{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T14:36:19Z","timestamp":1775658979422,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,8,19]],"date-time":"2011-08-19T00:00:00Z","timestamp":1313712000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1007\/s11307-011-0512-4","type":"journal-article","created":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T16:18:41Z","timestamp":1313684321000},"page":"500-508","source":"Crossref","is-referenced-by-count":26,"title":["Integrin \u03b1v\u03b23 as a PET Imaging Biomarker for Osteoclast Number in Mouse Models of Negative and Positive Osteoclast Regulation"],"prefix":"10.1007","volume":"14","author":[{"given":"Alexander","family":"Zheleznyak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaddeus J.","family":"Wadas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D.","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Kostenuik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine N.","family":"Weilbaecher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,8,19]]},"reference":[{"key":"512_CR1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/cncr.11132","volume":"97","author":"SM Kakonen","year":"2003","unstructured":"Kakonen SM, Mundy GR (2003) Mechanisms of osteolytic bone metastases in breast carcinoma. Cancer 97:834\u2013839","journal-title":"Cancer"},{"key":"512_CR2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrc867","volume":"2","author":"GR Mundy","year":"2002","unstructured":"Mundy GR (2002) Metastasis to bone: causes, consequences and theraputic opportunities. Nature Rev Cancer 2:584\u2013593","journal-title":"Nature Rev Cancer"},{"key":"512_CR3","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMoa050434","volume":"353","author":"S Braun","year":"2005","unstructured":"Braun S, Vogl FD, Naume B et al (2005) A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med 353:793\u2013802","journal-title":"N Engl J Med"},{"key":"512_CR4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2353\/ajpath.2007.060834","volume":"170","author":"SL Teitelbaum","year":"2007","unstructured":"Teitelbaum SL (2007) Osteoclasts: what do they do and how do they do it? Am J Pathol 170:427\u2013435","journal-title":"Am J Pathol"},{"key":"512_CR5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/jbmr.5650080215","volume":"8","author":"MA Horton","year":"1993","unstructured":"Horton MA, Dorey EL, Nesbitt SA et al (1993) Modulation of vitronectin receptor-mediated osteoclast adhesion by arg-gly-asp peptide analogs: a structure-function analysis. J Bone Miner Res 8:239\u2013247","journal-title":"J Bone Miner Res"},{"key":"512_CR6","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1357-2725(96)00155-0","volume":"29","author":"MA Horton","year":"1997","unstructured":"Horton MA (1997) The alpha v beta 3 integrin \u201cvitronectin receptor\u201d. Int J Biochem Cell Biol 29:721\u2013725","journal-title":"Int J Biochem Cell Biol"},{"key":"512_CR7","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1557::AID-CNCR5>3.0.CO;2-H","volume":"80","author":"GD Roodman","year":"1997","unstructured":"Roodman GD (1997) Mechanisms of bone lesions in multiple myeloma and lymphoma. Cancer 80:1557\u20131563","journal-title":"Cancer"},{"key":"512_CR8","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1097\/01.blo.0000093051.96273.7c","volume":"415S","author":"JJ Peterson","year":"2003","unstructured":"Peterson JJ, Kransdorf MJ, O'Connor MI (2003) Diagnosis of occult bone metastases: positron emission tomography. Clin Orthop Relat Res 415S:S120\u2013S128","journal-title":"Clin Orthop Relat Res"},{"key":"512_CR9","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1200\/JCO.2004.08.181","volume":"22","author":"T Hamaoka","year":"2004","unstructured":"Hamaoka T, Madewell JE, Podoloff DA, Hortobagyi GN, Ueno NT (2004) Bone imaging in metastatic breast cancer. J Clin Oncol 22:2942\u20132953","journal-title":"J Clin Oncol"},{"key":"512_CR10","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1200\/JCO.2007.11.2854","volume":"25","author":"Y Du","year":"2007","unstructured":"Du Y, Cullum I, Illidge TM, Ell PJ (2007) Fusion of metabolic function and morphology: sequential [18f]fluorodeoxyglucose positron-emission tomography\/computed tomography studies yield new insights into the natural history of bone metastases in breast cancer. J Clin Oncol 25:3440\u20133447","journal-title":"J Clin Oncol"},{"key":"512_CR11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/cbr.2008.0556","volume":"24","author":"M Bjurberg","year":"2009","unstructured":"Bjurberg M, Henriksson E, Brun E et al (2009) Early changes in 