{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:47:09Z","timestamp":1788565629419,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T00:00:00Z","timestamp":1471910400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s11307-016-1000-7","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T11:46:11Z","timestamp":1471952771000},"page":"298-304","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Peritumoral Brain Edema in Meningiomas Depends on Aquaporin-4 Expression and Not on Tumor Grade, Tumor Volume, Cell Count, or Ki-67 Labeling Index"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1229-3352","authenticated-orcid":false,"given":"Matthias","family":"Gawlitza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhard","family":"Fiedler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Titus","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Surov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,23]]},"reference":[{"key":"1000_CR1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1227\/01.NEU.0000188281.91351.B9","volume":"57","author":"EB Claus","year":"2005","unstructured":"Claus EB, Bondy ML, Schildkraut JM, et al. (2005) Epidemiology of intracranial meningioma. Neurosurgery 57:1088\u20131095","journal-title":"Neurosurgery"},{"key":"1000_CR2","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0140-6736(04)16153-9","volume":"363","author":"IR Whittle","year":"2004","unstructured":"Whittle IR, Smith C, Navoo P, Collie D (2004) Meningiomas. Lancet 363:1535\u20131543","journal-title":"Lancet"},{"key":"1000_CR3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11060-013-1074-x","volume":"112","author":"A Surov","year":"2013","unstructured":"Surov A, Gottschling S, Bolz J, et al. (2013) Distant metastases in meningioma: an underestimated problem. J Neuro-Oncol 112:323\u2013327","journal-title":"J Neuro-Oncol"},{"key":"1000_CR4","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.4238\/vol10-3gmr1212","volume":"10","author":"P Wang","year":"2011","unstructured":"Wang P, Ni RY, Chen MN, et al. (2011) Expression of aquaporin-4 in human supratentorial meningiomas with peritumoral brain edema and correlation of VEGF with edema formation. Genet Mol Res 10:2165\u20132171","journal-title":"Genet Mol Res"},{"key":"1000_CR5","first-page":"337","volume":"39","author":"M Alaywan","year":"1993","unstructured":"Alaywan M, Sindou M (1993) Prognostic factors in the surgery for intracranial meningioma. Role of the tumoral size and arterial vascularization originating from the pia mater. Study of 150 cases. Neurochirurgie 39:337\u2013347","journal-title":"Neurochirurgie"},{"key":"1000_CR6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jocn.2008.04.028","volume":"16","author":"WH Ng","year":"2009","unstructured":"Ng WH, Hy JW, Tan WL, et al. (2009) Aquaporin-4 expression is increased in edematous meningiomas. J Clin Neurosci 16:441\u2013443","journal-title":"J Clin Neurosci"},{"key":"1000_CR7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3171\/jns.2006.104.3.382","volume":"104","author":"M Tanaka","year":"2006","unstructured":"Tanaka M, Imhof HG, Schucknecht B, et al. (2006) Correlation between the efferent venous drainage of the tumor and peritumoral edema in intracranial meningiomas: superselective angiographic analysis of 25 cases. J Neurosurg 104:382\u2013388","journal-title":"J Neurosurg"},{"key":"1000_CR8","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1097\/00006123-199706000-00029","volume":"40","author":"CK Goldman","year":"1997","unstructured":"Goldman CK, Bharara S, Palmer CA, et al. (1997) Brain edema in meningiomas is associated with increased vascular endothelial growth factor expression. Neurosurgery 40:1269\u20131277","journal-title":"Neurosurgery"},{"key":"1000_CR9","doi-asserted-by":"crossref","first-page":"646853","DOI":"10.1155\/2015\/646853","volume":"2015","author":"J Reszec","year":"2015","unstructured":"Reszec J, Hermanowicz A, Rutkowski R, et al. (2015) Expression of MMP-9 and VEGF in meningiomas and their correlation with peritumoral brain edema. BioMed Res Int 2015:646853","journal-title":"BioMed Res