{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T03:22:30Z","timestamp":1781493750779,"version":"3.54.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["366633"],"award-info":[{"award-number":["366633"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001805","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["36848"],"award-info":[{"award-number":["36848"]}],"id":[{"id":"10.13039\/501100001805","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003400","name":"Ontario Ministry of Research, Innovation and Science","doi-asserted-by":"publisher","award":["ER17-13-119"],"award-info":[{"award-number":["ER17-13-119"]}],"id":[{"id":"10.13039\/501100003400","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s11307-021-01626-9","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T19:02:31Z","timestamp":1625598151000},"page":"93-103","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Selective Imaging of Matrix Metalloproteinase-13 to Detect Extracellular Matrix Remodeling in Atherosclerotic Lesions"],"prefix":"10.1007","volume":"24","author":[{"given":"Ariel","family":"Buchler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Munch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gedaliah","family":"Farber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Al-Haddad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eadan","family":"Farber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9707-9357","authenticated-orcid":false,"given":"Benjamin H.","family":"Rotstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"1626_CR1","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nrm3904","volume":"15","author":"C Bonnans","year":"2014","unstructured":"Bonnans C, Chou J, Werb Z (2014) Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol 15:786\u2013801","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1626_CR2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1183\/09031936.00146510","volume":"38","author":"S L\u00f6ffek","year":"2011","unstructured":"L\u00f6ffek S, Schilling O, Franzke C-W (2011) Biological role of matrix metalloproteinases: a critical balance. Eur Respir J 38:191\u2013208","journal-title":"Eur Respir J"},{"key":"1626_CR3","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1186\/s13075-017-1454-2","volume":"19","author":"H Li","year":"2017","unstructured":"Li H, Wang D, Yuan Y, Min J (2017) New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis. Arthritis Res Ther 19:248","journal-title":"Arthritis Res Ther"},{"key":"1626_CR4","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/nrd2308","volume":"6","author":"J Hu","year":"2007","unstructured":"Hu J, Van den Steen PE, Sang Q-XA, Opdenakker G (2007) Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases. Nat Rev Drug Discov 6:480\u2013498","journal-title":"Nat Rev Drug Discov"},{"key":"1626_CR5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ejphar.2017.09.007","volume":"816","author":"JL Johnson","year":"2017","unstructured":"Johnson JL (2017) Metalloproteinases in Atherosclerosis. Eur J Pharmacol 816:93\u2013106","journal-title":"Eur J Pharmacol"},{"key":"1626_CR6","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s12149-020-01458-7","volume":"34","author":"S Giannakou","year":"2020","unstructured":"Giannakou S, Angelidis G, Tsougos I, Valotassiou V, Kappas K, Georgoulias P (2020) Pet tracers for vulnerable plaque imaging. Ann Nucl Med 34:305\u2013313","journal-title":"Ann Nucl Med"},{"key":"1626_CR7","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1053\/j.semnuclmed.2014.05.004","volume":"44","author":"R Heo","year":"2014","unstructured":"Heo R, Nakazato R, Kalra D, Min JK (2014) Noninvasive imaging in coronary artery disease. Semin Nucl Med 44:398\u2013409","journal-title":"Semin Nucl Med"},{"key":"1626_CR8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev-med-041709-133809","volume":"62","author":"DRJ Owen","year":"2011","unstructured":"Owen DRJ, Lindsay AC, Choudhury RP, Fayad ZA (2011) Imaging of atherosclerosis. Annu Rev Med 62:25\u201340","journal-title":"Annu Rev Med"},{"key":"1626_CR9","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1038\/nature01323","volume":"420","author":"P