{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:12:59Z","timestamp":1788462779295,"version":"build-2803163510"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MFE-194064"],"award-info":[{"award-number":["MFE-194064"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG070257"],"award-info":[{"award-number":["AG070257"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA273010"],"award-info":[{"award-number":["CA273010"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"DOI":"10.1007\/s11306-026-02512-7","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T07:06:53Z","timestamp":1786086413000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of serum NMR metabolomics in fibrotic diseases of the myocardium"],"prefix":"10.1007","volume":"22","author":[{"given":"Mark V.","family":"F\u00fczesi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella J.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajshree","family":"Ghosh Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Leist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Laura M.","family":"Hasubek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella H.","family":"Muti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Habbel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-5406","authenticated-orcid":false,"given":"Leo L.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"issue":"3","key":"2512_CR11","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1161\/HYPERTENSIONAHA.114.03697","volume":"64","author":"B Ambale Venkatesh","year":"2014","unstructured":"Ambale Venkatesh, B., Volpe, G.J., Donekal, S., Mewton, N., Liu, C.-Y., Shea, S., Liu, K., Burke, G., Wu, C., Bluemke, D.A. and Lima, J.A.C. (2014) Association of Longitudinal Changes in Left Ventricular Structure and Function With Myocardial Fibrosis: The Multi-Ethnic Study of Atherosclerosis Study. Hypertension 64, 508-515. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.114.03697","journal-title":"Hypertension"},{"key":"2512_CR4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/1471-2407-10-105","volume":"10","author":"V Askoxylakis","year":"2010","unstructured":"Askoxylakis, V., Thieke, C., Pleger, S. T., et al. (2010). Long-term survival of cancer patients compared to heart failure and stroke: A systematic review. Bmc Cancer, 10, 105.Askoxylakis, V., Thieke, C., Pleger, S.T., Most, P., Tanner, J., Lindel, K., Katus, H.A., Debus, J. and Bischof, M. (2010) Long-term survival of cancer patients compared to heart failure and stroke: a systematic review. BMC cancer 10, 105. https:\/\/doi.org\/10.1186\/1471-2407-10-105","journal-title":"Bmc Cancer"},{"issue":"1","key":"2512_CR5","doi-asserted-by":"publisher","first-page":"62","DOI":"10.5935\/abc.20160005","volume":"106","author":"PS Azevedo","year":"2016","unstructured":"Azevedo, P. S., Polegato, B. F., Minicucci, M. F., Paiva, S. A. R., & Zornoff, L. A. M. (2016). Cardiac remodeling: Concepts, clinical impact, pathophysiological mechanisms and pharmacologic treatment. Arquivos Brasileiros de Cardiologia, 106(1), 62\u201369. https:\/\/doi.org\/10.5935\/abc.20160005","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"2512_CR51","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.pharmthera.2018.08.015","volume":"194","author":"AL Birkenfeld","year":"2019","unstructured":"Birkenfeld, A. L., Jordan, J., Dworak, M., Merkel, T., & Burnstock, G. (2019). Myocardial metabolism in heart failure: Purinergic signalling and other metabolic concepts. Pharmacology & Therapeutics, 194, 132\u2013144. https:\/\/doi.org\/10.1016\/j.pharmthera.2018.08.015","journal-title":"Pharmacology & Therapeutics"},{"issue":"1","key":"2512_CR56","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0008-6363(99)00021-8","volume":"42","author":"J Bishop","year":"1999","unstructured":"Bishop, J. (1999). Regulation of cardiovascular collagen synthesis by mechanical load. Cardiovascular Research, 42(1), 27\u201344. https:\/\/doi.org\/10.1016\/S0008-6363(99)00021-8","journal-title":"Cardiovascular Research"},{"issue":"19","key":"2512_CR24","doi-asserted-by":"publisher","first-page":"e030478","DOI":"10.1161\/JAHA.123.030478","volume":"12","author":"C Bueno-Beti","year":"2023","unstructured":"Bueno-Beti, C., Lim, C. X., Protonotarios, A.,Szabo, P.L., Westaby, J., Mazic, M., Sheppard, M.N., Behr, E., Hamza, O., Kiss, A., Podesser, B.K., Hengstschl\u00e4ger, M., Weichhart, T. and Asimaki, A.et al. (2023). An mTORC1\u2010dependent mouse model for cardiac sarcoidosis. Journal of the American Heart Association, 12(19), e030478. https:\/\/doi.org\/10.1161\/JAHA.123.030478","journal-title":"Journal of the American Heart Association"},{"issue":"10","key":"2512_CR16","doi-asserted-by":"publisher","first-page":"e70131","DOI":"10.1002\/nbm.70131","volume":"38","author":"J Chen","year":"2025","unstructured":"Chen, J., Rao, A., Ghosh Biswas, R., Zhang, E.J., Zhou, J.X., Zhang, E., Kobus, Z., Kobus, M., Su, L., Christiani, D.C., Wishart, D.S. and Cheng, L.L.et al. (2025). Automatic identification of potential cellular metabolites for untargeted NMR metabolomics. NMR Biomedicine, 38(10), e70131. https:\/\/doi.org\/10.1002\/nbm.70131","journal-title":"NMR Biomedicine"},{"issue":"15","key":"2512_CR33","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/j.jacc.2015.02.018","volume":"65","author":"M-L Cheng","year":"2015","unstructured":"Cheng, M-L., Wang, C-H., Shiao, M-S., Liu, M.-H., Huang, Y.-Y., Huang, C.-Y., Mao, C.-T., Lin, J.-F., Ho, H.-Y. and Yang, N.-I. (2015). Metabolic disturbances identified in plasma are associated with outcomes in patients with heart failure: Diagnostic and prognostic value of metabolomics. Journal of the American College of Cardiology, 65(15), 1509\u20131520 https:\/\/doi.org\/10.1016\/j.jacc.2015.02.018","journal-title":"Journal of the American College of Cardiology"},{"issue":"21","key":"2512_CR54","doi-asserted-by":"publisher","first-page":"e009974","DOI":"10.1161\/jaha.118.009974","volume":"7","author":"TS Clemmensen","year":"2018","unstructured":"Clemmensen, T. S., Soerensen, J., Hansson, N. H.,Tolbod, L.P., Harms, H.J., Eiskj\u00e6r, H., Mikkelsen, F., Wiggers, H., Andersen, N.F. and Poulsen, S.H. (2018). Myocardial oxygen consumption and efficiency in patients with cardiac amyloidosis. Journal of the American Heart Association, 7(21), e009974. https:\/\/doi.org\/10.1161\/jaha.118.009974","journal-title":"Journal of the American Heart Association"},{"issue":"1","key":"2512_CR43","first-page":"10","volume":"33","author":"B Duchemann","year":"2016","unstructured":"Duchemann, B., Triba, M. N., Guez, D.,Rzeznik, M., Savarin, P., Nunes, H., Valeyre, D., Bernaudin, J.-F. and Le Moyec, L. (2016). Nuclear magnetic resonance spectroscopic analysis of salivary metabolome in sarcoidosis. Sarcoidosis Vasculitis and Diffuse Lung Diseases: Official Journal of WASOG, 33(1), 10\u201316.","journal-title":"Sarcoidosis Vasculitis and Diffuse Lung Diseases: Official Journal of WASOG"},{"issue":"7","key":"2512_CR35","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s11306-019-1559-5","volume":"15","author":"T Fatima","year":"2019","unstructured":"Fatima, T., Hashmi, S., Iqbal, A., Siddiqui, A.J., Sami, S.A., Basir, N., Bokhari, S.S., Sharif, H. and Musharraf, S.G.