{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:51:51Z","timestamp":1774659111274,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,8,24]],"date-time":"2013-08-24T00:00:00Z","timestamp":1377302400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s11307-013-0677-0","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T09:47:31Z","timestamp":1377251251000},"page":"246-254","source":"Crossref","is-referenced-by-count":24,"title":["In Vivo Molecular Imaging of Apoptosisand Necrosis in Atherosclerotic PlaquesUsing MicroSPECT-CT and MicroPET-CT Imaging"],"prefix":"10.1007","volume":"16","author":[{"given":"M.","family":"De Saint-Hubert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bauwens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Deckers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Drummen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Douma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Granton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Hendrikx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kusters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bucerius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. P. M.","family":"Reutelingsperger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. M.","family":"Mottaghy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,8,24]]},"reference":[{"issue":"11","key":"677_CR1","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.biocel.2009.06.002","volume":"41","author":"QT Bui","year":"2009","unstructured":"Bui QT, Prempeh M, Wilensky RL (2009) Atherosclerotic plaque development. Int J Biochem Cell Biol 41(11):2109\u20132113","journal-title":"Int J Biochem Cell Biol"},{"key":"677_CR2","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1161\/01.CIR.0000105761.00573.50","volume":"108","author":"FD Kolodgie","year":"2003","unstructured":"Kolodgie FD, Petrov A, Virmani R et al (2003) Targeting of apoptotic macrophages and experimental atheroma with radiolabeled annexin V: a technique with potential for noninvasive imaging of vulnerable plaque. Circulation 108:3134\u20133139","journal-title":"Circulation"},{"key":"677_CR3","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1056\/NEJM200404013501425","volume":"350","author":"BL Kietselaer","year":"2004","unstructured":"Kietselaer BL, Reutelingsperger CP, Heidendal GA et al (2004) Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis. N Engl J Med 350:1472\u20131473","journal-title":"N Engl J Med"},{"issue":"5","key":"677_CR4","first-page":"807","volume":"46","author":"JF Tait","year":"2005","unstructured":"Tait JF, Smith C, Blankenberg FG (2005) Structural requirements for in vivo detection of cell death with 99mTc-annexin V. J Nucl Med 46(5):807\u2013815","journal-title":"J Nucl Med"},{"key":"677_CR5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.nucmedbio.2010.09.008","volume":"38","author":"M Bauwens","year":"2011","unstructured":"Bauwens M, De Saint-Hubert M, Devos E et al (2011) Site-specific 68Ga-labeled Annexin A5 as a PET imaging agent for apoptosis. Nucl Med Biol 38:381\u2013392","journal-title":"Nucl Med Biol"},{"key":"677_CR6","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.bmc.2009.12.021","volume":"18","author":"M Saint-Hubert De","year":"2010","unstructured":"De Saint-Hubert M, Mottaghy FM, Vunckx K et al (2010) Site-specific labeling of \u2018second generation\u2019 annexin V with 99mTc(CO)3 for improved imaging of apoptosis in vivo. Bioorg Med Chem 18:1356\u20131363","journal-title":"Bioorg Med Chem"},{"key":"677_CR7","first-page":"187","volume":"57","author":"M Bauwens","year":"2013","unstructured":"Bauwens M, De Saint-Hubert M, Cleynhens J et al (2013) In vitro and in vivo comparison of 18F and 123I-labeled ML10 with 68Ga-Cys2-AnxA5 for molecular imaging of apoptosis. Q J Nucl Med Mol Imaging 57:187\u2013200","journal-title":"Q J Nucl Med Mol Imaging"},{"key":"677_CR8","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s11307-010-0412-z","volume":"13","author":"M Saint-Hubert De","year":"2010","unstructured":"De Saint-Hubert M, Wang H, Devos E et al (2010) Preclinical imaging of therapy response using metabolic and apoptosis molecular imaging. Mol Imaging Biol 13:995\u20131002","journal-title":"Mol Imaging Biol"},{"key":"677_CR9","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1016\/j.bmcl.2008.05.044","volume":"18","author":"H Fonge","year":"2008","unstructured":"Fonge H, de Saint HM, Vunckx K et al (2008) Preliminary in vivo evaluation of a novel 99mTc-labeled HYNIC-cys-annexin A5 as an apoptosis imaging agent. Bioorg Med Chem Lett 