Libby","year":"2002","unstructured":"Libby P (2002) Inflammation in atherosclerosis. Nature 420:868\u2013874","journal-title":"Nature"},{"key":"1626_CR10","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1161\/01.CIR.99.19.2503","volume":"99","author":"GK Sukhova","year":"1999","unstructured":"Sukhova GK, Sch\u00f6nbeck U, Rabkin E et al (1999) Evidence for Increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques. Circulation 99:2503\u20132509","journal-title":"Circulation"},{"key":"1626_CR11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.tcm.2003.12.009","volume":"14","author":"SM Lessner","year":"2004","unstructured":"Lessner SM, Galis ZS (2004) Matrix metalloproteinases and vascular endothelium-mononuclear cell close encounters. Trends Cardiovasc Med 14:105\u2013111","journal-title":"Trends Cardiovasc Med"},{"key":"1626_CR12","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.vph.2012.01.007","volume":"56","author":"AC Newby","year":"2012","unstructured":"Newby AC (2012) Matrix metalloproteinase inhibition therapy for vascular diseases. Vasc Pharmacol 56:232\u2013244","journal-title":"Vasc Pharmacol"},{"key":"1626_CR13","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.ehj.2004.01.002","volume":"25","author":"J Schaar","year":"2004","unstructured":"Schaar J (2004) Terminology for high-risk and vulnerable coronary artery plaques. Eur Heart J 25:1077\u20131082","journal-title":"Eur Heart J"},{"key":"1626_CR14","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1097\/MOL.0000000000000111","volume":"25","author":"AC Newby","year":"2014","unstructured":"Newby AC (2014) Proteinases and plaque rupture: unblocking the road to translation. Curr Opin Lipidol 25:358\u2013366","journal-title":"Curr Opin Lipidol"},{"key":"1626_CR15","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1161\/ATVBAHA.114.303326","volume":"34","author":"T Quillard","year":"2014","unstructured":"Quillard T, Ara\u00fajo HA, Franck G, Tesmenitsky Y, Libby P (2014) Matrix metalloproteinase-13 predominates over matrix metalloproteinase-8 as the functional interstitial collagenase in mouse atheromata. Arterioscler Thromb Vasc Biol 34:1179\u20131186","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1626_CR16","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1161\/ATVBAHA.111.231563","volume":"31","author":"T Quillard","year":"2011","unstructured":"Quillard T, Tesmenitsky Y, Croce K, Travers R, Shvartz E, Koskinas KC, Sukhova GK, Aikawa E, Aikawa M, Libby P (2011) Selective inhibition of matrix metalloproteinase-13 Increases collagen content of established mouse Atherosclerosis. Arterioscler Thromb Vasc Biol 31:2464\u20132472","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1626_CR17","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.1161\/CIRCULATIONAHA.105.562041","volume":"112","author":"J Deguchi","year":"2005","unstructured":"Deguchi J, Aikawa E, Libby P et al (2005) Matrix metalloproteinase-13\/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques. Circulation 112:2708\u20132715","journal-title":"Circulation"},{"key":"1626_CR18","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/jlcr.3476","volume":"60","author":"N Vazquez","year":"2017","unstructured":"Vazquez N, Missault S, Vangestel C, Deleye S, Thomae D, van der Veken P, Augustyns K, Staelens S, Dedeurwaerdere S, wyffels L (2017) Evaluation of [18F]BR420 and [18F]BR351 as radiotracers for MMP-9 imaging in colorectal cancer. J Label Compd Radiopharm 60:69\u201379","journal-title":"J Label Compd Radiopharm"},{"key":"1626_CR19","doi-asserted-by":"publisher","first-page":"11647","DOI":"10.1038\/s41598-018-29941-2","volume":"8","author":"Y Ye","year":"2018","unstructured":"Ye Y, Toczek J, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Ghosh M, Jung JJ, Sadeghi MM (2018) Novel arginine-containing macrocyclic MMP inhibitors: synthesis, 99mTc-labeling, and evaluation. Sci Rep 8:11647","journal-title":"Sci Rep"},{"key":"1626_CR20","doi-asserted-by":"publisher","first-page":"7562","DOI":"10.1158\/0008-5472.CAN-10-1584","volume":"70","author":"U auf dem Keller","year":"2010","unstructured":"auf dem Keller U, Bellac CL, Li Y et al (2010) Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer. Cancer