{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:13:30Z","timestamp":1783487610741,"version":"3.55.0"},"reference-count":94,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100015153","name":"Fondation Air Liquide","doi-asserted-by":"publisher","award":["IDIVIA-MET"],"award-info":[{"award-number":["IDIVIA-MET"]}],"id":[{"id":"10.13039\/100015153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015153","name":"Fondation Air Liquide","doi-asserted-by":"publisher","award":["IDIVIA-MET"],"award-info":[{"award-number":["IDIVIA-MET"]}],"id":[{"id":"10.13039\/100015153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019979","name":"Fondation Universit\u00e9 Grenoble Alpes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019979","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008656","name":"Fondation Innovations en Infectiologie","doi-asserted-by":"publisher","award":["AO#15-11"],"award-info":[{"award-number":["AO#15-11"]}],"id":[{"id":"10.13039\/100008656","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"DOI":"10.1007\/s11306-026-02454-0","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:33:33Z","timestamp":1780392813000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Host metabolic responses to SARS-CoV-2 and influenza viruses: parallels and contrasts"],"prefix":"10.1007","volume":"22","author":[{"given":"Charles","family":"Terra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Terrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Le Gouellec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"issue":"3","key":"2454_CR1","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1172\/JCI114499","volume":"85","author":"T Akaike","year":"1990","unstructured":"Akaike, T., Ando, M., Oda, T., Doi, T., Ijiri, S., Araki, S., & Maeda, H. (1990). Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice. The Journal of Clinical Investigation, 85(3), 739\u2013745. https:\/\/doi.org\/10.1172\/JCI114499","journal-title":"The Journal of Clinical Investigation"},{"key":"2454_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1020624","volume":"13","author":"AA Al-Qahtani","year":"2022","unstructured":"Al-Qahtani, A. A., Pantazi, I., Alhamlan, F. S., Alothaid, H., Matou-Nasri, S., Sourvinos, G., et al. (2022). SARS-CoV-2 modulates inflammatory responses of alveolar epithelial type II cells via PI3K\/AKT pathway. Frontiers in Immunology, 13, Article 1020624. https:\/\/doi.org\/10.3389\/fimmu.2022.1020624","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"2454_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-023-02239-0","volume":"20","author":"HAM Al-Shalan","year":"2023","unstructured":"Al-Shalan, H. A. M., Zhou, L., Dong, Z., Wang, P., Nicholls, P. K., Boughton, B., et al. (2023). Systemic perturbations in amino acids\/amino acid derivatives and tryptophan pathway metabolites associated with murine influenza A virus infection. Virology Journal, 20(1), Article 270. https:\/\/doi.org\/10.1186\/s12985-023-02239-0","journal-title":"Virology Journal"},{"issue":"3","key":"2454_CR4","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1021\/acs.jproteome.1c00786","volume":"21","author":"OE Alb\u00f3niga","year":"2022","unstructured":"Alb\u00f3niga, O. E., Jim\u00e9nez, D., S\u00e1nchez-Conde, M., Vizcarra, P., Ron, R., Herrera, S., et al. (2022). Metabolic snapshot of plasma samples reveals new pathways implicated in SARS-CoV-2 pathogenesis. Journal of Proteome Research, 21(3), 623\u2013634. https:\/\/doi.org\/10.1021\/acs.jproteome.1c00786","journal-title":"Journal of Proteome Research"},{"issue":"3","key":"2454_CR5","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00338-21","volume":"9","author":"L Ansone","year":"2021","unstructured":"Ansone, L., Briviba, M., Silamikelis, I., Terentjeva, A., Perkons, I., Birzniece, L., et al. (2021). Amino acid metabolism is significantly altered at the time of admission in hospital for severe COVID-19 patients: Findings from longitudinal targeted metabolomics analysis. Microbiology Spectrum, 9(3), Article e0033821. https:\/\/doi.org\/10.1128\/spectrum.00338-21","journal-title":"Microbiology Spectrum"},{"issue":"1","key":"2454_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13054-017-1672-7","volume":"21","author":"MM Banoei","year":"2017","unstructured":"Banoei, M. M., Vogel, H. J., Weljie, A. M., Kumar, A., Yende, S., Angus, D. C., et al. (2017). Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia. Critical Care (London, England), 21(1), 97. https:\/\/doi.org\/10.1186\/s13054-017-1672-7","journal-title":"Critical Care (London, England)"},{"issue":"22","key":"2454_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228623","volume":"21","author":"E Barberis","year":"2020","unstructured":"Barberis, E., Timo, S., Amede, E., Vanella, V. V., Puricelli, C., Cappellano, G., et al. (2020). Large-scale plasma analysis revealed new mechanisms and molecules associated with the host response to SARS-CoV-2. International Journal of Molecular Sciences, 21(22), Article 8623. https:\/\/doi.org\/10.3390\/ijms21228623","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"2454_CR8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s11306-019-1499-0","volume":"15","author":"DJ Beale","year":"2019","unstructured":"Beale, D. J., Oh, D. Y., Karpe, A. V., Tai, C., Dunn, M. S., Tilmanis, D., et al. (2019). Untargeted metabolomics analysis of the upper respiratory tract of ferrets following influenza A virus infection and oseltamivir treatment. Metabolomics\u202f: Official Journal of the Metabolomic Society, 15(3), 33. https:\/\/doi.org\/10.1007\/s11306-019-1499-0","journal-title":"Metabolomics : Official Journal of the Metabolomic Society"},{"issue":"5","key":"2454_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11050327","volume":"11","author":"DJ Beale","year":"2021","unstructured":"Beale, D. J., Shah, R., Karpe, A. V., Hillyer, K. E., McAuley, A. J., Au, G. G., et al. (2021). Metabolic profiling from an asymptomatic ferret model of SARS-CoV-2 infection. Metabolites, 11(5), Article 327. https:\/\/doi.org\/10.3390\/metabo11050327","journal-title":"Metabolites"},{"issue":"11","key":"2454_CR10","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000294","volume":"7","author":"J Bei","year":"2023","unstructured":"Bei, J., Chen, Y., Zhang, Q., Wang, X., Lin, L., Huang, J., et al. (2023). HBV suppresses macrophage immune responses by impairing the TCA cycle through the induction of CS\/PDHC hyperacetylation. Hepatology Communications, 7(11), Article e0294. https:\/\/doi.org\/10.1097\/HC9.0000000000000294","journal-title":"Hepatology Communications"},{"key":"2454_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2023.108487","volume":"122","author":"P Boonamnaj","year":"2023","unstructured":"Boonamnaj, P., Pandey, R. B., & Sompornpisut, P. (2023). Exploring polyamine interactions and binding pockets in SARS-CoV-2 ORF3a. Journal of Molecular Graphics & Modelling, 122, Article 108487. https:\/\/doi.org\/10.1016\/j.jmgm.2023.108487","journal-title":"Journal of Molecular Graphics & Modelling"},{"issue":"10","key":"2454_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101645","volume":"23","author":"C Bruzzone","year":"2020","unstructured":"Bruzzone, C., Bizkarguenaga, M., Gil-Redondo, R., Diercks, T., Arana, E., Garc\u00eda de Vicu\u00f1a, A., et al. (2020). SARS-CoV-2 infection dysregulates the metabolomic and lipidomic profiles of serum. iScience, 23(10), Article 101645. https:\/\/doi.org\/10.1016\/j.isci.2020.101645","journal-title":"iScience"},{"issue":"9","key":"2454_CR13","doi-asserted-by":"publisher","first-page":"e632","DOI":"10.1016\/S2589-7500(22)00112-1","volume":"4","author":"SK Byeon","year":"2022","unstructured":"Byeon, S. K., Madugundu, A. K., Garapati, K., Ramarajan, M. G., Saraswat, M., Kumar-M, P., et al. (2022). Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: A retrospective cohort study. The Lancet. Digital Health, 4(9), e632\u2013e645. https:\/\/doi.org\/10.1016\/S2589-7500(22)00112-1","journal-title":"The Lancet. Digital Health"},{"issue":"17","key":"2454_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179548","volume":"22","author":"M Caterino","year":"2021","unstructured":"Caterino, M., Costanzo, M., Fedele, R., Cevenini, A., Gelzo, M., Di Minno, A., et al. (2021). The serum metabolome of moderate and severe COVID-19 patients reflects possible liver alterations involving carbon and nitrogen metabolism. International Journal of Molecular Sciences, 22(17), Article 9548. https:\/\/doi.org\/10.3390\/ijms22179548","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"2454_CR15","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040584","volume":"13","author":"NS Chandel","year":"2021","unstructured":"Chandel, N. S. (2021). Amino acid metabolism. Cold Spring Harbor Perspectives in Biology, 13(4), Article a040584. https:\/\/doi.org\/10.1101\/cshperspect.a040584","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"5","key":"2454_CR16","doi-asserted-by":"publisher","first-page":"R906","DOI":"10.1152\/ajpregu.00298.2016","volume":"311","author":"JD Chandler","year":"2016","unstructured":"Chandler, J. D., Hu, X., Ko, E.-J., Park, S., Lee, Y.-T., Orr, M., et al. (2016). Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 311(5), R906\u2013R916. https:\/\/doi.org\/10.1152\/ajpregu.00298.2016","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"key":"2454_CR17","doi-asserted-by":"publisher","first-page":"577","DOI":"10.2217\/fmb-2021-0047","volume":"16","author":"X Chen","year":"2021","unstructured":"Chen, X., Gu, M., Li, T., & Sun, Y. (2021). Metabolite reanalysis revealed potential biomarkers for COVID-19: A potential link with immune response. Future Microbiology, 16, 577\u2013588. https:\/\/doi.org\/10.2217\/fmb-2021-0047","journal-title":"Future Microbiology"},{"issue":"5","key":"2454_CR18","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00443-2020","volume":"57","author":"SJ Cho","year":"2021","unstructured":"Cho, S. J., Hong, K. S., Schenck, E., Lee, S., Harris, R., Yang, J., et al. (2021). Decreased IDO1-dependent tryptophan metabolism in aged lung during influenza. The European Respiratory Journal, 57(5), Article 2000443. https:\/\/doi.org\/10.1183\/13993003.00443-2020","journal-title":"The European Respiratory Journal"},{"issue":"6","key":"2454_CR19","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1007\/s00705-013-1841-1","volume":"159","author":"C Claus","year":"2014","unstructured":"Claus, C., & Liebert, U. G. (2014). A renewed focus on the interplay between viruses and mitochondrial metabolism. Archives of Virology, 159(6), 1267\u20131277. https:\/\/doi.org\/10.1007\/s00705-013-1841-1","journal-title":"Archives of Virology"},{"issue":"7","key":"2454_CR20","doi-asserted-by":"publisher","first-page":"2614","DOI":"10.1021\/acs.jproteome.7b00173","volume":"16","author":"L Cui","year":"2017","unstructured":"Cui, L., Fang, J., Ooi, E. E., & Lee, Y. H. (2017). Serial metabolome changes in a prospective cohort of subjects with Influenza Viral Infection and comparison with Dengue Fever. Journal of Proteome Research, 16(7), 2614\u20132622. https:\/\/doi.org\/10.1021\/acs.jproteome.7b00173","journal-title":"Journal of Proteome Research"},{"key":"2454_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/srep26076","volume":"6","author":"L Cui","year":"2016","unstructured":"Cui, L., Zheng, D., Lee, Y. H., Chan, T. K., Kumar, Y., Ho, W. E., et al. (2016). Metabolomics investigation reveals metabolite mediators associated with Acute Lung Injury and repair in a murine model of Influenza Pneumonia. Scientific Reports, 6, Article 