{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:21:05Z","timestamp":1792783265257,"version":"4.5.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Burke Judd Endowment","id":[{"id":"https:\/\/ror.org\/0229evh14","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100026241","name":"American Academy of Underwater Sciences Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100026241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016024","name":"International Coral Reef Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stengl Wyer Foundation","award":["SWG-22-01"],"award-info":[{"award-number":["SWG-22-01"]}]},{"name":"National Science Foundation","award":["OCE-1737312"],"award-info":[{"award-number":["OCE-1737312"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"DOI":"10.1007\/s11306-026-02545-y","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:34:29Z","timestamp":1791668069000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Environmental drivers of metabolomic profiles within and between cryptic lineages of Montastraea cavernosa, the great star coral"],"prefix":"10.1007","volume":"22","author":[{"given":"Dominique N.","family":"Gallery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn A.","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa K.","family":"Huzar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim D.","family":"Primov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille P.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payton L.","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Sedio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail V.","family":"Matz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"2545_CR1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nclimate1191","volume":"1","author":"M B\u00e1lint","year":"2011","unstructured":"B\u00e1lint, M., Domisch, S., Engelhardt, C. H. M., Haase, P., Lehrian, S., Sauer, J., et al. (2011). Cryptic biodiversity loss linked to global climate change. Nat Clim Change, 1, 313\u2013318.","journal-title":"Nat Clim Change"},{"key":"2545_CR2","doi-asserted-by":"publisher","first-page":"e17634","DOI":"10.1111\/mec.17634","volume":"34","author":"KL Black","year":"2025","unstructured":"Black, K. L., Bay, L. K., & Matz, M. V. (2025a). A Genetic Variant of Delta-9 Desaturase Is Associated With Latitudinal Adaptation in a Coral from the Great Barrier Reef. Molecular Ecology, 34, e17634.","journal-title":"Molecular Ecology"},{"key":"2545_CR3","doi-asserted-by":"publisher","first-page":"e70126","DOI":"10.1111\/eva.70126","volume":"18","author":"KL Black","year":"2025","unstructured":"Black, K. L., Rippe, J. P., & Matz, M. V. (2025b). Environmental Drivers of Genetic Divergence in Two Corals From the Florida Keys. Evolutionary Applications, 18, e70126.","journal-title":"Evolutionary Applications"},{"key":"2545_CR4","doi-asserted-by":"publisher","first-page":"e0318653","DOI":"10.1371\/journal.pone.0318653","volume":"20","author":"GN Cabacungan","year":"2025","unstructured":"Cabacungan, G. N., Kankanamalage, T. N. W., Azam, A. F., Collins, M. R., Arratia, A. R., Gutting, A. N., et al. (2025). Cryptic coral community composition across environmental gradients. PLOS ONE, 20, e0318653.","journal-title":"PLOS ONE"},{"key":"2545_CR5","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1126\/science.1159196","volume":"321","author":"KE Carpenter","year":"2008","unstructured":"Carpenter, K. E., Abrar, M., Aeby, G., Aronson, R. B., Banks, S., Bruckner, A., et al. (2008). One-Third of Reef-Building Corals Face Elevated Extinction Risk from Climate Change and Local Impacts. Science, 321, 560\u2013563.","journal-title":"Science"},{"key":"2545_CR6","doi-asserted-by":"publisher","first-page":"7859","DOI":"10.1038\/s41598-024-57319-0","volume":"14","author":"KD