(2019). Untargeted metabolomic analysis of coronary artery disease patients with diastolic dysfunction show disturbed oxidative pathway. Metabolomics: Official Journal of the Metabolomic Society, 15(7), 98. https:\/\/doi.org\/10.1007\/s11306-019-1559-5","journal-title":"Metabolomics: Official Journal of the Metabolomic Society"},{"issue":"3","key":"2512_CR39","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1097\/00041433-199906000-00007","volume":"10","author":"JC Fruchart","year":"1999","unstructured":"Fruchart, J. C., Duriez, P., & Staels, B. (1999). Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Current Opinion in Lipidology, 10(3), 245\u2013257. https:\/\/doi.org\/10.1097\/00041433-199906000-00007","journal-title":"Current Opinion in Lipidology"},{"issue":"1","key":"2512_CR48","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12968-019-0519-6","volume":"21","author":"M Gastl","year":"2019","unstructured":"Gastl, M., Peereboom, S. M., Gotschy, A., Fuetterer, M., von Deuster, C., Boenner, F., Kelm, M., Schwotzer, R., Flammer, A.J., Manka, R. and Kozerke, S.(2019). Myocardial triglycerides in cardiac amyloidosis assessed by proton cardiovascular magnetic resonance spectroscopy. Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance, 21(1), 10 https:\/\/doi.org\/10.1186\/s12968-019-0519-6","journal-title":"Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance"},{"key":"2512_CR47","doi-asserted-by":"publisher","first-page":"14","DOI":"10.12703\/b\/9-14","volume":"9","author":"F Gianella","year":"2020","unstructured":"Gianella, F., Hsia, C. C., & Sakhaee, K. (2020). The role of vitamin D in sarcoidosis. Faculty Reviews, 9, 14. https:\/\/doi.org\/10.12703\/b\/9-14","journal-title":"Faculty Reviews"},{"issue":"5","key":"2512_CR49","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1080\/14789450.2021.1948330","volume":"18","author":"N Gupta","year":"2021","unstructured":"Gupta, N., Ramakrishnan, S., & Wajid, S. (2021). Emerging role of metabolomics in protein conformational disorders. Expert Review of Proteomics, 18(5), 395\u2013410. https:\/\/doi.org\/10.1080\/14789450.2021.1948330","journal-title":"Expert Review of Proteomics"},{"issue":"12","key":"2512_CR18","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.cardfail.2020.07.010","volume":"26","author":"C Hage","year":"2020","unstructured":"Hage, C., L\u00f6fgren, L., Michopoulos, F., Nilsson, R., Davidsson, P., Kumar, C., Ekstr\u00f6m, M., Eriksson, M.J., Lyng\u00e5, P., Persson, B., Wall\u00e9n, H., Gan, L.M., Persson, H. and Linde, C. (2020). Metabolomic profile in HFpEF vs HFrEF Patients. Journal of Cardiac Failure, 26(12), 1050\u20131059 https:\/\/doi.org\/10.1016\/j.cardfail.2020.07.010","journal-title":"Journal of Cardiac Failure"},{"issue":"3","key":"2512_CR3","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1161\/HHF.0b013e318291329a","volume":"6","author":"PA Heidenreich","year":"2013","unstructured":"Heidenreich, P. A., Albert, N. M., Allen, L. A.,Bluemke, D.A., Butler, J., Fonarow, G.C., Ikonomidis, J.S., Khavjou, O., Konstam, M.A., Maddox, T.M., Nichol, G., Pham, M., Pi\u00f1a, I.L., Trogdon, J.G. (2013). Forecasting the impact of heart failure in the United States: A policy statement from the American Heart Association. Circulation Heart Failure, 6(3), 606\u2013619 https:\/\/doi.org\/10.1161\/HHF.0b013e318291329a","journal-title":"Circulation Heart Failure"},{"issue":"19","key":"2512_CR14","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1056\/NEJMoa2102953","volume":"385","author":"LA Inker","year":"2021","unstructured":"Inker, L. A., Eneanya, N. D., Coresh, J., Tighiouart, H., Wang, D., Sang, Y., Crews, D.C., Doria, A., Estrella, M.M., Froissart, M., Grams, M.E., Greene, T., Grubb, A., Gudnason, V., Guti\u00e9rrez, O.M., Kalil, R., Karger, A.B., Mauer, M., Navis, G., Nelson, R.G., Poggio, E.D., Rodby, R., Rossing, P., Rule, A.D., Selvin, E., Seegmiller, J.C., Shlipak, M.G., Torres, V.E., Yang, W., Ballew, S.H., Couture, S.J., Powe, N.R., Levey, A.S. and Chronic Kidney Disease Epidemiology, C.