{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:31:34Z","timestamp":1772688694829,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Shandong Provincial Medical and Health Science and Technology Development Program","award":["202009040347"],"award-info":[{"award-number":["202009040347"]}]},{"name":"the Natural Science Foundation of Shandong Province","award":["ZR2021MH038"],"award-info":[{"award-number":["ZR2021MH038"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s11307-021-01702-0","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T16:02:55Z","timestamp":1641830575000},"page":"570-579","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis and Evaluation of Radioiodine-Labeled pH (Low) Insertion Peptide Variant 7-Like Peptide as a Noninvasive Tumor Microenvironment Imaging Agent in a Mouse MDA-MB-231 Triple-Negative Breast Cancer Model"],"prefix":"10.1007","volume":"24","author":[{"given":"FengYu","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YueHua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DaCheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZhenGuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1156-005X","authenticated-orcid":false,"given":"MingMing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"issue":"6","key":"1702_CR1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41571-018-0001-7","volume":"15","author":"F Pareja","year":"2018","unstructured":"Pareja F, Reis-Filho JS (2018) Triple-negative breast cancers\u2014a panoply of cancer types. Nat Rev Clin Oncol 15(6):347\u2013348","journal-title":"Nat Rev Clin Oncol"},{"issue":"Suppl 6","key":"1702_CR2","doi-asserted-by":"publisher","first-page":"vi19","DOI":"10.1093\/annonc\/mds190","volume":"23","author":"F Penault-Llorca","year":"2012","unstructured":"Penault-Llorca F, Viale G (2012) Pathological and molecular diagnosis of triple-negative breast cancer: a clinical perspective. Ann Oncol 23(Suppl 6):vi19-22","journal-title":"Ann Oncol"},{"issue":"Suppl 6","key":"1702_CR3","doi-asserted-by":"publisher","first-page":"vi12","DOI":"10.1093\/annonc\/mdr371","volume":"22","author":"S Aebi","year":"2011","unstructured":"Aebi S, Davidson T, Gruber G et al (2011) Primary breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 22(Suppl 6):vi12-24","journal-title":"Ann Oncol"},{"issue":"20","key":"1702_CR4","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1056\/NEJMra1001389","volume":"363","author":"WD Foulkes","year":"2010","unstructured":"Foulkes WD, Smith IE, Reis-Filho JS (2010) Triple-negative breast cancer. N Engl J Med 363(20):1938\u20131948","journal-title":"N Engl J Med"},{"issue":"28","key":"1702_CR5","doi-asserted-by":"publisher","first-page":"46652","DOI":"10.18632\/oncotarget.16938","volume":"8","author":"AA Jitariu","year":"2017","unstructured":"Jitariu AA, C\u00eempean AM, Ribatti D et al (2017) Triple negative breast cancer: the kiss of death. Oncotarget 8(28):46652\u201346662","journal-title":"Oncotarget"},{"issue":"3","key":"1702_CR6","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1159\/000516419","volume":"16","author":"N Ditsch","year":"2021","unstructured":"Ditsch N, Kolberg-Liedtke C, Friedrich M et al (2021) AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2021. Breast Care (Basel) 16(3):214\u2013227","journal-title":"Breast Care (Basel)"},{"issue":"22","key":"1702_CR7","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1056\/NEJMoa1903986","volume":"381","author":"MF Bakker","year":"2019","unstructured":"Bakker MF, de Lange SV, Pijnappel RM et al (2019) Supplemental MRI screening for women with extremely dense breast tissue. N Engl J Med 381(22):2091\u20132102","journal-title":"N Engl J Med"},{"issue":"9","key":"1702_CR8","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.3390\/cancers13092262","volume":"13","author":"H Elghazaly","year":"2021","unstructured":"Elghazaly H, Rugo HS, Azim HA et al (2021) Breast-Gynaecological & Immuno-Oncology International Cancer Conference (BGICC) Consensus and Recommendations for the Management of Triple-Negative Breast Cancer. Cancers (Basel) 13(9):2262","journal-title":"Cancers (Basel)"},{"issue":"2","key":"1702_CR9","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1634\/theoncologist.2013-0359","volume":"19","author":"K Beusterien","year":"2014","unstructured":"Beusterien K, Grinspan J, Kuchuk I et al (2014) Use of conjoint analysis to assess breast cancer patient preferences for chemotherapy side effects. Oncologist 19(2):127\u2013134","journal-title":"Oncologist"},{"issue":"7","key":"1702_CR10","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/jvh.12672","volume":"24","author":"Z Liu","year":"2017","unstructured":"Liu Z, Jiang L, Liang G et al (2017) Hepatitis B virus reactivation in breast cancer patients undergoing chemotherapy: a review and meta-analysis of prophylaxis management. J Viral Hepat 24(7):561\u2013572","journal-title":"J Viral Hepat"},{"issue":"2","key":"1702_CR11","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1158\/1541-7786.MCR-06-0002","volume":"4","author":"R Cairns","year":"2006","unstructured":"Cairns R, Papandreou I, Denko N (2006) Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment. Mol Cancer Res 4(2):61\u201370","journal-title":"Mol Cancer Res"},{"key":"1702_CR12","first-page":"3","volume":"386","author":"AP Pathak","year":"2004","unstructured":"Pathak AP, Gimi B, Glunde K et al (2004) Molecular and functional imaging of cancer: advances in MRI and MRS. Methods Enzymol 386:3\u201360","journal-title":"Methods