{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:14:56Z","timestamp":1777338896247,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s11307-020-01498-5","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T13:02:48Z","timestamp":1589202168000},"page":"1235-1243","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Volumetric Optoacoustic Tomography Differentiates Myocardial Remodelling"],"prefix":"10.1007","volume":"22","author":[{"given":"Ivana","family":"Ivankovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xos\u00e9 Lu\u00eds","family":"D\u00e9an-Ben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Haas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie A.","family":"Kimm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Wildgruber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Razansky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"issue":"1","key":"1498_CR1","first-page":"187","volume":"6","author":"E Tanai","year":"2011","unstructured":"Tanai E, Frantz S (2011) Pathophysiology of heart failure. Compr Physiol 6(1):187\u2013214","journal-title":"Compr Physiol"},{"issue":"25","key":"1498_CR2","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","volume":"101","author":"MGSJ Sutton","year":"2000","unstructured":"Sutton MGSJ, Sharpe N (2000) Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 101(25):2981\u20132988","journal-title":"Circulation"},{"key":"1498_CR3","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1146\/annurev-cellbio-101011-155739","volume":"28","author":"K Kikuchi","year":"2012","unstructured":"Kikuchi K, Poss KD (2012) Cardiac regenerative capacity and mechanisms. Annual Rev Cell Dev Biol 28:719\u2013741","journal-title":"Annual Rev Cell Dev Biol"},{"issue":"7","key":"1498_CR4","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1161\/01.RES.0000183733.53101.11","volume":"97","author":"K Urbanek","year":"2005","unstructured":"Urbanek K, Rota M, Cascapera S, Bearzi C, Nascimbene A, De Angelis A, Hosoda T, Chimenti S, Baker M, Limana, Nurzynska D, Torella D, Rotatori F, Rastaldo R, Musso E, Quaini F, Leri A, Kajstura J, Anversa P (2005) Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ Res 97(7):663\u2013673","journal-title":"Circ Res"},{"issue":"5923","key":"1498_CR5","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1126\/science.1164680","volume":"324","author":"O Bergmann","year":"2009","unstructured":"Bergmann O, Bhardwaj RD, Bernanrd S, Zdunek S, Barnabe-Heider F, Walsh S, Zupicich J, Alkass K, Burchholz BA, Duird H, Jovinge S, Frisen J (2009) Evidence for cardiomyocyte renewal in humans. Science 324(5923):98\u2013102","journal-title":"Science"},{"issue":"2","key":"1498_CR6","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3390\/bioengineering5020028","volume":"5","author":"M Madigan","year":"2018","unstructured":"Madigan M, Atoui R (2018) Therapeutic use of stem cells for myocardial infarction. Bioengineering 5(2):28","journal-title":"Bioengineering"},{"issue":"4","key":"1498_CR7","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nrcardio.2014.9","volume":"11","author":"A Behfar","year":"2014","unstructured":"Behfar A, Crespo-Diaz R, Terzic A, Gersh BJ (2014) Cell therapy for cardiac repair\u2014lessons from clinical trials. Nat Rev Cardiol 11(4):232\u2013246","journal-title":"Nat Rev Cardiol"},{"issue":"7","key":"1498_CR8","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1161\/CIRCRESAHA.117.312486","volume":"122","author":"BA Tompkins","year":"2018","unstructured":"Tompkins BA, Balkan W, Winkler J, Gy\u00f6ngy\u00f6si M, Goliasch G, Fern\u00e1ndez-Avil\u00e9s F, Hare JM (2018) Preclinical studies of stem cell therapy for heart disease. Circ Res 122(7):1006\u20131020","journal-title":"Circ Res"},{"issue":"1","key":"1498_CR9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nmeth.2730","volume":"11","author":"X Yu","year":"2014","unstructured":"Yu X, Qian C, Chen DY, Dodd SJ, Koretsky AP (2014) Deciphering laminar-specific neural inputs with line-scanning fMRI. Nat Methods 11(1):55\u201358","journal-title":"Nat Methods"},{"issue":"4","key":"1498_CR10","doi-asserted-by":"publisher","first-page":"H733","DOI":"10.1152\/ajpheart.00339.2017","volume":"314","author":"ML Lindsey","year":"2018","unstructured":"Lindsey ML, Kassiri Z, Virag