{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T01:28:08Z","timestamp":1778203688726,"version":"3.51.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Shanghai Jiading District Health Committee Fund","award":["2023-KY-21"],"award-info":[{"award-number":["2023-KY-21"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Early diagnosis and complete resection of cancer are pivotal for enhancing patient survival rates and prognosis. However, a significant current challenge lies in the lack of specific imaging probes for the identifying various tumor types. The expression levels of neuropilin-1 (NRP1) and glucose transporter 1 (GLUT1) in most tumors, including breast cancer, are closely linked to tumor proliferation and metastasis. This study seeks to develop a novel near-infrared fluorescence (NIRF) probe aimed at precise tumor detection by targeting NRP1 and GLUT1.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Procedures<\/jats:title>\n            <jats:p>G<jats:sub>0<\/jats:sub> was conjugated with N<jats:sub>3<\/jats:sub>-PEG<jats:sub>4<\/jats:sub>-ALKADK and 2-Azido-2-deoxy-D-glucose to synthesize the NGF probe. The spectral properties (fluorescence and absorbance spectra) of NGF were studied in both methanol and water. The targeting specificity of NGF towards NRP1 and GLUT1 was evaluated using confocal fluorescence microscopy imaging, flow cytometry assays and in vivo IVIS spectrum imaging.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A dual-targeting fluorescent probe named NGF was successfully synthesized to bind to both NRP1 and GLUT1 receptors. NGF exhibited greater hydrophilicity (Log <jats:italic>P<\/jats:italic>\u2009=\u2009-0.95\u2009\u00b1\u20090.07) and superior optical properties compared to its precursor, G<jats:sub>0<\/jats:sub>. Confocal fluorescence imaging, flow cytometry assays, and blocking studies revealed that the cellular uptake of NGF correlated with the NRP1 and GLUT1 expression levels across cell lines. Moreover, a strong linear relationship (R<jats:sup>2<\/jats:sup>\u2009=\u20090.98) was observed between fluorescence intensity and increasing NGF concentrations in MDA-MB-231 cells. In vivo IVIS imaging in animal models demonstrated specific binding of NGF to breast cancer (MDA-MB-231) and colorectal cancer (HCT116), with prolonged retention observed up to 72\u00a0h.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>This study highlighted the efficient targeting and sustained retention of the dual-target heterodimeric fluorescent probe NGF, binding to NRP1 and GLUT1 receptors. These findings suggest significant potential for clinical applications in early cancer detection and fluorescence image-guided surgery.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11307-025-01993-7","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T15:23:00Z","timestamp":1741274580000},"page":"250-259","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dual Targeting of Neuropilin-1 and Glucose Transporter for Efficient Fluorescence Imaging of Cancer"],"prefix":"10.1007","volume":"27","author":[{"given":"Jianwei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"1993_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A (2024) Cancer statistics, 2024. CA Cancer J Clin 74:12\u201349","journal-title":"CA Cancer J Clin"},{"key":"1993_CR2","doi-asserted-by":"publisher","first-page":"286","DOI":"10.3322\/caac.21766","volume":"73","author":"V Wadhwa","year":"2023","unstructured":"Wadhwa V, Patel N, Grover D et al (2023) Interventional gastroenterology in oncology. CA Cancer J Clin 73:286\u2013319","journal-title":"CA Cancer J Clin"},{"key":"1993_CR3","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1136\/gutjnl-2022-327736","volume":"72","author":"E Morgan","year":"2023","unstructured":"Morgan E, Arnold M, Gini A et al (2023) Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut 72:338\u2013344","journal-title":"Gut"},{"key":"1993_CR4","first-page":"e076625","volume":"384","author":"CTG Eric","year":"2024","unstructured":"Eric CTG, Evelien JMK, Jannie O et al (2024) Illness trajectories of incurable solid cancers. BMJ 384:e076625","journal-title":"BMJ"},{"key":"1993_CR5","doi-asserted-by":"publisher","first-page":"130856","DOI":"10.1016\/j.ijbiomac.2024.130856","volume":"265","author":"L