(2021). New creatinine- and Cystatin C-based equations to estimate GFR without race. The New England Journal of Medicine, 385(19), 1737\u20131749. https:\/\/doi.org\/10.1056\/NEJMoa2102953","journal-title":"The New England Journal of Medicine"},{"issue":"10","key":"2512_CR46","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1055\/a-1240-5850","volume":"52","author":"R Isnuwardana","year":"2020","unstructured":"Isnuwardana, R., Bijukchhe, S., Thadanipon, K., Ingsathit, A., & Thakkinstian, A. (2020). Association between Vitamin D and uric acid in adults: A systematic review and meta-analysis. Hormone and Metabolic Research, 52(10), 732\u2013741. https:\/\/doi.org\/10.1055\/a-1240-5850","journal-title":"Hormone and Metabolic Research"},{"issue":"11","key":"2512_CR2","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1002\/ejhf.1594","volume":"21","author":"NR Jones","year":"2019","unstructured":"Jones, N. R., Roalfe, A. K., Adoki, I., Hobbs, F. D. R., & Taylor, C. J. (2019). Survival of patients with chronic heart failure in the community: A systematic review and meta-analysis. European Journal of Heart Failure, 21(11), 1306\u20131325. https:\/\/doi.org\/10.1002\/ejhf.1594","journal-title":"European Journal of Heart Failure"},{"issue":"5","key":"2512_CR10","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.jcmg.2019.06.030","volume":"13","author":"TD Karamitsos","year":"2020","unstructured":"Karamitsos, T. D., Arvanitaki, A., Karvounis, H., Neubauer, S., & Ferreira, V. M. (2020). Myocardial tissue characterization and fibrosis by imaging. JACC Cardiovascular Imaging, 13(5), 1221\u20131234. https:\/\/doi.org\/10.1016\/j.jcmg.2019.06.030","journal-title":"JACC Cardiovascular Imaging"},{"issue":"2","key":"2512_CR23","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1017\/s0954422423000197","volume":"37","author":"MS Kaspy","year":"2023","unstructured":"Kaspy, M. S., Hannaian, S. J., Bell, Z. W., & Churchward-Venne, T. A. (2023). The effects of branched-chain amino acids on muscle protein synthesis, muscle protein breakdown and associated molecular signalling responses in humans: an update. Nutrition Research Reviews, 37(2), 273\u2013286. https:\/\/doi.org\/10.1017\/s0954422423000197","journal-title":"Nutrition Research Reviews"},{"issue":"2","key":"2512_CR15","first-page":"92","volume":"50","author":"SY Kim","year":"2007","unstructured":"Kim, S. Y., Yim, H. J., Lee, J., Lee, B.J., Kim, D.I., Jung, S.W., Han, W.S., Lee, J.S., Koo, J.S., Seo, Y.S., Yeon, J.E., Lee, H.S., Lee, S.W., Um, S.H., Byun, K.S., Choi, J.H. and Ryu, H.S. (2007). [Comparison of CTP, MELD, and MELD-Na scores for predicting short term mortality in patients with liver cirrhosis]. The Korean Journal of Gastroenterology\u2009=\u2009Taehan Sohwagi Hakhoe Chi, 50(2), 92\u2013100.","journal-title":"The Korean Journal of Gastroenterology\u2009=\u2009Taehan Sohwagi Hakhoe Chi"},{"issue":"1","key":"2512_CR12","doi-asserted-by":"publisher","first-page":"e70186","DOI":"10.1002\/nbm.70186","volume":"39","author":"Z Kobus","year":"2026","unstructured":"Kobus, Z., Kobus, M., Zhang, E. J., Ghosh Biswas, R., Chen, J., Zhou, J.X., Rao, A., Hollmann, K.S., Habbel, P., Nowak, J., Su, L., Kaul, D.P., Arnold, S.E., Christiani, D.C. and Cheng, L.L. (2026). Metabolomic relationships between