{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:16:37Z","timestamp":1778152597062,"version":"3.51.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100018786","name":"Al-Zaytoonah University of Jordan","doi-asserted-by":"publisher","award":["2025 \u2212 2024\/06\/28"],"award-info":[{"award-number":["2025 \u2212 2024\/06\/28"]}],"id":[{"id":"10.13039\/501100018786","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministerium f\u00fcr Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen, and the Bundesmin isterium f\u00fcr Bildung und Forschung"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"DOI":"10.1007\/s11306-026-02426-4","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:55:11Z","timestamp":1775757311000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma 1H NMR-based metabolomic analysis reveals the lipid regulating effect of novel carboxamide derivatives in hyperlipidemic rats"],"prefix":"10.1007","volume":"22","author":[{"given":"Mohammad","family":"Alwahsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahaf","family":"Alejel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lama","family":"Hamadneh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Al-Hiari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Al-Qirim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Hergenr\u00f6der","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"2426_CR1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s41936-018-0065-z","volume":"79","author":"HM Abdou","year":"2018","unstructured":"Abdou, H. M., Yousef, M. I., & Newairy, A. A. (2018). Triton WR-1339-induced hyperlipidemia, DNA fragmentation, neurotransmitters inhibition, oxidative damage, histopathological and morphometric changes: the protective role of soybean oil. The Journal of Basic and Applied Zoology, 79, 51.","journal-title":"The Journal of Basic and Applied Zoology"},{"key":"2426_CR2","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1080\/14756366.2016.1222581","volume":"31","author":"R Abu Farha","year":"2016","unstructured":"Abu Farha, R., Bustanji, Y., Al-Hiari, Y., Al-Qirim, T., Abu Shiekha, G., & Albashiti, R. (2016). Lipid lowering activity of novel N-(benzoylphenyl) pyridine-3-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats. Journal of enzyme inhibition and medicinal chemistry, 31, 138\u2013144.","journal-title":"Journal of enzyme inhibition and medicinal chemistry"},{"key":"2426_CR3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1515\/znc-2011-3-402","volume":"66","author":"G Abu Sheikha","year":"2011","unstructured":"Abu Sheikha, G., Hussin, B., Al-Hiari, Y., Al-Qirim, T., & Shattat, G. (2011). Synthesis of benzothiophene carboxamide derivatives and their pharmacological evaluation as potent antihypertriglyceridemic agents in rats. Zeitschrift f\u00fcr Naturforschung C, 66, 93\u2013103.","journal-title":"Zeitschrift f\u00fcr Naturforschung C"},{"key":"2426_CR4","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/j.micinf.2012.05.011","volume":"14","author":"S Adriouch","year":"2012","unstructured":"Adriouch, S., Haag, F., Boyer, O., Seman, M., & Koch-Nolte, F. (2012). Extracellular NAD+: a danger signal hindering regulatory T cells. Microbes and infection, 14, 1284\u20131292.","journal-title":"Microbes and infection"},{"key":"2426_CR5","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.1021\/ac981422i","volume":"71","author":"S Akoka","year":"1999","unstructured":"Akoka, S., Barantin, L., & Trierweiler, M. (1999). Concentration measurement by proton NMR using the ERETIC method. Analytical Chemistry, 71, 2554\u20132557.","journal-title":"Analytical Chemistry"},{"key":"2426_CR6","doi-asserted-by":"publisher","first-page":"22193","DOI":"10.1039\/D3RA03581F","volume":"13","author":"B