Shanmugam","year":"2024","unstructured":"Shanmugam L, Venkatasubbu GD, Jayaraman M (2024) Hyaluronan-based nano-formulation with mesoporous silica enhances the anticancer efficacy of phloroglucinol against gastrointestinal cancers. Int J Biol Macromol 265:130856","journal-title":"Int J Biol Macromol"},{"key":"1993_CR6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/s41419-024-06572-2","volume":"15","author":"H Liu","year":"2024","unstructured":"Liu H, Zhou D, Liu D et al (2024) Synergistic antitumor activity between HER2 antibody-drug conjugate and chemotherapy for treating advanced colorectal cancer. Cell Death Dis 15:187","journal-title":"Cell Death Dis"},{"key":"1993_CR7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13045-023-01451-3","volume":"16","author":"WL Guan","year":"2023","unstructured":"Guan WL, He Y, Xu RH (2023) Gastric cancer treatment: recent progress and future perspectives. J Hematol Oncol 16:57","journal-title":"J Hematol Oncol"},{"key":"1993_CR8","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1038\/s41467-024-46557-5","volume":"15","author":"Y Li","year":"2024","unstructured":"Li Y, Zhang S, Liu C et al (2024) Thermophoretic glycan profiling of extracellular vesicles for triple-negative breast cancer management. Nat Commun 15:2292","journal-title":"Nat Commun"},{"key":"1993_CR9","doi-asserted-by":"publisher","first-page":"150057","DOI":"10.1016\/j.cej.2024.150057","volume":"485","author":"L Cheng","year":"2024","unstructured":"Cheng L, Qiu Y, He L et al (2024) Advancing immunotherapy in triple negative breast cancer: a novel multimodal theranostic nanoplatform integrating synergetic ferroptosis and photothermal therapy. Chem Eng J 485:150057","journal-title":"Chem Eng J"},{"key":"1993_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.semcancer.2023.09.001","volume":"96","author":"J Zhang","year":"2023","unstructured":"Zhang J, Wu J, Zhou XS et al (2023) Recent advancements in artificial intelligence for breast cancer: Image augmentation, segmentation, diagnosis, and prognosis approaches. Semin Cancer Biol 96:11\u201325","journal-title":"Semin Cancer Biol"},{"key":"1993_CR11","doi-asserted-by":"publisher","first-page":"216635","DOI":"10.1016\/j.canlet.2024.216635","volume":"583","author":"L Chen","year":"2024","unstructured":"Chen L, Xu G, Song X et al (2024) A novel antagonist of the CCL5\/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation. Cancer Lett 583:216635","journal-title":"Cancer Lett"},{"key":"1993_CR12","doi-asserted-by":"publisher","first-page":"3744","DOI":"10.3390\/cells11233744","volume":"11","author":"JP Chuang","year":"2022","unstructured":"Chuang JP, Tsai HL, Chen PJ et al (2022) Comprehensive Review of Biomarkers for the Treatment of Locally Advanced Colon Cancer. Cells 11:3744","journal-title":"Cells"},{"key":"1993_CR13","doi-asserted-by":"publisher","first-page":"1337319","DOI":"10.3389\/fphar.2023.1337319","volume":"14","author":"LEA Young","year":"2024","unstructured":"Young LEA, Nietert PJ, Stubler R et al (2024) Utilizing multimodal mass spectrometry imaging for profiling immune cell composition and N-glycosylation across colorectal carcinoma disease progression. Front Pharmacol 14:1337319","journal-title":"Front Pharmacol"},{"key":"1993_CR14","doi-asserted-by":"publisher","first-page":"458","DOI":"10.14309\/ajg.0000000000001122","volume":"116","author":"A Shaukat","year":"2021","unstructured":"Shaukat A, Kahi CJ, Burke CA et al (2021) ACG clinical guidelines: colorectal cancer screening 2021. Am J Gastroenterol 116:458\u2013479","journal-title":"Am J Gastroenterol"},{"key":"1993_CR15","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s10456-020-09715-z","volume":"23","author":"AL Bayliss","year":"2020","unstructured":"Bayliss AL, Sundararaman A, Granet C et al (2020) Raftlin is recruited by neuropilin-1 to the activated VEGFR2 complex to control proangiogenic signaling. Angiogenesis 23:371\u2013383","journal-title":"Angiogenesis"},{"key":"1993_CR16","doi-asserted-by":"publisher","first-page":"119113","DOI":"10.1016\/j.lfs.2021.119113","volume":"270","author":"L Zhao","year":"2021","unstructured":"Zhao L, Chen H, Lu L et al (2021) Design and screening of a novel neuropilin-1 targeted penetrating