Castillo","year":"2024","unstructured":"Castillo, K. D., Bove, C. B., Hughes, A. M., Powell, M. E., Ries, J. B., & Davies, S. W. (2024). Gene expression plasticity facilitates acclimatization of a long-lived Caribbean coral across divergent reef environments. Scientific Reports, 14, 7859.","journal-title":"Scientific Reports"},{"key":"2545_CR7","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3354\/meps14712","volume":"748","author":"CS Clements","year":"2024","unstructured":"Clements, C. S., Ladd, M. C., Gallagher, J. P., & Hay, M. E. (2024). Coral performance is comparable when transplanted to disparate reef sites despite divergent histories of reef decline and recovery. Marine Ecology Progress Series, 748, 53\u201367.","journal-title":"Marine Ecology Progress Series"},{"key":"2545_CR8","doi-asserted-by":"publisher","first-page":"giab008","DOI":"10.1093\/gigascience\/giab008","volume":"10","author":"P Danecek","year":"2021","unstructured":"Danecek, P., Bonfield, J. K., Liddle, J., Marshall, J., Ohan, V., Pollard, M. O., et al. (2021). Twelve years of SAMtools and BCFtools. GigaScience, 10, giab008.","journal-title":"GigaScience"},{"key":"2545_CR9","doi-asserted-by":"publisher","first-page":"e0174000","DOI":"10.1371\/journal.pone.0174000","volume":"12","author":"C Drury","year":"2017","unstructured":"Drury, C., Manzello, D., & Lirman, D. (2017). Genotype and local environment dynamically influence growth, disturbance response and survivorship in the threatened coral, Acropora cervicornis. PLOS ONE, 12, e0174000.","journal-title":"PLOS ONE"},{"key":"2545_CR10","doi-asserted-by":"publisher","first-page":"12580","DOI":"10.1073\/pnas.1509788112","volume":"112","author":"K D\u00fchrkop","year":"2015","unstructured":"D\u00fchrkop, K., Shen, H., Meusel, M., Rousu, J., & B\u00f6cker, S. (2015). Searching molecular structure databases with tandem mass spectra using CSI:FingerID. Proceedings Of National Academy Of Sciences, 112, 12580\u201312585.","journal-title":"Proceedings Of National Academy Of Sciences"},{"key":"2545_CR11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s41592-019-0344-8","volume":"16","author":"K D\u00fchrkop","year":"2019","unstructured":"D\u00fchrkop, K., Fleischauer, M., Ludwig, M., Aksenov, A. A., Melnik, A. V., Meusel, M., et al. (2019). SIRIUS 4: a rapid tool for turning tandem mass spectra into metabolite structure information. Nature Methods, 16, 299\u2013302.","journal-title":"Nature Methods"},{"key":"2545_CR12","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/s41587-020-0740-8","volume":"39","author":"K D\u00fchrkop","year":"2021","unstructured":"D\u00fchrkop, K., Nothias, L. F., Fleischauer, M., Reher, R., Ludwig, M., Hoffmann, M. A., et al. (2021). Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra. Nature Biotechnology, 39, 462\u2013471.","journal-title":"Nature Biotechnology"},{"key":"2545_CR13","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1021\/acs.jproteome.7b00929","volume":"17","author":"MA Farag","year":"2018","unstructured":"Farag, M. A., Meyer, A., Ali, S. E., Salem, M. A., Giavalisco, P., Westphal, H., et al. (2018). Comparative Metabolomics Approach Detects Stress-Specific Responses during Coral Bleaching in Soft Corals. Journal Of Proteome Research, 17, 2060\u20132071.","journal-title":"Journal Of Proteome Research"},{"key":"2545_CR14","doi-asserted-by":"crossref","unstructured":"Frys, C., Saint-Amand, A., H\u00e9naff, L., Figueiredo, M., Kuba, J., Walker, A. (2020). B.,. Fine-Scale Coral Connectivity Pathways in the Florida Reef Tract: Implications for Conservation and Restoration. Front Mar Sci, 7.","DOI":"10.3389\/fmars.2020.00312"},{"key":"2545_CR15","doi-asserted-by":"crossref","unstructured":"Gallery, D. N., Rippe, J. P., & Matz, M. V. (2024). Decrypting