/10.3389\/fendo.2024.1413890","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2273_CR138","doi-asserted-by":"publisher","first-page":"101216","DOI":"10.1016\/j.preteyeres.2023.101216","volume":"97","author":"Z Zhong","year":"2023","unstructured":"Zhong, Z., Su, G., & Yang, P. (2023). Risk factors, clinical features and treatment of Beh\u00e7et\u2019s disease uveitis. Progress in Retinal and Eye Research, 97, 101216. https:\/\/doi.org\/10.1016\/j.preteyeres.2023.101216","journal-title":"Progress in Retinal and Eye Research"},{"key":"2273_CR139","doi-asserted-by":"publisher","first-page":"108573","DOI":"10.1016\/j.exer.2021.108573","volume":"207","author":"JF Ziemanski","year":"2021","unstructured":"Ziemanski, J. F., Wilson, L., Barnes, S., & Nichols, K. K. (2021). Triacylglycerol lipidome from human meibomian gland epithelial cells: Description, response to culture conditions, and perspective on function. Experimental Eye Research, 207, 108573. https:\/\/doi.org\/10.1016\/j.exer.2021.108573","journal-title":"Experimental Eye Research"},{"key":"2273_CR140","doi-asserted-by":"publisher","first-page":"110011","DOI":"10.1016\/j.exer.2024.110011","volume":"246","author":"Y Zong","year":"2024","unstructured":"Zong, Y., Cheng, C., Lin, L., Yu, Y., Liu, S., Liu, X., & Wu, K. (2024). Targeted metabolomic analysis of serum free fatty acids: Lipidomics disturbance in patients with superior limbic keratoconjunctivitis. Experimental Eye Research, 246, 110011. https:\/\/doi.org\/10.1016\/j.exer.2024.110011","journal-title":"Experimental Eye Research"},{"issue":"4","key":"2273_CR141","doi-asserted-by":"publisher","first-page":"100894","DOI":"10.1016\/j.waojou.2024.100894","volume":"17","author":"X Zou","year":"2024","unstructured":"Zou, X., Huang, H., & Tan, Y. (2024). Genetically determined metabolites in allergic conjunctivitis: A Mendelian randomization study. The World Allergy Organization Journal, 17(4), 100894. https:\/\/doi.org\/10.1016\/j.waojou.2024.100894","journal-title":"The World Allergy Organization Journal"},{"issue":"5","key":"2273_CR142","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1210\/endo-97-5-1089","volume":"97","author":"DR Zusman","year":"1975","unstructured":"Zusman, D. R., & Burrow, G. N. (1975). Thyroid-stimulating hormone regulation of ornithine decarboxylase activity in the thyroid. Endocrinology, 97(5), 1089\u20131095. https:\/\/doi.org\/10.1210\/endo-97-5-1089","journal-title":"Endocrinology"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-025-02273-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-025-02273-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-025-02273-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T17:17:47Z","timestamp":1757179067000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-025-02273-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,2]]},"references-count":142,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["2273"],"URL":"https:\/\/doi.org\/10.1007\/s11306-025-02273-9","relation":{},"ISSN":["1573-3890"],"issn-type":[{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,2]]},"assertion":[{"value":"20 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Acknowledgement section has been included in the article.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"74"}}