{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:13:01Z","timestamp":1777525981223,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81901829"],"award-info":[{"award-number":["No. 81901829"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["No.3332019032"],"award-info":[{"award-number":["No.3332019032"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s11307-020-01565-x","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T15:02:38Z","timestamp":1605279758000},"page":"446-455","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Non-invasive Differentiation of Endometrial Adenocarcinoma from Benign Lesions in the Uterus by Utilization of Amide Proton Transfer-Weighted MRI"],"prefix":"10.1007","volume":"23","author":[{"given":"Yuan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Fei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Long","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2567-9710","authenticated-orcid":false,"given":"Yong-Lan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Dan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Yu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"1565_CR1","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1007\/s00330-018-5515-y","volume":"29","author":"S Nougaret","year":"2019","unstructured":"Nougaret S, Horta M, Sala E, Lakhman Y, Thomassin-Naggara I, Kido A, Masselli G, Bharwani N, Sadowski E, Ertmer A, Otero-Garcia M, Kubik-Huch RA, Cunha TM, Rockall A, Forstner R (2019) Endometrial cancer MRI staging: updated guidelines of the European Society of Urogenital Radiology. Eur Radiol 29:792\u2013805","journal-title":"Eur Radiol"},{"key":"1565_CR2","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1007\/s00330-017-5157-5","volume":"28","author":"RA Kubik-Huch","year":"2018","unstructured":"Kubik-Huch RA, Weston M, Nougaret S, Leonhardt H, Thomassin-Naggara I, Horta M, Cunha TM, Maciel C, Rockall A, Forstner R (2018) European Society of Urogenital Radiology (ESUR) Guidelines: MR imaging of leiomyomas. Eur Radiol 28:3125\u20133137","journal-title":"Eur Radiol"},{"key":"1565_CR3","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1093\/humupd\/dmz049","volume":"26","author":"C Chapron","year":"2020","unstructured":"Chapron C, Vannuccini S, Santulli P, Abr\u00e3o MS, Carmona F, Fraser IS, Gordts S, Guo SW, Just PA, No\u00ebl JC, Pistofidis G, van den Bosch T, Petraglia F (2020) Diagnosing adenomyosis: an integrated clinical and imaging approach. Hum Reprod Update 26:392\u2013411","journal-title":"Hum Reprod Update"},{"key":"1565_CR4","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.rcl.2019.10.004","volume":"58","author":"S Nougaret","year":"2020","unstructured":"Nougaret S, Sbarra M, Robbins J (2020) Imaging spectrum of benign uterine disease and treatment options. Radiol Clin N Am 58:239\u2013256","journal-title":"Radiol Clin N Am"},{"key":"1565_CR5","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3348\/kjr.2018.0090","volume":"20","author":"YT Huang","year":"2019","unstructured":"Huang YT, Huang YL, Ng KK, Lin G (2019) Current status of magnetic resonance imaging in patients with malignant uterine neoplasms: a review. Korean J Radiol 20:18\u201333","journal-title":"Korean J Radiol"},{"key":"1565_CR6","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1002\/mrm.10651","volume":"50","author":"J Zhou","year":"2003","unstructured":"Zhou J, Lal B, Wilson DA, Laterra J, van Zijl PC (2003) Amide proton transfer (APT) contrast for imaging of brain tumors. Magn Reson Med 50:1120\u20131126","journal-title":"Magn Reson Med"},{"key":"1565_CR7","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1002\/jmri.26645","volume":"50","author":"J Zhou","year":"2019","unstructured":"Zhou J, Heo HY, Knutsson L, van Zijl PCM, Jiang S (2019) APT-weighted MRI: techniques, current neuro applications, and challenging issues. J Magn Reson Imaging 50:347\u2013364","journal-title":"J Magn Reson Imaging"},{"key":"1565_CR8","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1158\/1078-0432.CCR-18-1233","volume":"25","author":"S Jiang","year":"2019","unstructured":"Jiang S, Eberhart CG, Lim M, Heo HY, Zhang Y, Blair L, Wen Z, Holdhoff M, Lin D, Huang P, Qin H, Quinones-Hinojosa A, Weingart JD, Barker PB, Pomper MG, Laterra J, van Zijl PCM, Blakeley JO, Zhou J (2019) Identifying recurrent malignant glioma after treatment using amide proton transfer-weighted MR imaging: a validation study with image-guided stereotactic biopsy. Clin Cancer Res 25:552\u2013561","journal-title":"Clin Cancer Res"},{"key":"1565_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ejca.2017.06.009","volume":"83","author":"S Jiang","year":"2017","unstructured":"Jiang S, Eberhart CG, Zhang Y, Heo HY, Wen Z, Blair L, Qin H, Lim M, Quinones-Hinojosa A, Weingart JD, Barker PB, Pomper MG, Laterra J, van Zijl PCM, Blakeley JO, Zhou J (2017) Amide proton transfer-weighted magnetic resonance image-guided stereotactic biopsy in patients with newly diagnosed gliomas. Eur J Cancer (Oxford, England: 1990) 83:9\u201318","journal-title":"Eur J Cancer (Oxford, England: 1990)"},{"key":"1565_CR10","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/mrm.22761","volume":"65","author":"PC van Zijl","year":"2011","unstructured":"van Zijl PC, Yadav NN (2011) Chemical exchange saturation transfer (CEST): what is in a name and what isn\u2019t? Magn Reson Med 65:927\u2013948","journal-title":"Magn Reson Med"},{"key":"1565_CR11","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/nm.2268","volume":"17","author":"J Zhou","year":"2011","unstructured":"Zhou J, Tryggestad E, Wen Z, Lal B, Zhou T, Grossman R, Wang S, Yan K, Fu DX, Ford E, Tyler B, Blakeley J, Laterra J, van Zijl PCM (2011) Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nat Med 17:130\u2013134","journal-title":"Nat Med"},{"key":"1565_CR12","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s11604-018-0787-3","volume":"37","author":"K Kamimura","year":"2018","unstructured":"Kamimura K, Nakajo M, Yoneyama T et al (2018) Amide proton transfer imaging of tumors: theory, clinical applications, pitfalls, and future directions. Jpn J Radiol 37:109\u2013116","journal-title":"Jpn J Radiol"},{"key":"1565_CR13","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1148\/radiol.2018171528","volume":"288","author":"BKH Law","year":"2018","unstructured":"Law BKH, King AD, Ai QY, Poon DMC, Chen W, Bhatia KS, Ahuja AT, Ma BB, Ka-Wai Yeung D, Fai Mo FK, Wang YX, Yuan J (2018) Head and neck tumors: amide proton transfer MRI. Radiology 288:782\u2013790","journal-title":"Radiology"},{"key":"1565_CR14","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s00330-018-5615-8","volume":"29","author":"C Su","year":"2018","unstructured":"Su C, Zhao L, Li S et al (2018) Amid proton transfer (APT) and magnetization transfer (MT) MRI contrasts provide complimentary assessment of brain tumors similarly to proton magnetic resonance spectroscopy imaging (MRSI). Eur Radiol 29:1203\u20131210","journal-title":"Eur Radiol"},{"key":"1565_CR15","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1002\/mrm.27983","volume":"83","author":"F Zimmermann","year":"2020","unstructured":"Zimmermann F, Korzowski A, Breitling J, Meissner JE, Schuenke P, Loi L, Zaiss M, Bickelhaupt S, Schott S, Schlemmer HP, Paech D, Ladd ME, Bachert P, Goerke S (2020) A novel normalization for amide proton transfer CEST MRI to correct for fat signal-induced artifacts: application to human breast cancer imaging. Magn Reson Med 83:920\u2013934","journal-title":"Magn Reson Med"},{"key":"1565_CR16","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1002\/jmri.25832","volume":"47","author":"Y Ohno","year":"2018","unstructured":"Ohno Y, Kishida Y, Seki S, Yui M, Miyazaki M, Koyama H, Yoshikawa T (2018) Amide proton transfer-weighted imaging to differentiate malignant from benign pulmonary lesions: comparison with diffusion-weighted imaging and FDG-PET\/CT. J Magn Reson Imaging 47:1013\u20131021","journal-title":"J Magn Reson Imaging"},{"key":"1565_CR17","first-page":"671","volume":"29","author":"Y