Al-Jammal","year":"2023","unstructured":"Al-Jammal, B., Hussein, B., Al-Hiari, Y., Al-Qirim, T., Al-Najdawi, M., Hamadneh, L., Alwahsh, M., & Ikhmais, B. (2023). Synthesis of microwave-assisted carboxamides in Triton WR-1339-induced hyperlipidemic rats: possible hypolipidemic heterocyclic compounds. RSC advances, 13, 22193\u201322204.","journal-title":"RSC advances"},{"key":"2426_CR7","first-page":"52","volume":"17","author":"A Alloubani","year":"2021","unstructured":"Alloubani, A., Nimer, R., & Samara, R. (2021). Relationship between hyperlipidemia, cardiovascular disease and stroke: a systematic review. Current cardiology reviews, 17, 52\u201366.","journal-title":"Current cardiology reviews"},{"key":"2426_CR8","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s11306-025-02318-z","volume":"21","author":"M Alwahsh","year":"2025","unstructured":"Alwahsh, M., Alejel, R., Hamadneh, L., Aleidi, S. M., Marchan, R., Hasan, A., Jasim, S., Saqallah, F. G., Al-Kouz, S., Hussein, B., Alhusban, A. A., Al-Hiari, Y., Al-Qirim, T., & Hergenr\u00f6der, R. (2025). Identification of potential biomarkers of triton WR-1339 induced hyperlipidemia: NMR-based plasma metabolomics approach and gene expression analysis. Metabolomics, 21, 132.","journal-title":"Metabolomics"},{"key":"2426_CR9","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s11892-018-1048-7","volume":"18","author":"Z Arany","year":"2018","unstructured":"Arany, Z., & Neinast, M. (2018). Branched chain amino acids in metabolic disease. Current Diabetes Reports, 18, 76.","journal-title":"Current Diabetes Reports"},{"key":"2426_CR10","doi-asserted-by":"publisher","first-page":"1968450","DOI":"10.1155\/2018\/1968450","volume":"2018","author":"A Bevilacqua","year":"2018","unstructured":"Bevilacqua, A., & Bizzarri, M. (2018). Inositols in insulin signaling and glucose metabolism. International Journal of Endocrinology, 2018, 1968450.","journal-title":"International Journal of Endocrinology"},{"key":"2426_CR11","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1139\/y59-099","volume":"37","author":"EG Bligh","year":"1959","unstructured":"Bligh, E. G., & Dyer, W. J. (1959). A rapid method of total lipid extraction and purification. Canadian journal of biochemistry and physiology, 37, 911\u2013917.","journal-title":"Canadian journal of biochemistry and physiology"},{"key":"2426_CR12","first-page":"290","volume":"16","author":"J Chen","year":"2007","unstructured":"Chen, J., & Li, X. (2007). Hypolipidemic effect of flavonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice. Asia Pacific Journal of Clinical Nutrition, 16, 290.","journal-title":"Asia Pacific Journal of Clinical Nutrition"},{"key":"2426_CR13","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1172\/JCI5392","volume":"103","author":"X Chen","year":"1999","unstructured":"Chen, X., Tsukaguchi, H., Chen, X. Z., Berger, U. V., & Hediger, M. A. (1999). Molecular and functional analysis of SDCT2, a novel rat sodium-dependent dicarboxylate transporter. The Journal of clinical investigation, 103, 1159\u20131168.","journal-title":"The Journal of clinical investigation"},{"key":"2426_CR14","doi-asserted-by":"publisher","first-page":"24754","DOI":"10.1074\/jbc.273.38.24754","volume":"273","author":"G Fiermonte","year":"1998","unstructured":"Fiermonte, G., Palmieri, L., Dolce, V., Lasorsa, F. M., Palmieri, F., Runswick, M. J., & Walker, J. E. (1998). The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans. Journal of Biological Chemistry, 273, 24754\u201324759.","journal-title":"Journal of Biological Chemistry"},{"key":"2426_CR15","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1152\/ajplegacy.1957.190.3.439","volume":"190","author":"M