{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:58:46Z","timestamp":1788562726484,"version":"build-2803163510"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["PMDS22070734755"],"award-info":[{"award-number":["PMDS22070734755"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024216","name":"College of Health Sciences, University of KwaZulu-Natal","doi-asserted-by":"publisher","award":["CHS PhD Scholarship"],"award-info":[{"award-number":["CHS PhD Scholarship"]}],"id":[{"id":"10.13039\/501100024216","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH","award":["R01AI137043 and R01AI152110"],"award-info":[{"award-number":["R01AI137043 and R01AI152110"]}]},{"name":"UKZN Research Flagship","award":["Afrocentric Precision Approach to Control Health Epidemics (APACHE)"],"award-info":[{"award-number":["Afrocentric Precision Approach to Control Health Epidemics (APACHE)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"DOI":"10.1007\/s11306-025-02366-5","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T17:11:33Z","timestamp":1763226693000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mycobacterium tuberculosis curli pili (MTP) facilitates pathogenicity by modulating oxidative phosphorylation and carbon flux during early infection of A549 epithelial cells"],"prefix":"10.1007","volume":"21","author":[{"given":"Tarien J.","family":"Naidoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinese","family":"Ashokcoomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Truebody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared S.","family":"Mackenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridgette M.","family":"Cumming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrie J. C.","family":"Steyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manormoney","family":"Pillay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,15]]},"reference":[{"issue":"4","key":"2366_CR1","first-page":"e0167222","volume":"13","author":"C Adolph","year":"2022","unstructured":"Adolph, C., McNeil, M. B., & Cook, G. M. (2022). Impaired succinate oxidation prevents growth and influences drug susceptibility in Mycobacterium tuberculosis. Molecular Biology, 13(4), e0167222.","journal-title":"Molecular Biology"},{"key":"2366_CR2","doi-asserted-by":"publisher","unstructured":"Akram, S., Masakapalli, S. K., & Nanda, R. K. (2024). Isotopic tracing in Mycobacterium tuberculosis-infected alveolar epithelial cells indicates metabolic specificity to their virulence and drug-resistance status. BioRxiv. https:\/\/doi.org\/10.1101\/2024.12.03.625217","DOI":"10.1101\/2024.12.03.625217"},{"key":"2366_CR3","doi-asserted-by":"crossref","unstructured":"Alteri, C. J., Xicoht\u00e9ncatl-Cortes, J., Hess, S., Caballero-Ol\u00edn, G., Giron, J. A., & Friedman, R. L. (2007). Mycobacterium tuberculosis produces pili during human infection. Proceedings of the National Academy of Sciences of the United States of America, 104(12), 5145\u20135150.","DOI":"10.1073\/pnas.0602304104"},{"issue":"5","key":"2366_CR4","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1099\/jmm.0.016006-0","volume":"59","author":"OT Ashiru","year":"2010","unstructured":"Ashiru, O. T., Pillay, M., & Sturm, A. W. (2010). Adhesion to and invasion of pulmonary epithelial cells by the F15\/LAM4\/KZN and Beijing strains of Mycobacterium tuberculosis. Journal of Medical Microbiology, 59(5), 528\u2013533.","journal-title":"Journal of Medical Microbiology"},{"key":"2366_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11306-020-01720-z","volume":"16","author":"S Ashokcoomar","year":"2020","unstructured":"Ashokcoomar, S., Reedoy, K., Senzani, S., Loots, D., Beukes, D., Van Reenen, M., Pillay, B., & Pillay, M. (2020). Mycobacterium tuberculosis curli pili (MTP) deficiency is associated with alterations in cell wall biogenesis, fatty acid metabolism and amino acid synthesis. Metabolomics, 16, 1\u201315.","journal-title":"Metabolomics"},{"key":"2366_CR7","doi-asserted-by":"crossref","unstructured":"Ashokcoomar, S., Naidoo, T. J., Cumming, B. M., Baig, Z. Truebody, B., Mackenzie, J.S., Steyn, A. J., & Pillay, M. (2025). Mycobacterium tuberculosis