Corals: Does Regulatory Evolution Underlie Environmental Specialisation of Coral Cryptic Lineages? Mol Ecol, e17546.","DOI":"10.1101\/2023.10.11.561896"},{"key":"2545_CR16","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1439-0485.2011.00452.x","volume":"33","author":"G Goodbody-Gringley","year":"2012","unstructured":"Goodbody-Gringley, G., Woollacott, R. M., & Giribet, G. (2012). Population structure and connectivity in the Atlantic scleractinian coral Montastraea cavernosa (Linnaeus, 1767). Marine Ecology, 33, 32\u201348.","journal-title":"Marine Ecology"},{"key":"2545_CR17","doi-asserted-by":"crossref","unstructured":"Grupstra, C. G. B., G\u00f3mez-Corrales, M., Fifer, J. E., Aichelman, H. E., Meyer-Kaiser, K. S., Prada, C. (2024). Integrating cryptic diversity into coral evolution, symbiosis and conservation. Nat Ecol Evol, 1\u201315.","DOI":"10.1038\/s41559-023-02319-y"},{"key":"2545_CR18","doi-asserted-by":"publisher","first-page":"4814","DOI":"10.1111\/mec.17072","volume":"32","author":"S Hackerott","year":"2023","unstructured":"Hackerott, S., Virdis, F., Flood, P. J., Souto, D. G., Paez, W., & Eirin-Lopez, J. M. (2023). Relationships between phenotypic plasticity and epigenetic variation in two Caribbean Acropora corals. Molecular Ecology, 32, 4814\u20134828.","journal-title":"Molecular Ecology"},{"key":"2545_CR19","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1086\/714821","volume":"241","author":"CG Hays","year":"2021","unstructured":"Hays, C. G., Hanley, T. C., Hughes, A. R., Truskey, S. B., Zerebecki, R. A., & Sotka, E. E. (2021). Local adaptation in marine foundation species at microgeographic scales. Biological Bulletin, 241, 16\u201329.","journal-title":"Biological Bulletin"},{"issue":"6","key":"2545_CR20","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/aec.12019","volume":"38","author":"OAH Jones","year":"2013","unstructured":"Jones, O. A. H., Maguire, M. L., Griffin, J. L., Dias, D. A., Spurgeon, D. J., & Svendsen, C. (2013). Metabolomics and its use in ecology. Austral Ecology, 38(6), 713\u2013720. https:\/\/doi.org\/10.1111\/aec.12019","journal-title":"Austral Ecology"},{"key":"2545_CR21","doi-asserted-by":"crossref","unstructured":"Kellogg, C., Carvalho, R. C., & Lemay, M. (2024). DNA Extraction from 0.22\u00b5m Sterivex Filters\u2014Qiagen Blood and Tissue Kit. https:\/\/www.protocols.io\/view\/dna-extraction-from-0-22-m-sterivex-filters-qiagen-bp2l6221kgqe\/v1","DOI":"10.17504\/protocols.io.bp2l6221kgqe\/v1"},{"key":"2545_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41559-016-0014","volume":"1","author":"CD Kenkel","year":"2016","unstructured":"Kenkel, C. D., & Matz, M. V. (2016). Gene expression plasticity as a mechanism of coral adaptation to a variable environment. Nat Ecol Evol, 1, 1\u20136.","journal-title":"Nat Ecol Evol"},{"key":"2545_CR23","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/hdy.2015.52","volume":"115","author":"CD Kenkel","year":"2015","unstructured":"Kenkel, C. D., Setta, S. P., & Matz, M. V. (2015). Heritable differences in fitness-related traits among populations of the mustard hill coral. Porites astreoides Heredity, 115, 509\u2013516.","journal-title":"Porites astreoides Heredity"},{"key":"2545_CR24","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1021\/acs.jnatprod.1c00399","volume":"84","author":"HW Kim","year":"2021","unstructured":"Kim, H. W., Wang, M., Leber, C. A., Nothias, L. F., Reher, R., Kang, K. B., et al. (2021). NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products. Journal Of Natural Products, 84, 2795\u20132807.","journal-title":"Journal Of Natural Products"},{"key":"2545_CR25","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1146\/annurev.es.24.110193.001201","volume":"24","author":"N Knowlton","year":"1993","unstructured":"Knowlton, N. (1993). Sibling Species in the Sea. Annual Review Of Ecology And Systematics, 24, 189\u2013216.","journal-title":"Annual Review Of Ecology And Systematics"},{"key":"2545_CR26","unstructured":"Kolde, R. (2019). pheatmap: Pretty Heatmaps."