lung cancer and Alzheimer\u2019s disease using serum nuclear magnetic resonance spectroscopy. NMR Biomedicine, 39(1), e70186. https:\/\/doi.org\/10.1002\/nbm.70186","journal-title":"NMR Biomedicine"},{"issue":"11","key":"2512_CR32","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.jchf.2017.07.009","volume":"5","author":"DE Lanfear","year":"2017","unstructured":"Lanfear, D. E., Gibbs, J. J., Li, J.,She, R., Petucci, C., Culver, J.A., Tang, W.H.W., Pinto, Y.M., Williams, L.K., Sabbah, H.N. and Gardell, S.J. (2017). Targeted metabolomic profiling of plasma and survival in heart failure patients. JACC Heart Failure, 5(11), 823\u2013832. https:\/\/doi.org\/10.1016\/j.jchf.2017.07.009","journal-title":"JACC Heart Failure"},{"issue":"9","key":"2512_CR52","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1161\/circulationaha.121.054885","volume":"144","author":"Q Li","year":"2021","unstructured":"Li, Q., Li, C., Elnwasany, A.,Sharma, G., An, Y.A., Zhang, G., Elhelaly, W.M., Lin, J., Gong, Y., Chen, G., Wang, M., Zhao, S., Dai, C., Smart, C.D., Liu, J., Luo, X., Deng, Y., Tan, L., Lv, S.J., Davidson, S.M., Locasale, J.W., Lorenzi, P.L., Malloy, C.R., Gillette, T.G., Vander Heiden, M.G., Scherer, P.E., Szweda, L.I., Fu, G. and Wang, Z.V. (2021). PKM1 exerts critical roles in cardiac remodeling under pressure overload in the heart. Circulation, 144(9), 712\u2013727. https:\/\/doi.org\/10.1161\/circulationaha.121.054885","journal-title":"Circulation"},{"issue":"10","key":"2512_CR38","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.1038\/s41401-022-00885-8","volume":"43","author":"K Lin","year":"2022","unstructured":"Lin, K., Yang, N., Luo, W.,Qian, J.-F., Zhu, W.-W., Ye, S.-J., Yuan, C.-X., Xu, D.-Y., Liang, G., Huang, W.-J. and Shan, P.-R. (2022). Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1\/MAPK signaling. Acta Pharmacologica Sinica, 43(10), 2624\u20132635. https:\/\/doi.org\/10.1038\/s41401-022-00885-8","journal-title":"Acta Pharmacologica Sinica"},{"issue":"22","key":"2512_CR9","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1016\/j.jacc.2015.04.026","volume":"65","author":"B L\u00f3pez","year":"2015","unstructured":"L\u00f3pez, B., Gonz\u00e1lez, A., Ravassa, S.,Beaumont, J., Moreno, M.U., San Jos\u00e9, G., Querejeta, R. and D\u00edez, J. (2015). Circulating biomarkers of myocardial fibrosis. Journal of the American College of Cardiology, 65(22), 2449\u20132456. https:\/\/doi.org\/10.1016\/j.jacc.2015.04.026","journal-title":"Journal of the American College of Cardiology"},{"issue":"24","key":"2512_CR50","doi-asserted-by":"publisher","first-page":"16133","DOI":"10.3390\/ijms232416133","volume":"23","author":"M Luigetti","year":"2022","unstructured":"Luigetti, M., Guglielmino, V., Romano, A., Sciarrone, M.A., Vitali, F., Sabino, A., Gervasoni, J., Primiano, A., Santucci, L., Moroni, R. and Primiano, G. (2022). A metabolic signature of hereditary transthyretin amyloidosis: A pilot study. International Journal of Molecular Sciences, 23(24), 16133. https:\/\/doi.org\/10.3390\/ijms232416133","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"2512_CR6","doi-asserted-by":"publisher","first-page":"321","DOI":"10.31083\/j.rcm.2020.03.102","volume":"21","author":"E Markatis","year":"2020","unstructured":"Markatis, E., Afthinos, A., Antonakis, E., & Papanikolaou, I. C. (2020). Cardiac sarcoidosis: Diagnosis and management. Reviews in Cardiovascular Medicine, 21(3), 321\u2013338. https:\/\/doi.org\/10.31083\/j.rcm.2020.03.102","journal-title":"Reviews in Cardiovascular Medicine"},{"issue":"2","key":"2512_CR21","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41569-022-00760-3","volume":"20","author":"RW