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Overlapping datasets included 89 (urine) and 58 (stool) infants. Current asthma at age 6 was assessed by validated questionnaires. Nested sparse partial least squares discriminant analysis prioritized metabolites and amplicon sequence variants (ASVs) feature selection, followed by Spearman rank correlations to evaluate metabolite-microbiome associations with Bonferroni correction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Several significant correlations were identified in associations between the stool microbiome and metabolites, primarily involving lipid-related metabolites and microbiome taxa such as\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      sp. (unclassified)\n                      <jats:italic>,<\/jats:italic>\n                      <jats:italic>Enterobacteriaceae<\/jats:italic>\n                      sp. (unclassified)\n                      <jats:italic>,<\/jats:italic>\n                      <jats:italic>Veillonella<\/jats:italic>\n                      sp. (unclassified)\n                      <jats:italic>,<\/jats:italic>\n                      <jats:italic>Thomasclavelia ramosa<\/jats:italic>\n                      <jats:italic>,<\/jats:italic>\n                      <jats:italic>Bacteroides<\/jats:italic>\n                      sp.(unclassified), and\n                      <jats:italic>Clostridium innocuum<\/jats:italic>\n                      group. The correlations between stool microbiome and urine metabolites were weak. Many associated metabolites are likely diet-derived, with microbiome co-metabolising.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Exploratory microbiome-metabolite correlations suggest diet-related metabolites may link the infant gut environment to later asthma risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11306-026-02540-3","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:58:37Z","timestamp":1790513917000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploratory integrative analysis of infant gut microbiome and metabolome suggests diet- and microbiome-derived metabolites associated with childhood asthma"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3853-9357","authenticated-orcid":false,"given":"Kedir N.","family":"Turi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiliu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Rosas-Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tebeb","family":"Gebretsadik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan H.","family":"Shilts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman R.","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Gern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaomin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina V.","family":"Hartert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"2540_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072021","author":"M Aguilar-Ballester","year":"2020","unstructured":"Aguilar-Ballester, M., Herrero-Cervera, A., Vinu\u00e9, \u00c1., Mart\u00ednez-Herv\u00e1s, S., & Gonz\u00e1lez-Navarro, H. 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