{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:56:45Z","timestamp":1793642205458,"version":"4.5.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K01HL143034"],"award-info":[{"award-number":["K01HL143034"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES032470"],"award-info":[{"award-number":["R01ES032470"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG051600"],"award-info":[{"award-number":["R01AG051600"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG051600"],"award-info":[{"award-number":["R01AG051600"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG051600"],"award-info":[{"award-number":["R01AG051600"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50CA217685"],"award-info":[{"award-number":["P50CA217685"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA163451"],"award-info":[{"award-number":["CA163451"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"DOI":"10.1007\/s11306-025-02287-3","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T18:38:11Z","timestamp":1751395091000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plasma and ovarian metabolomic responses to chronic stress in female mice"],"prefix":"10.1007","volume":"21","author":[{"given":"Nan","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag J.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Poole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clary B.","family":"Clish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo N.","family":"Armaiz-Pena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana S.","family":"Nagaraja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Heather","family":"Eliassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine H.","family":"Shutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raji","family":"Balasubramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D.","family":"Kubzansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Hankinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana A.","family":"Zeleznik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Sood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley S.","family":"Tworoger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"2287_CR1","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.psyneuen.2012.11.014","volume":"38","author":"E Altmaier","year":"2013","unstructured":"Altmaier, E., Emeny, R. T., Krumsiek, J., Lacruz, M. E., Lukaschek, K., Hafner, S., Kastenmuller, G., Romisch-Margl, W., Prehn, C., Mohney, R. P., & Evans, A. M. (2013). Metabolomic profiles in individuals with negative affectivity and social inhibition: A population-based study of type D personality. Psychoneuroendocrinology,38, 1299\u20131309.","journal-title":"Psychoneuroendocrinology"},{"key":"2287_CR2","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.bbi.2023.08.010","volume":"114","author":"R Balasubramanian","year":"2023","unstructured":"Balasubramanian, R., Shutta, K. H., Guasch-Ferre, M., Huang, T., Jha, S. C., Zhu, Y., Shadyab, A. H., Manson, J. E., Corella, D., Fit\u00f3, M., & Hu, F. B. (2023). Metabolomic profiles of chronic distress are associated with cardiovascular disease risk and inflammation-related risk factors. Brain, Behavior, and Immunity,114, 262\u2013274. https:\/\/doi.org\/10.1016\/j.bbi.2023.08.010","journal-title":"Brain, Behavior, and Immunity"},{"key":"2287_CR3","first-page":"172","volume":"46","author":"M Bandopadhyay","year":"2000","unstructured":"Bandopadhyay, M., & Ganguly, A. K. (2000). Putrescine, DNA, RNA and protein contents in human uterine, breast and rectal cancer. Journal of Postgraduate Medicine, 46, 172\u2013175.","journal-title":"Journal of Postgraduate Medicine"},{"key":"2287_CR4","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini, Y., & Hochberg, Y. (1995). Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society: Series B (Methodological), 57, 289\u2013300.","journal-title":"Journal of the Royal Statistical Society: Series B (Methodological)"},{"key":"2287_CR5","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.biopsych.2019.08.016","volume":"87","author":"M Bot","year":"2020","unstructured":"Bot, M., Milaneschi, Y., Al-Shehri, T., Amin, N., Garmaeva, S., Onderwater, G. L., Pool, R., Thesing, C. S., Vijfhuizen, L. S., & Vogelzangs, N. (2020). Metabolomics profile in depression: A pooled analysis of 230 metabolic markers in 5283 cases with depression and 10,145 controls. Biological Psychiatry,87, 409\u2013418. https:\/\/doi.org\/10.1016\/j.biopsych.2019.08.016","journal-title":"Biological Psychiatry"},{"key":"2287_CR6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/psy.0000000000000637","volume":"81","author":"SH Boyle","year":"2019","unstructured":"Boyle, S. H., Brummett, B. H., Kuhn, C. M., Barefoot, J. C., Siegler, I. C., Williams, R. B., & Georgiades, A. (2019). The effects of tryptophan enhancement and depletion on plasma catecholamine levels in healthy individuals. Psychosomatic Medicine,81, 34\u201340. https:\/\/doi.org\/10.1097\/psy.0000000000000637","journal-title":"Psychosomatic Medicine"},{"key":"2287_CR7","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jpsychores.2005.06.074","volume":"60","author":"JF Brosschot","year":"2006","unstructured":"Brosschot, J. F., Gerin, W., & Thayer, J. F. (2006). The perseverative cognition hypothesis: A review of worry, prolonged stress-related physiological activation, and health. Journal of Psychosomatic Research, 60, 113\u2013124. https:\/\/doi.org\/10.1016\/j.jpsychores.2005.06.074","journal-title":"Journal of Psychosomatic Research"},{"key":"2287_CR8","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jpba.2015.07.002","volume":"115","author":"JL Chen","year":"2015","unstructured":"Chen, J. L., Shi, B. Y., Xiang, H., Hou, W. J., Qin, X. M., Tian, J. S., & Du, G. H. (2015). (1)H NMR-based metabolic profiling of liver in chronic unpredictable mild stress rats with Genipin treatment. Journal of Pharmaceutical and Biomedical Analysis,115, 150\u2013158.","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"2287_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.940463","author":"HY Chen","year":"2022","unstructured":"Chen, H. Y., Liu, J., Weng, D. Z., Yan, L., Pan, C. S., Sun, K., Guo, X., Wang, D., Anwaier, G., Jiao, Y. Q., & Li, Z. X. (2022a). Ameliorative effect and mechanism of Si-Ni-San on chronic stress-induced diarrhea-irritable bowel syndrome in rats. Frontiers in Pharmacology. https:\/\/doi.org\/10.3389\/fphar.2022.940463","journal-title":"Frontiers in Pharmacology"},{"key":"2287_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.903004","author":"L Chen","year":"2022","unstructured":"Chen, L., Jiang, H., Bao, T., Wang, Y., Meng, H., Sun, Y., Liu, P., Quan, S., Li, W., Qi, S., & Ren, X. (2022b). Acupuncture ameliorates depressive behaviors by modulating the expression of hippocampal Iba-1 and HMGB1 in rats exposed to chronic restraint stress. Frontiers in Psychiatry. https:\/\/doi.org\/10.3389\/fpsyt.2022.903004","journal-title":"Frontiers in Psychiatry"},{"key":"2287_CR11","doi-asserted-by":"publisher","first-page":"11696","DOI":"10.1073\/pnas.1934666100","volume":"100","author":"MF Dallman","year":"2003","unstructured":"Dallman, M. F., Pecoraro, N., Akana, S. F., La Fleur, S. E., Gomez, F., Houshyar, H., Bell, M. E., Bhatnagar, S., Laugero, K. D., & Manalo, S. (2003). Chronic stress and obesity: A new view of comfort food. Proceedings of the National Academy of Sciences,100, 11696\u201311701.","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"2287_CR12","doi-asserted-by":"publisher","first-page":"14334","DOI":"10.1038\/s41598-021-93506-z","volume":"11","author":"S Dash","year":"2021","unstructured":"Dash, S., Yoder, S., Mesa, T., Smith, A., Cen, L., Eschrich, S., Armaiz-Pena, G. N., & Monteiro, A. N. (2021). Effects of long-term norepinephrine treatment on normal immortalized ovarian and fallopian tube cells. Scientific Reports,11, 14334.","journal-title":"Scientific Reports"},{"key":"2287_CR13","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1097\/PSY.0000000000000169","volume":"77","author":"RT