McGarrah","year":"2023","unstructured":"McGarrah, R. W., & White, P. J. (2023). Branched-chain amino acids in cardiovascular disease. Nature Reviews Cardiology, 20(2), 77\u201389. https:\/\/doi.org\/10.1038\/s41569-022-00760-3","journal-title":"Nature Reviews Cardiology"},{"issue":"1","key":"2512_CR44","first-page":"29","volume":"33","author":"M Mirsaeidi","year":"2016","unstructured":"Mirsaeidi, M., Banoei, M. M., Nienow, C. K.,Abassi, T., Hakim, A., Schraufnagel, D., Winston, B.W., Sweiss, N., Baughman, R., Garcia, J.G.N. and Machado, R. (2016). Plasma metabolomic profile in fibrosing pulmonary sarcoidosis. Sarcoidosis Vasculitis and Diffuse Lung Diseases: Official Journal of WASOG, 33(1), 29\u201338.","journal-title":"Sarcoidosis Vasculitis and Diffuse Lung Diseases: Official Journal of WASOG"},{"issue":"7","key":"2512_CR8","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1161\/CIRCRESAHA.117.310982","volume":"121","author":"E Muchtar","year":"2017","unstructured":"Muchtar, E., Blauwet, L. A., & Gertz, M. A. (2017). Restrictive cardiomyopathy: Genetics, pathogenesis, clinical manifestations, diagnosis, and therapy. Circulation Research, 121(7), 819\u2013837. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.310982","journal-title":"Circulation Research"},{"issue":"11","key":"2512_CR19","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1016\/j.cmet.2022.09.008","volume":"34","author":"D Murashige","year":"2022","unstructured":"Murashige, D., Jung, J. W., Neinast, M. D., Levin, M.G., Chu, Q., Lambert, J.P., Garbincius, J.F., Kim, B., Hoshino, A., Marti-Pamies, I., McDaid, K.S., Shewale, S.V., Flam, E., Yang, S., Roberts, E., Li, L., Morley, M.P., Bedi, K.C., Jr., Hyman, M.C., Frankel, D.S., Margulies, K.B., Assoian, R.K., Elrod, J.W., Jang, C., Rabinowitz, J.D. and Arany, Z. (2022). Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure. Cell Metabolism, 34(11), 1749\u20131764e1747. https:\/\/doi.org\/10.1016\/j.cmet.2022.09.008","journal-title":"Cell Metabolism"},{"issue":"4","key":"2512_CR22","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1080\/14737159.2022.2065196","volume":"22","author":"GM Nava","year":"2022","unstructured":"Nava, G. M., & Madrigal Perez, L. A. (2022). Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer. Expert Review of Molecular Diagnostics, 22(4), 439\u2013447. https:\/\/doi.org\/10.1080\/14737159.2022.2065196","journal-title":"Expert Review of Molecular Diagnostics"},{"key":"2512_CR17","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.pharmthera.2017.08.001","volume":"182","author":"H Noordali","year":"2018","unstructured":"Noordali, H., Loudon, B. L., Frenneaux, M. P., & Madhani, M. (2018). Cardiac metabolism - A promising therapeutic target for heart failure. Pharmacology & Therapeutics, 182, 95\u2013114. https:\/\/doi.org\/10.1016\/j.pharmthera.2017.08.001","journal-title":"Pharmacology & Therapeutics"},{"issue":"Suppl 48","key":"2512_CR37","doi-asserted-by":"publisher","first-page":"284S","DOI":"10.1042\/CS103S284S","volume":"103","author":"T Ogata","year":"2002","unstructured":"Ogata, T., Miyauchi, T., Sakai, S., Irukayama-Tomobe, Y., Goto, K., & Yamaguchi, I. (2002). Stimulation of peroxisome-proliferator-activated receptor alpha (PPAR alpha) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts. Clinical Science (London England: 1979), 103(Suppl 48), 284S\u2013288S. https:\/\/doi.org\/10.1042\/CS103S284S","journal-title":"Clinical Science (London England: 1979)"},{"issue":"1","key":"2512_CR41","doi-asserted-by":"publisher","first-page":"e002314","DOI":"10.1161\/CIRCHEARTFAILURE.115.002314","volume":"9","author":"CL Organ","year":"2016","unstructured":"Organ, C. L., Otsuka, H., Bhushan, S., Wang, Z., Bradley, J., Trivedi, R., Polhemus, D.J., Tang, W.H.W., Wu, Y., Hazen, S.L. and Lefer, D.J. (2016). Choline diet and its gut microbe-derived metabolite, trimethylamine N-oxide, exacerbate pressure overload-induced heart failure. Circulation Heart Failure, 9(1), e002314. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.115.002314","journal-title":"Circulation Heart Failure"},{"issue":"1","key":"2512_CR53","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00109-009-0524-6","volume":"88","author":"L Piao","year":"2010","unstructured":"Piao, L., Fang, Y. H., Cadete, V. J., Wietholt, C., Urboniene, D., Toth, P.T., Marsboom, G., Zhang, H.J., Haber, I., Rehman, J., Lopaschuk, G.D. and Archer, S.L. (2010). The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: Resuscitating the hibernating right ventricle. Journal of Molecular Medicine (Berlin), 88(1), 47\u201360. https:\/\/doi.org\/10.1007\/s00109-009-0524-6","journal-title":"Journal of Molecular Medicine (Berlin)"},{"issue":"17","key":"2512_CR1","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","volume":"118","author":"G Savarese","year":"2022","unstructured":"Savarese, G., Becher, P. M., Lund, L. H., Seferovic, P., Rosano, G. M. C., & Coats, A. (2022). Global burden of heart failure: A comprehensive and updated review of epidemiology. Cardiovascular Research, 118(17), 3272\u20133287. https:\/\/doi.org\/10.1093\/cvr\/cvac013","journal-title":"Cardiovascular Research"},{"issue":"2","key":"2512_CR7","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.hfc.2018.12.009","volume":"15","author":"EB Schelbert","year":"2019","unstructured":"Schelbert, E. B. (2019). Myocardial scar and fibrosis: The ultimate mediator of outcomes? Heart Failure Clinics, 15(2), 179\u2013189. https:\/\/doi.org\/10.1016\/j.hfc.2018.12.009","journal-title":"Heart Failure Clinics"},{"key":"2512_CR13","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1073\/pnas.2110633118","volume":"118","author":"TA Schult","year":"2021","unstructured":"Schult, T. A., Lauer, M. J., Berker, Y.,Cardoso, M.R., Vandergrift, L.A., Habbel, P., Nowak, J., Taupitz, M., Aryee, M., Mino-Kenudson, M.A., Christiani, D.C. and Cheng, L.L. (2021). Screening human lung cancer with predictive models of serum magnetic resonance spectroscopy metabolomics. Proc Natl Acad Sci U S A, 118, 51. https:\/\/doi.org\/10.1073\/pnas.2110633118","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"2512_CR25","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1161\/circulationaha.115.020226","volume":"133","author":"H Sun","year":"2016","unstructured":"Sun, H., Olson, K. C., Gao, C., Prosdocimo, D.A., Zhou, M., Wang, Z., Jeyaraj, D., Youn, J.Y., Ren, S., Liu, Y., Rau, C.D., Shah, S., Ilkayeva, O., Gui, W.J., William, N.S., Wynn, R.M., Newgard, C.B., Cai, H., Xiao, X., Chuang, D.T., Schulze, P.C., Lynch, C., Jain, M.K. and Wang, Y.(2016). Catabolic defect of branched-chain amino acids promotes heart failure. Circulation, 133(21), 2038\u20132049. https:\/\/doi.org\/10.1161\/circulationaha.115.020226","journal-title":"Circulation"},{"key":"2512_CR34","doi-asserted-by":"publisher","first-page":"3784589","DOI":"10.1155\/2018\/3784589","volume":"2018","author":"C-H Wang","year":"2018","unstructured":"Wang, C-H., Cheng, M-L., & Liu, M-H. (2018). Amino acid-based metabolic panel provides robust prognostic value additive to B-natriuretic peptide and traditional risk factors in heart failure. Disease Markers, 2018, 3784589. https:\/\/doi.org\/10.1155\/2018\/3784589","journal-title":"Disease Markers"},{"issue":"29","key":"2512_CR36","doi-asserted-by":"publisher","first-page":"22293","DOI":"10.1074\/jbc.M000248200","volume":"275","author":"K Watanabe","year":"2000","unstructured":"Watanabe, K., Fujii, H., Takahashi, T., Kodama, M., Aizawa, Y., Ohta, Y., Ono, T., Hasegawa, G., Naito, M., Nakajima, T., Kamijo, Y., Gonzalez, F.J. and Aoyama, T.