{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:29:44Z","timestamp":1790764184445,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T00:00:00Z","timestamp":1517529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s11307-018-1162-6","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T14:51:48Z","timestamp":1517583108000},"page":"562-574","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Anatomy, Functionality, and Neuronal Connectivity with Manganese Radiotracers for Positron Emission Tomography"],"prefix":"10.1007","volume":"20","author":[{"given":"Galit","family":"Saar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina M.","family":"Millo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence P.","family":"Szajek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Herscovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan P.","family":"Koretsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,2]]},"reference":[{"issue":"3","key":"1162_CR1","doi-asserted-by":"publisher","first-page":"E573","DOI":"10.1152\/ajpendo.90336.2008","volume":"296","author":"PF Antkowiak","year":"2009","unstructured":"Antkowiak PF, Tersey SA, Carter JD, Vandsburger MH, Nadler JL, Epstein FH, Mirmira RG (2009) Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging. Am J Physiol Endocrinol Metab 296(3):E573\u2013E578. \n                    https:\/\/doi.org\/10.1152\/ajpendo.90336.2008","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"1162_CR2","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1002\/mrm.20516","volume":"54","author":"TC Hu","year":"2005","unstructured":"Hu TC, Christian TF, Aletras AH et al (2005) Manganese enhanced magnetic resonance imaging of normal and ischemic canine heart. Magn Reson Med 54(1):196\u2013200. \n                    https:\/\/doi.org\/10.1002\/mrm.20516","journal-title":"Magn Reson Med"},{"issue":"5","key":"1162_CR3","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1097\/00004424-198409000-00012","volume":"19","author":"YS Kang","year":"1984","unstructured":"Kang YS, Gore JC (1984) Studies of tissue NMR relaxation enhancement by manganese. Dose Time Depend Invest Radiol 19(5):399\u2013407. \n                    https:\/\/doi.org\/10.1097\/00004424-198409000-00012","journal-title":"Dose Time Depend Invest Radiol"},{"key":"1162_CR4","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1080\/02841859709172402","volume":"38","author":"Y Ni","year":"1997","unstructured":"Ni Y, Petre C, Bosmans H et al (1997) Comparison of manganese biodistribution and MR contrast enhancement in rats after intravenous injection of MnDPDP and MnCl2. Acta Radiol 38:700\u2013707","journal-title":"Acta Radiol"},{"issue":"3","key":"1162_CR5","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.neuroimage.2004.03.031","volume":"22","author":"I Aoki","year":"2004","unstructured":"Aoki I, Wu YJ, Silva AC et al (2004) In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI. NeuroImage 22(3):1046\u20131059. \n                    https:\/\/doi.org\/10.1016\/j.neuroimage.2004.03.031","journal-title":"NeuroImage"},{"issue":"5","key":"1162_CR6","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1002\/mrm.10276","volume":"48","author":"T Watanabe","year":"2002","unstructured":"Watanabe T, Natt O, Boretius S, Frahm J, Michaelis T (2002) In vivo 3D MRI staining of mouse brain after subcutaneous application of MnCl2. Magn Reson Med 48(5):852\u2013859. \n                    https:\/\/doi.org\/10.1002\/mrm.10276","journal-title":"Magn Reson Med"},{"key":"1162_CR7","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/mrm.10320","volume":"48","author":"I Aoki","year":"2002","unstructured":"Aoki I, Tanaka C, Takegami T et al (2002) Dynamic activity-induced manganese-dependent contrast magnetic resonance imaging (DAIM MRI). Magn Reson Med 48:927\u2013933","journal-title":"Magn Reson Med"},{"issue":"5","key":"1162_CR8","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1002\/mrm.1273","volume":"46","author":"TC Hu","year":"2001","unstructured":"Hu TC, Pautler RG, MacGowan GA, Koretsky AP (2001) Manganese-enhanced MRI of mouse heart during changes in inotropy. Magn Reson Med 46(5):884\u2013890. \n                    https:\/\/doi.org\/10.1002\/mrm.1273","journal-title":"Magn Reson Med"},{"issue":"3","key":"1162_CR9","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/mrm.1910380305","volume":"38","author":"YJ Lin","year":"1997","unstructured":"Lin YJ, Koretsky AP (1997) Manganese ion enhances T1-weighted