{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:15:55Z","timestamp":1790968555986,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T00:00:00Z","timestamp":1297900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1007\/s11307-011-0476-4","type":"journal-article","created":{"date-parts":[[2011,2,16]],"date-time":"2011-02-16T16:37:04Z","timestamp":1297874224000},"page":"70-78","source":"Crossref","is-referenced-by-count":50,"title":["Positron Emission Tomography of Copper Metabolism in the Atp7b \u2212\/\u2212 Knock-out Mouse Model of Wilson\u2019s Disease"],"prefix":"10.1007","volume":"14","author":[{"given":"Fangyu","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Lutsenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiankai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Muzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,2,17]]},"reference":[{"issue":"5","key":"476_CR1","doi-asserted-by":"crossref","first-page":"791S","DOI":"10.1093\/ajcn\/63.5.791","volume":"63","author":"M Olivares","year":"1996","unstructured":"Olivares M, Uauy R (1996) Copper as an essential nutrient. Am J Clin Nutr 63(5):791S\u20136S","journal-title":"Am J Clin Nutr"},{"issue":"5 Suppl","key":"476_CR2","doi-asserted-by":"crossref","first-page":"952S","DOI":"10.1093\/ajcn\/67.5.952S","volume":"67","author":"R Uauy","year":"1998","unstructured":"Uauy R, Olivares M, Gonzalez M (1998) Essentiality of copper in humans. Am J Clin Nutr 67(5 Suppl):952S\u2013959S","journal-title":"Am J Clin Nutr"},{"key":"476_CR3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/ajcn\/14.4.224","volume":"14","author":"GE Cartwright","year":"1964","unstructured":"Cartwright GE, Wintrobe MM (1964) Copper metabolism in normal subjects. Am J Clin Nutr 14:224\u201332","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"476_CR4","doi-asserted-by":"crossref","first-page":"960S","DOI":"10.1093\/ajcn\/67.5.960S","volume":"67","author":"JR Turnlund","year":"1998","unstructured":"Turnlund JR (1998) Human whole-body copper metabolism. Am J Clin Nutr 67(5):960S\u2013964S","journal-title":"Am J Clin Nutr."},{"key":"476_CR5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1367-5931(02)00298-3","volume":"6","author":"S Puig","year":"2002","unstructured":"Puig S, Thiele DJ (2002) Molecular mechanisms of copper uptake and distribution. Curr Opin Chem Biol 6:171\u2013180","journal-title":"Curr Opin Chem Biol"},{"key":"476_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbpa.2009.12.001","volume":"14","author":"S Lutsenko","year":"2010","unstructured":"Lutsenko S (2010) Human copper homeostasis: a network of interconnected pathways. Curr Opin Chem Biol 14:1\u20137","journal-title":"Curr Opin Chem Biol"},{"key":"476_CR7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S1471-4914(01)01920-7","volume":"7","author":"JF Mercer","year":"2001","unstructured":"Mercer JF (2001) The molecular basis of copper-transport diseases. Trends Mol Med 7:64\u201369","journal-title":"Trends Mol Med"},{"key":"476_CR8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/ng1293-327","volume":"5","author":"PC Bull","year":"1993","unstructured":"Bull PC, Thomas GR, Rommens JM, Forbes JR, Cox DW (1993) The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat Genet 5:327\u2013337","journal-title":"Nat Genet"},{"key":"476_CR9","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/ng1293-344","volume":"5","author":"RE Tanzi","year":"1993","unstructured":"Tanzi RE, Petrukhin K, Chernov I, Pellequer JL, Wasco W, Ross B et al (1993) The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nat Genet 5:344\u2013350","journal-title":"Nat Genet"},{"key":"476_CR10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/ng0193-7","volume":"3","author":"C Vulpe","year":"1993","unstructured":"Vulpe C, Levinson B, Whitney S, Packman S, Gitschier J (1993) Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting. Nat Genet 3:7\u201313","journal-title":"Nat Genet"},{"key":"476_CR11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ng0193-20","volume":"3","author":"JF Mercer","year":"1993","unstructured":"Mercer JF, Livingston J, Hall B, Paynter JA, Begy C, Chandrasekharappa S et al (1993) Isolation of a partial candidate gene for Menkes disease by positional cloning. Nat Genet 3:20\u201325","journal-title":"Nat