Int"},{"key":"1000_CR10","doi-asserted-by":"crossref","first-page":"e11231","DOI":"10.1371\/journal.pone.0011231","volume":"5","author":"K Zhou","year":"2010","unstructured":"Zhou K, Wang G, Wang Y, et al. (2010) The potential involvement of E-cadherin and beta-catenins in meningioma. PLoS One 5:e11231","journal-title":"PLoS One"},{"key":"1000_CR11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.68.1.425","volume":"68","author":"M Borgnia","year":"1999","unstructured":"Borgnia M, Nielsen S, Engel A, Agre P (1999) Cellular and molecular biology of the aquaporin water channels. Annu Rev Biochem 68:425\u2013458","journal-title":"Annu Rev Biochem"},{"key":"1000_CR12","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.bbagen.2013.10.032","volume":"1840","author":"J Badaut","year":"2014","unstructured":"Badaut J, Fukuda AM, Jullienne A, Petry KG (2014) Aquaporin and brain diseases. Biochim Biophys Acta 1840:1554\u20131565","journal-title":"Biochim Biophys Acta"},{"key":"1000_CR13","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00004647-200204000-00001","volume":"22","author":"J Badaut","year":"2002","unstructured":"Badaut J, Lasbennes F, Magistretti PJ, Regli L (2002) Aquaporins in brain: distribution, physiology, and pathophysiology. J Cereb Blood Flow Metab 22:367\u2013378","journal-title":"J Cereb Blood Flow Metab"},{"key":"1000_CR14","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/jnnp.72.2.262","volume":"72","author":"S Saadoun","year":"2002","unstructured":"Saadoun S, Papadopoulos M, Davies D, et al. (2002) Aquaporin-4 expression is increased in oedematous human brain tumours. J Neurol Neurosurg Psychiatry 72:262\u2013265","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1000_CR15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11060-012-0989-y","volume":"111","author":"T Osawa","year":"2013","unstructured":"Osawa T, Tosaka M, Nagaishi M, Yoshimoto Y (2013) Factors affecting peritumoral brain edema in meningioma: special histological subtypes with prominently extensive edema. J Neuro-Oncol 111:49\u201357","journal-title":"J Neuro-Oncol"},{"key":"1000_CR16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00701-003-0173-4","volume":"146","author":"F Roser","year":"2004","unstructured":"Roser F, Samii M, Ostertag H, Bellinzona M (2004) The Ki-67 proliferation antigen in meningiomas. Experience in 600 cases. Acta Neurochir 146:37\u201344 discussion 44","journal-title":"Acta Neurochir"},{"key":"1000_CR17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1365-2133.2008.08608.x","volume":"159","author":"E Fiedler","year":"2008","unstructured":"Fiedler E, Helmbold P, Marsch WC (2008) Increased vessel density in psoriasis: involvement of lymphatic vessels in the papillary dermis. Br J Dermatol 159:258\u2013261","journal-title":"Br J Dermatol"},{"key":"1000_CR18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10143-003-0261-1","volume":"26","author":"PH Aguiar","year":"2003","unstructured":"Aguiar PH, Tsanaclis AM, Jr OIT, Plese JP (2003) Proliferation rate of intracranial meningiomas as defined by the monoclonal antibody MIB-1. Neurosurg Rev 26:221\u2013228","journal-title":"Neurosurg Rev"},{"key":"1000_CR19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/72256","volume":"6","author":"GT Manley","year":"2000","unstructured":"Manley GT, Fujimura M, Ma T, et al. (2000) Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 6:159\u2013163","journal-title":"Nat Med"},{"key":"1000_CR20","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.bbamem.2006.02.018","volume":"1758","author":"AS Verkman","year":"2006","unstructured":"Verkman AS, Binder DK, Bloch O, et al. (2006) Three distinct roles of aquaporin-4 in brain function revealed by knockout mice. Biochim Biophys Acta 1758:1085\u20131093","journal-title":"Biochim Biophys Acta"},{"key":"1000_CR21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/(SICI)1097-0142(19960701)78:1<133::AID-CNCR19>3.0.CO;2-0","volume":"78","author":"M Ide","year":"1996","unstructured":"Ide M, Jimbo M, Yamamoto M, et al. (1996) MIB-1 staining index and peritumoral brain edema of meningiomas. Cancer 