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Among them are the pathogenic outbreaks that can compromise the health of the stocks from various perspectives, including broodstock reproduction. This study focused on identifying the metabolite alterations produced after a bacterial infection by\n                      <jats:italic>Vibrio anguillarum<\/jats:italic>\n                      in the gonads of European seabass (\n                      <jats:italic>Dicentrarchus labrax<\/jats:italic>\n                      ). Sex-related response to the infection challenge was studied using a metabolomics approach.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The metabolome of testes and ovaries of adult fish were extracted and analyzed after 48\u00a0h of bacterial exposure by\u00a0ultra-high-performance liquid chromatography-mass spectrometer using negative-mode electrospray ionization (ESI) (UHPLC-MS, Vanquish Horizon UHPLC coupled to a Thermo Fisher Scientific Q-Exactive HF). To further decipher the molecular events, metabolomic and transcriptomic data were interconnected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 97 metabolites were identified. In the ovary, uric acid, O-phosphoethanolamine, allantoin, and acetoacetic acid were more represented. By contrast, nine metabolites were altered after the infection in testes, including uridine, N-acetylglucosamine-6-Phosphate, and Gamma-aminobutyric acid (GABA). The most abundant metabolic cascades triggered by infection in ovaries were related to glyoxylate and dicarboxylate metabolism, nitrogen metabolism, and purine metabolism, while in testes, we observed changes in glycerolipid metabolism, glycerophospholipid metabolism, and galactose metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present results demonstrate, for the first time in fish, that changes in metabolic pathways induced following infection are sex-dependent. The findings will help develop sex-specific immune therapies, identify resistant phenotypes, and improve aquaculture infection protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11306-025-02356-7","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T16:50:36Z","timestamp":1763225436000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identifying sex-linked metabolomic biomarkers in fish gonads after bacterial infection"],"prefix":"10.1007","volume":"21","author":[{"given":"M.","family":"Caballero-Huertas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ladisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"L\u00f3pez-Chillar\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Joly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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