(2000). Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity. The Journal of Biological Chemistry, 275(29), 22293\u201322299. https:\/\/doi.org\/10.1074\/jbc.M000248200","journal-title":"The Journal of Biological Chemistry"},{"issue":"4","key":"2512_CR55","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1097\/00001573-200007000-00010","volume":"15","author":"KT Weber","year":"2000","unstructured":"Weber, K. T. (2000). Fibrosis and hypertensive heart disease. Current Opinion in Cardiology, 15(4), 264\u2013272. https:\/\/doi.org\/10.1097\/00001573-200007000-00010","journal-title":"Current Opinion in Cardiology"},{"key":"2512_CR40","doi-asserted-by":"publisher","first-page":"175355","DOI":"10.1016\/j.ejphar.2022.175355","volume":"940","author":"H Xu","year":"2023","unstructured":"Xu, H., Yang, F., & Bao, Z. (2023). Gut microbiota and myocardial fibrosis. European Journal of Pharmacology, 940, 175355. https:\/\/doi.org\/10.1016\/j.ejphar.2022.175355","journal-title":"European Journal of Pharmacology"},{"key":"2512_CR42","doi-asserted-by":"publisher","first-page":"8937427","DOI":"10.1155\/2019\/8937427","volume":"2019","author":"T Yang","year":"2019","unstructured":"Yang, T., Qu, H., Song, X.,Liu, Q., Yang, X., Xu, J., Yang, T., Lan, Z., Sha, W. and Zhou, H. (2019). Luhong granules prevent ventricular remodelling after myocardial infarction by reducing the metabolites TMAO and LPS of the intestinal flora. Evidence-Based Complementary and Alternative Medicine: eCAM, 2019, 8937427. https:\/\/doi.org\/10.1155\/2019\/8937427","journal-title":"Evidence-Based Complementary and Alternative Medicine: eCAM"},{"issue":"1","key":"2512_CR45","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1186\/s12890-025-03863-y","volume":"25","author":"D Zhu","year":"2025","unstructured":"Zhu, D., Chen, J., Zhang, L., Li, H., Wang, J., Song, J., Weng, D., Zhang, P., Li, Q., Zhang, Y. and Zhao, M. (2025). Serum metabolomics in pulmonary sarcoidosis: Metabolic signatures across prognoses. BMC Pulmonary Medicine, 25(1), 373. https:\/\/doi.org\/10.1186\/s12890-025-03863-y","journal-title":"BMC Pulmonary Medicine"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-026-02512-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-026-02512-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-026-02512-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:20:50Z","timestamp":1788459650000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-026-02512-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":49,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["2512"],"URL":"https:\/\/doi.org\/10.1007\/s11306-026-02512-7","relation":{},"ISSN":["1573-3890"],"issn-type":[{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"assertion":[{"value":"4 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors report no competing or financial interests. The authors have no relevant financial or non-financial interests to disclose.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Massachusetts General Brigham (MGB, Boston, Massachusetts) Institutional Review Board. All experiments were performed in accordance with the National Institutes of Health guidelines and regulations. At the time of patient sample collection, informed consent was obtained.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"137"}}