26076. https:\/\/doi.org\/10.1038\/srep26076","journal-title":"Scientific Reports"},{"issue":"9","key":"2454_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092293","volume":"10","author":"A D\u2019Alessandro","year":"2021","unstructured":"D\u2019Alessandro, A., Thomas, T., Akpan, I. J., Reisz, J. A., Cendali, F. I., Gamboni, F., et al. (2021). Biological and clinical factors contributing to the metabolic heterogeneity of hospitalized patients with and without COVID-19. Cells, 10(9), Article 2293. https:\/\/doi.org\/10.3390\/cells10092293","journal-title":"Cells"},{"issue":"1","key":"2454_CR23","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s11427-010-4116-z","volume":"54","author":"X Dai","year":"2011","unstructured":"Dai, X., Zhang, L., & Hong, T. (2011). Host cellular signaling induced by influenza virus. Science China Life Sciences, 54(1), 68\u201374. https:\/\/doi.org\/10.1007\/s11427-010-4116-z","journal-title":"Science China Life Sciences"},{"issue":"3","key":"2454_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03540-y","volume":"12","author":"F-X Danlos","year":"2021","unstructured":"Danlos, F.-X., Grajeda-Iglesias, C., Durand, S., Sauvat, A., Roumier, M., Cantin, D., et al. (2021). Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers. Cell Death & Disease, 12(3), Article 258. https:\/\/doi.org\/10.1038\/s41419-021-03540-y","journal-title":"Cell Death & Disease"},{"key":"2454_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.804976","author":"M De Angelis","year":"2022","unstructured":"De Angelis, M., Amatore, D., Checconi, P., Zevini, A., Fraternale, A., Magnani, M., et al. (2022). Influenza virus down-modulates G6PD expression and activity to induce oxidative stress and promote its replication. Frontiers in Cellular and Infection Microbiology. https:\/\/doi.org\/10.3389\/fcimb.2021.804976","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"issue":"1","key":"2454_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14292-w","volume":"12","author":"JP Dewulf","year":"2022","unstructured":"Dewulf, J. P., Martin, M., Marie, S., Oguz, F., Belkhir, L., De Greef, J., et al. (2022). Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19. Scientific Reports, 12(1), Article 9959. https:\/\/doi.org\/10.1038\/s41598-022-14292-w","journal-title":"Scientific Reports"},{"key":"2454_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109920","author":"X Duan","year":"2021","unstructured":"Duan, X., Tang, X., Nair, M. S., Zhang, T., Qiu, Y., Zhang, W., et al. (2021). An airway organoid-based screen identifies a role for the HIF1\u03b1-glycolysis axis in SARS-CoV-2 infection. Cell Reports. https:\/\/doi.org\/10.1016\/j.celrep.2021.109920","journal-title":"Cell Reports"},{"key":"2454_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2023.102288","volume":"74","author":"TMD Ebbels","year":"2023","unstructured":"Ebbels, T. M. D., van der Hooft, J. J. J., Chatelaine, H., Broeckling, C., Zamboni, N., Hassoun, S., & Math\u00e9, E. A. (2023). Recent advances in mass spectrometry-based computational metabolomics. Current Opinion in Chemical Biology, 74, Article 102288. https:\/\/doi.org\/10.1016\/j.cbpa.2023.102288","journal-title":"Current Opinion in Chemical Biology"},{"key":"2454_CR29","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202201880","author":"M Engler","year":"2023","unstructured":"Engler, M., Albers, D., Maltitz, P. V., Gro\u00df, R., M\u00fcnch, J., & Cirstea, I. C. (2023). ACE2-EGFR-MAPK signaling contributes to SARS-CoV-2 infection. Life Science Alliance. https:\/\/doi.org\/10.26508\/lsa.202201880","journal-title":"Life Science Alliance"},{"issue":"5","key":"2454_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04861-2","volume":"13","author":"RD Escarcega","year":"2022","unstructured":"Escarcega, R. D., Honarpisheh, P., Colpo, G. D., Ahnstedt, H. W., Couture, L., Juneja, S., et al. (2022). Sex differences in global metabolomic profiles of COVID-19 patients. Cell Death & Disease, 13(5), Article 461. https:\/\/doi.org\/10.1038\/s41419-022-04861-2","journal-title":"Cell Death & Disease"},{"issue":"1","key":"2454_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-024-00538-0","volume":"10","author":"M Essex","year":"2024","unstructured":"Essex, M., Millet Pascual-Leone, B., L\u00f6ber, U., Kuhring, M., Zhang, B., Br\u00fcning, U., et al. (2024). Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19. NPJ biofilms and microbiomes, 10(1), Article 66. https:\/\/doi.org\/10.1038\/s41522-024-00538-0","journal-title":"NPJ biofilms and microbiomes"},{"issue":"6","key":"2454_CR32","doi-asserted-by":"publisher","first-page":"852","DOI":"10.3390\/cells12060852","volume":"12","author":"E Fabbrizi","year":"2023","unstructured":"Fabbrizi, E., Fiorentino, F., Carafa, V., Altucci, L., Mai, A., & Rotili, D. (2023). Emerging roles of SIRT5 in metabolism, cancer, and SARS-CoV-2 infection. Cells (Basel), 12(6), 852. https:\/\/doi.org\/10.3390\/cells12060852","journal-title":"Cells (Basel)"},{"issue":"6","key":"2454_CR33","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1021\/acsinfecdis.0c00491","volume":"7","author":"MR Firpo","year":"2021","unstructured":"Firpo, M. R., Mastrodomenico, V., Hawkins, G. M., Prot, M., Levillayer, L., Gallagher, T., et al. (2021). Targeting polyamines inhibits coronavirus infection by reducing cellular attachment and entry. ACS infectious diseases, 7(6), 1423\u20131432. https:\/\/doi.org\/10.1021\/acsinfecdis.0c00491","journal-title":"ACS infectious diseases"},{"issue":"7","key":"2454_CR34","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/s41579-021-00542-7","volume":"19","author":"T Flerlage","year":"2021","unstructured":"Flerlage, T., Boyd, D. F., Meliopoulos, V., Thomas, P. G., & Schultz-Cherry, S. (2021). Influenza virus and SARS-CoV-2: Pathogenesis and host responses in the