{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T20:41:32Z","timestamp":1757450492047,"version":"3.37.3"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001721","name":"University of Groningen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001721","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s11307-018-1245-4","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T14:26:00Z","timestamp":1531146360000},"page":"240-248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Test-Retest Stability of Cerebral 2-Deoxy-2-[18F]Fluoro-D-Glucose ([18F]FDG) Positron Emission Tomography (PET) in Male and Female Rats"],"prefix":"10.1007","volume":"21","author":[{"given":"J\u00fcrgen W. A.","family":"Sijbesma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-1603","authenticated-orcid":false,"given":"Aren","family":"van Waarde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"V\u00e1llez Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrikus H.","family":"Boersma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riemer H. J. A.","family":"Slart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudi A. J. O.","family":"Dierckx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"Doorduin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"key":"1245_CR1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0165-1781(87)90028-X","volume":"21","author":"LR Baxter Jr","year":"1987","unstructured":"Baxter LR Jr, Mazziotta JC, Phelps ME, Selin CE, Guze BH, Fairbanks L (1987) Cerebral glucose metabolic rates in normal human females versus normal males. Psychiatry Res 21:237\u2013245","journal-title":"Psychiatry Res"},{"key":"1245_CR2","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0165-1781(94)90037-X","volume":"51","author":"PJ Andreason","year":"1994","unstructured":"Andreason PJ, Zametkin AJ, Guo AC, Baldwin P, Cohen RM (1994) Gender-related differences in regional cerebral glucose metabolism in normal volunteers. Psychiatry Res 51:175\u2013183","journal-title":"Psychiatry Res"},{"key":"1245_CR3","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.pscychresns.2013.10.009","volume":"221","author":"H Yoshizawa","year":"2014","unstructured":"Yoshizawa H, Gazes Y, Stern Y, Miyata Y, Uchiyama S (2014) Characterizing the normative profile of 18F-FDG PET brain imaging: sex difference, aging effect, and cognitive reserve. Psychiatry Res 221:78\u201385","journal-title":"Psychiatry Res"},{"key":"1245_CR4","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.apmr.2015.09.015","volume":"97","author":"JR Hebert","year":"2016","unstructured":"Hebert JR, Kindred JH, Bucci M, Tuulari JJ, Brenner LA, Forster JE, Koo PJ, Rudroff T (2016) Cognitive-motor related brain activity during walking: differences between men and women with multiple sclerosis. Arch Phys Med Rehabil 97:61\u201366","journal-title":"Arch Phys Med Rehabil"},{"key":"1245_CR5","first-page":"631","volume":"29","author":"JL Tyler","year":"1988","unstructured":"Tyler JL, Strother SC, Zatorre RJ, Zatorre RJ, Alivisatos B, Worsley KJ, Diksic M, Yamamoto YL (1988) Stability of regional cerebral glucose metabolism in the normal brain measured by positron emission tomography. J Nucl Med 29:631\u2013642","journal-title":"J Nucl Med"},{"key":"1245_CR6","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1002\/jnr.490270410","volume":"27","author":"SA Miura","year":"1990","unstructured":"Miura SA, Schapiro MB, Grady CL, Kumar A, Salerno JA, Kozachuk WE, Wagner E, Rapoport SI, Horwitz B (1990) Effect of gender on glucose utilization rates in healthy humans: a positron emission tomography study. J Neurosci Res 27:500\u2013504","journal-title":"J Neurosci Res"},{"key":"1245_CR7","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/0006-8993(92)90817-S","volume":"574","author":"NP Azari","year":"1992","unstructured":"Azari NP, Rapoport SI, Grady CL, DeCarli C, Haxby JV, Schapiro MB, Horwitz B (1992) Gender differences in correlations of cerebral glucose metabolic rates in young normal adults. Brain Res 574:198\u2013208","journal-title":"Brain Res"},{"key":"1245_CR8","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1176\/ajp.154.1.119","volume":"154","author":"ND Volkow","year":"1997","unstructured":"Volkow ND, Wang