},{"key":"2545_CR27","doi-asserted-by":"crossref","unstructured":"Korneliussen, T. S., Albrechtsen, A., & Nielsen, R. (2014). ANGSD: Analysis of Next Generation Sequencing Data. BMC Bioinformatics, 15.","DOI":"10.1186\/s12859-014-0356-4"},{"key":"2545_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v082.i13","volume":"82","author":"A Kuznetsova","year":"2017","unstructured":"Kuznetsova, A., Brockhoff, P. B., & Christensen, R. H. B. (2017). lmerTest Package: Tests in Linear Mixed Effects Models. Journal Of Statistical Software, 82, 1\u201326.","journal-title":"Journal Of Statistical Software"},{"key":"2545_CR29","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead, B., & Salzberg, S. L. (2012). Fast gapped-read alignment with Bowtie 2. Nature Methods, 9, 357\u2013359.","journal-title":"Nature Methods"},{"key":"2545_CR30","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jembe.2004.01.019","volume":"308","author":"BE Lapointe","year":"2004","unstructured":"Lapointe, B. E., Barile, P. J., & Matzie, W. R. (2004). Anthropogenic nutrient enrichment of seagrass and coral reef communities in the Lower Florida Keys: discrimination of local versus regional nitrogen sources. Journal Of Experimental Marine Biology And Ecology, 308, 23\u201358.","journal-title":"Journal Of Experimental Marine Biology And Ecology"},{"key":"2545_CR31","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1093\/plcell\/koac267","volume":"35","author":"JR Lasky","year":"2023","unstructured":"Lasky, J. R., Josephs, E. B., & Morris, G. P. (2023). Genotype\u2013environment associations to reveal the molecular basis of environmental adaptation. The Plant Cell, 35, 125\u2013138.","journal-title":"The Plant Cell"},{"key":"2545_CR32","first-page":"35","volume":"64","author":"TN Lee","year":"1999","unstructured":"Lee, T. N., & Williams, E. (1999). Mean distribution and seasonal variability of coastal currents and temperature in the Florida Keys with implications for larval recruitment. Bulletin Of Marine Science, 64, 35\u201356.","journal-title":"Bulletin Of Marine Science"},{"key":"2545_CR33","unstructured":"Lenth, R. V. (2024). emmeans: Estimated Marginal Means, aka Least-Squares Means."},{"key":"2545_CR34","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., et al. (2009). The Sequence Alignment\/Map format and SAMtools. Bioinforma Oxf Engl, 25, 2078\u20132079.","journal-title":"Bioinforma Oxf Engl"},{"issue":"9","key":"2545_CR35","doi-asserted-by":"publisher","first-page":"20140615","DOI":"10.1098\/rsbl.2014.0615","volume":"10","author":"M Liebeke","year":"2014","unstructured":"Liebeke, M., Bruford, M. W., Donnelly, R. K., Ebbels, T. M. D., Hao, J., Kille, P., Lahive, E., Madison, R. M., Morgan, A. J., Pinto-Juma, G. A., Spurgeon, D. J., Svendsen, C., & Bundy, J. G. (2014). Identifying biochemical phenotypic differences between cryptic species. Biology Letters, 10(9), 20140615. https:\/\/doi.org\/10.1098\/rsbl.2014.0615","journal-title":"Biology Letters"},{"issue":"1","key":"2545_CR36","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s00248-022-02094-6","volume":"86","author":"LFO Lima","year":"2023","unstructured":"Lima, L. F. O., Alker, A. T., Papudeshi, B., Morris, M. M., Edwards, R. A., de Putron, S. J., & Dinsdale, E. A. (2023). Coral and Seawater Metagenomes Reveal Key Microbial Functions to Coral Health and Ecosystem Functioning Shaped at Reef Scale. Microbial Ecology, 86(1), 392\u2013407. https:\/\/doi.org\/10.1007\/s00248-022-02094-6","journal-title":"Microbial