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Under salt stress (SS), 201 DAMs (89 upregulated and 112 downregulated) were detected in JN relative to JU. Notably, metabolites such as allantoin, glycitin, nicotinamide ribotide, D-arabinono-1,4-lactone, violanthin, L-methionine S-oxide, ribitol, lysine, rutin, glutamine, pantothenic acid, and quinic acid, showed significant differential accumulation. Pathway enrichment analysis revealed significant enrichment of arginine biosynthesis, purine metabolism, and alanine, aspartate, and glutamate metabolism, indicating extensive reprogramming of nitrogen and energy-associated metabolic pathways under salinity stress. Integration of transcriptomic and metabolomic datasets from the SS experiments further identified ten differentially expressed genes (DEGs) associated with the metabolite network in the JN vs. JU comparison. Among these,\n                      <jats:italic>OsDHQDT\/SDH<\/jats:italic>\n                      ,\n                      <jats:italic>OsFd-GOGAT<\/jats:italic>\n                      ,\n                      <jats:italic>phenylalanyl-tRNA synthetase<\/jats:italic>\n                      ,\n                      <jats:italic>OsP5CS1<\/jats:italic>\n                      ,\n                      <jats:italic>OsP5CS2<\/jats:italic>\n                      , and a\n                      <jats:italic>pyridoxal phosphate-dependent transferase<\/jats:italic>\n                      were linked to metabolites involved in shikimate, amino acid, and proline metabolism.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11306-026-02525-2","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:12:26Z","timestamp":1788775946000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative metabolomic profiling reveals salinity tolerance mechanisms in a rice introgression line"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2041-6391","authenticated-orcid":false,"given":"Chander Kant","family":"Chaudhary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Guttula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirti","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0512-9076","authenticated-orcid":false,"given":"Prasanta Kumar","family":"Subudhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6243-6780","authenticated-orcid":false,"given":"Manas Ranjan","family":"Gartia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"2525_CR1","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1271\/bbb1961.49.1689","volume":"49","author":"T Akatsuka","year":"1985","unstructured":"Akatsuka, T., Kodama, O., Sekido, H., Kono, Y., & Takeuchi, S. 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