18:3794\u20133798","journal-title":"Bioorg Med Chem Lett"},{"key":"677_CR10","first-page":"1546","volume":"47","author":"JF Tait","year":"2006","unstructured":"Tait JF, Smith C, Levashova Z et al (2006) Improved detection of cell death in vivo with annexin V radiolabeled by site-specific methods. J Nucl Med 47:1546\u20131553","journal-title":"J Nucl Med"},{"key":"677_CR11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/cdd.2011.96","volume":"19","author":"L Galluzzi","year":"2011","unstructured":"Galluzzi L, Vitale I, Abrams JM et al (2011) Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 19:107\u2013120","journal-title":"Cell Death Differ"},{"key":"677_CR12","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00395-011-0192-x","volume":"106","author":"W Martinet","year":"2011","unstructured":"Martinet W, Schrijvers DM, De Meyer GR (2011) Necrotic cell death in atherosclerosis. Basic Res Cardiol 106:749\u2013760","journal-title":"Basic Res Cardiol"},{"issue":"2","key":"677_CR13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ymeth.2009.03.022","volume":"48","author":"M Saint-Hubert De","year":"2009","unstructured":"De Saint-Hubert M, Prinsen K et al (2009) Molecular imaging of cell death. Methods 48(2):178\u2013187","journal-title":"Methods"},{"key":"677_CR14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/cmmi.136","volume":"2","author":"H Fonge","year":"2007","unstructured":"Fonge H, Van de Putte M, Huyghe D, Bormans G, Ni Y, de Witte P et al (2007) Evaluation of tumor affinity of mono-[(123)I]iodohypericin and mono-[(123)I]iodoprotohypericin in a mouse model with a RIF-1 tumor. Contrast Media Mol Imaging 2:113\u2013119","journal-title":"Contrast Media Mol Imaging"},{"key":"677_CR15","doi-asserted-by":"crossref","first-page":"E129","DOI":"10.1002\/ijc.26492","volume":"131","author":"M Putte Van de","year":"2011","unstructured":"Van de Putte M, Marysael T, Fonge H et al (2011) Radiolabeled iodohypericin as tumor necrosis avid tracer: diagnostic and therapeutic potential. Int J Cancer 131:E129\u2013E137","journal-title":"Int J Cancer"},{"key":"677_CR16","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/01.CIR.103.8.1164","volume":"103","author":"JH Thusen von der","year":"2001","unstructured":"von der Thusen JH, van Berkel TJ, Biessen EA (2001) Induction of rapid atherogenesis by perivascular carotid collar placement in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice. Circulation 103:1164\u20131170","journal-title":"Circulation"},{"key":"677_CR17","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/01.ATV.5.3.293","volume":"5","author":"DN Ku","year":"1985","unstructured":"Ku DN, Giddens DP, Zarins CK, Glagov S (1985) Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress. Arteriosclerosis 5:293\u2013302","journal-title":"Arteriosclerosis"},{"key":"677_CR18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S1357-4310(98)01372-0","volume":"5","author":"JN Topper","year":"1999","unstructured":"Topper JN, Gimbrone MA Jr (1999) Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype. Mol Med Today 5:40\u201346","journal-title":"Mol Med Today"},{"key":"677_CR19","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1172\/JCI119461","volume":"99","author":"J Golledge","year":"1997","unstructured":"Golledge J, Turner RJ, Harley SL et al (1997) Circumferential deformation and shear stress induce differential responses in saphenous vein endothelium exposed to arterial flow. J Clin Invest 99:2719\u20132726","journal-title":"J Clin Invest"},{"key":"677_CR20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/01.ATV.14.1.133","volume":"14","author":"Y Nakashima","year":"1994","unstructured":"Nakashima Y, Plump AS, Raines EW et al (1994) ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb 14:133\u2013140","journal-title":"Arterioscler Thromb"},{"key":"677_CR21","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/MOL.0b013e3283395093","volume":"21","author":"D Lievens","year":"2010","unstructured":"Lievens D, Gerdes N, Schober A, Weber C (2010) Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol 21:284\u2013285","journal-title":"Curr Opin Lipidol"},{"key":"677_CR22","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1182\/blood-2010-01-261206","volume":"116","author":"D Lievens","year":"2010","unstructured":"Lievens D, Zernecke A, Seijkens T et al (2010) Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood 116:4317\u20134327","journal-title":"Blood"},{"key":"677_CR23","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.cmet.2009.03.003","volume":"9","author":"E Thorp","year":"2009","unstructured":"Thorp E, Li G, Seimon TA