respiratory tract. Nature Reviews Microbiology, 19(7), 425\u2013441. https:\/\/doi.org\/10.1038\/s41579-021-00542-7","journal-title":"Nature Reviews Microbiology"},{"issue":"2","key":"2454_CR35","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/febs.13966","volume":"284","author":"L Gaelings","year":"2017","unstructured":"Gaelings, L., S\u00f6derholm, S., Bugai, A., Fu, Y., Nandania, J., Schepens, B., et al. (2017). Regulation of kynurenine biosynthesis during influenza virus infection. The FEBS journal, 284(2), 222\u2013236. https:\/\/doi.org\/10.1111\/febs.13966","journal-title":"The FEBS journal"},{"issue":"1","key":"2454_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24007-w","volume":"12","author":"NC Gassen","year":"2021","unstructured":"Gassen, N. C., Papies, J., Bajaj, T., Emanuel, J., Dethloff, F., Chua, R. L., et al. (2021). SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals. Nature Communications, 12(1), Article 3818. https:\/\/doi.org\/10.1038\/s41467-021-24007-w","journal-title":"Nature Communications"},{"issue":"1","key":"2454_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-014-0228-6","volume":"11","author":"A Generous","year":"2014","unstructured":"Generous, A., Thorson, M., Barcus, J., Jacher, J., Busch, M., & Sleister, H. (2014). Identification of putative interactions between swine and human influenza A virus nucleoprotein and human host proteins. Virology Journal, 11(1), Article 228. https:\/\/doi.org\/10.1186\/s12985-014-0228-6","journal-title":"Virology Journal"},{"key":"2454_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.686240","volume":"12","author":"LB Giron","year":"2021","unstructured":"Giron, L. B., Dweep, H., Yin, X., Wang, H., Damra, M., Goldman, A. R., et al. (2021). Plasma markers of disrupted gut permeability in severe COVID-19 patients. Frontiers in Immunology, 12, Article 686240. https:\/\/doi.org\/10.3389\/fimmu.2021.686240","journal-title":"Frontiers in Immunology"},{"issue":"7816","key":"2454_CR39","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/s41586-020-2286-9","volume":"583","author":"DE Gordon","year":"2020","unstructured":"Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., et al. (2020). A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature, 583(7816), 459\u2013468. https:\/\/doi.org\/10.1038\/s41586-020-2286-9","journal-title":"Nature"},{"issue":"12","key":"2454_CR40","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108306","volume":"41","author":"A Guillon","year":"2022","unstructured":"Guillon, A., Brea-Diakite, D., Cezard, A., Wacquiez, A., Baranek, T., Bourgeais, J., et al. (2022). Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein. The EMBO journal, 41(12), Article e108306. https:\/\/doi.org\/10.15252\/embj.2021108306","journal-title":"The EMBO journal"},{"issue":"8","key":"2454_CR41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0256784","volume":"16","author":"AS Herrera-Van Oostdam","year":"2021","unstructured":"Herrera-Van Oostdam, A. S., Casta\u00f1eda-Delgado, J. E., Oropeza-Valdez, J. J., Borrego, J. C., Mon\u00e1rrez-Espino, J., Zheng, J., et al. (2021). Immunometabolic signatures predict risk of progression to sepsis in COVID-19. PloS One, 16(8), Article e0256784. https:\/\/doi.org\/10.1371\/journal.pone.0256784","journal-title":"PloS One"},{"issue":"1","key":"2454_CR42","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2325067","volume":"16","author":"S Heumel","year":"2024","unstructured":"Heumel, S., de Rezende Rodovalho, V., Urien, C., Specque, F., Brito Rodrigues, P., Robil, C., et al. (2024). Shotgun metagenomics and systemic targeted metabolomics highlight indole-3-propionic acid as a protective gut microbial metabolite against influenza infection. Gut Microbes, 16(1), Article 2325067. https:\/\/doi.org\/10.1080\/19490976.2024.2325067","journal-title":"Gut Microbes"},{"issue":"5","key":"2454_CR43","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1097\/SHK.0000000000001099","volume":"50","author":"JL Izquierdo-Garcia","year":"2018","unstructured":"Izquierdo-Garcia, J. L., Nin, N., Jimenez-Clemente, J., Horcajada, J. P., Arenas-Miras, M. D. M., Gea, J., et al. (2018). Metabolomic profile of ARDS by nuclear magnetic resonance spectroscopy in patients with H1N1 influenza virus pneumonia. Shock, 50(5), 504\u2013510. https:\/\/doi.org\/10.1097\/SHK.0000000000001099","journal-title":"Shock"},{"issue":"2","key":"2454_CR44","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00284-2021","volume":"59","author":"H Jia","year":"2022","unstructured":"Jia, H., Liu, C., Li, D., Huang, Q., Liu, D., Zhang, Y., et al. (2022). Metabolomic analyses reveal new stage-specific features of COVID-19. European Respiratory Journal, 59(2), Article 2100284. https:\/\/doi.org\/10.1183\/13993003.00284-2021","journal-title":"European Respiratory Journal"},{"issue":"1","key":"2454_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06706-4","volume":"7","author":"A Jo","year":"2024","unstructured":"Jo, A., Kim, K.-S., Won, J., Shin, H., Kim, S., Kim, B., et al. (2024). Nasal symbiont Staphylococcus epidermidis restricts influenza A virus replication via the creation of a polyamine-deficient cellular environment. Communications Biology, 7(1), Article 1031. https:\/\/doi.org\/10.1038\/s42003-024-06706-4","journal-title":"Communications Biology"},{"issue":"7928","key":"2454_CR46","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/s41586-022-05128-8","volume":"609","author":"F Karagiannis","year":"2022","unstructured":"Karagiannis, F., Peukert, K., Surace, L., Michla, M., Nikolka, F., Fox, M., et al. (2022). Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19. Nature, 609(7928), 801\u2013807. https:\/\/doi.org\/10.1038\/s41586-022-05128-8","journal-title":"Nature"},{"issue":"10","key":"2454_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/v13102068","volume":"13","author":"J Kleinehr","year":"2021","unstructured":"Kleinehr, J., Wilden, J. J., Boergeling, Y., Ludwig, S., & Hrincius, E. R. (2021). Metabolic modifications by common respiratory viruses and their potential as new antiviral targets. Viruses, 13(10), Article 2068. https:\/\/doi.org\/10.3390\/v13102068","journal-title":"Viruses"},{"key":"2454_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2021.100159","volume":"20","author":"S Krishnan","year":"2021","unstructured":"Krishnan, S., Nordqvist, H., Ambikan, A. T., Gupta, S., Sperk, M., Svensson-Akusj\u00e4rvi, S., et al. (2021). Metabolic perturbation associated with COVID-19 disease severity and SARS-CoV-2 replication. Molecular & Cellular Proteomics, 20, Article 100159. https:\/\/doi.org\/10.1016\/j.mcpro.2021.100159","journal-title":"Molecular & Cellular Proteomics"},{"issue":"7","key":"2454_CR49","doi-asserted-by":"publisher","first-page":"3139","DOI":"10.1021\/pr400464p","volume":"12","author":"AL Kroeker","year":"2013","unstructured":"Kroeker, A. L., Ezzati, P., Coombs, K. M., & Halayko, A. J. (2013). Influenza A infection of primary human airway epithelial cells up-regulates proteins related to purine metabolism and ubiquitin-related signaling. Journal of Proteome Research, 12(7), 3139\u20133151. https:\/\/doi.org\/10.1021\/pr400464p","journal-title":"Journal of Proteome Research"},{"issue":"5","key":"2454_CR50","doi-asserted-by":"publisher","first-page":"2796","DOI":"10.1021\/acs.jproteome.1c00052","volume":"20","author":"NG Lawler","year":"2021","unstructured":"Lawler, N. G., Gray, N., Kimhofer, T., Boughton, B., Gay, M., Yang, R., et al. (2021). Systemic perturbations in amine and kynurenine metabolism associated with acute SARS-CoV-2 infection and inflammatory cytokine responses. Journal of Proteome Research, 20(5), 2796\u20132811. https:\/\/doi.org\/10.1021\/acs.jproteome.1c00052","journal-title":"Journal of Proteome Research"},{"issue":"1","key":"2454_CR51","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1093\/infdis\/jiad442","volume":"230","author":"C Ledderose","year":"2024","unstructured":"Ledderose, C., Valsami, E. A., Elevado, M., & Junger, W. G. (2024). Adenosine triphosphate release from Influenza-infected lungs enhances neutrophil activation and promotes disease progression. The Journal of Infectious Diseases, 230(1), 120\u2013130. https:\/\/doi.org\/10.1093\/infdis\/jiad442","journal-title":"The Journal of Infectious Diseases"},{"issue":"1","key":"2454_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04843-0","volume":"28","author":"CH Lee","year":"2024","unstructured":"Lee, C. H., Banoei, M. M., Ansari, M., Cheng, M. P., Lamontagne, F., Griesdale, D., et al. (2024). Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia. Critical Care, 28(1), Article 63. https:\/\/doi.org\/10.1186\/s13054-024-04843-0","journal-title":"Critical Care"},{"issue":"8","key":"2454_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12080713","volume":"12","author":"H-M Lewis","year":"2022","unstructured":"Lewis, H.-M., Liu, Y., Frampas, C. F., Longman, K., Spick, M., Stewart, A., et al. (2022). Metabolomics markers of COVID-19 are dependent on collection wave. Metabolites, 12(8), Article 713. https:\/\/doi.org\/10.3390\/metabo12080713","journal-title":"Metabolites"},{"key":"2454_CR54","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.145027","author":"S Li","year":"2023","unstructured":"Li, S., Ma, F., Yokota, T., Garcia, G., Palermo, A., Wang, Y., et al. (2023). Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2\u2013induced systemic toxicity. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.145027","journal-title":"JCI Insight"},{"key":"2454_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.723818","author":"T Li","year":"2021","unstructured":"Li, T., Ning, N., Li, B., Luo, D., Qin, E., Yu, W., et al. (2021). Longitudinal metabolomics reveals ornithine cycle dysregulation correlates with inflammation and coagulation in COVID-19 severe patients. Frontiers in Microbiology. https:\/\/doi.org\/10.3389\/fmicb.2021.723818","journal-title":"Frontiers in Microbiology"},{"issue":"1","key":"2454_CR56","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-022-01022-z","volume":"15","author":"J Liu","year":"2022","unstructured":"Liu, J., Hong, S., Yang, J., Zhang, X., Wang, Y., Wang, H., et al. (2022). Targeting purine metabolism in ovarian cancer. Journal of Ovarian Research, 15(1), Article 93. https:\/\/doi.org\/10.1186\/s13048-022-01022-z","journal-title":"Journal of Ovarian Research"},{"issue":"14","key":"2454_CR57","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411614","volume":"24","author":"S Lodge","year":"2023","unstructured":"Lodge, S., Lawler, N. G., Gray, N., Masuda, R., Nitschke, P., Whiley, L., et al. (2023). Integrative plasma metabolic and lipidomic modelling of SARS-CoV-2 infection in relation to clinical severity and early mortality prediction. International Journal of Molecular Sciences, 24(14), Article 11614. https:\/\/doi.org\/10.3390\/ijms241411614","journal-title":"International Journal of Molecular Sciences"},{"key":"2454_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2020.198246","volume":"292","author":"J Luban","year":"2021","unstructured":"Luban, J., Sattler, R. A., M\u00fchlberger, E., Graci, J. D., Cao, L., Weetall, M., et al. (2021). The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines. Virus Research, 292, Article 198246. https:\/\/doi.org\/10.1016\/j.virusres.2020.198246","journal-title":"Virus Research"},{"issue":"1","key":"2454_CR59","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07979-y","volume":"23","author":"S Ma","year":"2023","unstructured":"Ma, S., Yang, L., Li, H., Chen, X., Lin, X., Ge, W., et al. (2023). Understanding metabolic alterations after SARS-CoV-2 infection: Insights from the patients\u2019 oral microenvironmental metabolites. BMC Infectious Diseases, 23(1), Article 42. https:\/\/doi.org\/10.1186\/s12879-022-07979-y","journal-title":"BMC Infectious Diseases"},{"issue":"1","key":"2454_CR60","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44266-z","volume":"14","author":"R Maeda","year":"2023","unstructured":"Maeda, R., Seki, N., Uwamino, Y., Wakui, M., Nakagama, Y., Kido, Y., et al. (2023). Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19. Nature Communications, 14(1), Article 8469. https:\/\/doi.org\/10.1038\/s41467-023-44266-z","journal-title":"Nature Communications"},{"key":"2454_CR61","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.936106","author":"LE Mart\u00ednez-G\u00f3mez","year":"2022","unstructured":"Mart\u00ednez-G\u00f3mez, L. E., Ibarra-Gonz\u00e1lez, I., Fern\u00e1ndez-Lainez, C., Tusie, T., Moreno-Mac\u00edas, H., Martinez-Armenta, C., et al. (2022). Metabolic reprogramming in SARS-CoV-2 infection impacts the outcome of COVID-19 patients. Frontiers in Immunology. https:\/\/doi.org\/10.3389\/fimmu.2022.936106","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"2454_CR62","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13668-3","volume":"11","author":"I Mart\u00ednez-Reyes","year":"2020","unstructured":"Mart\u00ednez-Reyes, I., & Chandel, N. S. (2020). Mitochondrial TCA cycle metabolites control physiology and disease. Nature Communications, 11(1), Article 102. https:\/\/doi.org\/10.1038\/s41467-019-13668-3","journal-title":"Nature Communications"},{"issue":"4","key":"2454_CR63","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s00109-022-02177-4","volume":"100","author":"M Masoodi","year":"2022","unstructured":"Masoodi, M., Peschka, M., Schmiedel, S., Haddad, M., Frye, M., Maas, C., et al. (2022). Disturbed lipid and amino acid metabolisms in COVID-19 patients. Journal of Molecular Medicine (Berlin, Germany), 100(4), 555\u2013568. https:\/\/doi.org\/10.1007\/s00109-022-02177-4","journal-title":"Journal of Molecular Medicine (Berlin, Germany)"},{"issue":"2","key":"2454_CR64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009243","volume":"17","author":"G Meoni","year":"2021","unstructured":"Meoni, G., Ghini, V., Maggi, L., Vignoli, A., Mazzoni, A., Salvati, L., et al. (2021). Metabolomic\/lipidomic profiling of COVID-19 and individual response to tocilizumab. PLoS pathogens, 17(2), Article e1009243. https:\/\/doi.org\/10.1371\/journal.ppat.1009243","journal-title":"PLoS pathogens"},{"issue":"1","key":"2454_CR65","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22166-4","volume":"12","author":"PJ Mullen","year":"2021","unstructured":"Mullen, P. J., Garcia, G., Purkayastha, A., Matulionis, N., Schmid, E. W., Momcilovic, M., et al. (2021). SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition. Nature Communications, 12(1), Article 1876. https:\/\/doi.org\/10.1038\/s41467-021-22166-4","journal-title":"Nature Communications"},{"issue":"8","key":"2454_CR66","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.tibtech.2016.04.012","volume":"34","author":"BC Mulukutla","year":"2016","unstructured":"Mulukutla, B. C., Yongky, A., Le, T., Mashek, D. G., & Hu, W. S. (2016). Regulation of glucose metabolism - A perspective from cell bioprocessing. Trends in Biotechnology, 34(8), 638\u2013651. https:\/\/doi.org\/10.1016\/j.tibtech.2016.04.012","journal-title":"Trends in Biotechnology"},{"key":"2454_CR67","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.995069","volume":"9","author":"C Occelli","year":"2022","unstructured":"Occelli, C., Guigonis, J.-M., Lindenthal, S., Cagnard, A., Graslin, F., Brglez, V., et al. (2022). Untargeted plasma metabolomic fingerprinting highlights several biomarkers for the diagnosis and prognosis of coronavirus disease 19. Frontiers in Medicine, 9, Article 995069. https:\/\/doi.org\/10.3389\/fmed.2022.995069","journal-title":"Frontiers in Medicine"},{"issue":"1","key":"2454_CR68","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67879-6","volume":"10","author":"M Ohno","year":"2020","unstructured":"Ohno, M., Sekiya, T., Nomura, N., Daito, T. J., Shingai, M., & Kida, H. (2020). Influenza virus infection affects insulin signaling, fatty acid-metabolizing enzyme expressions, and the tricarboxylic acid cycle in mice. Scientific Reports, 10(1), Article 10879. https:\/\/doi.org\/10.1038\/s41598-020-67879-6","journal-title":"Scientific Reports"},{"issue":"1","key":"2454_CR69","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85788-0","volume":"11","author":"JC P\u00e1ez-Franco","year":"2021","unstructured":"P\u00e1ez-Franco, J. C., Torres-Ruiz, J., Sosa-Hern\u00e1ndez, V. A., Cervantes-D\u00edaz, R., Romero-Ram\u00edrez, S., P\u00e9rez-Fragoso, A., et al. (2021). Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients. Scientific Reports, 11(1), Article 6350. https:\/\/doi.org\/10.1038\/s41598-021-85788-0","journal-title":"Scientific Reports"},{"issue":"1","key":"2454_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.105895","volume":"26","author":"SM Pinto","year":"2023","unstructured":"Pinto, S. M., Subbannayya, Y., Kim, H., Hagen, L., G\u00f3rna, M. W., Nieminen, A. I., et al. (2023). Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells. iScience, 26(1), Article 105895. https:\/\/doi.org\/10.1016\/j.isci.2022.105895","journal-title":"iScience"},{"issue":"6","key":"2454_CR71","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/irv.12677","volume":"13","author":"A Pizzini","year":"2019","unstructured":"Pizzini, A., Kurz, K., Santifaller, J., Tschurtschenthaler, C., Theurl, I., Fuchs, D., et al. (2019). Assessment of neopterin and indoleamine 2,3-dioxygenase activity in patients with seasonal influenza: A pilot study. Influenza and Other Respiratory Viruses, 13(6), 603\u2013609. https:\/\/doi.org\/10.1111\/irv.12677","journal-title":"Influenza and Other Respiratory Viruses"},{"issue":"3","key":"2454_CR72","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3390\/metabo12030239","volume":"12","author":"JRC Ramos","year":"2022","unstructured":"Ramos, J. R. C., Bissinger, T., Genzel, Y., & Reichl, U. (2022). Impact of Influenza A Virus Infection on Growth and Metabolism of Suspension MDCK Cells Using a Dynamic Model. Metabolites, 12(3), 239. https:\/\/doi.org\/10.3390\/metabo12030239","journal-title":"Metabolites"},{"issue":"6","key":"2454_CR73","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1007\/s12250-021-00433-4","volume":"36","author":"L Ren","year":"2021","unstructured":"Ren, L., Zhang, W., Zhang, J., Zhang, J., Zhang, H., Zhu, Y., et al. (2021). Influenza A Virus (H1N1) Infection Induces Glycolysis to Facilitate Viral Replication. Virologica Sinica, 36(6), 1532\u20131542. https:\/\/doi.org\/10.1007\/s12250-021-00433-4","journal-title":"Virologica Sinica"},{"key":"2454_CR74","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1752-0509-4-61","volume":"4","author":"JB Ritter","year":"2010","unstructured":"Ritter, J. B., Wahl, A. S., Freund, S., Genzel, Y., & Reichl, U. (2010). Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling. BMC systems biology, 4, 61. https:\/\/doi.org\/10.1186\/1752-0509-4-61","journal-title":"BMC systems biology"},{"issue":"11","key":"2454_CR75","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11306-022-01936-1","volume":"18","author":"N Saheb Sharif-Askari","year":"2022","unstructured":"Saheb Sharif-Askari, N., Soares, N. C., Mohamed, H. A., Sharif-Askari, S., Alsayed, F., Al-Hroub, H. A. H., H., et al. (2022). Saliva metabolomic profile of COVID-19 patients associates with disease severity. Metabolomics: Official Journal of the Metabolomic Society, 18(11), 81. https:\/\/doi.org\/10.1007\/s11306-022-01936-1","journal-title":"Metabolomics: Official Journal of the Metabolomic Society"},{"key":"2454_CR76","doi-asserted-by":"publisher","first-page":"725043","DOI":"10.3389\/fcimb.2021.725043","volume":"11","author":"FJ S\u00e1nchez-Garc\u00eda","year":"2021","unstructured":"S\u00e1nchez-Garc\u00eda, F. J., P\u00e9rez-Hern\u00e1ndez, C. A., Rodr\u00edguez-Murillo, M., & Moreno-Altamirano, M. M. B. (2021). The Role of Tricarboxylic Acid Cycle Metabolites in Viral Infections. Frontiers in Cellular and Infection Microbiology, 11, 725043. https:\/\/doi.org\/10.3389\/fcimb.2021.725043","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"2454_CR77","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.virol.2015.02.038","volume":"479\u2013480","author":"EL Sanchez","year":"2015","unstructured":"Sanchez, E. L., & Lagunoff, M. (2015). Viral activation of cellular metabolism. Virology, 479\u2013480, 609\u2013618. https:\/\/doi.org\/10.1016\/j.virol.2015.02.038","journal-title":"Virology"},{"key":"2454_CR78","doi-asserted-by":"publisher","first-page":"154739","DOI":"10.1016\/j.metabol.2021.154739","volume":"118","author":"D Shi","year":"2021","unstructured":"Shi, D., Yan, R., Lv, L., Jiang, H., Lu, Y., Sheng, J., et al. (2021). The serum metabolome of COVID-19 patients is distinctive and predictive. Metabolism: Clinical and Experimental, 118, 154739. https:\/\/doi.org\/10.1016\/j.metabol.2021.154739","journal-title":"Metabolism: Clinical and Experimental"},{"key":"2454_CR79","doi-asserted-by":"publisher","first-page":"1478876","DOI":"10.3389\/fcimb.2024.1478876","volume":"14","author":"X Shi","year":"2024","unstructured":"Shi, X., Hua, S., Chen, Z., Cao, W., Xiao, M., Pei, W., et al. (2024). Characterization of serum metabolome and respiratory microbiota in children with influenza A virus infection. Frontiers in Cellular and Infection Microbiology, 14, 1478876. https:\/\/doi.org\/10.3389\/fcimb.2024.1478876","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"issue":"10","key":"2454_CR80","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.3390\/v14102281","volume":"14","author":"G Sibille","year":"2022","unstructured":"Sibille, G., Luganini, A., Sainas, S., Boschi, D., Lolli, M. L., & Gribaudo, G. (2022). The Novel hDHODH Inhibitor MEDS433 Prevents Influenza Virus Replication by Blocking Pyrimidine Biosynthesis. Viruses, 14(10), 2281. https:\/\/doi.org\/10.3390\/v14102281","journal-title":"Viruses"},{"issue":"1","key":"2454_CR81","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12915-019-0678-9","volume":"17","author":"SK Thaker","year":"2019","unstructured":"Thaker, S. K., Ch\u2019ng, J., & Christofk, H. R. (2019). Viral hijacking of cellular metabolism. BMC Biology, 17(1), 59. https:\/\/doi.org\/10.1186\/s12915-019-0678-9","journal-title":"BMC Biology"},{"issue":"11","key":"2454_CR82","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.1021\/acs.jproteome.0c00606","volume":"19","author":"T Thomas","year":"2020","unstructured":"Thomas, T., Stefanoni, D., Dzieciatkowska, M., Issaian, A., Nemkov, T., Hill, R. C., et al. (2020a). Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 Patients. Journal of Proteome Research, 19(11), 4455\u20134469. https:\/\/doi.org\/10.1021\/acs.jproteome.0c00606","journal-title":"Journal of Proteome Research"},{"issue":"14","key":"2454_CR83","doi-asserted-by":"publisher","first-page":"e140327","DOI":"10.1172\/jci.insight.140327","volume":"5","author":"T Thomas","year":"2020","unstructured":"Thomas, T., Stefanoni, D., Reisz, J. A., Nemkov, T., Bertolone, L., Francis, R. O., et al. (2020b). COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status. JCI insight, 5(14), e140327. https:\/\/doi.org\/10.1172\/jci.insight.140327","journal-title":"JCI insight"},{"issue":"1","key":"2454_CR84","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/s41392-021-00726-w","volume":"6","author":"M Tian","year":"2021","unstructured":"Tian, M., Liu, W., Li, X., Zhao, P., Shereen, M. A., Zhu, C., et al. (2021). HIF-1\u03b1 promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19. Signal Transduction and Targeted Therapy, 6(1), 308. https:\/\/doi.org\/10.1038\/s41392-021-00726-w","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"2454_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101298","author":"S van Liempd","year":"2021","unstructured":"van Liempd, S., Cabrera, D., Pilzner, C., Kollmus, H., Schughart, K., & Falc\u00f3n-P\u00e9rez, J. M. (2021). Impaired beta-oxidation increases vulnerability to Influenza A infection. Journal of Biological Chemistry. https:\/\/doi.org\/10.1016\/j.jbc.2021.101298","journal-title":"Journal of Biological Chemistry"},{"issue":"14","key":"2454_CR86","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.2174\/0929867323666160411125803","volume":"23","author":"S Vincenzetti","year":"2016","unstructured":"Vincenzetti, S., Polzonetti, V., Micozzi, D., & Pucciarelli, S. (2016). Enzymology of Pyrimidine Metabolism and Neurodegeneration. Current Medicinal Chemistry, 23(14), 1408\u20131431. https:\/\/doi.org\/10.2174\/0929867323666160411125803","journal-title":"Current Medicinal Chemistry"},{"issue":"4","key":"2454_CR87","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1021\/acs.jproteome.3c00797","volume":"23","author":"L Whiley","year":"2024","unstructured":"Whiley, L., Lawler, N. G., Zeng, A. X., Lee, A., Chin, S. T., Bizkarguenaga, M., et al. (2024). Cross-Validation of Metabolic Phenotypes in SARS-CoV-2 Infected Subpopulations Using Targeted Liquid Chromatography-Mass Spectrometry (LC-MS). Journal of Proteome Research, 23(4), 1313\u20131327. https:\/\/doi.org\/10.1021\/acs.jproteome.3c00797","journal-title":"Journal of Proteome Research"},{"issue":"7","key":"2454_CR88","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1093\/nsr\/nwaa086","volume":"7","author":"D Wu","year":"2020","unstructured":"Wu, D., Shu, T., Yang, X., Song, J. X., Zhang, M., Yao, C., et al. (2020). Plasma metabolomic and lipidomic alterations associated with COVID-19. National Science Review, 7(7), 1157\u20131168. https:\/\/doi.org\/10.1093\/nsr\/nwaa086","journal-title":"National Science Review"},{"issue":"3","key":"2454_CR89","doi-asserted-by":"publisher","first-page":"BSR20204201","DOI":"10.1042\/BSR20204201","volume":"41","author":"J Wu","year":"2021","unstructured":"Wu, J., Zhao, M., Li, C., Zhang, Y., & Wang, D. W. (2021). The SARS-CoV-2 induced targeted amino acid profiling in patients at hospitalized and convalescent stage. Bioscience Reports, 41(3), BSR20204201. https:\/\/doi.org\/10.1042\/BSR20204201","journal-title":"Bioscience Reports"},{"issue":"1","key":"2454_CR90","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1038\/s41467-021-21907-9","volume":"12","author":"N Xiao","year":"2021","unstructured":"Xiao, N., Nie, M., Pang, H., Wang, B., Hu, J., Meng, X., et al. (2021). Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications. Nature Communications, 12(1), 1618. https:\/\/doi.org\/10.1038\/s41467-021-21907-9","journal-title":"Nature Communications"},{"key":"2454_CR91","doi-asserted-by":"publisher","first-page":"1367734","DOI":"10.3389\/fimmu.2024.1367734","volume":"15","author":"L Xu","year":"2024","unstructured":"Xu, L., Lin, L., Xie, N., Chen, W., Nong, W., & Li, R. (2024). Role of aryl hydrocarbon receptors in infection and inflammation. Frontiers in Immunology, 15, 1367734. https:\/\/doi.org\/10.3389\/fimmu.2024.1367734","journal-title":"Frontiers in Immunology"},{"issue":"5","key":"2454_CR92","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1159\/000527535","volume":"184","author":"J Yuan","year":"2023","unstructured":"Yuan, J., Li, R., Song, H., & Liu, X. (2023). Sirtuin3 alleviated Influenza A Virus-induced mitochondrial oxidative stress and inflammation in lung epithelial cells via regulating Poly (ADP-Ribose) Polymerase 1 activity. International Archives of Allergy and Immunology, 184(5), 447\u2013459. https:\/\/doi.org\/10.1159\/000527535","journal-title":"International Archives of Allergy and Immunology"},{"issue":"1","key":"2454_CR93","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1038\/s41467-021-21903-z","volume":"12","author":"Y Zhang","year":"2021","unstructured":"Zhang, Y., Guo, R., Kim, S. H., Shah, H., Zhang, S., Liang, J. H., et al. (2021). SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication. Nature Communications, 12(1), 1676. https:\/\/doi.org\/10.1038\/s41467-021-21903-z","journal-title":"Nature Communications"},{"key":"2454_CR94","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.semcancer.2018.11.003","volume":"57","author":"S Zhu","year":"2019","unstructured":"Zhu, S., Dong, Z., Ke, X., Hou, J., Zhao, E., Zhang, K., et al. (2019). The roles of sirtuins family in cell metabolism during tumor development. Seminars in Cancer Biology, 57, 59\u201371. https:\/\/doi.org\/10.1016\/j.semcancer.2018.11.003","journal-title":"Seminars in Cancer Biology"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-026-02454-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-026-02454-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-026-02454-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:16:12Z","timestamp":1783484172000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-026-02454-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,2]]},"references-count":94,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["2454"],"URL":"https:\/\/doi.org\/10.1007\/s11306-026-02454-0","relation":{},"ISSN":["1573-3890"],"issn-type":[{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,2]]},"assertion":[{"value":"7 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors declare that ethical approval was not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"92"}}