Demmer","year":"2015","unstructured":"Demmer, R. T., Gelb, S., Suglia, S. F., Keyes, K. M., Aiello, A. E., Colombo, P. C., Galea, S., Uddin, M., Koenen, K. C., & Kubzansky, L. D. (2015). Sex differences in the association between depression, anxiety, and type 2 diabetes mellitus. Psychosomatic Medicine,77, 467\u2013477.","journal-title":"Psychosomatic Medicine"},{"key":"2287_CR14","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1210\/en.2008-0038","volume":"149","author":"M Depke","year":"2008","unstructured":"Depke, M., Fusch, G., Domanska, G., Geffers, R., Volker, U., Schuett, C., & Kiank, C. (2008). Hypermetabolic syndrome as a consequence of repeated psychological stress in mice. Endocrinology,149, 2714\u20132723.","journal-title":"Endocrinology"},{"key":"2287_CR15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.pbb.2013.12.013","volume":"117","author":"X Gao","year":"2014","unstructured":"Gao, X., Guo, B., Yang, L., Liu, J., Zhang, X., Qin, X., & Du, G. (2014). Selection and dynamic metabolic response of rat biomarkers by metabonomics and multivariate statistical analysis combined with GC-MS. Pharmacology, Biochemistry and Behavior,117, 85\u201391.","journal-title":"Pharmacology, Biochemistry and Behavior"},{"key":"2287_CR16","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1093\/bioinformatics\/btv406","volume":"31","author":"MJ Ha","year":"2015","unstructured":"Ha, M. J., Baladandayuthapani, V., & Do, K. A. (2015). DINGO: Differential network analysis in genomics. Bioinformatics, 31, 3413\u20133420. https:\/\/doi.org\/10.1093\/bioinformatics\/btv406","journal-title":"Bioinformatics"},{"key":"2287_CR17","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1001\/jama.284.5.592","volume":"284","author":"C Heim","year":"2000","unstructured":"Heim, C., Newport, D. J., Heit, S., Graham, Y. P., Wilcox, M., Bonsall, R., Miller, A. H., & Nemeroff, C. B. (2000). Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. Jama,284, 592\u2013597.","journal-title":"Jama"},{"key":"2287_CR18","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1007\/s00213-017-4712-8","volume":"234","author":"S Hess","year":"2017","unstructured":"Hess, S., Baker, G., Gyenes, G., Tsuyuki, R., Newman, S., & Le Melledo, J. M. (2017). Decreased serum L-arginine and L-citrulline levels in major depression. Psychopharmacology (Berl), 234, 3241\u20133247. https:\/\/doi.org\/10.1007\/s00213-017-4712-8","journal-title":"Psychopharmacology (Berl)"},{"key":"2287_CR19","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1158\/1055-9965.EPI-16-0534","volume":"25","author":"T Huang","year":"2016","unstructured":"Huang, T., Tworoger, S. S., Hecht, J. L., Rice, M. S., Sood, A. K., Kubzansky, L. D., & Poole, E. M. (2016). Association of ovarian tumor \u03b22-Adrenergic receptor status with ovarian cancer risk factors and survival. Cancer Epidemiology, Biomarkers, Prevention,25, 1587\u20131594.","journal-title":"Cancer Epidemiology, Biomarkers, Prevention"},{"key":"2287_CR20","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/annonc\/mdy546","volume":"30","author":"T Huang","year":"2019","unstructured":"Huang, T., Tworoger, S. S., Willett, W. C., Stampfer, M. J., & Rosner, B. A. (2019). Associations of early life and adulthood adiposity with risk of epithelial ovarian cancer. Annals of Oncology, 30, 303\u2013309. https:\/\/doi.org\/10.1093\/annonc\/mdy546","journal-title":"Annals of Oncology"},{"key":"2287_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00870-9","author":"T Huang","year":"2020","unstructured":"Huang, T., Balasubramanian, R., Yao, Y., Clish, C. B., Shadyab, A. H., Liu, B., Tworoger, S. S., Rexrode, K. M., Manson, J. E., Kubzansky, L. D., & Hankinson, S. E. (2020). Associations of depression status with plasma levels of candidate lipid and amino acid metabolites: A meta-analysis of individual data from three independent samples of US postmenopausal women. Molecular Psychiatry. https:\/\/doi.org\/10.1038\/s41380-020-00870-9","journal-title":"Molecular