GJ, Fowler JS, Hitzemann R, Pappas N, Pascani K, Wong C (1997) Gender differences in cerebellar metabolism: test-retest reproducibility. Am J Psychiatry 154:119\u2013121","journal-title":"Am J Psychiatry"},{"key":"1245_CR9","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1126\/science.7824953","volume":"267","author":"RC Gur","year":"1995","unstructured":"Gur RC, Mozley LH, Mozley PD, Resnick S, Karp J, Alavi A, Arnold S, Gur R (1995) Sex differences in regional cerebral glucose metabolism during a resting state. Science 267:528\u2013531","journal-title":"Science"},{"key":"1245_CR10","doi-asserted-by":"publisher","first-page":"e83821","DOI":"10.1371\/journal.pone.0083821","volume":"8","author":"Y Hu","year":"2013","unstructured":"Hu Y, Xu Q, Li K, Zhu H, Qi R, Zhang Z, Lu G (2013) Gender differences of brain glucose metabolic networks revealed by FDG-PET: evidence from a large cohort of 400 young adults. PLoS One 8:e83821","journal-title":"PLoS One"},{"key":"1245_CR11","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0022-510X(02)00112-0","volume":"199","author":"T Kawachi","year":"2002","unstructured":"Kawachi T, Ishii K, Sakamoto S, Matsui M, Mori T, Sasaki M (2002) Gender differences in cerebral glucose metabolism: a PET study. J Neurol Sci 199:79\u201383","journal-title":"J Neurol Sci"},{"key":"1245_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1552-6569.2010.00543.x","volume":"22","author":"TC Hsieh","year":"2012","unstructured":"Hsieh TC, Lin WY, Ding HJ, Sun SS, Wu YC, Yen KY, Kao CH (2012) Sex- and age-related differences in brain FDG metabolism of healthy adults: an SPM analysis. J Neuroimaging 22:21\u201327","journal-title":"J Neuroimaging"},{"key":"1245_CR13","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1097\/00004647-200010000-00011","volume":"20","author":"AH Moore","year":"2000","unstructured":"Moore AH, Osteen CL, Chatziioannou AF, Hovda DA, Cherry SR (2000) Quantitative assessment of longitudinal metabolic changes in vivo after traumatic brain injury in the adult rat using FDG-microPET. J Cereb Blood Flow Metab 20:1492\u20131501","journal-title":"J Cereb Blood Flow Metab"},{"key":"1245_CR14","doi-asserted-by":"publisher","first-page":"611","DOI":"10.2967\/jnumed.116.182402","volume":"58","author":"CC Huang","year":"2017","unstructured":"Huang CC, Wu CH, Huang YY, Tzen KY, Chen SF, Tsai ML, Wu HM (2017) Performing repeated quantitative small-animal PET with an arterial input function is routinely feasible in rats. J Nucl Med 58:611\u2013616","journal-title":"J Nucl Med"},{"key":"1245_CR15","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1001\/archpsyc.1996.01830070031007","volume":"53","author":"DG Murphy","year":"1996","unstructured":"Murphy DG, DeCarli C, McIntosh AR, Daly E, Mentis MJ, Pietrini P, Szczepanik J, Schapiro MB, Grady CL, Horwitz B, Rapoport SI (1996) Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging. Arch Gen Psychiatry 53:585\u2013594","journal-title":"Arch Gen Psychiatry"},{"key":"1245_CR16","first-page":"235","volume":"27","author":"K Hamacher","year":"1986","unstructured":"Hamacher K, Coenen HH, Stocklin G (1986) Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med 27:235\u2013238","journal-title":"J Nucl Med"},{"key":"1245_CR17","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1080\/10520290500138422","volume":"80","author":"CH Hubscher","year":"2005","unstructured":"Hubscher CH, Brooks DL, Johnson JR (2005) A quantitative method for assessing stages of the rat estrous cycle. Biotech Histochem 80:79\u201387","journal-title":"Biotech Histochem"},{"key":"1245_CR18","doi-asserted-by":"crossref","unstructured":"Sijbesma JW, Zhou X, V\u00e1llez Garc\u00eda D et al (2016) Novel approach to repeated arterial blood sampling in small animal PET: application in a test-retest study with the adenosine A1 receptor ligand [11C]MPDX. Mol Imaging Biol 18:715\u2013723","DOI":"10.1007\/s11307-016-0954-9"},{"key":"1245_CR19","doi-asserted-by":"publisher","first-page":"e0122363","DOI":"10.1371\/journal.pone.0122363","volume":"10","author":"D V\u00e1llez Garc\u00eda","year":"2015","unstructured":"V\u00e1llez Garc\u00eda D, Casteels C, Schwarz AJ et al (2015) A standardized method for the construction of tracer specific PET and