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Additionally, 5 WT mice and 7 HET animals received a second [<jats:sup>11<\/jats:sup>C]SCH23390 PET scan for test\u2013retest reproducibility. Parallel assessment of the simplified reference tissue model (SRTM), the multilinear reference tissue model (MRTM) and the Logan reference tissue model (Logan Ref) using the striatum as a receptor-rich region and the cerebellum as a receptor-free (reference) region was performed to define the most suitable method for regional- and voxel-based quantification of the binding potential (<jats:italic>BP<\/jats:italic><jats:sub>ND<\/jats:sub>). Finally, standardised uptake value ratio (SUVR-1) was assessed as a potential simplified measurement.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>For all models, we measured a significant decline in dopamine D<jats:sub>1<\/jats:sub>R density (<jats:italic>e.g.<\/jats:italic> SRTM\u2009=\u2009\u2212\u200938.5\u2009\u00b1\u20095.0\u00a0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) in HET mice compared to WT littermates. Shortening the 90-min scan duration resulted in large underestimation of striatal <jats:italic>BP<\/jats:italic><jats:sub>ND<\/jats:sub> in both WT mice (SRTM 60\u00a0min: \u2212\u200917.7\u2009\u00b1\u20092.8\u00a0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0078) and diseased HET (SRTM 60\u00a0min: \u2212\u200913.1\u2009\u00b1\u20094.1\u00a0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0001). Striatal <jats:italic>BP<\/jats:italic><jats:sub>ND<\/jats:sub> measurements were very reproducible with an average test\u2013retest variability below 5\u00a0% when using both MRTM and SRTM. Parametric <jats:italic>BP<\/jats:italic><jats:sub>ND<\/jats:sub> maps generated with SRTM were highly reliable, showing nearly perfect agreement to the regional analysis (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.99, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Finally, SRTM provided the most accurate estimate for relative tracer delivery <jats:italic>R<\/jats:italic><jats:sub>1<\/jats:sub> with both regional- and voxel-based analyses. SUVR-1 at different time intervals were not sufficiently reliable when compared to <jats:italic>BP<\/jats:italic><jats:sub>ND<\/jats:sub> (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009&lt;\u20090.66).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Ninety-minute acquisition and the use of SRTM for pharmacokinetic modelling is recommended. [<jats:sup>11<\/jats:sup>C]SCH23390 PET imaging demonstrates optimal characteristics for the study of dopamine D<jats:sub>1<\/jats:sub>R density in models of psychiatric and neurological disorders as exemplified in the Q175DN mouse model of HD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11307-020-01561-1","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T17:02:50Z","timestamp":1605114170000},"page":"208-219","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Kinetic Modelling and Test\u2013Retest Reproducibility for the Dopamine D1R Radioligand [11C]SCH23390 in Healthy and Diseased Mice"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4205-5432","authenticated-orcid":false,"given":"Daniele","family":"Bertoglio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Verhaeghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"Wyffels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid","family":"Stroobants","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Munoz-Sanjuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Skinbjerg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Staelens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"1561_CR1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pharmthera.2010.05.003","volume":"128","author":"AS Undieh","year":"2010","unstructured":"Undieh AS (2010) Pharmacology of signaling induced by dopamine D(1)-like receptor activation. 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Experiments were performed according to the European Committee Guidelines (decree 2010\/63\/CEE) and the Animal Welfare Act (7 USC 2131), and they were approved by the Ethical Committee for Animal Testing (ECD 2018-82) at the University of Antwerp (Belgium).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The Antwerp University group received financial support from the CHDI Foundation, Inc., a non-profit biomedical research organisation exclusively dedicated to collaboratively developing therapeutics that will substantially improve the lives of HD-affected individuals. CD, IMS, MS and LL are employed by CHDI Management, Inc. as advisors to the CHDI Foundation, Inc. The authors declare no other potential conflicts of interest relevant to this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}