curli pili reduces oxygen consumption rate of THP-1 macrophages during early infection. The International Journal of Biochemistry & Cell Biology, 185, 106802.","DOI":"10.1016\/j.biocel.2025.106802"},{"key":"2366_CR6","doi-asserted-by":"publisher","first-page":"101907","DOI":"10.1016\/j.cimid.2022.101907","volume":"90","author":"S Ashokcoomar","year":"2022","unstructured":"Ashokcoomar, S., Reedoy, K. S., Beukes, D., van Reenen, M., Pillay, B., & Pillay, M. (2022). M. tuberculosis curli pili (MTP) facilitates a reduction of microbicidal activity of infected THP-1 macrophages during early stages of infection. Comparative Immunology Microbiology and Infectious Diseases, 90, 101907.","journal-title":"Comparative Immunology Microbiology and Infectious Diseases"},{"key":"2366_CR59","doi-asserted-by":"publisher","unstructured":"Bals, R., & Hiemstra, P. S. (2004). Innate immunity in the lung: How epithelial cells fight against respiratory pathogens. European Respiratory Journal, 23(2), 327\u201333. https:\/\/doi.org\/10.1183\/09031936.03.00098803.","DOI":"10.1183\/09031936.03.00098803"},{"issue":"10","key":"2366_CR9","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1099\/00221287-148-10-3007","volume":"148","author":"S Bardarov","year":"2002","unstructured":"Bardarov, S., Bardarov Jr, S., Pavelka Jr, M. S., Sambandamurthy, V., Larsen, M., Tufariello, J., Chan, J., Hatfull, G., & Jacobs Jr, W. R. (2002). Specialized transduction: An efficient method for generating marked And unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG And M. smegmatis. Microbiology, 148(10), 3007\u20133017.","journal-title":"Microbiology"},{"issue":"8","key":"2366_CR10","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/S0891-5849(00)00380-4","volume":"29","author":"M Benrahmoune","year":"2000","unstructured":"Benrahmoune, M., Th\u00e9rond, P., & Abedinzadeh, Z. (2000). The reaction of superoxide radical with N-acetylcysteine. Free Radical Biology and Medicine, 29(8), 775\u2013782.","journal-title":"Free Radical Biology and Medicine"},{"issue":"4","key":"2366_CR11","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1128\/iai.64.4.1400-1406.1996","volume":"64","author":"LE Bermudez","year":"1996","unstructured":"Bermudez, L. E., & Goodman, J. (1996). Mycobacterium tuberculosis invades and replicates within type II alveolar cells. Infection and Immunity, 64(4), 1400\u20131406.","journal-title":"Infection and Immunity"},{"issue":"3","key":"2366_CR12","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s42255-019-0043-x","volume":"1","author":"L Chen","year":"2019","unstructured":"Chen, L., Zhang, Z., Hoshino, A., Zheng, H. D., Morley, M., Arany, Z., & Rabinowitz, J. D. (2019). NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nature Metabolism, 1(3), 404\u2013415.","journal-title":"Nature Metabolism"},{"issue":"W1","key":"2366_CR13","doi-asserted-by":"publisher","first-page":"W486","DOI":"10.1093\/nar\/gky310","volume":"46","author":"J Chong","year":"2018","unstructured":"Chong, J., Soufan, O., Li, C., Caraus, I., Li, S., Bourque, G., Wishart, D. S., & Xia, J. (2018). MetaboAnalyst 4.0: Towards more transparent and integrative metabolomics analysis. Nucleic Acids Research, 46(W1), W486\u2013W494.","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"2366_CR14","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1128\/IAI.00950-12","volume":"81","author":"OD Chuquimia","year":"2013","unstructured":"Chuquimia, O. D., Petursdottir, D. H., Periolo, N., & Fern\u00e1ndez, C. (2013). Alveolar epithelial cells are critical in protection of the respiratory tract by secretion of factors able to modulate the activity of pulmonary macrophages and directly control bacterial growth. Infection and Immunity, 81(1), 381\u2013389.","journal-title":"Infection and Immunity"},{"key":"2366_CR15","doi-asserted-by":"publisher","first-page":"e39169","DOI":"10.7554\/eLife.39169","volume":"7","author":"BM Cumming","year":"2018","unstructured":"Cumming, B. M., Addicott, K. W., Adamson, J. H., & Steyn, A. J. (2018). Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages. Elife, 7, e39169.","journal-title":"Elife"},{"key":"2366_CR16","doi-asserted-by":"publisher","first-page":"1465448","DOI":"10.3389\/fimmu.2024.1465448","volume":"15","author":"BM Cumming","year":"2024","unstructured":"Cumming, B. M., Addicott, K. W., Maruri, F., Pillay, V., Asmal, R., Moodley, S., Barreto-Durate, B., Ara\u00fajo-Pereira, M., Mazibuko, M., & Mhlane, Z. (2024). Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients Monocyte\/lymphocyte bioenergetic signatures post-TB treatment. Frontiers in Immunology, 15, 1465448.","journal-title":"Frontiers in Immunology"},{"issue":"11","key":"2366_CR17","doi-asserted-by":"publisher","first-page":"6300","DOI":"10.1128\/IAI.68.11.6300-6310.2000","volume":"68","author":"KM Dobos","year":"2000","unstructured":"Dobos, K. M., Spotts, E. A., Quinn, F. D., & King, C. H. (2000). Necrosis of lung epithelial cells during infection with Mycobacterium tuberculosis is preceded by cell permeation. Infection and Immunity, 68(11), 6300\u20136310.","journal-title":"Infection and Immunity"},{"issue":"49","key":"2366_CR18","doi-asserted-by":"publisher","first-page":"30761","DOI":"10.1016\/S0021-9258(18)47344-9","volume":"269","author":"T Fernandes-Alnemri","year":"1994","unstructured":"Fernandes-Alnemri, T., Litwack, G., & Alnemri, E. S. (1994). CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. Journal of Biological Chemistry, 269(49), 30761\u201330764.","journal-title":"Journal of Biological Chemistry"},{"issue":"10","key":"2366_CR19","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.micinf.2015.06.003","volume":"17","author":"K Fine-Coulson","year":"2015","unstructured":"Fine-Coulson, K., Gigu\u00e8re, S., Quinn, F. D., & Reaves, B. J. (2015). Infection of A549 human type II epithelial cells with Mycobacterium tuberculosis induces changes in mitochondrial morphology, distribution and mass that are dependent on the early secreted antigen, ESAT-6. Microbes and Infection, 17(10), 689\u2013697.","journal-title":"Microbes and Infection"},{"issue":"9547","key":"2366_CR20","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1016\/S0140-6736(06)69573-1","volume":"368","author":"NR Gandhi","year":"2006","unstructured":"Gandhi, N. R., Moll, A., Sturm, A. W., Pawinski, R., Govender, T., Lalloo, U., Zeller, K., Andrews, J., & Friedland, G. (2006). Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. The Lancet, 368(9547), 1575\u20131580.","journal-title":"The Lancet"},{"issue":"4","key":"2366_CR21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3390\/metabo6040041","volume":"6","author":"P Gierok","year":"2016","unstructured":"Gierok, P., Harms, M., Methling, K., Hochgr\u00e4fe, F., & Lalk, M. (2016). Staphylococcus aureus infection reduces nutrition uptake and nucleotide biosynthesis in a human airway epithelial cell line. Metabolites, 6(4), 41.","journal-title":"Metabolites"},{"issue":"9","key":"2366_CR23","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1099\/mic.0.082206-0","volume":"160","author":"VS Govender","year":"2014","unstructured":"Govender, V. S., Ramsugit, S., & Pillay, M. (2014). Mycobacterium tuberculosis adhesins: Potential biomarkers as anti-tuberculosis therapeutic and diagnostic targets. Microbiology, 160(9), 1821\u20131831.","journal-title":"Microbiology"},{"issue":"5","key":"2366_CR24","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1113\/jphysiol.2012.244145","volume":"591","author":"R Grygorczyk","year":"2013","unstructured":"Grygorczyk, R., Furuya, K., & Sokabe, M. (2013). Imaging and characterization of stretch-induced ATP release from alveolar A549 cells. The Journal of Physiology, 591(5), 1195\u20131215.","journal-title":"The Journal of Physiology"},{"key":"2366_CR25","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3389\/fphar.2018.00043","volume":"9","author":"W Hong","year":"2018","unstructured":"Hong, W., Cai, P., Xu, C., Cao, D., Yu, W., Zhao, Z., Huang, M., & Jin, J. (2018). Inhibition of glucose-6-phosphate dehydrogenase reverses cisplatin resistance in lung cancer cells via the redox system. Frontiers in Pharmacology, 9, 43.","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"2366_CR26","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev-nutr-120420-025558","volume":"41","author":"M