Friedman","year":"1957","unstructured":"Friedman, M., & Byers, S. O. (1957). Mechanism underlying hypercholesteremia induced by Triton WR-1339. American Journal of Physiology-Legacy Content, 190, 439\u2013445.","journal-title":"American Journal of Physiology-Legacy Content"},{"key":"2426_CR16","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.2174\/1568026619666181120141603","volume":"18","author":"A Guleria","year":"2018","unstructured":"Guleria, A., Kumar, A., Kumar, U., Raj, R., & Kumar, D. (2018). NMR based metabolomics: an exquisite and facile method for evaluating therapeutic efficacy and screening drug toxicity. Current topics in medicinal chemistry, 18, 1827\u20131849.","journal-title":"Current topics in medicinal chemistry"},{"key":"2426_CR17","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s11302-006-9038-7","volume":"3","author":"F Haag","year":"2007","unstructured":"Haag, F., Adriouch, S., Bra\u00df, A., Jung, C., M\u00f6ller, S., Scheuplein, F., Bannas, P., Seman, M., & Koch-Nolte, F. (2007). Extracellular NAD and ATP: Partners in immune cell modulation. Purinergic signalling, 3, 71\u201381.","journal-title":"Purinergic signalling"},{"key":"2426_CR18","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s11010-017-2983-3","volume":"431","author":"L Hamadneh","year":"2017","unstructured":"Hamadneh, L., Al-Essa, L., Hikmat, S., Al-Qirim, T., Abu Sheikha, G., Al-Hiari, Y., Azmy, N., & Shattat, G. (2017). N-(3-Benzoylphenyl)-1H-Indole-2-Carboxamide decreases triglyceride levels by downregulation of Apoc3 gene expression in acute hyperlipidemic rat model. Molecular and Cellular Biochemistry, 431, 133\u2013138.","journal-title":"Molecular and Cellular Biochemistry"},{"key":"2426_CR19","doi-asserted-by":"publisher","first-page":"1404441","DOI":"10.3389\/fimmu.2024.1404441","volume":"15","author":"H Huang","year":"2024","unstructured":"Huang, H., Li, G., He, Y., Chen, J., Yan, J., Zhang, Q., Li, L., & Cai, X. (2024). Cellular succinate metabolism and signaling in inflammation: implications for therapeutic intervention. Frontiers in Immunology, 15, 1404441.","journal-title":"Frontiers in Immunology"},{"key":"2426_CR20","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1007\/s00044-024-03273-5","volume":"33","author":"B Hussein","year":"2024","unstructured":"Hussein, B., Alwahsh, M., Al-Hiari, Y., Bourghli, L., Al-Jammal, B., Al-Qirim, T., AlBujuq, N. R., Abu-zaid, R., Saqallah, F. G., & Hamadneh, L. (2024). Substituted furan-carboxamide and Schiff base derivatives as potential hypolipidemic compounds: Evaluation in Triton WR-1339 hyperlipidemic rat model. Medicinal Chemistry Research, 33, 1643\u20131656.","journal-title":"Medicinal Chemistry Research"},{"key":"2426_CR21","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1248\/cpb.c18-00346","volume":"66","author":"SH Jasim","year":"2018","unstructured":"Jasim, S. H., Sheikha, G. M. A., Abuzaid, H. M., Al-Qirim, T. M., Shattat, G. F., Sabbah, D. A., Ala, S. A., Aboumair, M. S., Sweidan, K. A., & Bkhaitan, M. M. (2018). Synthesis and in vivo lipid-lowering activity of novel imidazoles-5-carboxamide derivatives in Triton-WR-1339-induced hyperlipidemic Wistar rats. Chemical and Pharmaceutical Bulletin, 66, 953\u2013958.","journal-title":"Chemical and Pharmaceutical Bulletin"},{"key":"2426_CR22","doi-asserted-by":"publisher","DOI":"10.59049\/2790-0231.11.4.2554","author":"RA Khalaf","year":"2025","unstructured":"Khalaf, R. A., NasrAllah, A., Sabbah, D., Ikhmais, B., AlBadawi, G., & Awad, M. (2025). Trifluorooxoacetamido benzamides as breakthrough CETP inhibitors: A synergistic approach of synthesis, biological assessment, and molecular modeling. Palestinian