MRI during brain activation: an approach to direct imaging of brain function. Magn Reson Med 38(3):378\u2013388. \n                    https:\/\/doi.org\/10.1002\/mrm.1910380305","journal-title":"Magn Reson Med"},{"issue":"5","key":"1162_CR10","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1002\/mrm.1910400515","volume":"40","author":"RG Pautler","year":"1998","unstructured":"Pautler RG, Silva AC, Koretsky AP (1998) In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging. Magn Reson Med 40(5):740\u2013748. \n                    https:\/\/doi.org\/10.1002\/mrm.1910400515","journal-title":"Magn Reson Med"},{"key":"1162_CR11","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/mrm.1209","volume":"46","author":"T Watanabe","year":"2001","unstructured":"Watanabe T, Michaelis T, Frahm J (2001) Mapping of retinal projections in the living rat using high-resolution 3D gradient-echo MRI with Mn2+-induced contrast. Magn Reson Med 46:424\u2013429","journal-title":"Magn Reson Med"},{"issue":"5","key":"1162_CR12","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.mri.2008.10.006","volume":"27","author":"KH Chuang","year":"2009","unstructured":"Chuang KH, Koretsky AP (2009) Accounting for nonspecific enhancement in neuronal tract tracing using manganese enhanced magnetic resonance imaging. Magn Reson Imaging 27(5):594\u2013600. \n                    https:\/\/doi.org\/10.1016\/j.mri.2008.10.006","journal-title":"Magn Reson Imaging"},{"key":"1162_CR13","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1016\/j.neuroimage.2004.07.038","volume":"23","author":"DJ Cross","year":"2004","unstructured":"Cross DJ, Minoshima S, Anzai Y et al (2004) Statistical mapping of functional olfactory connections of the rat brain in vivo. NeuroImage 23:1326\u20131335","journal-title":"NeuroImage"},{"key":"1162_CR14","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.mri.2005.12.031","volume":"24","author":"Y Murayama","year":"2006","unstructured":"Murayama Y, Weber B, Saleem KS et al (2006) Tracing neural circuits in vivo with Mn-enhanced MRI. Magn Reson Imaging 24:349\u2013358","journal-title":"Magn Reson Imaging"},{"key":"1162_CR15","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S0306-4522(02)00070-2","volume":"112","author":"A Linden Van der","year":"2002","unstructured":"Van der Linden A, Verhoye M, Van Meir V et al (2002) In vivo manganese-enhanced magnetic resonance imaging reveals connections and functional properties of the songbird vocal control system. Neuroscience 112:467\u2013474","journal-title":"Neuroscience"},{"issue":"5","key":"1162_CR16","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/nbm.834","volume":"16","author":"PR Allegrini","year":"2003","unstructured":"Allegrini PR, Wiessner C (2003) Three-dimensional MRI of cerebral projections in rat brain in vivo after intracortical injection of MnCl2. NMR Biomed 16(5):252\u2013256. \n                    https:\/\/doi.org\/10.1002\/nbm.834","journal-title":"NMR Biomed"},{"issue":"3","key":"1162_CR17","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.neuroimage.2008.07.036","volume":"44","author":"J Tucciarone","year":"2009","unstructured":"Tucciarone J, Chuang KH, Dodd SJ, Silva A, Pelled G, Koretsky AP (2009) Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI. NeuroImage 44(3):923\u2013931. \n                    https:\/\/doi.org\/10.1016\/j.neuroimage.2008.07.036","journal-title":"NeuroImage"},{"issue":"5","key":"1162_CR18","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S0896-6273(02)00718-3","volume":"34","author":"KS Saleem","year":"2002","unstructured":"Saleem KS, Pauls JM, Augath M, Trinath T, Prause BA, Hashikawa T, Logothetis NK (2002) Magnetic resonance imaging of neuronal connections in the macaque monkey. Neuron 34(5):685\u2013700. \n                    https:\/\/doi.org\/10.1016\/S0896-6273(02)00718-3","journal-title":"Neuron"},{"key":"1162_CR19","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/mrm.10498","volume":"50","author":"RG Pautler","year":"2003","unstructured":"Pautler RG, Mongeau R, Jacobs RE (2003) In vivo trans-synaptic tract tracing from the murine striatum and amygdala utilizing manganese enhanced MRI (MEMRI). Magn Reson Med 50:33\u201339","journal-title":"Magn Reson Med"},{"issue":"1","key":"1162_CR20","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/1522-2586(200007)12:1<186::AID-JMRI21>3.0.CO;2-2","volume":"12","author":"MP Federle","year":"2000","unstructured":"Federle MP, Chezmar JL, Rubin DL, Weinreb