peptide for anti-angiogenic therapy in glioma. Life Sci 270:119113","journal-title":"Life Sci"},{"key":"1993_CR17","doi-asserted-by":"publisher","first-page":"C424","DOI":"10.1152\/ajpcell.00405.2018","volume":"316","author":"M Mahmoud","year":"2019","unstructured":"Mahmoud M, Evans IM, Mehta V et al (2019) Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation. Am J Physiol Cell Physiol 316:C424\u2013C433","journal-title":"Am J Physiol Cell Physiol"},{"key":"1993_CR18","doi-asserted-by":"publisher","first-page":"eabo4863","DOI":"10.1126\/scisignal.abo4863","volume":"16","author":"E Bosseboeuf","year":"2023","unstructured":"Bosseboeuf E, Chikh A, Chaker AB et al (2023) Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow. Sci Signal 16:eabo4863","journal-title":"Sci Signal"},{"key":"1993_CR19","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/s41419-020-02896-x","volume":"11","author":"H Zhu","year":"2020","unstructured":"Zhu H, Zhai B, He C et al (2020) LncRNA TTN-AS1 promotes the progression of cholangiocarcinoma via the miR-320a\/neuropilin-1 axis. Cell Death Dis 11:637","journal-title":"Cell Death Dis"},{"key":"1993_CR20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1476-4598-9-9","volume":"9","author":"S Zhang","year":"2010","unstructured":"Zhang S, Zhau HE, Osunkoya AO et al (2010) Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells. Mol Cancer 9:9","journal-title":"Mol Cancer"},{"key":"1993_CR21","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/s41419-020-2370-y","volume":"11","author":"LL Ma","year":"2020","unstructured":"Ma LL, Guo LL, Luo Y et al (2020) Cdc42 subcellular relocation in response to VEGF\/NRP1 engagement is associated with the poor prognosis of colorectal cancer. Cell Death Dis 11:171","journal-title":"Cell Death Dis"},{"key":"1993_CR22","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1007\/s00259-024-06632-x","volume":"51","author":"Q Liu","year":"2024","unstructured":"Liu Q, Cai S, Ye J et al (2024) Preclinical evaluation of 68Ga-labeled peptide CK2 for PET imaging of NRP-1 expression in vivo. Eur J Nucl Med Mol Imaging 51:1826\u20131840","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1993_CR23","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1186\/s13046-023-02927-3","volume":"42","author":"HJ Yun","year":"2023","unstructured":"Yun HJ, Li M, Guo D et al (2023) AMPK-HIF-1\u03b1 signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth. J Exp Clin Cancer Res 42:340","journal-title":"J Exp Clin Cancer Res"},{"key":"1993_CR24","doi-asserted-by":"publisher","first-page":"126233","DOI":"10.1016\/j.neucom.2023.126233","volume":"545","author":"Y Su","year":"2023","unstructured":"Su Y, Cheng J, Zhong C et al (2023) Accurate polyp segmentation through enhancing feature fusion and boosting boundary performance. Neurocomputing 545:126233","journal-title":"Neurocomputing"},{"key":"1993_CR25","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1038\/s41388-022-02230-z","volume":"41","author":"B Li","year":"2022","unstructured":"Li B, Kang H, Xiao Y et al (2022) LncRNA GAL promotes colorectal cancer liver metastasis through stabilizing GLUT1. Oncogene 41:1882\u20131894","journal-title":"Oncogene"},{"key":"1993_CR26","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1039\/D0TB02787A","volume":"9","author":"N Ding","year":"2021","unstructured":"Ding N, Xu S, Zheng S et al (2021) \u201cSweet tooth\u201d-oriented SN38 prodrug delivery nanoplatform for targeted gastric cancer therapy. J Mater Chem B 9:2816\u20132830","journal-title":"J Mater Chem B"},{"key":"1993_CR27","doi-asserted-by":"publisher","first-page":"107719","DOI":"10.1016\/j.cclet.2022.07.062","volume":"34","author":"Y Xu","year":"2023","unstructured":"Xu Y, Huang L, Bi Y et al (2023) Dual inhibition of glucose uptake and energy supply synergistically restrains the growth and metastasis of breast cancer. Chin Chem Lett 34:107719","journal-title":"Chin Chem Lett"},{"key":"1993_CR28","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1158\/0008-5472.CAN-20-2870","volume":"81","author":"PB Ancey","year":"2021","unstructured":"Ancey PB, Contat C, Boivin G et al (2021) GLUT1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy. Cancer Res 81:2345\u20132357","journal-title":"Cancer