78:133\u2013143","journal-title":"Cancer"},{"key":"1000_CR22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3340\/jkns.2011.49.1.26","volume":"49","author":"B-W Kim","year":"2011","unstructured":"Kim B-W, Kim M-S, Kim S-W, et al. (2011) Peritumoral brain edema in meningiomas\u202f: correlation of radiologic and pathologic features. J Korean Neurosurg Soc 49:26\u201330","journal-title":"J Korean Neurosurg Soc"},{"key":"1000_CR23","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/BF00333435","volume":"28","author":"GB Bradac","year":"1986","unstructured":"Bradac GB, Ferszt R, Bender A, Sch\u00f6rner W (1986) Peritumoral edema in meningiomas. Neuroradiology 28:304\u2013312","journal-title":"Neuroradiology"},{"key":"1000_CR24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0090-3019(87)90109-1","volume":"27","author":"F Maiuri","year":"1987","unstructured":"Maiuri F, Gangemi M, Cirillo S, et al. (1987) Cerebral edema associated with meningiomas. Surg Neurol 27:64\u201368","journal-title":"Surg Neurol"},{"key":"1000_CR25","first-page":"1046","volume":"49","author":"T Tamiya","year":"2001","unstructured":"Tamiya T, Ono Y, Matsumoto K, Ohmoto T (2001) Peritumoral brain edema in intracranial meningiomas: effects of radiological and histological factors. Neurosurgery 49:1046\u20131052","journal-title":"Neurosurgery"},{"key":"1000_CR26","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/BF01411166","volume":"138","author":"RD Lobato","year":"1996","unstructured":"Lobato RD, Alday R, G\u00f3mez PA, et al. (1996) Brain oedema in patients with intracranial meningioma. Acta Neurochir 138:485\u2013494","journal-title":"Acta Neurochir"},{"key":"1000_CR27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/BF01401825","volume":"125","author":"J Vries de","year":"1993","unstructured":"de Vries J, Wakhloo AK (1993) Cerebral oedema associated with WHO-I, WHO-II, and WHO-III-meningiomas: correlation of clinical, computed tomographic, operative and histological findings. Acta Neurochir 125:34\u201340","journal-title":"Acta Neurochir"},{"key":"1000_CR28","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jocn.2004.09.029","volume":"12","author":"D Gurkanlar","year":"2005","unstructured":"Gurkanlar D, Er U, Sanli M, et al. (2005) Peritumoral brain edema in intracranial meningiomas. J Clin Neurosci 12:750\u2013753","journal-title":"J Clin Neurosci"},{"key":"1000_CR29","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.surneu.2007.03.027","volume":"69","author":"K-J Lee","year":"2008","unstructured":"Lee K-J, Joo W-I, Rha H-K, et al. (2008) Peritumoral brain edema in meningiomas: correlations between magnetic resonance imaging, angiography, and pathology. Surg Neurol 69:350\u2013355","journal-title":"Surg Neurol"},{"key":"1000_CR30","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1161\/STROKEAHA.114.007343","volume":"46","author":"AJS Webb","year":"2015","unstructured":"Webb AJS, Ullman NL, Morgan TC, et al. (2015) Accuracy of the ABC\/2 score for intracerebral hemorrhage: systematic review and analysis of MISTIE, CLEAR-IVH, and CLEAR III. Stroke 46:2470\u20132476","journal-title":"Stroke"},{"key":"1000_CR31","doi-asserted-by":"crossref","first-page":"e0140065","DOI":"10.1371\/journal.pone.0140065","volume":"10","author":"JB Fiebach","year":"2015","unstructured":"Fiebach JB, Stief JD, Ganeshan R, et al. (2015) Reliability of two diameters method in determining acute infarct size. Validation as new imaging biomarker. PLoS One 10:e0140065","journal-title":"PLoS One"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-016-1000-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11307-016-1000-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-016-1000-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-016-1000-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T17:13:41Z","timestamp":1498324421000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11307-016-1000-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,23]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["1000"],"URL":"https:\/\/doi.org\/10.1007\/s11307-016-1000-7","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,23]]}}}