JC, Freeny PC, Semelka RC, Brown JJ, Borrello JA, Lee JKT, Mattrey R, Dachman AH, Saini S, Harmon B, Fenstermacher M, Pelsang RE, Harms SE, Mitchell DG, Halford III HH, Anderson MW, Johnson CD, Francis IR, Bova JG, Kenney PJ, Klippenstein DL, Foster GS, Turner DA, Stillman AE, Nelson RC, Young SW, Patt RH, Rifkin M, Seltzer SE, Gay SB, Robison RO, Sherwin PF, Ballerini R (2000) Safety and efficacy of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: results of the U.S. multicenter phase III clinical trials (safety). J Magn Reson Imaging 12(1):186\u2013197. \n                    https:\/\/doi.org\/10.1002\/1522-2586(200007)12:1<186::AID-JMRI21>3.0.CO;2-2","journal-title":"J Magn Reson Imaging"},{"issue":"3","key":"1162_CR21","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/jmri.21065","volume":"26","author":"A Skjold","year":"2007","unstructured":"Skjold A, Amundsen BH, Wiseth R, St\u00f8ylen A, Haraldseth O, Larsson HBW, Jynge P (2007) Manganese dipyridoxyl-diphosphate (MnDPDP) as a viability marker in patients with myocardial infarction. J Magn Reson Imaging 26(3):720\u2013727. \n                    https:\/\/doi.org\/10.1002\/jmri.21065","journal-title":"J Magn Reson Imaging"},{"key":"1162_CR22","doi-asserted-by":"publisher","first-page":"717","DOI":"10.2214\/ajr.179.3.1790717","volume":"179","author":"W Schima","year":"2002","unstructured":"Schima W, Fugger R, Schober E et al (2002) Diagnosis and staging of pancreatic cancer: comparison of mangafodipir trisodium-enhanced MR imaging and contrast-enhanced helical hydro-CT. AJR Am J Roentgenol 179:717\u2013724","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"1162_CR23","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1172\/JCI106487","volume":"50","author":"DK Dastur","year":"1971","unstructured":"Dastur DK, Manghani DK, Raghavendran KV (1971) Distribution and fate of 54Mn in the monkey: studies of differnnt parts of the central nervous system and other organs. J Clin Invest 50(1):9\u201320. \n                    https:\/\/doi.org\/10.1172\/JCI106487","journal-title":"J Clin Invest"},{"issue":"3","key":"1162_CR24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/j.1600-0773.1983.tb01087.x","volume":"52","author":"A Lyden","year":"1983","unstructured":"Lyden A, Larsson BS, Lindquist NG (1983) Autoradiography of manganese: accumulation and retention in the pancreas. Acta Pharmacol Toxicol (Copenh) 52(3):205\u2013210","journal-title":"Acta Pharmacol Toxicol (Copenh)"},{"issue":"1-2","key":"1162_CR25","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/0006-8993(94)90959-8","volume":"657","author":"WN Sloot","year":"1994","unstructured":"Sloot WN, Gramsbergen JB (1994) Axonal transport of manganese and its relevance to selective neurotoxicity in the rat basal ganglia. Brain Res 657(1-2):124\u2013132. \n                    https:\/\/doi.org\/10.1016\/0006-8993(94)90959-8","journal-title":"Brain Res"},{"key":"1162_CR26","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/j.1600-0773.1996.tb00021.x","volume":"79","author":"H Tjalve","year":"1996","unstructured":"Tjalve H, Henriksson J, Tallkvist J et al (1996) Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats. Pharmacol Toxicol 79:347\u2013356","journal-title":"Pharmacol Toxicol"},{"issue":"2","key":"1162_CR27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0361-9230(97)00330-4","volume":"45","author":"A Takeda","year":"1998","unstructured":"Takeda A, Kodama Y, Ishiwatari S, Okada S (1998) Manganese transport in the neural circuit of rat CNS. Brain Res Bull 45(2):149\u2013152. \n                    https:\/\/doi.org\/10.1016\/S0361-9230(97)00330-4","journal-title":"Brain Res Bull"},{"issue":"2","key":"1162_CR28","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1212\/WNL.17.2.128","volume":"17","author":"I Mena","year":"1967","unstructured":"Mena I, Marin O, Fuenzalida S, Cotzias GC (1967) Chronic manganese poisoning. Clinical picture and manganese turnover. Neurology 17(2):128\u2013136. \n                    https:\/\/doi.org\/10.1212\/WNL.17.2.128","journal-title":"Neurology"},{"issue":"3","key":"1162_CR29","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1172\/JCI105760","volume":"47","author":"JP Mahoney","year":"1968","unstructured":"Mahoney JP, Small WJ (1968) Studies on manganese. 