2-deoxy-2-[18f]fluoro-d-glucose metabolism in squamous-cell carcinoma during chemotherapy in vivo and in vitro. Cancer Biother Radiopharm 24:327\u2013332","journal-title":"Cancer Biother Radiopharm"},{"key":"512_CR12","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1200\/JCO.2001.19.11.2797","volume":"19","author":"JE Mortimer","year":"2001","unstructured":"Mortimer JE, Dehdashti F, Siegel BA et al (2001) Metabolic flare: indicator of hormone responsiveness in advanced breast cancer. J Clin Oncol 19:2797\u20132803","journal-title":"J Clin Oncol"},{"key":"512_CR13","first-page":"1061","volume":"40","author":"R Haubner","year":"1999","unstructured":"Haubner R, Wester HJ, Reuning U et al (1999) Radiolabeled alpha(v)beta3 integrin antagonists: a new class of tracers for tumor targeting. J Nucl Med 40:1061\u20131071","journal-title":"J Nucl Med"},{"key":"512_CR14","first-page":"311","volume":"48","author":"JE Sprague","year":"2007","unstructured":"Sprague JE, Kitaura H, Zou W et al (2007) Noninvasive imaging of osteoclasts in parathyroid hormone-induced osteolysis using a 64cu-labeled rgd peptide. J Nucl Med 48:311\u2013318","journal-title":"J Nucl Med"},{"key":"512_CR15","first-page":"1333","volume":"46","author":"AJ Beer","year":"2005","unstructured":"Beer AJ, Haubner R, Goebel M et al (2005) Biodistribution and pharmacokinetics of the {alpha}v{beta}3-selective tracer 18f-galacto-rgd in cancer patients. J Nucl Med 46:1333\u20131341","journal-title":"J Nucl Med"},{"key":"512_CR16","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1158\/1078-0432.CCR-06-0266","volume":"12","author":"AJ Beer","year":"2006","unstructured":"Beer AJ, Haubner R, Sarbia M et al (2006) Positron emission tomography using [18f]galacto-rgd identifies the level of integrin {alpha}v{beta}3 expression in man. Clin Cancer Res 12:3942\u20133949","journal-title":"Clin Cancer Res"},{"key":"512_CR17","first-page":"763","volume":"47","author":"AJ Beer","year":"2006","unstructured":"Beer AJ, Haubner R, Wolf I et al (2006) Pet-based human dosimetry of 18f-galacto-rgd, a new radiotracer for imaging alpha v beta3 expression. J Nucl Med 47:763\u2013769","journal-title":"J Nucl Med"},{"key":"512_CR18","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10555-008-9158-3","volume":"27","author":"AJ Beer","year":"2008","unstructured":"Beer AJ, Schwaiger M (2008) Imaging of integrin alphavbeta3 expression. Cancer Metastasis Rev 27:631\u2013644","journal-title":"Cancer Metastasis Rev"},{"key":"512_CR19","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1215\/15228517-2009-024","volume":"11","author":"O Schnell","year":"2009","unstructured":"Schnell O, Krebs B, Carlsen J et al (2009) Imaging of integrin alpha(v)beta(3) expression in patients with malignant glioma by [18f] galacto-rgd positron emission tomography. Neuro Oncol 11:861\u2013870","journal-title":"Neuro Oncol"},{"key":"512_CR20","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.2967\/jnumed.109.067140","volume":"50","author":"TJ Wadas","year":"2009","unstructured":"Wadas TJ, Deng H, Sprague JE et al (2009) Targeting the alphavbeta3 integrin for small-animal pet\/ct of osteolytic bone metastases. J Nucl Med 50:1873\u20131880","journal-title":"J Nucl Med"},{"key":"512_CR21","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1038\/nprot.2006.431","volume":"1","author":"TJ Wadas","year":"2006","unstructured":"Wadas TJ, Anderson CJ (2006) Radiolabeling of teta- and cb-te2a-conjugated peptides with copper-64. Nat Protoc 1:3062\u20133068","journal-title":"Nat Protoc"},{"key":"512_CR22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1109\/42.870259","volume":"19","author":"J Qi","year":"2000","unstructured":"Qi J, Leahy RM (2000) Resolution and noise properties of map reconstruction for fully 3-d pet. IEEE Trans Med Imaging 19:493\u2013506","journal-title":"IEEE Trans Med Imaging"},{"key":"512_CR23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1162\/153535003322556877","volume":"2","author":"AM Loening","year":"2003","unstructured":"Loening AM, Gambhir SS (2003) Amide: a free software tool for multimodality medical image analysis. Mol Imaging 2:131\u2013137","journal-title":"Mol Imaging"},{"key":"512_CR24","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s00223-008-9127-4","volume":"82","author":"K Shidara","year":"2008","unstructured":"Shidara K, Inaba M, Okuno S et al (2008) Serum levels of trap5b, a new bone resorption marker unaffected by renal dysfunction, as a useful marker of cortical bone loss in hemodialysis patients. Calcif Tissue Int 82:278\u2013287","journal-title":"Calcif Tissue Int"},{"key":"512_CR25","first-page":"379","volume":"4","author":"Y