Res 70:7562\u20137569","journal-title":"Cancer Res"},{"key":"1626_CR21","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1161\/01.CIR.102.16.1944","volume":"102","author":"FG Spinale","year":"2000","unstructured":"Spinale FG, Coker ML, Heung LJ, Bond BR, Gunasinghe HR, Etoh T, Goldberg AT, Zellner JL, Crumbley AJ (2000) A Matrix Metalloproteinase Induction\/Activation System Exists in the Human Left Ventricular Myocardium and Is Upregulated in Heart Failure. Circulation 102:1944\u20131949","journal-title":"Circulation"},{"key":"1626_CR22","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1021\/acs.jmedchem.6b01284","volume":"60","author":"V Hugenberg","year":"2017","unstructured":"Hugenberg V, Wagner S, Kopka K, Sch\u00e4fers M, Schuit RC, Windhorst AD, Hermann S (2017) Radiolabeled Selective matrix metalloproteinase 13 (MMP-13) inhibitors: (radio)syntheses and in vitro and first in vivo evaluation. J Med Chem 60:307\u2013321","journal-title":"J Med Chem"},{"key":"1626_CR23","doi-asserted-by":"publisher","first-page":"8886","DOI":"10.1021\/jm500981k","volume":"57","author":"H Nara","year":"2014","unstructured":"Nara H, Sato K, Naito T, Mototani H, Oki H, Yamamoto Y, Kuno H, Santou T, Kanzaki N, Terauchi J, Uchikawa O, Kori M (2014) Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach. J Med Chem 57:8886\u20138902","journal-title":"J Med Chem"},{"key":"1626_CR24","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.3390\/molecules24162982","volume":"24","author":"L Rangasamy","year":"2019","unstructured":"Rangasamy L, Di Geronimo B, Ort\u00edn I et al (2019) Molecular Imaging probes based on matrix metalloproteinase inhibitors (MMPIs). Molecules 24:2982","journal-title":"Molecules"},{"key":"1626_CR25","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.chembiol.2004.11.014","volume":"12","author":"CK Engel","year":"2005","unstructured":"Engel CK, Pirard B, Schimanski S, Kirsch R, Habermann J, Klingler O, Schlotte V, Weithmann KU, Wendt KU (2005) Structural basis for the highly selective inhibition of MMP-13. Chem Biol 12:181\u2013189","journal-title":"Chem Biol"},{"key":"1626_CR26","doi-asserted-by":"publisher","first-page":"5752","DOI":"10.1021\/jm0708533","volume":"50","author":"S Wagner","year":"2007","unstructured":"Wagner S, Breyholz H-J, Law MP, Faust A, H\u00f6ltke C, Schr\u00f6er S, Haufe G, Levkau B, Schober O, Sch\u00e4fers M, Kopka K (2007) Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N -hydroxy-2( R )-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem 50:5752\u20135764","journal-title":"J Med Chem"},{"key":"1626_CR27","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1158\/0008-5472.CAN-16-2628","volume":"77","author":"B Zinnhardt","year":"2017","unstructured":"Zinnhardt B, Pigeon H, Th\u00e9z\u00e9 B, Viel T, Wachsmuth L, Fricke IB, Schelhaas S, Honold L, Schwegmann K, Wagner S, Faust A, Faber C, Kuhlmann MT, Hermann S, Sch\u00e4fers M, Winkeler A, Jacobs AH (2017) Combined PET imaging of the inflammatory tumor microenvironment identifies margins of unique radiotracer uptake. Cancer Res 77:1831\u20131841","journal-title":"Cancer Res"},{"key":"1626_CR28","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1038\/jcbfm.2015.149","volume":"35","author":"B Zinnhardt","year":"2015","unstructured":"Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz HJ, Faust A, Hermann S, Kopka K, Faber C, Doll\u00e9 F, Pappata S, Planas AM, Tavitian B, Sch\u00e4fers M, Sorokin LM, Kuhlmann MT, Jacobs AH (2015) Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. J Cereb Blood Flow Metab 35:1711\u20131721","journal-title":"J Cereb Blood Flow Metab"},{"key":"1626_CR29","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1161\/01.ATV.14.1.133","volume":"14","author":"Y Nakashima","year":"1994","unstructured":"Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R (1994) ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb Vasc Biol 14:133\u2013140","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1626_CR30","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/978-1-4939-2929-0_5","volume":"1339","author":"MJ Andr\u00e9s-Manzano","year":"2015","unstructured":"Andr\u00e9s-Manzano