JAI, de Castro Br\u00e1s LE, Scherrer-Crosbie M (2018) Guidelines for measuring cardiac physiology in mice. Am J Physiol-Heart C 314(4):H733\u2013H752","journal-title":"Am J Physiol-Heart C"},{"issue":"19","key":"1498_CR11","doi-asserted-by":"publisher","first-page":"L1","DOI":"10.1088\/0031-9155\/59\/19\/L1","volume":"59","author":"J Provost","year":"2014","unstructured":"Provost J, Papadacci C, Arango JE, Imbault M, Fink M, Gennisson JL, Tanter M, Pernot M (2014) 3D ultrafast ultrasound imaging in vivo. Phys Med Biol 59(19):L1\u2013L13","journal-title":"Phys Med Biol"},{"issue":"4","key":"1498_CR12","doi-asserted-by":"publisher","first-page":"180","DOI":"10.18383\/j.tom.2017.00016","volume":"3","author":"FW Damen","year":"2017","unstructured":"Damen FW, Berman AG, Soepriatna AH, Ellis JM, Buttars SD, Aasa KL, Goergen CJ (2017) High-frequency 4-dimensional ultrasound (4DUS): a reliable method for assessing murine cardiac function. Tomography 3(4):180\u2013187","journal-title":"Tomography"},{"key":"1498_CR13","doi-asserted-by":"publisher","first-page":"10133","DOI":"10.1038\/srep10133","volume":"5","author":"XL De\u00e1n-Ben","year":"2015","unstructured":"De\u00e1n-Ben XL, Ford SJ, Razansky D (2015) High-frame rate four dimensional optoacoustic tomography enables visualization of cardiovascular dynamics and mouse heart perfusion. Sci Rep 5:10133","journal-title":"Sci Rep"},{"issue":"18","key":"1498_CR14","doi-asserted-by":"publisher","first-page":"4470","DOI":"10.7150\/thno.20616","volume":"7","author":"H-CA Lin","year":"2017","unstructured":"Lin H-CA, Dean-Ben XL, Ivankovic I, Kimm MA, Kosanke K, Haas H, Meier R, Lohofer F, Wildgruber M, Razansky D (2017) Characterization of cardiac dynamics in an acute myocardial infarction model by four-dimensional optoacoustic and magnetic resonance imaging. Theranostics 7(18):4470\u20134479","journal-title":"Theranostics"},{"issue":"1","key":"1498_CR15","doi-asserted-by":"publisher","first-page":"8369","DOI":"10.1038\/s41598-019-44818-8","volume":"9","author":"I Ivankovic","year":"2019","unstructured":"Ivankovic I, De\u00e1n-Ben XL, Lin HCA, Zhang Z, Trautz B, Petry A, Gorlach A, Razansky D (2019) Volumetric optoacoustic tomography enables non-invasive in vivo characterization of impaired heart function in hypoxic conditions. Sci Rep 9(1):8369","journal-title":"Sci Rep"},{"key":"1498_CR16","doi-asserted-by":"crossref","unstructured":"Marino F, Scalise M, Cianflone E, Mancuso T, Aquila I, Agosti V, Torella M, Paolino D, Mollace V, Nadal-Ginard B, Torella D (2019) Role of c-kit in myocardial regeneration and aging. Front Endocrinol 10","DOI":"10.3389\/fendo.2019.00371"},{"issue":"2","key":"1498_CR17","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1161\/CIRCIMAGING.113.001270","volume":"7","author":"M Wildgruber","year":"2014","unstructured":"Wildgruber M, Bielicki I, Aichler M, Kosanke K, Feuchtinger A, Settles M, Onthank DC, Cesati RR, Robinson SP, Huber AM, Rummeny EJ, Walch AK, Botnar RM (2014) Assessment of myocardial infarction and postinfarction scar remodeling with an elastin-specific magnetic resonance agent. Circ. Cardiovasc Imaging 7(2):321\u2013329","journal-title":"Circ. Cardiovasc Imaging"},{"key":"1498_CR18","doi-asserted-by":"crossref","unstructured":"Di Siena S, Gimmelli R, Nori SL, Barbagallo F, Campolo F, Dolci S, Feigenbaum L, Lenzi A, Naro F, Cianflone E, Mancuso T, Torella D, Isidori AM, Pellegrini M (2016) Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury. Cell Death Dis 7(7):e2317","DOI":"10.1038\/cddis.2016.205"},{"issue":"11","key":"1498_CR19","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1109\/TMI.2013.2272079","volume":"32","author":"XL De\u00e1n-Ben","year":"2013","unstructured":"De\u00e1n-Ben XL, Ozbek A, Razansky D (2013) Volumetric real-time tracking of peripheral human vasculature with GPU-accelerated three-dimensional optoacoustic tomography. IEEE Trans Med Imaging 32(11):2050\u20132055","journal-title":"IEEE Trans Med Imaging"},{"key":"1498_CR20","doi-asserted-by":"crossref","unstructured":"Muthuramu I, Lox M, Jacobs F, De Geest B (2014) Permanent ligation of the left anterior descending coronary artery in mice: a model of post-myocardial infarction remodelling and heart failure. Jove-J Vis Exp 