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We aimed to evaluate the correlation between brain perfusion SPECT and quantitative indices calculated from DAT-SPECT in patients with LBD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Procedures<\/jats:title>\n                <jats:p>We retrospectively enrolled 35 patients with LBD who underwent brain perfusion SPECT with N-isopropyl-p-[<jats:sup>123<\/jats:sup>I] iodoamphetamine and DAT-SPECT with <jats:sup>123<\/jats:sup>I-ioflupane. Mini-mental state examination (MMSE) data were also collected from 19 patients. Quantitative indices (specific binding ratio [SBR], putamen-to-caudate ratio [PCR], and caudate-to-putamen ratio [CPR]) were calculated using DAT-SPECT. These data were analysed by the statistical parametric mapping procedure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In patients with LBD, decreased PCR index correlated with hypoperfusion in the brainstem (medulla oblongata and midbrain) (uncorrected <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>k<\/jats:italic>\u2009&gt;\u2009100), while decreased CPR index correlated with hypoperfusion in the right temporoparietal cortex (family-wise error corrected <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), right precuneus (uncorrected <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>k<\/jats:italic>\u2009&gt;\u2009100), and bilateral temporal cortex (uncorrected <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>k<\/jats:italic>\u2009&gt;\u2009100). However, there was no significant correlation between decreased SBR index and brain perfusion. Additionally, the MMSE score was correlated with hypoperfusion in the left temporoparietal cortex (uncorrected <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study suggests that regional changes in striatal <jats:sup>123<\/jats:sup>I-ioflupane accumulation on DAT-SPECT are related to brain perfusion changes in patients with LBD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11307-022-01745-x","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T19:02:49Z","timestamp":1655233369000},"page":"950-958","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Striatal Dopaminergic Depletion Pattern Reflects Pathological Brain Perfusion Changes in Lewy Body Diseases"],"prefix":"10.1007","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-6651","authenticated-orcid":false,"given":"Yu","family":"Iwabuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Shiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kameyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raita","family":"Miyazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morinobu","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Tabuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Jinzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"1745_CR1","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/mds.21507","volume":"22","author":"M Emre","year":"2007","unstructured":"Emre M, Aarsland D, Brown R et al (2007) Clinical diagnostic criteria for dementia associated with Parkinson\u2019s disease. 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This article does not contain any data from experiments with animals performed by any of the authors. All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The institutional review board of the hospital granted permission for this retrospective review of imaging and clinical data and waived the requirement for obtaining informed consent from the patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"MJ received research grants from Nihon Medi-Physics Co., Ltd. and GE Healthcare Corp. MK received a research grant from Nihon Medi-Physics Co., Ltd. Other authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}