Kang","year":"2004","unstructured":"Kang Y (2004) Breast cancer bone metastasis: molecular basis of tissue tropism. J Musculoskelet Neuronal Interact 4:379\u2013380","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"512_CR26","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/carcin\/bgm050","volume":"28","author":"Z Wu","year":"2007","unstructured":"Wu Z, McRoberts KS, Theodorescu D (2007) The role of pten in prostate cancer cell tropism to the bone micro-environment. Carcinogenesis 28:1393\u20131400","journal-title":"Carcinogenesis"},{"key":"512_CR27","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.lungcan.2007.10.016","volume":"61","author":"I Roato","year":"2008","unstructured":"Roato I, Gorassini E, Buffoni L et al (2008) Spontaneous osteoclastogenesis is a predictive factor for bone metastases from non-small cell lung cancer. Lung Cancer 61:109\u2013116","journal-title":"Lung Cancer"},{"key":"512_CR28","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nrrheum.2009.175","volume":"5","author":"Y Choi","year":"2009","unstructured":"Choi Y, Arron JR, Townsend MJ (2009) Promising bone-related therapeutic targets for rheumatoid arthritis. Nat Rev Rheumatol 5:543\u2013548","journal-title":"Nat Rev Rheumatol"},{"key":"512_CR29","first-page":"1776","volume":"45","author":"X Chen","year":"2004","unstructured":"Chen X, Hou Y, Tohme M et al (2004) Pegylated arg-gly-asp peptide: 64cu labeling and pet imaging of brain tumor alphavbeta3-integrin expression. J Nucl Med 45:1776\u20131783","journal-title":"J Nucl Med"},{"key":"512_CR30","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1055\/s-0038-1623911","volume":"43","author":"R Haubner","year":"2004","unstructured":"Haubner R, Bruchertseifer F, Bock M et al (2004) Synthesis and biological evaluation of a (99m)tc-labelled cyclic rgd peptide for imaging the alphavbeta3 expression. Nuklearmedizin 43:26\u201332","journal-title":"Nuklearmedizin"},{"key":"512_CR31","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2967\/jnumed.107.050179","volume":"49","author":"AR Hsu","year":"2008","unstructured":"Hsu AR, Chen X (2008) Advances in anatomic, functional, and molecular imaging of angiogenesis. J Nucl Med 49:511\u2013514","journal-title":"J Nucl Med"},{"key":"512_CR32","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1586\/era.09.74","volume":"9","author":"A Kyrgidis","year":"2009","unstructured":"Kyrgidis A, Triaridis S, Vahtsevanos K, Antoniades K (2009) Osteonecrosis of the jaw and bisphosphonate use in breast cancer patients. Expert Rev Anticancer Ther 9:1125\u20131134","journal-title":"Expert Rev Anticancer Ther"},{"key":"512_CR33","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/s00774-008-0857-1","volume":"26","author":"H Nakamura","year":"2008","unstructured":"Nakamura H, Hiraga T, Ninomiya T et al (2008) Involvement of cell-cell and cell-matrix interactions in bone destruction induced by metastatic MDA-MB-231 human breast cancer cells in nude mice. J Bone Miner Metab 26:642\u2013647","journal-title":"J Bone Miner Metab"},{"key":"512_CR34","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.1158\/1078-0432.CCR-09-0426","volume":"15","author":"S Pozzi","year":"2009","unstructured":"Pozzi S, Vallet S, Mukherjee S et al (2009) High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical properties. Clin Cancer Res 15:5829\u20135839","journal-title":"Clin Cancer Res"},{"key":"512_CR35","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/01.bor.0000127824.42507.68","volume":"16","author":"NC Walsh","year":"2004","unstructured":"Walsh NC, Gravallese EM (2004) Bone loss in inflammatory arthritis: mechanisms and treatment strategies. Curr Opin Rheumatol 16:419\u2013427","journal-title":"Curr Opin Rheumatol"},{"key":"512_CR36","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0002-9440(10)64556-7","volume":"157","author":"DL Lacey","year":"2000","unstructured":"Lacey DL, Tan HL, Lu J et al (2000) Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am J Pathol 157:435\u2013448","journal-title":"Am J Pathol"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-011-0512-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11307-011-0512-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-011-0512-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T05:10:33Z","timestamp":1560489033000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11307-011-0512-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,19]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["512"],"URL":"https:\/\/doi.org\/10.1007\/s11307-011-0512-4","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,19]]}}}