MJ, Andr\u00e9s V, Dorado B (2015) Oil Red O and hematoxylin and eosin staining for quantification of atherosclerosis burden in mouse aorta and aortic root. Methods Mol Biol Clifton 1339:85\u201399","journal-title":"Methods Mol Biol Clifton"},{"key":"1626_CR31","doi-asserted-by":"publisher","first-page":"e1600224","DOI":"10.1126\/sciadv.1600224","volume":"2","author":"D Karunakaran","year":"2016","unstructured":"Karunakaran D, Geoffrion M, Wei L, Gan W, Richards L, Shangari P, DeKemp EM, Beanlands RA, Perisic L, Maegdefessel L, Hedin U, Sad S, Guo L, Kolodgie FD, Virmani R, Ruddy T, Rayner KJ (2016) Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis. Sci Adv 2:e1600224","journal-title":"Sci Adv"},{"key":"1626_CR32","doi-asserted-by":"publisher","first-page":"612","DOI":"10.2967\/jnumed.108.055889","volume":"50","author":"S Ohshima","year":"2009","unstructured":"Ohshima S, Petrov A, Fujimoto S, Zhou J, Azure M, Edwards DS, Murohara T, Narula N, Tsimikas S, Narula J (2009) Molecular imaging of matrix metalloproteinase expression in atherosclerotic plaques of mice deficient in apolipoprotein E or low-density-lipoprotein receptor. J Nucl Med 50:612\u2013617","journal-title":"J Nucl Med"},{"key":"1626_CR33","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1161\/ATVBAHA.110.216036","volume":"31","author":"S Tavakoli","year":"2011","unstructured":"Tavakoli S, Razavian M, Zhang J, Nie L, Marfatia R, Dobrucki LW, Sinusas AJ, Robinson S, Edwards DS, Sadeghi MM (2011) Matrix metalloproteinase activation predicts amelioration of remodeling after dietary modification in injured arteries. Arterioscler Thromb Vasc Biol 31:102\u2013109","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1626_CR34","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1161\/CIRCULATIONAHA.108.789743","volume":"118","author":"J Zhang","year":"2008","unstructured":"Zhang J, Nie L, Razavian M, Ahmed M, Dobrucki LW, Asadi A, Edwards DS, Azure M, Sinusas AJ, Sadeghi MM (2008) Molecular imaging of activated matrix metalloproteinases in vascular remodeling. Circulation 118:1953\u20131960","journal-title":"Circulation"},{"key":"1626_CR35","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.2967\/jnumed.111.092379","volume":"52","author":"M Razavian","year":"2011","unstructured":"Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki LW, Sinusas AJ, Azure M, Robinson S, Sadeghi MM (2011) Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation. J Nucl Med 52:1795\u20131802","journal-title":"J Nucl Med"},{"key":"1626_CR36","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1016\/j.jacc.2008.08.048","volume":"52","author":"S Fujimoto","year":"2008","unstructured":"Fujimoto S, Hartung D, Ohshima S, Edwards DS, Zhou J, Yalamanchili P, Azure M, Fujimoto A, Isobe S, Matsumoto Y, Boersma H, Wong N, Yamazaki J, Narula N, Petrov A, Narula J (2008) Molecular imaging of matrix metalloproteinase in atherosclerotic lesions: resolution with dietary modification and statin therapy. J Am Coll Cardiol 52:1847\u20131857","journal-title":"J Am Coll Cardiol"},{"key":"1626_CR37","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.1161\/01.CIR.0000129088.49276.83","volume":"109","author":"M Sch\u00e4fers","year":"2004","unstructured":"Sch\u00e4fers M, Riemann B, Kopka K et al (2004) Scintigraphic imaging of matrix metalloproteinase activity in the arterial wall in vivo. Circulation 109:2554\u20132559","journal-title":"Circulation"},{"key":"1626_CR38","doi-asserted-by":"publisher","first-page":"3168","DOI":"10.3390\/molecules23123168","volume":"23","author":"M Kiugel","year":"2018","unstructured":"Kiugel M, Hellberg S, K\u00e4kel\u00e4 M, Liljenb\u00e4ck H, Saanijoki T, Li XG, Tuomela J, Knuuti J, Saraste A, Roivainen A (2018) Evaluation of [68Ga]Ga-DOTA-TCTP-1 for the detection of metalloproteinase 2\/9 expression in mouse atherosclerotic plaques. Molecules 23:3168","journal-title":"Molecules"},{"key":"1626_CR39","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ejphar.2017.05.010","volume":"816","author":"BE Veseli","year":"2017","unstructured":"Veseli BE, Perrotta P, De Meyer GRA et al (2017) Animal models of atherosclerosis. Eur J Pharmacol 816:3\u201313","journal-title":"Eur