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All these effects may influence the oxygenation levels, but it is the vasculature changes that have the main impact on pO<jats:sub>2<\/jats:sub>. The purpose of our study was to monitor changes in tumor oxygenation after PDT and explore its significance for predicting long-term treatment response.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Procedures<\/jats:title>\n                <jats:p>Electron paramagnetic resonance (EPR) spectroscopy enables direct, quantitative, and sequential measurements of partial pressure of oxygen (pO<jats:sub>2<\/jats:sub>) in the same animal. The levels of chlorophyll derived photosensitizers in tumor tissue were determined by transdermal emission measurements.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The noninvasive monitoring of pO<jats:sub>2<\/jats:sub> in the tumor tissue after PDT showed that the higher \u0394pO<jats:sub>2<\/jats:sub> (pO<jats:sub>2<\/jats:sub> after PDT minus pO<jats:sub>2<\/jats:sub> before PDT), the greater the inhibition of tumor growth. \u0394pO<jats:sub>2<\/jats:sub> also correlated with higher levels of the photosensitizers in the tumor and with the occurrence of a severe edema\/erythema after PDT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Monitoring of PDT-induced changes in tumor oxygenation is a valuable prognostic factor and could be also used to identify potentially resistant tumors, which is important in predicting long-term treatment response.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11307-023-01886-7","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T22:01:40Z","timestamp":1706738500000},"page":"411-423","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["EPR Monitoring of Oxygenation Levels in Tumors After Chlorophyllide-Based Photodynamic Therapy May Allow for Early Prediction of Treatment Outcome"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9548-1868","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Szczygie\u0142","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Kalinowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1735-916X","authenticated-orcid":false,"given":"Dariusz","family":"Szczygie\u0142","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2038-8105","authenticated-orcid":false,"given":"Martyna","family":"Krzykawska-Serda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5287-439X","authenticated-orcid":false,"given":"Leszek","family":"Fiedor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-8285","authenticated-orcid":false,"given":"Aleksandra Anna","family":"Murzyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Sopel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5915-5088","authenticated-orcid":false,"given":"Zenon","family":"Matuszak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6296-2844","authenticated-orcid":false,"given":"Martyna","family":"Elas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"issue":"3","key":"1886_CR1","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.semradonc.2004.04.008","volume":"14","author":"P Vaupel","year":"2004","unstructured":"Vaupel P (2004) Tumor microenvironmental physiology and its implications for radiation oncology. 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