Ecology"},{"key":"2545_CR37","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.marpolbul.2006.12.014","volume":"54","author":"D Lirman","year":"2007","unstructured":"Lirman, D., & Fong, P. (2007). Is proximity to land-based sources of coral stressors an appropriate measure of risk to coral reefs? An example from the Florida Reef Tract. Marine Pollution Bulletin, 54, 779\u2013791.","journal-title":"Marine Pollution Bulletin"},{"key":"2545_CR38","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1080\/17451000.2018.1528011","volume":"14","author":"LD Lizcano-Sandoval","year":"2018","unstructured":"Lizcano-Sandoval, L. D., Londo\u00f1o-Cruz, E., & Zapata, F. A. (2018). Growth and survival of Pocillopora damicornis (Scleractinia: Pocilloporidae) coral fragments and their potential for coral reef restoration in the Tropical Eastern Pacific. Marine Biology Research, 14, 887\u2013897.","journal-title":"Marine Biology Research"},{"key":"2545_CR39","doi-asserted-by":"publisher","first-page":"6067","DOI":"10.1038\/s41598-019-42434-0","volume":"9","author":"KE Lohr","year":"2019","unstructured":"Lohr, K. E., Khattri, R. B., Guingab-Cagmat, J., Camp, E. F., Merritt, M. E., Garrett, T. J., et al. (2019). Metabolomic profiles differ among unique genotypes of a threatened Caribbean coral. Scientific Reports, 9, 6067.","journal-title":"Scientific Reports"},{"key":"2545_CR40","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W., & Anders, S. (2014). Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology, 15, 550.","journal-title":"Genome Biology"},{"key":"2545_CR41","doi-asserted-by":"crossref","unstructured":"Marhoefer, S. R., Zenger, K. R., Strugnell, J. M., Logan, M., van Oppen, M. J. H., Kenkel, C. D. (2021). Signatures of Adaptation and Acclimatization to Reef Flat and Slope Habitats in the Coral Pocillopora damicornis. Front Mar Sci, 8.","DOI":"10.3389\/fmars.2021.704709"},{"key":"2545_CR42","doi-asserted-by":"publisher","unstructured":"Martin, M. (2011). Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet.Journal, 17(1), Article 1.https:\/\/doi.org\/10.14806\/ej.17.1.200","DOI":"10.14806\/ej.17.1.200"},{"key":"2545_CR43","doi-asserted-by":"publisher","first-page":"e2203925119","DOI":"10.1073\/pnas.2203925119","volume":"119","author":"WC Million","year":"2022","unstructured":"Million, W. C., Ruggeri, M., O\u2019Donnell, S., Bartels, E., Conn, T., Krediet, C. J., et al. (2022). Evidence for adaptive morphological plasticity in the Caribbean coral, Acropora cervicornis. Proceedings Of National Academy Of Sciences, 119, e2203925119.","journal-title":"Proceedings Of National Academy Of Sciences"},{"key":"2545_CR44","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/s41592-020-0933-6","volume":"17","author":"LF Nothias","year":"2020","unstructured":"Nothias, L. F., Petras, D., Schmid, R., D\u00fchrkop, K., Rainer, J., Sarvepalli, A., et al. (2020). Feature-based molecular networking in the GNPS analysis environment. Nature Methods, 17, 905\u2013908.","journal-title":"Nature Methods"},{"key":"2545_CR45","unstructured":"Oksanen, J., Simpson, G. L., Blanchet, F. G., Kindt, R., Legendre, P., Minchin, P. R. (2022). vegan: Community Ecology Package."},{"key":"2545_CR46","unstructured":"Ondarra, S., & Milagrosa, A. (2020). Local adaptation to serpentine soils. a review of adaptive traits and underlying genetic bases."},{"key":"2545_CR47","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1006\/pmed.1996.0117","volume":"25","author":"R Ottman","year":"1996","unstructured":"Ottman, R. (1996). Gene\u2013Environment Interaction: Definitions and Study Design. Preventive Medicine, 25, 764\u2013770.","journal-title":"Preventive Medicine"},{"key":"2545_CR48","unstructured":"R Core Team. (2023). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing."},{"key":"2545_CR49","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.aquabot.2012.03.017","volume":"102","author":"J Riedl","year":"2012","unstructured":"Riedl, J., Kluender, C., Sans-Pich\u00e9, F., Heilmeier, H., Altenburger, R., & Schmitt-Jansen, M. (2012). Spatial and temporal variation in metabolic fingerprints of field-growing Myriophyllum spicatum. Aquatic Botany, 102, 34\u201343. https:\/\/doi.org\/10.1016\/j.aquabot.2012.03.017","journal-title":"Aquatic Botany"},{"key":"2545_CR50","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1111\/mec.15931","volume":"30","author":"JP Rippe","year":"2021","unstructured":"Rippe, J. P., Dixon, G., Fuller, Z. L., Liao, Y., & Matz, M. (2021). Environmental specialization and cryptic genetic divergence in two massive coral species from the Florida Keys Reef Tract. Molecular Ecology, 30, 3468\u20133484.","journal-title":"Molecular Ecology"},{"key":"2545_CR51","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/s41559-020-01388-7","volume":"5","author":"TNF Roach","year":"2021","unstructured":"Roach, T. N. F., Dilworth, J., Jones, H. C. M., Quinn, A. D., R.A., & Drury, C. (2021). Metabolomic signatures of coral bleaching history. Nat Ecol Evol, 5, 495\u2013503.","journal-title":"Nat Ecol Evol"},{"key":"2545_CR52","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1146\/annurev-marine-120709-142756","volume":"3","author":"E Sanford","year":"2011","unstructured":"Sanford, E., & Kelly, M. W. (2011). Local adaptation in marine invertebrates. Annu Rev Mar Sci, 3, 509\u2013535.","journal-title":"Annu Rev Mar Sci"},{"key":"2545_CR53","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/s41587-023-01690-2","volume":"41","author":"R Schmid","year":"2023","unstructured":"Schmid, R., Heuckeroth, S., Korf, A., Smirnov, A., Myers, O., Dyrlund, T. S., et al. (2023). Integrative analysis of multimodal mass spectrometry data in MZmine 3. Nature Biotechnology, 41, 447\u2013449.","journal-title":"Nature Biotechnology"},{"key":"2545_CR54","doi-asserted-by":"publisher","first-page":"e1033","DOI":"10.1002\/aps3.1033","volume":"6","author":"BE Sedio","year":"2018","unstructured":"Sedio, B. E., P, C.A.B., & Echeverri, J. C. R. (2018). A protocol for high-throughput, untargeted forest community metabolomics using mass spectrometry molecular networks. Appl Plant Sci, 6, e1033.","journal-title":"Appl Plant Sci"},{"key":"2545_CR55","doi-asserted-by":"crossref","unstructured":"Sedio, B. E., Spasojevic, M. J., Myers, J. A., Wright, S. J., Person, M. D., Chandrasekaran, H. (2021). Chemical Similarity of Co-occurring Trees Decreases With Precipitation and Temperature in North American Forests. Front Ecol Evol, 9.","DOI":"10.3389\/fevo.2021.679638"},{"key":"2545_CR56","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1534\/genetics.113.154138","volume":"195","author":"L Skotte","year":"2013","unstructured":"Skotte, L., Korneliussen, T. S., & Albrechtsen, A. (2013). Estimating individual admixture proportions from next generation sequencing data. Genetics, 195, 693\u2013702.","journal-title":"Genetics"},{"key":"2545_CR57","doi-asserted-by":"publisher","first-page":"e03413","DOI":"10.1002\/ecs2.3413","volume":"12","author":"HA Stewart","year":"2021","unstructured":"Stewart, H. A., Kline, D. I., Chapman, L. J., & Altieri, A. H. (2021). Caribbean mangrove forests act as coral refugia by reducing light stress and increasing coral richness. Ecosphere, 12, e03413.","journal-title":"Ecosphere"},{"key":"2545_CR58","doi-asserted-by":"publisher","first-page":"e10622","DOI":"10.1002\/ece3.10622","volume":"13","author":"AB Sturm","year":"2023","unstructured":"Sturm, A. B., Eckert, R. J., Carreiro, A. M., Klein, A. M., Studivan, M. S., Farelli, D., D., et al. (2023). Does depth