J Pharmacol"},{"key":"1626_CR40","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.nucmedbio.2014.04.085","volume":"41","author":"A M\u00fcller","year":"2014","unstructured":"M\u00fcller A, Kr\u00e4mer SD, Meletta R, Beck K, Selivanova SV, Rancic Z, Kaufmann PA, Vos B, Meding J, Stellfeld T, Heinrich TK, Bauser M, H\u00fctter J, Dinkelborg LM, Schibli R, Ametamey SM (2014) Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability. Nucl Med Biol 41:562\u2013569","journal-title":"Nucl Med Biol"},{"key":"1626_CR41","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.tcm.2007.09.001","volume":"17","author":"AC Newby","year":"2007","unstructured":"Newby AC (2007) Metalloproteinases and vulnerable atherosclerotic plaques. Trends Cardiovasc Med 17:253\u2013258","journal-title":"Trends Cardiovasc Med"},{"key":"1626_CR42","doi-asserted-by":"publisher","first-page":"12931","DOI":"10.1038\/srep12931","volume":"5","author":"R Schierwagen","year":"2015","unstructured":"Schierwagen R, Mayb\u00fcchen L, Zimmer S et al (2015) Seven weeks of western diet in apoliprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis. Sci Rep 5:12931","journal-title":"Sci Rep"},{"key":"1626_CR43","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.matbio.2015.01.004","volume":"44-46","author":"S Duarte","year":"2015","unstructured":"Duarte S, Baber J, Fujii T, Coito AJ (2015) Matrix metalloproteinases in liver injury, repair and fibrosis. Matrix Biol 44-46:147\u2013156","journal-title":"Matrix Biol"},{"key":"1626_CR44","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1124\/dmd.108.022566","volume":"36","author":"D Dalvie","year":"2008","unstructured":"Dalvie D, Cosker T, Boyden T, Zhou S, Schroeder C, Potchoiba MJ (2008) Metabolism distribution and excretion of a matrix metalloproteinase-13 inhibitor, 4-[4-(4-fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic acid hydroxyamide (CP-544439), in rats and dogs: assessment of the metabolic profile of CP-544439 in plasma and urine of humans. Drug Metab Dispos 36:1869\u20131883","journal-title":"Drug Metab Dispos"},{"key":"1626_CR45","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1161\/01.ATV.0000218496.60097.e0","volume":"26","author":"M Kuzuya","year":"2006","unstructured":"Kuzuya M, Nakamura K, Sasaki T, Wu Cheng X, Itohara S, Iguchi A (2006) Effect of MMP-2 deficiency on atherosclerotic lesion formation in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 26:1120\u20131125","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1626_CR46","doi-asserted-by":"publisher","first-page":"15575","DOI":"10.1073\/pnas.0506201102","volume":"102","author":"JL Johnson","year":"2005","unstructured":"Johnson JL, George SJ, Newby AC, Jackson CL (2005) Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries. Proc Natl Acad Sci U S A 102:15575\u201315580","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1626_CR47","doi-asserted-by":"publisher","first-page":"5578","DOI":"10.1073\/pnas.87.14.5578","volume":"87","author":"HE Van Wart","year":"1990","unstructured":"Van Wart HE, Birkedal-Hansen H (1990) The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proc Natl Acad Sci U S A 87:5578\u20135582","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1626_CR48","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1161\/01.ATV.0000261545.53586.f0","volume":"27","author":"CL Jackson","year":"2007","unstructured":"Jackson CL (2007) Defining and defending murine models of plaque rupture. Arterioscler Thromb Vasc Biol 27:973\u2013977","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-021-01626-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11307-021-01626-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-021-01626-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T09:14:36Z","timestamp":1666862076000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11307-021-01626-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,6]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["1626"],"URL":"https:\/\/doi.org\/10.1007\/s11307-021-01626-9","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,6]]},"assertion":[{"value":"12 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}