94","DOI":"10.3791\/52206"},{"key":"1498_CR21","doi-asserted-by":"crossref","unstructured":"Lindsey ML, Bolli R, Canty JM Jr, Du XJ, Frandogiannis NG, Frantz S, Gourdie RG, Holmes JW, Jones SP, Kloner RA, Lefer DJ, Liao R, Murphy E, Ping P, Przyklenk K, Recchia FA, Schwartz Longacre L, Ripplinger CM, Van Eyk JE, Heusch G (2018) Guidelines for experimental models of myocardial ischemia and infarction. Am J Physiol-Heart C 314(4):H812\u2013H838","DOI":"10.1152\/ajpheart.00335.2017"},{"issue":"12","key":"1498_CR22","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1093\/eurheartj\/ehp093","volume":"30","author":"J Ganame","year":"2009","unstructured":"Ganame J, Messalli G, Dymarkowski S, Rademakers FE, Desmet W, Van de Werf F, Bogaert J (2009) Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction. Eur Heart J 30(12):1440\u20131449","journal-title":"Eur Heart J"},{"issue":"8","key":"1498_CR23","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/nm1618","volume":"13","author":"PC Hsieh","year":"2007","unstructured":"Hsieh PC et al (2007) Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med 13(8):970\u2013974","journal-title":"Nat Med"},{"key":"1498_CR24","doi-asserted-by":"crossref","unstructured":"Granger DN, Kvietys PR (2017) Reperfusion therapy\u2014What\u2019s with the obstructed, leaky and broken capillaries? Pathophysiology 24(4):213\u2013228","DOI":"10.1016\/j.pathophys.2017.09.003"},{"issue":"2","key":"1498_CR25","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s10456-010-9170-4","volume":"13","author":"K Vandoorne","year":"2010","unstructured":"Vandoorne K, Addadi Y, Neeman M (2010) Visualizing vascular permeability and lymphatic drainage using labeled serum albumin. Angiogenesis 13(2):75\u201385","journal-title":"Angiogenesis"},{"key":"1498_CR26","doi-asserted-by":"crossref","unstructured":"Alander JT, Kaartinen I, Laakso A, P\u00e4til\u00e4 T, Spillmann T, Tuchin VV, Venermo M, V\u00e4lisuo PA (2012) review of indocyanine green fluorescent imaging in surgery. Int J Biomed Imaging 940585","DOI":"10.1155\/2012\/940585"},{"issue":"1","key":"1498_CR27","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1364\/BOE.8.000151","volume":"8","author":"D Sonin","year":"2017","unstructured":"Sonin D, Papayan G, Pochkaeva E, Chefu S, Minasian S, Kurapeev D, Vaage J, Petrishchev N, Galagudza M (2017) In vivo visualization and ex vivo quantification of experimental myocardial infarction by indocyanine green fluorescence imaging. Biomed Opt Express 8(1):151\u2013161","journal-title":"Biomed Opt Express"},{"issue":"10","key":"1498_CR28","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1056\/NEJMra022700","volume":"348","author":"PJ Zimetbaum","year":"2003","unstructured":"Zimetbaum PJ, Josephson ME (2003) Use of the electrocardiogram in acute myocardial infarction. New Engl J Med 348(10):933\u2013940","journal-title":"New Engl J Med"},{"issue":"18","key":"1498_CR29","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1016\/j.jacc.2009.11.087","volume":"55","author":"M Cohen","year":"2010","unstructured":"Cohen M, Boiangiu C, Abidi M (2010) Therapy for ST-segment elevation myocardial infarction patients who present late or are ineligible for reperfusion therapy. J Am Coll of Cardiol 55(18):1895\u20131906","journal-title":"J Am Coll of Cardiol"},{"issue":"16","key":"1498_CR30","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1161\/CIR.0b013e31826e1058","volume":"126","author":"K Thygesen","year":"2012","unstructured":"Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD (2012) Third universal definition of myocardial infarction. Circulation 126(16):2020\u20132035","journal-title":"Circulation"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-020-01498-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11307-020-01498-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-020-01498-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T12:36:36Z","timestamp":1620736596000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11307-020-01498-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,11]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["1498"],"URL":"https:\/\/doi.org\/10.1007\/s11307-020-01498-5","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,11]]},"assertion":[{"value":"11 May 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}