Psychiatry"},{"key":"2287_CR22","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/mrc.2865","volume":"50","author":"XJ Liu","year":"2012","unstructured":"Liu, X. J., Li, Z. Y., Li, Z. F., Gao, X. X., Zhou, Y. Z., Sun, H. F., Zhang, L. Z., Guo, X. Q., Du, G. H., & Qin, X. M. (2012). Urinary metabonomic study using a CUMS rat model of depression. Magnetic Resonance in Chemistry,50, 187\u2013192.","journal-title":"Magnetic Resonance in Chemistry"},{"key":"2287_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/156720208783565654","volume":"5","author":"L Manni","year":"2008","unstructured":"Manni, L., Di Fausto, V., Fiore, M., & Aloe, L. (2008). Repeated restraint and nerve growth factor administration in male and female mice: Effect on sympathetic and cardiovascular mediators of the stress response. Current Neurovascular Research, 5, 1\u201312. https:\/\/doi.org\/10.2174\/156720208783565654","journal-title":"Current Neurovascular Research"},{"key":"2287_CR24","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/s1734-1140(10)70327-3","volume":"62","author":"C Meana","year":"2010","unstructured":"Meana, C., Bordallo, J., Bordallo, C., Su\u00e1rez, L., Cantabrana, B., & S\u00e1nchez, M. (2010). Functional effects of polyamines via activation of human \u03b21- and \u03b22-adrenoceptors stably expressed in CHO cells. Pharmacological Reports: Pr, 62, 696\u2013706. https:\/\/doi.org\/10.1016\/s1734-1140(10)70327-3","journal-title":"Pharmacological Reports: Pr"},{"key":"2287_CR25","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1016\/j.jmb.2015.06.020","volume":"427","author":"L Miller-Fleming","year":"2015","unstructured":"Miller-Fleming, L., Olin-Sandoval, V., Campbell, K., & Ralser, M. (2015). Remaining mysteries of molecular biology: The role of polyamines in the cell. Journal of Molecular Biology, 427, 3389\u20133406. https:\/\/doi.org\/10.1016\/j.jmb.2015.06.020","journal-title":"Journal of Molecular Biology"},{"key":"2287_CR26","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/nn1290","volume":"7","author":"C Mirescu","year":"2004","unstructured":"Mirescu, C., Peters, J. D., & Gould, E. (2004). Early life experience alters response of adult neurogenesis to stress. Nature Neuroscience, 7, 841\u2013846. https:\/\/doi.org\/10.1038\/nn1290","journal-title":"Nature Neuroscience"},{"key":"2287_CR27","doi-asserted-by":"publisher","first-page":"71","DOI":"10.31887\/DCNS.2007.9.1\/ammoeller","volume":"9","author":"AM M\u00f6ller-Leimk\u00fchler","year":"2007","unstructured":"M\u00f6ller-Leimk\u00fchler, A. M. (2007). Gender differences in cardiovascular disease and comorbid depression. Dialogues Clin Neurosci, 9, 71\u201383. https:\/\/doi.org\/10.31887\/DCNS.2007.9.1\/ammoeller","journal-title":"Dialogues Clin Neurosci"},{"key":"2287_CR28","doi-asserted-by":"publisher","first-page":"113523","DOI":"10.1016\/j.bbr.2021.113523","volume":"416","author":"S Moreno-Mart\u00ednez","year":"2022","unstructured":"Moreno-Mart\u00ednez, S., Tendilla-Beltr\u00e1n, H., Sandoval, V., Flores, G., & Terr\u00f3n, J. A. (2022). Chronic restraint stress induces anxiety-like behavior and remodeling of dendritic spines in the central nucleus of the amygdala. Behavioural Brain Research, 416, 113523. https:\/\/doi.org\/10.1016\/j.bbr.2021.113523","journal-title":"Behavioural Brain Research"},{"key":"2287_CR29","doi-asserted-by":"publisher","first-page":"8627","DOI":"10.1073\/pnas.1801609115","volume":"115","author":"C Nasca","year":"2018","unstructured":"Nasca, C., Bigio, B., Lee, F. S., Young, S. P., Kautz, M. M., Albright, A., Beasley, J., Millington, D. S., Math\u00e9, A. A., Kocsis, J. H., & Murrough, J. W. (2018). Acetyl-l-carnitine deficiency in patients with major depressive disorder. Proceedings of the National Academy of Sciences,115, 8627\u20138632.","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"2287_CR30","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1042\/bst0350295","volume":"35","author":"AE Pegg","year":"2007","unstructured":"Pegg, A. E., & Feith, D. J. (2007). Polyamines and neoplastic growth. Biochemical Society Transactions, 35, 295\u2013299. https:\/\/doi.org\/10.1042\/bst0350295","journal-title":"Biochemical Society Transactions"},{"key":"2287_CR31","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.170961","author":"HD Reavis","year":"2024","unstructured":"Reavis, H. D., Gysler, S. M., McKenney, G. B., Knarr, M., Lusk, H. J., Rawat, P., Rendulich, H. S., Mitchell, M. A., Berger, D. S., Moon, J. S., & Ryu, S. (2024). Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.170961","journal-title":"JCI Insight"},{"key":"2287_CR32","doi-asserted-by":"publisher","first-page":"5113","DOI":"10.1158\/0008-5472.Can-19-1222","volume":"79","author":"AL Roberts","year":"2019","unstructured":"Roberts, A. L., Huang, T., Koenen, K. C., Kim, Y., Kubzansky, L. D., & Tworoger, S. S. (2019). Posttraumatic stress disorder is associated with increased risk of ovarian cancer: A prospective and retrospective longitudinal cohort study. Cancer Research, 79, 5113\u20135120. https:\/\/doi.org\/10.1158\/0008-5472.Can-19-1222","journal-title":"Cancer Research"},{"key":"2287_CR33","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0165-5728(91)90046-a","volume":"31","author":"JF Sheridan","year":"1991","unstructured":"Sheridan, J. F., Feng, N. G., Bonneau, R. H., Allen, C. M., Huneycutt, B. S., & Glaser, R. (1991). Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice. Journal of Neuroimmunology, 31, 245\u2013255. https:\/\/doi.org\/10.1016\/0165-5728(91)90046-a","journal-title":"Journal of Neuroimmunology"},{"key":"2287_CR34","doi-asserted-by":"publisher","first-page":"9440","DOI":"10.1073\/pnas.1530509100","volume":"100","author":"JD Storey","year":"2003","unstructured":"Storey, J. D., & Tibshirani, R. (2003). Statistical significance for genomewide studies. Proc Natl Acad Sci USA,100, 9440\u20139445. https:\/\/doi.org\/10.1073\/pnas.1530509100","journal-title":"Proc Natl Acad Sci USA"},{"key":"2287_CR35","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences,102, 15545\u201315550.","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"2287_CR36","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.semcancer.2007.12.005","volume":"18","author":"PH Thaker","year":"2008","unstructured":"Thaker, P. H., & Sood, A. K. (2008). Neuroendocrine influences on cancer biology. Seminars in Cancer Biology, 18, 164\u2013170. https:\/\/doi.org\/10.1016\/j.semcancer.2007.12.005","journal-title":"Seminars in Cancer Biology"},{"key":"2287_CR37","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/nm1447","volume":"12","author":"PH Thaker","year":"2006","unstructured":"Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., & Merritt, W. M. (2006). Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nature Medicine,12, 939\u2013944.","journal-title":"Nature Medicine"},{"key":"2287_CR38","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.nut.2007.08.008","volume":"23","author":"SJ Torres","year":"2007","unstructured":"Torres, S. J., & Nowson, C. A. (2007). Relationship between stress, eating behavior, and obesity. Nutrition (Burbank, Los Angeles County, Calif.), 23, 887\u2013894. https:\/\/doi.org\/10.1016\/j.nut.2007.08.008","journal-title":"Nutrition (Burbank, Los Angeles County, Calif.)"},{"key":"2287_CR39","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/psy.0000000000000537","volume":"80","author":"N Veronese","year":"2018","unstructured":"Veronese, N., Stubbs, B., Solmi, M., Ajnakina, O., Carvalho, A. F., & Maggi, S. (2018). Acetyl-L-Carnitine supplementation and the treatment of depressive symptoms: A systematic review and meta-analysis. Psychosomatic Medicine,80, 154\u2013159. https:\/\/doi.org\/10.1097\/psy.0000000000000537","journal-title":"Psychosomatic Medicine"},{"key":"2287_CR40","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jpsychires.2014.02.005","volume":"53","author":"SM Wang","year":"2014","unstructured":"Wang, S. M., Han, C., Lee, S. J., Patkar, A. A., Masand, P. S., & Pae, C. U. (2014). A review of current evidence for