divide? Variable genetic connectivity patterns among shallow and mesophotic Montastraea cavernosa coral populations across the Gulf of Mexico and western Caribbean. Ecol Evol, 13, e10622.","journal-title":"Ecol Evol"},{"key":"2545_CR59","doi-asserted-by":"publisher","first-page":"105035","DOI":"10.1016\/j.marenvres.2020.105035","volume":"161","author":"R Tamir","year":"2020","unstructured":"Tamir, R., Ben-Zvi, O., Eyal, G., Kramer, N., & Loya, Y. (2020). Reciprocal-transplantation between shallow and mesophotic stony corals. Marine Environment Research, 161, 105035.","journal-title":"Marine Environment Research"},{"key":"2545_CR60","doi-asserted-by":"crossref","unstructured":"Voolstra, C. R., Raina, J. B., D\u00f6rr, M., C\u00e1rdenas, A., Pogoreutz, C., Silveira, C. B. (2024). The coral microbiome in sickness, in health and in a changing world. Nat Rev Microbiol, 1\u201316.","DOI":"10.1038\/s41579-024-01015-3"},{"key":"2545_CR61","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/nbt.3597","volume":"34","author":"M Wang","year":"2016","unstructured":"Wang, M., Carver, J. J., Phelan, V. V., Sanchez, L. M., Garg, N., Peng, Y., et al. (2016). Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology, 34, 828\u2013837.","journal-title":"Nature Biotechnology"},{"key":"2545_CR62","doi-asserted-by":"crossref","unstructured":"Wickham, H. (2016). ggplot2: Elegant Graphics for Data Analysis. Springer-.","DOI":"10.1007\/978-3-319-24277-4_9"},{"key":"2545_CR63","doi-asserted-by":"crossref","unstructured":"Williams, A. (2024). Multiomics data integration, limitations, and prospects to reveal the metabolic activity of the coral holobiont. FEMS Microbiol Ecol, fiae058.","DOI":"10.1093\/femsec\/fiae058"},{"key":"2545_CR64","doi-asserted-by":"publisher","first-page":"eabd4210","DOI":"10.1126\/sciadv.abd4210","volume":"7","author":"A Williams","year":"2021","unstructured":"Williams, A., Chiles, E. N., Conetta, D., Pathmanathan, J. S., Cleves, P. A., Putnam, H. M., et al. (2021). Metabolomic shifts associated with heat stress in coral holobionts. Science Advances, 7, eabd4210.","journal-title":"Science Advances"},{"key":"2545_CR65","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.5194\/bg-11-4321-2014","volume":"11","author":"KK Yates","year":"2014","unstructured":"Yates, K. K., Rogers, C. S., Herlan, J. J., Brooks, G. R., Smiley, N. A., & Larson, R. A. (2014). Diverse coral communities in mangrove habitats suggest a novel refuge from climate change. Biogeosciences, 11, 4321\u20134337.","journal-title":"Biogeosciences"},{"issue":"9","key":"2545_CR66","doi-asserted-by":"publisher","first-page":"4945","DOI":"10.1021\/acs.analchem.4c05142","volume":"97","author":"S Zuffa","year":"2025","unstructured":"Zuffa, S., Charron-Lamoureux, V., Brennan, C., Ambre, M., Knight, R., & Dorrestein, P. C. (2025). Human Untargeted Metabolomics in High-Throughput Gut Microbiome Research: Ethanol vs Methanol. Analytical Chemistry, 97(9), 4945\u20134953. https:\/\/doi.org\/10.1021\/acs.analchem.4c05142","journal-title":"Analytical Chemistry"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-026-02545-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-026-02545-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-026-02545-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:02:57Z","timestamp":1791669777000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-026-02545-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,10]]},"references-count":66,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2545"],"URL":"https:\/\/doi.org\/10.1007\/s11306-026-02545-y","relation":{},"ISSN":["1573-3890"],"issn-type":[{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,10]]},"assertion":[{"value":"4 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"169"}}