Enzymol"},{"issue":"5","key":"1702_CR13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.2967\/jnumed.107.043349","volume":"49","author":"MF Penet","year":"2008","unstructured":"Penet MF, Glunde K, Jacobs MA et al (2008) Molecular and functional MRI of the tumor microenvironment. J Nucl Med 49(5):687\u2013690","journal-title":"J Nucl Med"},{"issue":"2","key":"1702_CR14","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s10549-020-05560-2","volume":"180","author":"M Yu","year":"2020","unstructured":"Yu M, Chen Y, Wang Z et al (2020) pHLIP (Var7)-P1AP suppresses tumor cell proliferation in MDA-MB-231 triple-negative breast cancer by targeting protease activated receptor 1. Breast Cancer Res Treat 180(2):379\u2013384","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"1702_CR15","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1055\/a-1307-1923","volume":"60","author":"YH Chen","year":"2021","unstructured":"Chen YH, Yu MM, Wang ZG (2021) Inhibition of MDA-MB-231 cell proliferation by pHLIP (Var7)-P1AP and SPECT imaging of MDA-MB-231 breast cancer-bearing nude mice using 125I-pHLIP (Var7)-P1AP. Nuklearmedizin 60(3):240\u2013248","journal-title":"Nuklearmedizin"},{"key":"1702_CR16","doi-asserted-by":"publisher","first-page":"5565932","DOI":"10.1155\/2021\/5565932","volume":"2021","author":"M Yu","year":"2021","unstructured":"Yu M, Sun Y, Yang G et al (2021) An experimental study on [125I]I-pHLIP (Var7) for SPECT\/CT imaging of an MDA-MB-231 triple-negative breast cancer mouse model by targeting the tumor microenvironment. Mol Imaging 2021:5565932","journal-title":"Mol Imaging"},{"issue":"1","key":"1702_CR17","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/1097-0282(2000)55:1<4::AID-BIP30>3.0.CO;2-M","volume":"55","author":"A Tossi","year":"2000","unstructured":"Tossi A, Sandri L, Giangaspero A (2000) Amphipathic, alpha-helical antimicrobial peptides. Biopolymers 55(1):4\u201330","journal-title":"Biopolymers"},{"issue":"9","key":"1702_CR18","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1021\/acs.bioconjchem.6b00306","volume":"27","author":"DW Demoin","year":"2016","unstructured":"Demoin DW, Wyatt LC, Edwards KJ et al (2016) PET imaging of extracellular pH in tumors with (64) Cu- and (18)F-labeled pHLIP peptides: a structure-activity optimization study. Bioconjug Chem 27(9):2014\u20132023","journal-title":"Bioconjug Chem"},{"issue":"1","key":"1702_CR19","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1073\/pnas.1220038110","volume":"110","author":"EA Sosunov","year":"2013","unstructured":"Sosunov EA, Anyukhovsky EP, Sosunov AA et al (2013) pH (low) insertion peptide (pHLIP) targets ischemic myocardium. Proc Natl Acad Sci U S A 110(1):82\u201386","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"1702_CR20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s12149-009-0328-3","volume":"24","author":"M Yu","year":"2010","unstructured":"Yu M, Zhou H, Liu X et al (2010) Study on biodistribution and imaging of radioiodinated arginine-arginine-leucine peptide in nude mice bearing human prostate carcinoma. Ann Nucl Med 24(1):13\u201319","journal-title":"Ann Nucl Med"},{"issue":"11","key":"1702_CR21","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/jlcr.1542","volume":"51","author":"Yu MingMing","year":"2008","unstructured":"MingMing Yu, Wang RongFu, Yan P et al (2008) Design, synthesis and iodination of an Arg-Arg-Leu peptide for potential use as an imaging agent for human prostate carcinoma. J Label Compd Radiopharm 51(11):374\u2013378","journal-title":"J Label Compd Radiopharm"},{"issue":"2","key":"1702_CR22","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1046\/j.1365-201X.2002.00968.x","volume":"175","author":"M Josefsson","year":"2002","unstructured":"Josefsson M, Grunditz T, Ohlsson T et al (2002) Sodium\/iodide-symporter: distribution in different mammals and role in entero-thyroid circulation of iodide. Acta Physiol Scand 175(2):129\u2013137","journal-title":"Acta Physiol Scand"},{"issue":"19","key":"1702_CR23","doi-asserted-by":"publisher","first-page":"7893","DOI":"10.1073\/pnas.0702439104","volume":"104","author":"OA Andreev","year":"2007","unstructured":"Andreev OA, Dupuy AD, Segala M et al (2007) Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc Natl Acad Sci U S A 104(19):7893\u20137898","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"1702_CR24","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s11307-012-0549-z","volume":"14","author":"S Macholl","year":"2012","unstructured":"Macholl S, Morrison MS, Iveson P et al (2012) In vivo pH imaging with (99m)Tc-pHLIP. Mol Imaging Biol 14(6):725\u2013734","journal-title":"Mol Imaging Biol"},{"issue":"8","key":"1702_CR25","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1021\/bc3000222","volume":"23","author":"P Daumar","year":"2012","unstructured":"Daumar P, Wanger-Baumann CA, Pillarsetty N et al (2012) Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation. Bioconjug Chem 23(8):1557\u20131566","journal-title":"Bioconjug Chem"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-021-01702-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11307-021-01702-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-021-01702-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T13:17:52Z","timestamp":1658236672000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11307-021-01702-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["1702"],"URL":"https:\/\/doi.org\/10.1007\/s11307-021-01702-0","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,10]]},"assertion":[{"value":"14 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}