acetyl-l-carnitine in the treatment of depression. Journal of Psychiatric Research, 53, 30\u201337. https:\/\/doi.org\/10.1016\/j.jpsychires.2014.02.005","journal-title":"Journal of Psychiatric Research"},{"key":"2287_CR41","doi-asserted-by":"publisher","first-page":"9936","DOI":"10.1038\/s41598-022-14201-1","volume":"12","author":"L Wang","year":"2022","unstructured":"Wang, L., Zhou, C., Sun, J., Zhang, Q., & Lai, D. (2022). Glutamine and norepinephrine in follicular fluid synergistically enhance the antioxidant capacity of human granulosa cells and the outcome of IVF-ET. Scientific Reports, 12, 9936. https:\/\/doi.org\/10.1038\/s41598-022-14201-1","journal-title":"Scientific Reports"},{"key":"2287_CR42","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1158\/0008-5472.CAN-19-2567","volume":"80","author":"OA Zeleznik","year":"2020","unstructured":"Zeleznik, O. A., Eliassen, A. H., Kraft, P., Poole, E. M., Rosner, B. A., Jeanfavre, S., Deik, A. A., Bullock, K., Hitchcock, D. S., Avila-Pacheco, J., & Clish, C. B. (2020). A prospective analysis of Circulating plasma metabolites associated with ovarian Cancer risk. Cancer Research,80, 1357\u20131367.","journal-title":"Cancer Research"},{"key":"2287_CR43","doi-asserted-by":"publisher","first-page":"8890","DOI":"10.1038\/srep08890","volume":"5","author":"J Zhao","year":"2015","unstructured":"Zhao, J., Jung, Y. H., Jang, C. G., Chun, K. H., Kwon, S. W., & Lee, J. (2015). Metabolomic identification of biochemical changes induced by Fluoxetine and Imipramine in a chronic mild stress mouse model of depression. Scientific Reports, 5, 8890. https:\/\/doi.org\/10.1038\/srep08890","journal-title":"Scientific Reports"},{"key":"2287_CR44","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jad.2024.01.023","volume":"349","author":"T Zhao","year":"2024","unstructured":"Zhao, T., Liu, T., Wang, L., Xie, K., Tang, H., & Tang, M. (2024). Dysfunction of neurotransmitter metabolism is associated with the severity of depression in first-diagnosed, drug-na\u00efve depressed patients. Journal of Affective Disorders, 349, 332\u2013341. https:\/\/doi.org\/10.1016\/j.jad.2024.01.023","journal-title":"Journal of Affective Disorders"},{"key":"2287_CR45","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1021\/pr2010082","volume":"11","author":"P Zheng","year":"2012","unstructured":"Zheng, P., Gao, H. C., Li, Q., Shao, W. H., Zhang, M. L., Cheng, K., Yang, D. Y., Fan, S. H., Chen, L., Fang, L., & Xie, P. (2012). Plasma metabonomics as a novel diagnostic approach for major depressive disorder. Journal of Proteome Research,11, 1741\u20131748.","journal-title":"Journal of Proteome Research"},{"key":"2287_CR46","doi-asserted-by":"publisher","first-page":"5904","DOI":"10.1021\/pr400939q","volume":"12","author":"P Zheng","year":"2013","unstructured":"Zheng, P., Chen, J. J., Huang, T., Wang, M. J., Wang, Y., Dong, M. X., Huang, Y. J., Zhou, L. K., & Xie, P. (2013). A novel urinary metabolite signature for diagnosing major depressive disorder. Journal of Proteome Research,12, 5904\u20135911.","journal-title":"Journal of Proteome Research"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-025-02287-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-025-02287-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-025-02287-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T15:02:54Z","timestamp":1757948574000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-025-02287-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":46,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["2287"],"URL":"https:\/\/doi.org\/10.1007\/s11306-025-02287-3","relation":{},"ISSN":["1573-3890"],"issn-type":[{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"7 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All experiments were approved by the Institutional Animal Care and Use Committee of the M.D. Anderson Cancer Center (protocol code 01-12-01431, date of approval: 02\/09\/2012).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}}],"article-number":"99"}}