SPECT rat brain templates: validation and implementation of a toolbox. PLoS One 10:e0122363","journal-title":"PLoS One"},{"key":"1245_CR20","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.neuroimage.2006.04.214","volume":"32","author":"AJ Schwarz","year":"2006","unstructured":"Schwarz AJ, Danckaert A, Reese T, Gozzi A, Paxinos G, Watson C, Merlo-Pich EV, Bifone A (2006) A stereotaxic MRI template set for the rat brain with tissue class distribution maps and co-registered anatomical atlas: application to pharmacological MRI. Neuroimage 32:538\u2013550","journal-title":"Neuroimage"},{"key":"1245_CR21","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/jcbfm.1985.87","volume":"5","author":"CS Patlak","year":"1985","unstructured":"Patlak CS, Blasberg RG (1985) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab 5:584\u2013590","journal-title":"J Cereb Blood Flow Metab"},{"key":"1245_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/jcbfm.1983.1","volume":"3","author":"CS Patlak","year":"1983","unstructured":"Patlak CS, Blasberg RG, Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3:1\u20137","journal-title":"J Cereb Blood Flow Metab"},{"key":"1245_CR23","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1093\/bja\/aef182","volume":"89","author":"C Julien-Dolbec","year":"2002","unstructured":"Julien-Dolbec C, Tropres I, Montigon O, Reutenauer H, Ziegler A, Decorps M, Payen JF (2002) Regional response of cerebral blood volume to graded hypoxic hypoxia in rat brain. Br J Anaesth 89:287\u2013293","journal-title":"Br J Anaesth"},{"key":"1245_CR24","first-page":"1453","volume":"38","author":"JP Seibyl","year":"1997","unstructured":"Seibyl JP, Marek K, Sheff K, Baldwin RM, Zoghbi S, Zea-Ponce Y, Charney DS, van Dyck C, Hoffer PB, Innis RB (1997) Test\/retest reproducibility of iodine-123-betaCIT SPECT brain measurement of dopamine transporters in Parkinson's patients. J Nucl Med 38:1453\u20131459","journal-title":"J Nucl Med"},{"key":"1245_CR25","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2307\/2529310","volume":"33","author":"JR Landis","year":"1977","unstructured":"Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159\u2013174","journal-title":"Biometrics"},{"key":"1245_CR26","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1097\/00000542-199812000-00026","volume":"89","author":"C Lenz","year":"1998","unstructured":"Lenz C, Rebel A, van Ackern K, Kuschinsky W, Waschke KF (1998) Local cerebral blood flow, local cerebral glucose utilization, and flow-metabolism coupling during sevoflurane versus isoflurane anesthesia in rats. Anesthesiology 89:1480\u20131488","journal-title":"Anesthesiology"},{"key":"1245_CR27","first-page":"1398","volume":"45","author":"H Toyama","year":"2004","unstructured":"Toyama H, Ichise M, Liow JS, Modell KJ, Vines DC, Esaki T, Cook M, Seidel J, Sokoloff L, Green MV, Innis RB (2004) Absolute quantification of regional cerebral glucose utilization in mice by 18F-FDG small animal PET scanning and 2-14C-DG autoradiography. J Nucl Med 45:1398\u20131405","journal-title":"J Nucl Med"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-018-1245-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11307-018-1245-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-018-1245-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T20:23:13Z","timestamp":1567542193000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11307-018-1245-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,9]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["1245"],"URL":"https:\/\/doi.org\/10.1007\/s11307-018-1245-4","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"type":"print","value":"1536-1632"},{"type":"electronic","value":"1860-2002"}],"subject":[],"published":{"date-parts":[[2018,7,9]]},"assertion":[{"value":"9 July 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol complied to European Directive 2010\/63\/EU and the Law on Animal Experiments of The Netherlands; it was approved by the Central Committee on Animal Experiments of The Netherlands (The Hague, license no. AVD105002015166) and the Institutional Animal Care and Use Committee of the University of Groningen (protocol 15166-01-001).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}