Medical and Pharmaceutical Journal. https:\/\/doi.org\/10.59049\/2790-0231.11.4.2554","journal-title":"Palestinian Medical and Pharmaceutical Journal"},{"key":"2426_CR23","doi-asserted-by":"publisher","first-page":"104404","DOI":"10.1016\/j.yrtph.2019.104404","volume":"107","author":"R Khlifi","year":"2019","unstructured":"Khlifi, R., Lahmar, A., Dhaouefi, Z., Kalboussi, Z., Maatouk, M., Kilani-Jaziri, S., Ghedira, K., & Chekir-Ghedira, L. (2019). Assessment of hypolipidemic, anti-inflammatory and antioxidant properties of medicinal plant Erica multiflora in triton WR-1339-induced hyperlipidemia and liver function repair in rats: A comparison with fenofibrate. Regulatory toxicology and pharmacology, 107, 104404.","journal-title":"Regulatory toxicology and pharmacology"},{"key":"2426_CR24","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.3.6.3.4","author":"R Leonardi","year":"2007","unstructured":"Leonardi, R., & Jackowski, S. (2007). Biosynthesis of pantothenic acid and coenzyme A. EcoSal Plus. https:\/\/doi.org\/10.1128\/ecosalplus.3.6.3.4","journal-title":"EcoSal Plus"},{"key":"2426_CR25","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12967-016-0987-5","volume":"14","author":"M Li","year":"2016","unstructured":"Li, M., Shu, X., Xu, H., Zhang, C., Yang, L., Zhang, L., & Ji, G. (2016). Integrative analysis of metabolome and gut microbiota in diet-induced hyperlipidemic rats treated with berberine compounds. Journal of Translational Medicine, 14, 237.","journal-title":"Journal of Translational Medicine"},{"key":"2426_CR26","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1039\/D0AY00487A","volume":"12","author":"Y Li","year":"2020","unstructured":"Li, Y., & Zhao, X. (2020). NMR-based plasma metabonomics in hyperlipidemia mice. Analytical Methods, 12, 1995\u20132001.","journal-title":"Analytical Methods"},{"key":"2426_CR27","first-page":"51","volume":"15","author":"N Livingston Raja","year":"2020","unstructured":"Livingston Raja, N., Nair, A. R., Senthilpandian, S., & Ravi, V. (2020). Hypolipidemic action of Rutin on Triton WR-1339-induced hyperlipidemia in rats. Journal of Pre-Clinical and Clinical Research, 15, 51\u201355.","journal-title":"Journal of Pre-Clinical and Clinical Research"},{"key":"2426_CR28","doi-asserted-by":"publisher","first-page":"32434","DOI":"10.1074\/jbc.M503152200","volume":"280","author":"S Mizuarai","year":"2005","unstructured":"Mizuarai, S., Miki, S., Araki, H., Takahashi, K., & Kotani, H. (2005). Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. Journal of Biological Chemistry, 280, 32434\u201332441.","journal-title":"Journal of Biological Chemistry"},{"key":"2426_CR29","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/s41589-022-01004-8","volume":"18","author":"MP Murphy","year":"2022","unstructured":"Murphy, M. P., & Chouchani, E. T. (2022). Why succinate? Physiological regulation by a mitochondrial coenzyme Q sentinel. Nature chemical biology, 18, 461\u2013469.","journal-title":"Nature chemical biology"},{"key":"2426_CR30","first-page":"88563","volume":"10","author":"S Nalbantoglu","year":"2019","unstructured":"Nalbantoglu, S. (2019). Metabolomics: basic principles and strategies. Molecular Medicine, 10, 88563.","journal-title":"Molecular Medicine"},{"key":"2426_CR31","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.pop.2012.11.003","volume":"40","author":"RH Nelson","year":"2012","unstructured":"Nelson, R. H. (2012). Hyperlipidemia as a risk factor for cardiovascular disease. Primary care, 40, 195.","journal-title":"Primary care"},{"key":"2426_CR32","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00894-015-2758-2","volume":"21","author":"A