Res"},{"key":"1993_CR29","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s11307-022-01782-6","volume":"25","author":"C Ghezzi","year":"2023","unstructured":"Ghezzi C, Perez S, Ryan K et al (2023) Early reduction of glucose consumption is a biomarker of kinase inhibitor efficacy which can be reversed with GLUT1 overexpression in lung cancer cells. Mol Imaging Biol 25:541\u2013553","journal-title":"Mol Imaging Biol"},{"key":"1993_CR30","doi-asserted-by":"publisher","first-page":"108244","DOI":"10.1016\/j.biotechadv.2023.108244","volume":"68","author":"B Feng","year":"2023","unstructured":"Feng B, Chu F, Bi A et al (2023) Fidelity-oriented fluorescence imaging probes for beta-galactosidase: From accurate diagnosis to precise treatment. Biotechnol Adv 68:108244","journal-title":"Biotechnol Adv"},{"key":"1993_CR31","first-page":"538","volume":"19","author":"X Xiao","year":"2023","unstructured":"Xiao X, Cai H, Huang Q et al (2023) Polymeric dual-modal imaging nanoprobe with two-photon aggregation-induced emission for fluorescence imaging and gadolinium-chelation for magnetic resonance imaging. Bioact Mater 19:538\u2013549","journal-title":"Bioact Mater"},{"key":"1993_CR32","doi-asserted-by":"publisher","first-page":"114793","DOI":"10.1016\/j.addr.2023.114793","volume":"196","author":"QJ Duan","year":"2023","unstructured":"Duan QJ, Zhao ZY, Zhang YJ et al (2023) Activatable fluorescent probes for real-time imaging-guided tumor therapy. Adv Drug Deliv Rev 196:114793","journal-title":"Adv Drug Deliv Rev"},{"key":"1993_CR33","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s11307-022-01792-4","volume":"25","author":"F Azari","year":"2023","unstructured":"Azari F, Kennedy GT, Chang A et al (2023) Sodium multivitamin transporter-targeted fluorochrome facilitates enhanced metabolic evaluation of tumors through Coenzyme-R dependent intracellular signaling pathways. Mol Imaging Biol 25:569\u2013585","journal-title":"Mol Imaging Biol"},{"key":"1993_CR34","doi-asserted-by":"publisher","first-page":"102246","DOI":"10.1016\/j.nantod.2024.102246","volume":"56","author":"X Li","year":"2024","unstructured":"Li X, Huo F, Zhang L et al (2024) Hypoxia-activated and improved cell uptake near-infrared fluorescent probe for precise guiding surgical resection. Nano Today 56:102246","journal-title":"Nano Today"},{"key":"1993_CR35","doi-asserted-by":"publisher","first-page":"2200521","DOI":"10.1002\/adhm.202200521","volume":"11","author":"Z Wang","year":"2022","unstructured":"Wang Z, Zhang M, Chi S et al (2022) Brain tumor cell membrane-coated lanthanide-doped nanoparticles for NIR-IIb luminescence imaging and surgical navigation of glioma. Adv Healthc Mater 11:2200521","journal-title":"Adv Healthc Mater"},{"key":"1993_CR36","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s11307-023-01831-8","volume":"25","author":"TM Lwin","year":"2023","unstructured":"Lwin TM, Minnix M, Li L et al (2023) Multimodality PET and near-infrared fluorescence intraoperative imaging of CEA-positive colorectal cancer. Mol Imaging Biol 25:727\u2013734","journal-title":"Mol Imaging Biol"},{"key":"1993_CR37","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1007\/s11307-023-01799-5","volume":"25","author":"ML Johansen","year":"2023","unstructured":"Johansen ML, Vincent J, Rose M et al (2023) Comparison of near-infrared imaging agents targeting the PTPmu tumor biomarker. Mol Imaging Biol 25:744\u2013757","journal-title":"Mol Imaging Biol"},{"key":"1993_CR38","doi-asserted-by":"publisher","first-page":"2311673","DOI":"10.1002\/adfm.202311673","volume":"34","author":"Y Dang","year":"2024","unstructured":"Dang Y, Bai J, Lou K et al (2024) Intraoperative surgical margin assessment by NIR-II imaging with urine excretable Nd-based nanoprobe in breast cancers. Adv Funct Mater 34:2311673","journal-title":"Adv Funct Mater"},{"key":"1993_CR39","doi-asserted-by":"publisher","first-page":"116236","DOI":"10.1016\/j.ejmech.2024.116236","volume":"268","author":"P He","year":"2024","unstructured":"He P, Yu H, Deng X et al (2024) Novel estrogen receptor \u03b2\/histone deacetylase dual-targeted near-infrared fluorescent probes as theranostic agents for imaging and treatment of prostate cancer. Eur J Med Chem 268:116236","journal-title":"Eur J Med