Genet"},{"key":"476_CR12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/ng0193-14","volume":"3","author":"J Chelly","year":"1993","unstructured":"Chelly J, Tumer Z, Tonnesen T, Petterson A, Ishikawa-Brush Y, Tommerup N et al (1993) Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein. Nat Genet 3:14\u201319","journal-title":"Nat Genet"},{"key":"476_CR13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1046\/j.1469-1809.2001.6550459.x","volume":"65","author":"L Olivarez","year":"2001","unstructured":"Olivarez L, Caggana M, Pass KA, Ferguson P, Brewer GJ (2001) Estimate of the frequency of Wilson\u2019s disease in the US Caucasian population: a mutation analysis approach. Ann Hum Genet 65:459\u2013463","journal-title":"Ann Hum Genet"},{"issue":"3","key":"476_CR14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0753-3322(97)86907-7","volume":"51","author":"G Multhaup","year":"1997","unstructured":"Multhaup G (1997) Amyloid precursor protein, copper and Alzheimer\u2019s disease. Biomed Pharmacother 51(3):105\u201311","journal-title":"Biomed Pharmacother"},{"key":"476_CR15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1040-8428(02)00007-0","volume":"1","author":"T Theophanides","year":"2002","unstructured":"Theophanides T, Anastassopoulou J (2002) Copper and carcinogenesis. Crit Rev Oncol Hematol 1:57\u201364","journal-title":"Crit Rev Oncol Hematol"},{"issue":"2","key":"476_CR16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/(SICI)1520-670X(1996)9:2<57::AID-JTRA2>3.0.CO;2-E","volume":"9","author":"M Kusleikaite","year":"1996","unstructured":"Kusleikaite M, Masironi R (1996) Trace elements in prognosis of myocardial infarction and sudden coronary death. J Trace Elem Exp Med 9(2):57\u201362","journal-title":"J Trace Elem Exp Med"},{"key":"476_CR17","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1152\/ajplegacy.1964.207.2.446","volume":"207","author":"CA Owen Jr","year":"1964","unstructured":"Owen CA Jr (1964) Distribution of copper in the rat. Am J Physiol 207:446\u2013448","journal-title":"Am J Physiol"},{"key":"476_CR18","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1152\/ajplegacy.1965.209.5.900","volume":"209","author":"CA Owen Jr","year":"1965","unstructured":"Owen CA Jr (1965) Metabolism of radiocopper (Cu64) in the rat. Am J Physiol 209:900\u2013904","journal-title":"Am J Physiol"},{"key":"476_CR19","doi-asserted-by":"crossref","first-page":"E115","DOI":"10.1152\/ajpcell.1991.261.1.C115","volume":"261","author":"MA Dunn","year":"1991","unstructured":"Dunn MA, Green MH, Leach RM Jr (1991) Kinetics of copper metabolism in rats: a compartmental model. Am J Physiol 261:E115\u2013125","journal-title":"Am J Physiol"},{"key":"476_CR20","doi-asserted-by":"crossref","first-page":"15942","DOI":"10.1021\/ja065264l","volume":"128","author":"EL Que","year":"2006","unstructured":"Que EL, Chang CJ (2006) A smart magnetic resonance contrast agent for selective copper sensing. J Am Chem Soc 128:15942\u201315943","journal-title":"J Am Chem Soc"},{"issue":"24","key":"476_CR21","doi-asserted-by":"crossref","first-page":"8527","DOI":"10.1021\/ja900884j","volume":"131","author":"EL Que","year":"2009","unstructured":"Que EL, Gianolio E, Baker SL, Wong AP, Aime S, Chang CJ (2009) Copper-responsive magnetic resonance imaging contrast agents. J Am Chem Soc 131(24):8527\u20138536","journal-title":"J Am Chem Soc"},{"issue":"2","key":"476_CR22","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1021\/ja908326z","volume":"132","author":"AF Chaudhry","year":"2010","unstructured":"Chaudhry AF, Verma M, Morgan MT, Henary MM, Siegel N, Hales JM et al (2010) Kinetically controlled photoinduced electron transfer switching in Cu(I)-responsive fluorescent probes. J Am Chem Soc 132(2):737\u2013747","journal-title":"J Am Chem Soc"},{"issue":"4","key":"476_CR23","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1021\/ja907778b","volume":"132","author":"DW Domaille","year":"2010","unstructured":"Domaille DW, Zeng L, Chang CJ (2010) Visualizing ascorbate-triggered release of labile copper within living cells using a ratiometric fluorescent sensor. J Am Chem Soc 132(4):1194\u20131195","journal-title":"J Am Chem Soc"},{"key":"476_CR24","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0969-8051(96)00130-8","volume":"23","author":"PJ Blower","year":"1996","unstructured":"Blower PJ, Lewis JS, Zweit J (1996) Copper radionuclides and radiopharmaceuticals in nuclear medicine. Nucl Med Biol 23:957\u2013980","journal-title":"Nucl Med Biol"},{"issue":"10","key":"476_CR25","first-page":"1649","volume":"47","author":"F Peng","year":"2006","unstructured":"Peng F, Xin Lu, Janisse J, Muzik O, Shields AF (2006) Positron emission tomography of human prostate cancer xenografts in mice with increased uptake of copper (II)-64 chloride. J Nucl Med 47(10):1649\u20131652","journal-title":"J Nucl Med"},{"key":"476_CR26","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.2967\/jnumed.109.061879","volume":"50","author":"J Liu","year":"2009","unstructured":"Liu J, Hajibeigi A, Ren G, Lin M, Siyambalapitiyage W, Liu Z et al (2009) Retention of the radiotracers 64Cu-ATSM and 64Cu-PTSM in human and murine tumors is influenced by MDR1 protein expression. J Nucl Med 50:1332\u20131339","journal-title":"J Nucl Med"},{"key":"476_CR27","first-page":"538","volume":"37","author":"MG Stabin","year":"1996","unstructured":"Stabin MG (1996) MIRDOSE: personal computer software for internal dose assessment in nuclear medicine. J Nucl Med 37:538\u201346","journal-title":"J Nucl Med"},{"key":"476_CR28","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/00004032-200309000-00006","volume":"85","author":"MB Stabin","year":"2003","unstructured":"Stabin MB, Siegel JA (2003) Physical models and dose factors for use in internal dose assessment. Health Phys 85:294\u2013310","journal-title":"Health Phys"},{"key":"476_CR29","first-page":"467","volume":"38","author":"SB Osborn","year":"1969","unstructured":"Osborn SB, Szaz KF, Walshe JM (1969) Studies with radioactive copper (64Cu and 67Cu): abdominal scintiscans in patients with Wilson\u2019s disease. Q J Med 38:467\u2013474","journal-title":"Q J Med"},{"key":"476_CR30","first-page":"445","volume":"46","author":"JM Walshe","year":"1977","unstructured":"Walshe JM, Potter G (1977) The pattern of the whole body distribution of radioactive copper (67Cu, 64Cu) in Wilson\u2019s disease and various control groups. Q J Med 46:445\u2013462","journal-title":"Q J Med"},{"key":"476_CR31","first-page":"210","volume":"43","author":"MT Hays","year":"2002","unstructured":"Hays MT, Watson EE, Thomas SR, Stabin (2002) Radiation absorbed dose estimates from 18\u00a0F-FDG. J Nucl Med 43:210\u2013214","journal-title":"J Nucl Med"},{"key":"476_CR32","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1172\/JCI103232","volume":"34","author":"JA Bush","year":"1955","unstructured":"Bush JA, Mahoney JP, Markowitz H, Gubler CJ, Cartwright GE, Wintrobe MM (1955) Studies on copper metabolism. XVI. Radioactive copper studies in normal subjects and in patients with hepatolenticular degeneration. J Clin Invest 34:1766\u20131778","journal-title":"J Clin Invest"},{"issue":"8","key":"476_CR33","first-page":"787","volume":"16","author":"G Skromne-Kadlubik","year":"1975","unstructured":"Skromne-Kadlubik G, Diaz JF, Celis C (1975) Basal ganglia scans in the human. J Nucl Med 16(8):787\u2013788","journal-title":"J Nucl Med"},{"issue":"1","key":"476_CR34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10534-004-1800-0","volume":"18","author":"KD Bissig","year":"2005","unstructured":"Bissig KD, Honer M, Zimmermann K, Summer KH, Solioz M (2005) Whole animal copper flux assessed by positron emission tomography in the Long\u2013Evans cinnamon rat\u2014a feasibility study. Biometals 18(1):83\u201388","journal-title":"Biometals"},{"key":"476_CR35","first-page":"1190","volume":"34","author":"RL Wahl","year":"1993","unstructured":"Wahl RL, Quint LE, Cieslak RD, Aisen AM, Koeppe RA, Meyer CR (1993) Anatometabolic tumor imaging: fusion of FDG PET with CT or MRI to localize foci of increased activity. J Nucl Med 34:1190\u20131197","journal-title":"J Nucl Med"},{"issue":"4","key":"476_CR36","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nm1700","volume":"14","author":"MS Judenhofer","year":"2008","unstructured":"Judenhofer MS, Wehrl HF, Newport DF, Catana C, Siegel SB, Becker M et al (2008) Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nat Med 14(4):459\u2013465","journal-title":"Nat Med"},{"issue":"2","key":"476_CR37","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2353\/ajpath.2006.050312","volume":"168","author":"D