Takayama","year":"2016","unstructured":"Takayama Y, Nishie A, Sugimoto M et al (2016) Amide proton transfer (APT) magnetic resonance imaging of prostate cancer: comparison with Gleason scores. Magma (New York, NY) 29:671\u2013679","journal-title":"Magma (New York, NY)"},{"key":"1565_CR18","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/jgh.14315","volume":"34","author":"A Nishie","year":"2019","unstructured":"Nishie A, Asayama Y, Ishigami K, Ushijima Y, Takayama Y, Okamoto D, Fujita N, Tsurumaru D, Togao O, Sagiyama K, Manabe T, Oki E, Kubo Y, Hida T, Hirahashi-Fujiwara M, Keupp J, Honda H (2019) Amide proton transfer imaging to predict tumor response to neoadjuvant chemotherapy in locally advanced rectal cancer. J Gastroenterol Hepatol 34:140\u2013146","journal-title":"J Gastroenterol Hepatol"},{"key":"1565_CR19","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1148\/radiol.2017170349","volume":"286","author":"Y Takayama","year":"2018","unstructured":"Takayama Y, Nishie A, Togao O, Asayama Y, Ishigami K, Ushijima Y, Okamoto D, Fujita N, Sonoda K, Hida T, Ohishi Y, Keupp J, Honda H (2018) Amide proton transfer MR imaging of endometrioid endometrial adenocarcinoma: association with histologic grade. Radiology 286:909\u2013917","journal-title":"Radiology"},{"key":"1565_CR20","doi-asserted-by":"publisher","first-page":"81.e19","DOI":"10.1016\/j.crad.2018.09.008","volume":"74","author":"YL He","year":"2019","unstructured":"He YL, Ding N, Qi YF, Li Y, Xiang Y, Qian TY, Liu H, Lin CY, Yuan L, Zhou HL, Jin ZY, Xue HD (2019) Visualising the boundary sharpness of uterine zonal structures using high-resolution T2-weighted images during the menstrual cycle. Clin Radiol 74:81.e19\u201381.e24","journal-title":"Clin Radiol"},{"key":"1565_CR21","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1002\/jmri.24067","volume":"38","author":"J Zhou","year":"2013","unstructured":"Zhou J, Zhu H, Lim M, Blair L, Quinones-Hinojosa A, Messina SA, Eberhart CG, Pomper MG, Laterra J, Barker PB, van Zijl PCM, Blakeley JO (2013) Three-dimensional amide proton transfer MR imaging of gliomas: initial experience and comparison with gadolinium enhancement. J Magn Reson Imaging 38:1119\u20131128","journal-title":"J Magn Reson Imaging"},{"key":"1565_CR22","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1002\/mrm.22891","volume":"66","author":"X Zhao","year":"2011","unstructured":"Zhao X, Wen Z, Huang F, Lu S, Wang X, Hu S, Zu D, Zhou J (2011) Saturation power dependence of amide proton transfer image contrasts in human brain tumors and strokes at 3 T. Magn Reson Med 66:1033\u20131041","journal-title":"Magn Reson Med"},{"key":"1565_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155925","volume":"11","author":"O Togao","year":"2016","unstructured":"Togao O, Hiwatashi A, Keupp J, Yamashita K, Kikuchi K, Yoshiura T, Yoneyama M, Kruiskamp MJ, Sagiyama K, Takahashi M, Honda H (2016) Amide proton transfer imaging of diffuse gliomas: effect of saturation pulse length in parallel transmission-based technique. PLoS ONE 11:e0155925","journal-title":"PLoS ONE"},{"key":"1565_CR24","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/mrm.22578","volume":"65","author":"H Eggers","year":"2011","unstructured":"Eggers H, Brendel B, Duijndam A, Herigault G (2011) Dual-echo Dixon imaging with flexible choice of echo times. Magn Reson Med 65:96\u2013107","journal-title":"Magn Reson Med"},{"key":"1565_CR25","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1002\/mrm.26322","volume":"77","author":"O Togao","year":"2017","unstructured":"Togao O, Keupp J, Hiwatashi A, Yamashita K, Kikuchi K, Yoneyama M, Honda H (2017) Amide proton transfer imaging of brain tumors using a self-corrected 3D fast spin-echo Dixon method: comparison with separate B0 correction. Magn Reson Med 77:2272\u20132279","journal-title":"Magn Reson Med"},{"key":"1565_CR26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.mri.2019.07.007","volume":"63","author":"S Zhang","year":"2019","unstructured":"Zhang S, Sun H, Li B, Wang X, Pan S, Guo