et al (2009) Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe\u2212\/\u2212 and Ldlr\u2212\/\u2212 mice lacking CHOP. Cell Metab 9:474\u2013481","journal-title":"Cell Metab"},{"key":"677_CR24","first-page":"1497","volume":"47","author":"S Isobe","year":"2006","unstructured":"Isobe S, Tsimikas S, Zhou J et al (2006) Noninvasive imaging of atherosclerotic lesions in apolipoprotein E-deficient and low-density-lipoprotein receptor-deficient mice with annexin A5. J Nucl Med 47:1497\u20131505","journal-title":"J Nucl Med"},{"key":"677_CR25","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2967\/jnumed.108.051847","volume":"49","author":"Y Zhao","year":"2008","unstructured":"Zhao Y, Kuge Y, Zhao S et al (2008) Prolonged high-fat feeding enhances aortic 18F-FDG and 99mTc-annexin A5 uptake in apolipoprotein E-deficient and wild-type C57BL\/6J mice. J Nucl Med 49:1707\u20131714","journal-title":"J Nucl Med"},{"key":"677_CR26","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/bc100091q","volume":"21","author":"GA Tilborg van","year":"2010","unstructured":"van Tilborg GA, Vucic E, Strijkers GJ et al (2010) Annexin A5-functionalized bimodal nanoparticles for MRI and fluorescence imaging of atherosclerotic plaques. Bioconjug Chem 21:1794\u20131803","journal-title":"Bioconjug Chem"},{"key":"677_CR27","doi-asserted-by":"crossref","first-page":"H2121","DOI":"10.1152\/ajpheart.00308.2009","volume":"298","author":"SF Ding","year":"2010","unstructured":"Ding SF, Ni M, Liu XL et al (2010) A causal relationship between shear stress and atherosclerotic lesions in apolipoprotein E knockout mice assessed by ultrasound biomicroscopy. Am J Physiol Heart Circ Physiol 298:H2121\u2013H2129","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"677_CR28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2967\/jnumed.109.068429","volume":"51","author":"H Kenis","year":"2010","unstructured":"Kenis H, Zandbergen HR, Hofstra L et al (2010) Annexin A5 uptake in ischemic myocardium: demonstration of reversible phosphatidylserine externalization and feasibility of radionuclide imaging. J Nucl Med 51:259\u2013267","journal-title":"J Nucl Med"},{"key":"677_CR29","first-page":"2051","volume":"46","author":"D Hartung","year":"2005","unstructured":"Hartung D, Sarai M, Petrov A et al (2005) Resolution of apoptosis in atherosclerotic plaque by dietary modification and statin therapy. J Nucl Med 46:2051\u20132056","journal-title":"J Nucl Med"},{"key":"677_CR30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/jlcr.812","volume":"47","author":"G Bormans","year":"2004","unstructured":"Bormans G, Huyghe D, Christiaen A et al (2004) Preparation, analysis and biodistribution in mice of iodine-123 labelled derivatives of hypericin. J Label Compd Radiopharm 47:191\u2013198","journal-title":"J Label Compd Radiopharm"},{"key":"677_CR31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/med.2610150203","volume":"15","author":"G Lavie","year":"1995","unstructured":"Lavie G, Mazur Y, Lavie D, Meruelo D (1995) The chemical and biological properties of hypericin\u2014a compound with a broad spectrum of biological activities. Med Res Rev 15:111\u2013119","journal-title":"Med Res Rev"},{"key":"677_CR32","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1016\/j.bmc.2010.05.050","volume":"18","author":"K Prinsen","year":"2010","unstructured":"Prinsen K, Li J, Vanbilloen H, Vermaelen P et al (2010) Development and evaluation of a 68Ga labeled pamoic acid derivative for in vivo visualization of necrosis using positron emission tomography. Bioorg Med Chem 18:5274\u20135281","journal-title":"Bioorg Med Chem"},{"key":"677_CR33","doi-asserted-by":"crossref","first-page":"H1397","DOI":"10.1152\/ajpheart.00583.2012","volume":"303","author":"A Phinikaridou","year":"2012","unstructured":"Phinikaridou A, Andia ME, Shah AM, Botnar RM (2012) Advances in molecular imaging of atherosclerosis and myocardial infarction: shedding new light on in vivo cardiovascular biology. Am J Physiol Heart Circ Physiol 303:H1397\u2013H1410","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-013-0677-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11307-013-0677-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-013-0677-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T09:36:30Z","timestamp":1559381790000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11307-013-0677-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,24]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["677"],"URL":"https:\/\/doi.org\/10.1007\/s11307-013-0677-0","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,24]]}}}