{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T13:24:53Z","timestamp":1793453093185,"version":"4.5.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Better Than Ever Program - University of Arizona Cancer Center"},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01CA169774"],"award-info":[{"award-number":["R01CA169774"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL007955"],"award-info":[{"award-number":["T32HL007955"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL066988"],"award-info":[{"award-number":["T32HL066988"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s11307-016-1029-7","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T15:33:59Z","timestamp":1480347239000},"page":"617-625","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Clinical Translation of Tumor Acidosis Measurements with AcidoCEST MRI"],"prefix":"10.1007","volume":"19","author":[{"given":"Kyle M.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Randtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko S.","family":"Yoshimaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Howison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavani","family":"Chalasani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuko K.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip H.","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Pagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"1029_CR1","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O (1956) On the origin of cancer cells. Science 123:309\u2013314","journal-title":"Science"},{"key":"1029_CR2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/206405","author":"LQ Chen","year":"2015","unstructured":"Chen LQ, Pagel MD (2015) Evaluating pH in the extracellular tumor microenvironment using CEST MRI and other imaging methods. Adv Radiol. doi:\n                    10.1155\/2015\/206405","journal-title":"Adv Radiol"},{"key":"1029_CR3","doi-asserted-by":"publisher","first-page":"5216","DOI":"10.1158\/0008-5472.CAN-05-4193","volume":"66","author":"RA Gatenby","year":"2006","unstructured":"Gatenby RA, Gawlinski ET, Gmitro AF et al (2006) Acid mediated tumor invasion: a multidisciplinary study. Cancer Res 66:5216\u20135223","journal-title":"Cancer Res"},{"key":"1029_CR4","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1158\/0008-5472.CAN-12-2796","volume":"73","author":"V Estrella","year":"2013","unstructured":"Estrella V, Chen T, Lloyd M (2013) Acidity generated by the tumor microenvironment drives local invasion. Cancer Res 73:1524\u20131535","journal-title":"Cancer Res"},{"key":"1029_CR5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.4172\/1948-5956.1000382","volume":"8","author":"PA Akhenblit","year":"2016","unstructured":"Akhenblit PA, Pagel MD (2016) Recent advances in targeting tumor energy metabolism with tumor acidosis as a biomarker of drug efficacy. J Cancer Sci Therapy 8:20\u201329","journal-title":"J Cancer Sci Therapy"},{"key":"1029_CR6","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1002\/mrm.25053","volume":"72","author":"LQ Chen","year":"2013","unstructured":"Chen LQ, Howison CM, Jeffery JJ (2013) Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI. Magn Reson Med 72:1408\u20131417","journal-title":"Magn Reson Med"},{"key":"1029_CR7","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1002\/mrm.23038","volume":"67","author":"VR Sheth","year":"2012","unstructured":"Sheth VR, Li Y, Chen LQ (2012) Measuring in vivo tumor pHe with CEST-FISP MRI. Magn Reson Med 67:760\u2013768","journal-title":"Magn Reson Med"},{"key":"1029_CR8","first-page":"47","volume":"1","author":"G Liu","year":"2012","unstructured":"Liu G, Li Y, Sheth VR, Pagel MD (2012) Imaging in vivo extracellular pH with a single PARACEST MRI contrast agent. Mol Imaging 1:47\u201357","journal-title":"Mol Imaging"},{"key":"1029_CR9","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/cmmi.460","volume":"1","author":"VR Sheth","year":"2012","unstructured":"Sheth VR, Liu G, Li Y, Pagel MD (2012) Improved pH measurements with a single PARACEST MRI contrast agent. Contrast Media Mol Imaging 1:26\u201334","journal-title":"Contrast Media Mol Imaging"},{"key":"1029_CR10","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1002\/mrm.20441","volume":"53","author":"S Aime","year":"2005","unstructured":"Aime S, Calabi L, Biondi L (2005) Iopamidol: exploring the potential use of a well-established x ray contrast agent for MRI. Magn Reson Med 53:830\u2013834","journal-title":"Magn Reson Med"},{"key":"1029_CR11","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/mrm.1910350106","volume":"1","author":"E Liepinsh","year":"1996","unstructured":"Liepinsh E, Otting G (1996) Proton exchange rates from amino acid side chains\u2014implications for image contrast. Magn Reson Med 1:30\u201342","journal-title":"Magn Reson Med"},{"key":"1029_CR12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s11307-014-0784-6","volume":"2","author":"KM Jones","year":"2015","unstructured":"Jones KM, Randtke ER, Howison CM et al (2015) Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI. Mol Imaging and Biol 2:177\u2013184","journal-title":"Mol Imaging and Biol"},{"key":"1029_CR13","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1002\/mrm.20408","volume":"53","author":"DE Woessner","year":"2005","unstructured":"Woessner DE, Zhang S, Merritt MEG, Sherry AD (2005) Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI. Magn Reson Med 53:790\u2013799","journal-title":"Magn Reson Med"},{"key":"1029_CR14","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1002\/cmmi.1647","volume":"10","author":"BF Moon","year":"2015","unstructured":"Moon BF, Jones KM, Chen LQ et al (2015) A comparison of iopromide and iopamidol, two acidoCEST MRI contrast media that measure tumor extracellular pH. Contrast Media Mol Imaging 10:446\u2013455","journal-title":"Contrast Media Mol Imaging"},{"key":"1029_CR15","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1002\/cmmi.1672","volume":"11","author":"DV Hingorani","year":"2015","unstructured":"Hingorani DV, Montano LA, Randtke EA et al (2015) A single diamagnetic catalyCEST MRI contrast agent that detects cathepsin B enzyme activity by using a ratio of two CEST signals. Contrast Media Mol Imaging 11:130\u2013138","journal-title":"Contrast Media Mol Imaging"},{"key":"1029_CR16","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jmr.2014.03.008","volume":"243","author":"J Dopfert","year":"2014","unstructured":"Dopfert J, Zaiss M, Witte C, Schroeder L (2014) Ultrafast CEST imaging. J Magn Reson 243:47\u201353","journal-title":"J Magn Reson"},{"key":"1029_CR17","doi-asserted-by":"crossref","unstructured":"Muller-Lutz A, Khalil N, Schmitt B et al (2014) Pilot study of iopamidol-based quantitative pH imaging on a clinical 3\u00a0T MR scanner. Magn Reson Mater Phy 27:477\u2013485","DOI":"10.1007\/s10334-014-0433-8"},{"key":"1029_CR18","doi-asserted-by":"crossref","unstructured":"Harston GWJ, Tee YK, Blockley N et al (2015) Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging. \u00a0Brain A J Neurol 138:36-42","DOI":"10.1093\/brain\/awu374"},{"key":"1029_CR19","unstructured":"Ma B, Blakeley JO, Hong X et al (2016) Applying amide proton transfer-weighted MRI to distinguish pseudoprogression from true progression in malignant gliomas. J Magn Reson Imaging. doi:10.1002\/jmri.2515"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11307-016-1029-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-016-1029-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-016-1029-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T17:14:42Z","timestamp":1589649282000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11307-016-1029-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,28]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["1029"],"URL":"https:\/\/doi.org\/10.1007\/s11307-016-1029-7","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,28]]},"assertion":[{"value":"28 November 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}