Inigo","year":"2021","unstructured":"Inigo, M., Deja, S., & Burgess, S. C. (2021). Ins and outs of The TCA cycle: The central role of anaplerosis. Annual Review of Nutrition, 41(1), 19\u201347.","journal-title":"Annual Review of Nutrition"},{"issue":"1","key":"2366_CR27","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1038\/srep01328","volume":"3","author":"S Jamwal","year":"2013","unstructured":"Jamwal, S., Midha, M. K., Verma, H. N., Basu, A., Rao, K. V., & Manivel, V. (2013). Characterizing virulence-specific perturbations in the mitochondrial function of macrophages infected with Mycobacterium tuberculosis. Scientific Reports, 3(1), 1328.","journal-title":"Scientific Reports"},{"issue":"6","key":"2366_CR28","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.coi.2007.08.004","volume":"19","author":"A Kato","year":"2007","unstructured":"Kato, A., & Schleimer, R. P. (2007). Beyond inflammation: Airway epithelial cells are at the interface of innate and adaptive immunity. Current Opinion in Immunology, 19(6), 711\u2013720.","journal-title":"Current Opinion in Immunology"},{"issue":"7","key":"2366_CR29","first-page":"286","volume":"8","author":"AM Krachler","year":"2013","unstructured":"Krachler, A. M., & Orth, K. (2013). Made to stick: anti-adhesion therapy for bacterial infections. Microbe, 8(7), 286\u2013290.","journal-title":"Microbe"},{"key":"2366_CR30","doi-asserted-by":"crossref","unstructured":"Kumar, S., Puniya, B. L., Parween, S., Nahar, P., & Ramachandran, S. (2013). Identification of novel adhesins of M. tuberculosis H37Rv using integrated approach of multiple computational algorithms and experimental analysis. PLoS ONE, 8(7), e69790.","DOI":"10.1371\/journal.pone.0069790"},{"key":"2366_CR31","doi-asserted-by":"crossref","unstructured":"Larsen, M. H., Biermann, K., & Jacobs Jr, W. R. (2007). Laboratory maintenance of Mycobacterium tuberculosis. Current Protocols in Microbiology, 6(1), 10A.1.1\u201310A.1.8.","DOI":"10.1002\/9780471729259.mc10a01s6"},{"issue":"3","key":"2366_CR32","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1128\/IAI.66.3.1121-1126.1998","volume":"66","author":"Y Lin","year":"1998","unstructured":"Lin, Y., Zhang, M., & Barnes, P. F. (1998). Chemokine production by a human alveolar epithelial cell line in response to Mycobacterium tuberculosis. Infection and Immunity, 66(3), 1121\u20131126.","journal-title":"Infection and Immunity"},{"issue":"1","key":"2366_CR34","doi-asserted-by":"publisher","first-page":"6092","DOI":"10.1038\/s41467-020-19959-4","volume":"11","author":"JS Mackenzie","year":"2020","unstructured":"Mackenzie, J. S., Lamprecht, D. A., Asmal, R., Adamson, J. H., Borah, K., Beste, D. J., Lee, B. S., Pethe, K., Rousseau, S., & Krieger, I. (2020). Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis. Nature Communications, 11(1), 6092.","journal-title":"Nature Communications"},{"issue":"3","key":"2366_CR35","doi-asserted-by":"publisher","first-page":"e01066","DOI":"10.1128\/spectrum.01066-23","volume":"11","author":"M Martin","year":"2023","unstructured":"Martin, M., Devisch, A., Boudehen, Y. M., Barthe, P., Gutierrez, C., Turapov, O., Aydogan, T., Heriaud, L., Gracy J., & Neyrolles, O. (2023). A Mycobacterium tuberculosis effector targets mitochondrion, controls energy metabolism, and limits cytochrome c exit. Microbiology Spectrum, 11(3), e01066\u2013e01023.","journal-title":"Microbiology Spectrum"},{"issue":"7","key":"2366_CR36","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1128\/iai.64.7.2673-2679.1996","volume":"64","author":"PK Mehta","year":"1996","unstructured":"Mehta, P. K., King, C. H., White, E. H., MurtaghJr, J. J., & Quinn, F. D. (1996). Comparison of in vitro models for the study of Mycobacterium tuberculosis invasion and intracellular replication. Infection and Immunity, 64(7), 2673\u20132679.","journal-title":"Infection and Immunity"},{"issue":"3","key":"2366_CR38","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.tube.2014.03.004","volume":"94","author":"N Naidoo","year":"2014","unstructured":"Naidoo, N., Ramsugit, S., & Pillay, M. (2014). Mycobacterium tuberculosis pili (MTP), a putative