Q (2019) Variation of amide proton transfer signal intensity and apparent diffusion coefficient values among phases of the menstrual cycle in the normal uterus: a preliminary study. Magn Reson Imaging 63:21\u201328","journal-title":"Magn Reson Imaging"},{"key":"1565_CR27","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/mrm.20989","volume":"56","author":"CK Jones","year":"2006","unstructured":"Jones CK, Schlosser MJ, van Zijl PC, Pomper MG, Golay X, Zhou J (2006) Amide proton transfer imaging of human brain tumors at 3T. Magn Reson Med 56:585\u2013592","journal-title":"Magn Reson Med"},{"key":"1565_CR28","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/jmri.22480","volume":"33","author":"G Jia","year":"2011","unstructured":"Jia G, Abaza R, Williams JD et al (2011) Amide proton transfer MR imaging of prostate cancer: a preliminary study. J Magn Reson Imaging 33:647\u2013654","journal-title":"J Magn Reson Imaging"},{"key":"1565_CR29","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1002\/jmri.26710","volume":"50","author":"YL He","year":"2019","unstructured":"He YL, Li Y, Lin CY, Qi YF, Wang X, Zhou HL, Yang JJ, Xiang Y, Xue HD, Jin ZY (2019) Three-dimensional turbo-spin-echo amide proton transfer-weighted mri for cervical cancer: a preliminary study. J Magn Reson Imaging 50:1318\u20131325","journal-title":"J Magn Reson Imaging"},{"key":"1565_CR30","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s00330-017-4962-1","volume":"28","author":"B Joo","year":"2018","unstructured":"Joo B, Han K, Choi YS, Lee SK, Ahn SS, Chang JH, Kang SG, Kim SH, Zhou J (2018) Amide proton transfer imaging for differentiation of benign and atypical meningiomas. Eur Radiol 28:331\u2013339","journal-title":"Eur Radiol"},{"key":"1565_CR31","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.fertnstert.2018.01.024","volume":"109","author":"M Bazot","year":"2018","unstructured":"Bazot M, Darai E (2018) Role of transvaginal sonography and magnetic resonance imaging in the diagnosis of uterine adenomyosis. Fertil Steril 109:389\u2013397","journal-title":"Fertil Steril"},{"key":"1565_CR32","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.neuroimage.2010.02.050","volume":"51","author":"Z Wen","year":"2010","unstructured":"Wen Z, Hu S, Huang F, Wang X, Guo L, Quan X, Wang S, Zhou J (2010) MR imaging of high-grade brain tumors using endogenous protein and peptide-based contrast. NeuroImage 51:616\u2013622","journal-title":"NeuroImage"},{"key":"1565_CR33","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1007\/s00330-016-4328-0","volume":"27","author":"O Togao","year":"2017","unstructured":"Togao O, Hiwatashi A, Yamashita K, Kikuchi K, Keupp J, Yoshimoto K, Kuga D, Yoneyama M, Suzuki SO, Iwaki T, Takahashi M, Iihara K, Honda H (2017) Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging. Eur Radiol 27:578\u2013588","journal-title":"Eur Radiol"},{"key":"1565_CR34","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/nm907","volume":"9","author":"J Zhou","year":"2003","unstructured":"Zhou J, Payen JF, Wilson DA, Traystman RJ, van Zijl PC (2003) Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med 9:1085\u20131090","journal-title":"Nat Med"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-020-01565-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11307-020-01565-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-020-01565-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T01:11:11Z","timestamp":1620263471000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11307-020-01565-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["1565"],"URL":"https:\/\/doi.org\/10.1007\/s11307-020-01565-x","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,13]]},"assertion":[{"value":"17 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Author Xiao-Qi Wang is an employee of Philips Healthcare China. The other authors have no conflicts of interest to disclose. The authors not employed by Philips were in control of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}