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JR is a current employee of the MHRA; work herein was completed while JR was employed by Imperial College.PAM declares honoraria for speaking and travel support from Bayer, Biogen, Merck Serono and Novartis.DJB holds consultancies with GE Healthcare and Biogen.RG is an employee of Invicro, Ltd.All other authors have no disclosures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}