3. The biological half-life of radiomanganese in man and factors which affect this half-life. J Clin Invest 47(3):643\u2013653. \n                    https:\/\/doi.org\/10.1172\/JCI105760","journal-title":"J Clin Invest"},{"key":"1162_CR30","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1148\/133.3.769","volume":"133","author":"HL Atkins","year":"1979","unstructured":"Atkins HL, Som P, Fairchild RG et al (1979) Myocardial positron tomography with manganese-52m. Radiology 133:769\u2013774","journal-title":"Radiology"},{"issue":"9","key":"1162_CR31","first-page":"933","volume":"18","author":"DM Chauncey Jr","year":"1977","unstructured":"Chauncey DM Jr, Schelbert HR, Halpern SE et al (1977) Tissue distribution studies with radioactive manganese: a potential agent for myocardial imaging. J Nucl Med 18(9):933\u2013936","journal-title":"J Nucl Med"},{"issue":"4","key":"1162_CR32","doi-asserted-by":"publisher","DOI":"10.1118\/1.4793756","volume":"40","author":"GJ Topping","year":"2013","unstructured":"Topping GJ, Schaffer P, Hoehr C, Ruth TJ, Sossi V (2013) Manganese-52 positron emission tomography tracer characterization and initial results in phantoms and in vivo. Med Phys 40(4):042502. \n                    https:\/\/doi.org\/10.1118\/1.4793756","journal-title":"Med Phys"},{"key":"1162_CR33","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1002\/cmmi.1701","volume":"11","author":"CL Brunnquell","year":"2016","unstructured":"Brunnquell CL, Hernandez R, Graves SA et al (2016) Uptake and retention of manganese contrast agents for PET and MRI in the rodent brain. Contrast Media Mol Imaging 11:371\u2013380","journal-title":"Contrast Media Mol Imaging"},{"key":"1162_CR34","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1021\/acs.bioconjchem.5b00414","volume":"26","author":"SA Graves","year":"2015","unstructured":"Graves SA, Hernandez R, Fonslet J et al (2015) Novel preparation methods of (52)Mn for ImmunoPET imaging. Bioconjug Chem 26:2118\u20132124","journal-title":"Bioconjug Chem"},{"issue":"8","key":"1162_CR35","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.2337\/db16-1285","volume":"66","author":"R Hernandez","year":"2017","unstructured":"Hernandez R, Graves SA, Gregg T, VanDeusen HR, Fenske RJ, Wienkes HN, England CG, Valdovinos HF, Jeffery JJ, Barnhart TE, Severin GW, Nickles RJ, Kimple ME, Merrins MJ, Cai W (2017) Radiomanganese PET detects changes in functional beta-cell mass in mouse models of diabetes. Diabetes 66(8):2163\u20132174. \n                    https:\/\/doi.org\/10.2337\/db16-1285","journal-title":"Diabetes"},{"issue":"8","key":"1162_CR36","doi-asserted-by":"publisher","first-page":"4056","DOI":"10.1002\/mp.12300","volume":"44","author":"GJ Topping","year":"2017","unstructured":"Topping GJ, Yung A, Schaffer P, Hoehr C, Kornelsen R, Kozlowski P, Sossi V (2017) Manganese concentration mapping in the rat brain with MRI, PET, and autoradiography. Med Phys 44(8):4056\u20134067. \n                    https:\/\/doi.org\/10.1002\/mp.12300","journal-title":"Med Phys"},{"key":"1162_CR37","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.neuroimage.2017.06.058","volume":"158","author":"H Napieczynska","year":"2017","unstructured":"Napieczynska H, Severin GW, Fonslet J, Wiehr S, Menegakis A, Pichler BJ, Calaminus C (2017) Imaging neuronal pathways with 52Mn PET: toxicity evaluation in rats. NeuroImage 158:112\u2013125. \n                    https:\/\/doi.org\/10.1016\/j.neuroimage.2017.06.058","journal-title":"NeuroImage"},{"key":"1162_CR38","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1524\/ract.2002.90.3_2002.167","volume":"90","author":"ATJ Klein","year":"2002","unstructured":"Klein ATJ, Rosch F, Coenen HH, Qaim SM (2002) Production of the positron emitter Mn-51 via the Cr-50(d, n) reaction: targetry and separation of no-carrier-added radiomanganese. Radiochim Acta 90:167\u2013177","journal-title":"Radiochim Acta"},{"issue":"4","key":"1162_CR39","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/0020-708X(81)90060-0","volume":"32","author":"CS Sastri","year":"1981","unstructured":"Sastri CS, Petri H, Kueppers G, Erdtmann G (1981) Production of Mn-52 of high isotopic purity by He-3-activation of vanadium. Int J Appl Radiat Isot 32(4):246\u2013247. \n                    https:\/\/doi.org\/10.1016\/0020-708X(81)90060-0","journal-title":"Int J Appl Radiat Isot"},{"key":"1162_CR40","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3727\/000000006783982151","volume":"15","author":"B Gimi","year":"2006","unstructured":"Gimi B, Leoni L, Oberholzer J et al (2006) Functional MR microimaging of pancreatic beta-cell activation. Cell Transplant 15:195\u2013203","journal-title":"Cell