P\u00e9rez-Gonz\u00e1lez","year":"2015","unstructured":"P\u00e9rez-Gonz\u00e1lez, A., Alvarez-Idaboy, J. R., & Galano, A. (2015). Free-radical scavenging by tryptophan and its metabolites through electron transfer based processes. Journal of Molecular Modeling, 21, 213.","journal-title":"Journal of Molecular Modeling"},{"key":"2426_CR33","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1111\/febs.15531","volume":"288","author":"MD Pizzagalli","year":"2021","unstructured":"Pizzagalli, M. D., Bensimon, A., & Superti-Furga, G. (2021). A guide to plasma membrane solute carrier proteins. The FEBS journal, 288, 2784\u20132835.","journal-title":"The FEBS journal"},{"key":"2426_CR34","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/s41392-023-01399-3","volume":"8","author":"S Qiu","year":"2023","unstructured":"Qiu, S., Cai, Y., Yao, H., Lin, C., Xie, Y., Tang, S., & Zhang, A. (2023). Small molecule metabolites: discovery of biomarkers and therapeutic targets. Signal transduction and targeted therapy, 8, 132.","journal-title":"Signal transduction and targeted therapy"},{"key":"2426_CR35","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1007\/s00726-014-1823-y","volume":"46","author":"Z Ruan","year":"2014","unstructured":"Ruan, Z., Yang, Y., Wen, Y., Zhou, Y., Fu, X., Ding, S., Liu, G., Yao, K., Wu, X., Deng, Z., Wu, G., & Yin, Y. (2014). Metabolomic analysis of amino acid and fat metabolism in rats with L-tryptophan supplementation. Amino acids, 46, 2681\u20132691.","journal-title":"Amino acids"},{"key":"2426_CR36","doi-asserted-by":"publisher","first-page":"1934578X1986421","DOI":"10.1177\/1934578X19864218","volume":"14","author":"A Salazar-G\u00f3mez","year":"2019","unstructured":"Salazar-G\u00f3mez, A., S\u00e1nchez-Ch\u00e1vez, A. C., Zepeda-Vallejo, G., Chamorro-Cevallos, G., Gardu\u00f1o-Siciliano, L., & Vargas-D\u00edaz, E. (2019). Hypolipidemic effect of Trixis angustifolia aqueous extract on triton WR-1339-and high-fat diet-induced hyperlipidemic mice. Natural Product Communications, 14, 1934578X19864218.","journal-title":"Natural Product Communications"},{"key":"2426_CR37","doi-asserted-by":"publisher","first-page":"600","DOI":"10.3390\/genes12040600","volume":"12","author":"S Srinivasan","year":"2021","unstructured":"Srinivasan, S., Torres, A. G., & Ribas de Pouplana, L. (2021). Inosine in biology and disease. Genes, 12, 600.","journal-title":"Genes"},{"key":"2426_CR38","doi-asserted-by":"publisher","first-page":"100921","DOI":"10.1016\/j.jbior.2022.100921","volume":"87","author":"XB Su","year":"2023","unstructured":"Su, X. B., Ko, A. L. A., & Saiardi, A. (2023). Regulations of myo-inositol homeostasis: Mechanisms, implications, and perspectives. Advances in Biological Regulation, 87, 100921.","journal-title":"Advances in Biological Regulation"},{"key":"2426_CR39","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12944-017-0533-3","volume":"16","author":"JH Sun","year":"2017","unstructured":"Sun, J. H., Liu, X., Cong, L. X., Li, H., Zhang, C. Y., Chen, J. G., & Wang, C. M. (2017). Metabolomics study of the therapeutic mechanism of Schisandra Chinensis lignans in diet-induced hyperlipidemia mice. Lipids in Health and Disease, 16, 145.","journal-title":"Lipids in Health and Disease"},{"key":"2426_CR40","doi-asserted-by":"publisher","first-page":"e191142","DOI":"10.1590\/s2175-97902022e191142","volume":"58","author":"K Sweidan","year":"2022","unstructured":"Sweidan, K., Sheikha, G. A., Shattat, G., Al-qirim, T., & Bkhaitan, M. (2022). Synthesis and in vivo hypolipidemic effect of some N-(Benzoylphenyl)-carboxamide derivatives in triton WR-1339-induced hyperlipidemic rats. Brazilian Journal of Pharmaceutical Sciences 58, e191142.","journal-title":"Brazilian Journal of Pharmaceutical Sciences"},{"key":"2426_CR41","doi-asserted-by":"publisher","first-page":"41166","DOI":"10.1038\/srep41166","volume":"7","author":"A Van Steenbergen","year":"2017","unstructured":"Van Steenbergen, A., Balteau, M., Ginion, A., Fert\u00e9, L., Battault, S., Ravenstein, C. M., Balligand, J. L., Daskalopoulos, E. P., Gilon, P., Despa, F., Despa, S., Vanoverschelde, J. L., Horman, S., Koepsell, H., Berry, G., Hue, L., Bertrand, L., & Beauloye, C. (2017). Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart. Scientific reports, 7, 41166.","journal-title":"Scientific reports"},{"key":"2426_CR42","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1039\/D0AY00305K","volume":"12","author":"X Wang","year":"2020","unstructured":"Wang, X., Zhang, Y., & Ma, H. (2020). Targeted profiling of amino acid metabolome in serum by a liquid chromatography-mass spectrometry method: application to identify potential markers for diet-induced hyperlipidemia. Analytical Methods, 12, 2355\u20132362.","journal-title":"Analytical Methods"},{"key":"2426_CR43","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2018","author":"DS Wishart","year":"2019","unstructured":"Wishart, D. S. (2019). Metabolomics for investigating physiological and pathophysiological processes. Physiological reviews. https:\/\/doi.org\/10.1152\/physrev.00035.2018","journal-title":"Physiological reviews"},{"key":"2426_CR44","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1002\/jssc.202000911","volume":"44","author":"L Zeng","year":"2021","unstructured":"Zeng, L., Luo, L., Xue, Q., He, Q., Chen, X., Meng, J., Wang, S., & Liang, S. (2021). LC\u2013MS based plasma metabolomics study of the intervention effect of different polar parts of Hawthorn on hyperlipidemia rats. Journal of separation science, 44, 963\u2013972.","journal-title":"Journal of separation science"},{"key":"2426_CR45","first-page":"233","volume":"13","author":"C Zhang","year":"2025","unstructured":"Zhang, C., Yang, X., Xue, Y., Li, H., Zeng, C., & Chen, M. (2025). The role of solute carrier family transporters in hepatic steatosis and hepatic fibrosis. Journal of Clinical and Translational Hepatology, 13, 233.","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"2426_CR46","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1089\/dna.2021.0345","volume":"41","author":"S Zhang","year":"2022","unstructured":"Zhang, S., Liang, Y., Li, L., Chen, Y., Wu, P., & Wei, D. (2022). Succinate: a novel mediator to promote atherosclerotic lesion progression. DNA and Cell Biology, 41, 285\u2013291.","journal-title":"DNA and Cell Biology"},{"key":"2426_CR47","doi-asserted-by":"publisher","first-page":"1266973","DOI":"10.3389\/fcell.2023.1266973","volume":"11","author":"W Zhang","year":"2023","unstructured":"Zhang, W., & Lang, R. (2023). Succinate metabolism: a promising therapeutic target for inflammation, ischemia\/reperfusion injury and cancer. Frontiers in cell and developmental biology, 11, 1266973.","journal-title":"Frontiers in cell and developmental biology"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-026-02426-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-026-02426-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-026-02426-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:02:53Z","timestamp":1778151773000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-026-02426-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":47,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["2426"],"URL":"https:\/\/doi.org\/10.1007\/s11306-026-02426-4","relation":{},"ISSN":["1573-3890"],"issn-type":[{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,9]]},"assertion":[{"value":"9 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"49"}}