Chem"},{"key":"1993_CR40","doi-asserted-by":"publisher","first-page":"6117","DOI":"10.1039\/C7CC02418E","volume":"53","author":"M Collot","year":"2017","unstructured":"Collot M, Ponsot F, Klymchenko AS (2017) Ca-NIR: a ratiometric near-infrared calcium probe based on a dihydroxanthene-hemicyanine fluorophore. Chem Commun 53:6117\u20136120","journal-title":"Chem Commun"},{"key":"1993_CR41","doi-asserted-by":"publisher","first-page":"129196","DOI":"10.1016\/j.bmcl.2023.129196","volume":"84","author":"S Qin","year":"2023","unstructured":"Qin S, Liu Q, Li K et al (2023) Neuropilin 1-targeted near-infrared fluorescence probes for tumor diagnosis. Bioorg Med Chem Lett 84:129196","journal-title":"Bioorg Med Chem Lett"},{"key":"1993_CR42","doi-asserted-by":"publisher","first-page":"726","DOI":"10.2967\/jnumed.116.188045","volume":"59","author":"SJ Waaijer","year":"2018","unstructured":"Waaijer SJ, Kok IC, Eisses B et al (2018) Molecular imaging in cancer drug development. J Nucl Med 59:726\u2013732","journal-title":"J Nucl Med"},{"key":"1993_CR43","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3390\/ph13080173","volume":"13","author":"B Judmann","year":"2020","unstructured":"Judmann B, Braun D, W\u00e4ngler B et al (2020) Current state of radiolabeled heterobivalent peptidic ligands in tumor imaging and therapy. Pharmaceuticals 13:173","journal-title":"Pharmaceuticals"},{"key":"1993_CR44","doi-asserted-by":"publisher","first-page":"7180","DOI":"10.7150\/thno.79144","volume":"12","author":"J Zang","year":"2022","unstructured":"Zang J, Wen X, Lin R et al (2022) Synthesis, preclinical evaluation and radiation dosimetry of a dual targeting PET tracer [68Ga]Ga-FAPI-RGD. Theranostics 12:7180\u20137190","journal-title":"Theranostics"},{"key":"1993_CR45","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1007\/s00259-023-06587-5","volume":"51","author":"N Liu","year":"2024","unstructured":"Liu N, Wan Q, Wu X et al (2024) A comparison of [18F]AlF- and 68Ga-labeled dual targeting heterodimer FAPI-RGD in malignant tumor: preclinical evaluation and pilot clinical PET\/CT imaging. Eur J Nucl Med Mol Imaging 51:1685\u20131697","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1993_CR46","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s00259-023-06412-z","volume":"51","author":"X Lv","year":"2023","unstructured":"Lv X, Song X, Long Y et al (2023) Preclinical evaluation of a dual-receptor targeted tracer [68Ga]Ga-HX01 in 10 different subcutaneous and orthotopic tumor models. Eur J Nucl Med Mol Imaging 51:54\u201367","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1993_CR47","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1021\/acs.bioconjchem.9b00771","volume":"31","author":"SM Usama","year":"2020","unstructured":"Usama SM, Park GK, Nomura S et al (2020) Role of albumin in accumulation and persistence of tumor-seeking cyanine Dyes. Bioconjug Chem 31:248\u2013259","journal-title":"Bioconjug Chem"},{"key":"1993_CR48","doi-asserted-by":"publisher","first-page":"eaaw0672","DOI":"10.1126\/sciadv.aaw0672","volume":"5","author":"R Tian","year":"2019","unstructured":"Tian R, Zeng Q, Zhu S et al (2019) Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics. Sci Adv 5:eaaw0672","journal-title":"Sci Adv"},{"key":"1993_CR49","doi-asserted-by":"publisher","first-page":"8831","DOI":"10.1039\/C8OB02646G","volume":"16","author":"C Canovas","year":"2018","unstructured":"Canovas C, Bellaye PS, Moreau M et al (2018) Site-specific near-infrared fluorescent labelling of proteins on cysteine residues with meso-chloro-substituted heptamethine cyanine dyes. Org Biomol Chem 16:8831\u20138836","journal-title":"Org Biomol Chem"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-025-01993-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11307-025-01993-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-025-01993-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T21:01:57Z","timestamp":1746738117000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11307-025-01993-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["1993"],"URL":"https:\/\/doi.org\/10.1007\/s11307-025-01993-7","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,6]]},"assertion":[{"value":"11 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}