biomarker for a tuberculosis diagnostic test. Tuberculosis, 94(3), 338\u2013345.","journal-title":"Tuberculosis"},{"key":"2366_CR39","doi-asserted-by":"crossref","unstructured":"Naidoo, T. J., Senzani, S., Singh, R., Pillay, B., & Pillay, M. (2025). Mycobacterium tuberculosis curli pili (MTP) and heparin-binding hemagglutinin adhesin (HBHA) facilitate regulation of central carbon metabolism, enhancement of ATP synthesis and cell wall biosynthesis. Archives of Microbiology, 207(7), 156.","DOI":"10.1007\/s00203-025-04352-w"},{"key":"2366_CR41","doi-asserted-by":"publisher","first-page":"953056","DOI":"10.3389\/fnut.2022.953056","volume":"9","author":"SR Ortiz","year":"2022","unstructured":"Ortiz, S. R., Heinz, A., Hiller, K., & Field, M. S. (2022). Erythritol synthesis is elevated in response to oxidative stress and regulated by the non-oxidative Pentose phosphate pathway in A549 cells. Frontiers in Nutrition, 9, 953056.","journal-title":"Frontiers in Nutrition"},{"issue":"1","key":"2366_CR42","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1046\/j.1365-2958.2001.02206.x","volume":"39","author":"K Pethe","year":"2001","unstructured":"Pethe, K., Puech, V., Daff\u00e9, M., Josenhans, C., Drobecq, H., Locht, C., & Menozzi, F. D. (2001). Mycobacterium smegmatis laminin-binding glycoprotein shares epitopes with Mycobacterium tuberculosis heparin\u2010binding haemagglutinin. Molecular Microbiology, 39(1), 89\u201399.","journal-title":"Molecular Microbiology"},{"issue":"6","key":"2366_CR45","doi-asserted-by":"publisher","first-page":"476","DOI":"10.7883\/yoken.67.476","volume":"67","author":"S Ramsugit","year":"2014","unstructured":"Ramsugit, S., & Pillay, M. (2014). Mycobacterium tuberculosis pili promote adhesion to and invasion of THP-1 macrophages. Japanese Journal of Infectious Diseases, 67(6), 476\u2013478.","journal-title":"Japanese Journal of Infectious Diseases"},{"issue":"5","key":"2366_CR43","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s10482-013-9981-6","volume":"104","author":"S Ramsugit","year":"2013","unstructured":"Ramsugit, S., Guma, S., Pillay, B., Jain, P., Larsen, M. H., Danaviah, S., & Pillay, M. (2013). Pili contribute to biofilm formation in vitro in Mycobacterium tuberculosis. Antonie Van Leeuwenhoek, 104(5), 725\u2013735.","journal-title":"Antonie Van Leeuwenhoek"},{"key":"2366_CR44","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.bjid.2015.11.002","volume":"20","author":"S Ramsugit","year":"2016","unstructured":"Ramsugit, S., Pillay, B., & Pillay, M. (2016). Evaluation of the role of Mycobacterium tuberculosis pili (MTP) as an adhesin, invasin, and cytokine inducer of epithelial cells. Brazilian Journal of Infectious Diseases, 20, 160\u2013165.","journal-title":"Brazilian Journal of Infectious Diseases"},{"key":"2366_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11306-020-01736-5","volume":"16","author":"K Reedoy","year":"2020","unstructured":"Reedoy, K., Loots, D., Beukes, D., Reenen, M., Pillay, B., & Pillay, M. (2020). Mycobacterium tuberculosis curli pili (MTP) is associated with significant host metabolic pathways in an A549 epithelial cell infection model and contributes to the pathogenicity of Mycobacterium tuberculosis. Metabolomics, 16, 1\u201314.","journal-title":"Metabolomics"},{"key":"2366_CR47","doi-asserted-by":"crossref","unstructured":"Ryndak, M. B., Singh, K. K., Peng, Z., & Laal, S. (2015). Transcriptional profile of Mycobacterium tuberculosis replicating in type II alveolar epithelial cells. PLoS ONE, 10(4), e0123745.","DOI":"10.1371\/journal.pone.0123745"},{"issue":"1","key":"2366_CR48","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41467-019-14132-y","volume":"11","author":"V Saini","year":"2020","unstructured":"Saini, V., Chinta, K. C., Reddy, V. P., Glasgow, J. N., Stein, A., Lamprecht, D. A., Rahman, M. A., Mackenzie, J. S., Truebody, B. E., & Adamson, J. H. (2020). Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis. Nature Communications, 11(1), 557.","journal-title":"Nature Communications"},{"issue":"1","key":"2366_CR49","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1159\/000439275","volume":"8","author":"JM Scordo","year":"2016","unstructured":"Scordo, J. M., Knoell, D. L., & Torrelles, J. B. (2016). Alveolar epithelial cells in Mycobacterium tuberculosis infection: Active players or innocent bystanders? Journal of Innate Immunity, 8(1), 3\u201314.","journal-title":"Journal of Innate Immunity"},{"issue":"1","key":"2366_CR50","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1159\/000272066","volume":"25","author":"S Signorelli","year":"2009","unstructured":"Signorelli, S., Jennings, P., Leonard, M., & Pfaller, W. (2009). Differential effects of hypoxic stress in alveolar epithelial cells and microvascular endothelial cells. Cellular Physiology and Biochemistry, 25(1), 135\u2013144.","journal-title":"Cellular Physiology and Biochemistry"},{"issue":"3","key":"2366_CR51","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/brv.12140","volume":"90","author":"A Stincone","year":"2015","unstructured":"Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M., Campbell, K., Cheung, E., Olin-Sandoval, V., Gr\u00fcning, N. M., Kr\u00fcger, A., & Tauqeer Alam, M. (2015). The return of metabolism: Biochemistry and physiology of the Pentose phosphate pathway. Biological Reviews, 90(3), 927\u2013963.","journal-title":"Biological Reviews"},{"issue":"1","key":"2366_CR52","doi-asserted-by":"publisher","first-page":"A3B1","DOI":"10.1002\/0471142735.ima03bs21","volume":"21","author":"W Strober","year":"1997","unstructured":"Strober, W. (1997). Trypan blue exclusion test of cell viability. Current Protocols in Immunology, 21(1), A3B1\u2013A3B2.","journal-title":"Current Protocols in Immunology"},{"issue":"2","key":"2366_CR53","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/JLB.4MR0717-277R","volume":"103","author":"MD Stutz","year":"2018","unstructured":"Stutz, M. D., Clark, M. P., Doerflinger, M., & Pellegrini, M. (2018). Mycobacterium tuberculosis: Rewiring host cell signaling to promote infection. Journal of Leukocyte Biology, 103(2), 259\u2013268.","journal-title":"Journal of Leukocyte Biology"},{"issue":"5930","key":"2366_CR54","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"MG Vander Heiden","year":"2009","unstructured":"Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009). Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science, 324(5930), 1029\u20131033.","journal-title":"Science"},{"issue":"3191","key":"2366_CR55","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg, O. (1956). On the origin of cancer cells. Science, 123(3191), 309\u2013314.","journal-title":"Science"},{"key":"2366_CR56","unstructured":"WHO. (2023). Global tuberculosis report 2023. WHO. Retrieved August 2024, from https:\/\/www.who.int\/teams\/global-tuberculosis-programme\/tb-reports"},{"key":"2366_CR57","unstructured":"WHO. (2024). Global tuberculosis report 2024. WHO. Retrieved November 2024, from https:\/\/www.who.int\/teams\/global-tuberculosis-programme\/tb-reports\/global-tuberculosis-report-2024"},{"key":"2366_CR58","doi-asserted-by":"publisher","first-page":"0351","DOI":"10.34133\/research.0351","volume":"7","author":"J Wu","year":"2024","unstructured":"Wu, J., Liu, N., Chen, J., Tao, Q., Li, Q., Li, J., Chen, X., & Peng, C. (2024). The Tricarboxylic acid cycle metabolites for cancer: Friend or enemy. Research, 7, 0351.","journal-title":"Research"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-025-02366-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-025-02366-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-025-02366-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T12:01:51Z","timestamp":1764417711000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-025-02366-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,15]]},"references-count":54,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2366"],"URL":"https:\/\/doi.org\/10.1007\/s11306-025-02366-5","relation":{},"ISSN":["1573-3890"],"issn-type":[{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,15]]},"assertion":[{"value":"25 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Biomedical Research Ethics Committee (BREC\/00004043\/2022) of the University of KwaZulu-Natal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"173"}}