Transplant"},{"issue":"10","key":"1162_CR41","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1002\/nbm.1542","volume":"23","author":"L Leoni","year":"2010","unstructured":"Leoni L, Serai SD, Haque ME, Magin RL, Roman BB (2010) Functional MRI characterization of isolated human islet activation. NMR Biomed 23(10):1158\u20131165. \n                    https:\/\/doi.org\/10.1002\/nbm.1542","journal-title":"NMR Biomed"},{"key":"1162_CR42","unstructured":"Martin RF, Bowden DM (2000) Primate brain maps: structure of the macaque brain. Elsevier \u00a9 2000 University of Washington"},{"issue":"3","key":"1162_CR43","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/0301-0082(86)90022-5","volume":"27","author":"SF Takagi","year":"1986","unstructured":"Takagi SF (1986) Studies on the olfactory nervous system of the Old World monkey. Prog Neurobiol 27(3):195\u2013250. \n                    https:\/\/doi.org\/10.1016\/0301-0082(86)90022-5","journal-title":"Prog Neurobiol"},{"key":"1162_CR44","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1038\/s41598-017-03202-0","volume":"7","author":"SA Graves","year":"2017","unstructured":"Graves SA, Hernandez R, Valdovinos HF et al (2017) Preparation and in vivo characterization of 51MnCl2 as PET tracer of Ca2+ channel-mediated transport. Sci Rep 7:3033","journal-title":"Sci Rep"},{"issue":"1","key":"1162_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408440590905920","volume":"35","author":"M Aschner","year":"2005","unstructured":"Aschner M, Erikson KM, Dorman DC (2005) Manganese dosimetry: species differences and implications for neurotoxicity. Crit Rev Toxicol 35(1):1\u201332. \n                    https:\/\/doi.org\/10.1080\/10408440590905920","journal-title":"Crit Rev Toxicol"},{"key":"1162_CR46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s12194-010-0098-6","volume":"4","author":"M Nagata","year":"2011","unstructured":"Nagata M, Kagawa T, Koutou D et al (2011) Measurement of manganese content in various organs in rats with or without glucose stimulation. Radiol Phys Technol 4:7\u201312","journal-title":"Radiol Phys Technol"},{"issue":"3","key":"1162_CR47","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1002\/mrm.20368","volume":"53","author":"JH Lee","year":"2005","unstructured":"Lee JH, Silva AC, Merkle H, Koretsky AP (2005) Manganese-enhanced magnetic resonance imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast. Magn Reson Med 53(3):640\u2013648. \n                    https:\/\/doi.org\/10.1002\/mrm.20368","journal-title":"Magn Reson Med"},{"issue":"1","key":"1162_CR48","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.neuroimage.2007.08.029","volume":"39","author":"X Yu","year":"2008","unstructured":"Yu X, Zou J, Babb JS, Johnson G, Sanes DH, Turnbull DH (2008) Statistical mapping of sound-evoked activity in the mouse auditory midbrain using Mn-enhanced MRI. NeuroImage 39(1):223\u2013230. \n                    https:\/\/doi.org\/10.1016\/j.neuroimage.2007.08.029","journal-title":"NeuroImage"},{"key":"1162_CR49","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1016\/j.neuroimage.2009.10.079","volume":"49","author":"O Eschenko","year":"2010","unstructured":"Eschenko O, Canals S, Simanova I et al (2010) Mapping of functional brain activity in freely behaving rats during voluntary running using manganese-enhanced MRI: implication for longitudinal studies. NeuroImage 49:2544\u20132555","journal-title":"NeuroImage"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11307-018-1162-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-018-1162-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-018-1162-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T00:33:42Z","timestamp":1549067622000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11307-018-1162-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,2]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["1162"],"URL":"https:\/\/doi.org\/10.1007\/s11307-018-1162-6","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,2]]},"assertion":[{"value":"2 February 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal studies were approved by the Animal Care and Use Committees of the National Institute of Neurological Disorders and Stroke (rats), and the NIH Clinical Center (monkeys) and were performed in accordance with the regulations of the Division of Radiation Safety, at the National Institutes of Health (Bethesda, MD, USA).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}