Huster","year":"2006","unstructured":"Huster D, Finegold MJ, Morgan CT, Burkhead JL, Nixon R, Vanderwerf SM, Gilliam CT, Lutsenko S (2006) Consequences of copper accumulation in the livers of the Atp7b-\/(Wilson disease gene) knockout mice. Am J Pathol 168(2):423\u2013434","journal-title":"Am J Pathol"},{"issue":"4","key":"476_CR38","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3181\/00379727-203-43619","volume":"203","author":"SH Lee","year":"1993","unstructured":"Lee SH, Lancey R, Montaser A, Madani N, Linder MC (1993) Ceruloplasmin and copper transport during the latter part of gestation in the rat. Proc Soc Exp Biol Med 203(4):428\u201339","journal-title":"Proc Soc Exp Biol Med"},{"issue":"19","key":"476_CR39","doi-asserted-by":"crossref","first-page":"10812","DOI":"10.1073\/pnas.96.19.10812","volume":"96","author":"ZL Harris","year":"1999","unstructured":"Harris ZL, Durley AP, Man TK, Gitlin JD (1999) Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci USA 96(19):10812\u201310817","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"476_CR40","doi-asserted-by":"crossref","first-page":"F53","DOI":"10.1152\/ajprenal.00314.2007","volume":"294","author":"R Linz","year":"2008","unstructured":"Linz R, Barnes NL, Zimnicka AM, Kaplan JH, Eipper B, Lutsenko S (2008) The intracellular targeting of copper-transporting ATPase ATP7A in a normal and ATP7b \u2212\/\u2212 kidney. Am J Physiol Renal Electrolyte Physiol 294(1):F53\u201361","journal-title":"Am J Physiol Renal Electrolyte Physiol"},{"issue":"9","key":"476_CR41","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1093\/hmg\/8.9.1665","volume":"8","author":"OI Buiakova","year":"1999","unstructured":"Buiakova OI, Xu J, Lutsenko S, Zeitlin S, Das K, Das S, Ross BM, Mekios C, Scheinberg IH, Gilliam TC (1999) Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation. Hum Mol Genet 8(9):1665\u201371","journal-title":"Hum Mol Genet"},{"issue":"9","key":"476_CR42","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1093\/jn\/135.9.2130","volume":"135","author":"Y Li","year":"2005","unstructured":"Li Y, Wang L, Schuschke DA, Zhou Z, Saari JT, Kang YJ (2005) Marginal dietary copper restriction induces cardiomyopathy in rats. J Nutr 135(9):2130\u20132136","journal-title":"J Nutr"},{"issue":"21","key":"476_CR43","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1212\/01.wnl.0000262768.40174.33","volume":"68","author":"K Juhasz-Pocsine","year":"2007","unstructured":"Juhasz-Pocsine K, Rudnicki SA, Archer RL, Harik SI (2007) Neurologic complications of gastric bypass surgery for morbid obesity. Neurology 68(21):1843\u20131850","journal-title":"Neurology"},{"key":"476_CR44","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/ajcn\/49.5.870","volume":"49","author":"JR Turnlund","year":"1989","unstructured":"Turnlund JR, KeyesWR EHL, Acord LL (1989) Copper absorption and retention in young men at three levels of dietary copper using the stable isotope 65Cu. Am J Clin Nutr 49:870\u2013878","journal-title":"Am J Clin Nutr"},{"key":"476_CR45","first-page":"999","volume":"47","author":"BJ Fueger","year":"2006","unstructured":"Fueger BJ, Czernin J, Hildebrandt I, Tran C, Halpern BS, Stout D et al (2006) Impact of animal handling on the results of 18\u00a0F-FDG PET studies in mice. J Nucl Med 47:999\u20131006","journal-title":"J Nucl Med"},{"key":"476_CR46","first-page":"1","volume":"6","author":"GJ Brewer","year":"2000","unstructured":"Brewer GJ, Dick RD, Grover DK, LeClaire V, Tseng M, Wicha M et al (2000) Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: phase I study. Clin Cancer Res 6:1\u201310","journal-title":"Clin Cancer Res"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-011-0476-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11307-011-0476-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-011-0476-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T11:55:09Z","timestamp":1559994909000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11307-011-0476-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,17]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["476"],"URL":"https:\/\/doi.org\/10.1007\/s11307-011-0476-4","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,17]]}}}