{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:05:51Z","timestamp":1772892351595,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100012462","name":"Office of Academic Affiliations, Department of Veterans Affairs","doi-asserted-by":"publisher","award":["CX002228"],"award-info":[{"award-number":["CX002228"]}],"id":[{"id":"10.13039\/100012462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s11307-025-02060-x","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:58:52Z","timestamp":1764169132000},"page":"155-168","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Claudin-1 Near-Infrared Fluorescent Antibody Conjugate for In Vivo Primary and Metastatic Colorectal Cancer Detection"],"prefix":"10.1007","volume":"28","author":[{"given":"Mark","family":"Primeaux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritika","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iram","family":"Fatima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumbal","family":"Talib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar B.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron M.","family":"Mohs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bouvet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Punita","family":"Dhawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"2060_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN, Sung H, Jemal A (2025) Cancer statistics, 2025. CA Cancer J Clin 75:10\u201345. https:\/\/doi.org\/10.3322\/caac.21871","journal-title":"CA Cancer J Clin"},{"key":"2060_CR2","unstructured":"American Cancer Society AC (2025) Cancer facts & figures 2025"},{"issue":"4","key":"2060_CR3","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1093\/annonc\/mdu543","volume":"26","author":"S Pita-Fern\u00e1ndez","year":"2015","unstructured":"Pita-Fern\u00e1ndez S, Alhayek-A\u00ed M, Gonz\u00e1lez-Mart\u00edn C, L\u00f3pez-Calvi\u00f1o B, Seoane-Pillado T, P\u00e9rtega-D\u00edaz S (2015) Intensive follow-up strategies improve outcomes in nonmetastatic colorectal cancer patients after curative surgery: a systematic review and meta-analysis. Ann Oncol 26(4):644\u2013656. https:\/\/doi.org\/10.1093\/annonc\/mdu543","journal-title":"Ann Oncol"},{"key":"2060_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23403-5","volume":"8","author":"RK Orosco","year":"2018","unstructured":"Orosco RK, Tapia VJ, Califano JA, Clary B, Cohen EEW, Kane C, Lippman SM, Messer K, Molinolo A, Murphy JD et al (2018) Positive surgical margins in the 10 most common solid cancers. Sci Rep 8:5686. https:\/\/doi.org\/10.1038\/s41598-018-23403-5","journal-title":"Sci Rep"},{"key":"2060_CR5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/s44222-022-00017-1","volume":"1","author":"K Wang","year":"2023","unstructured":"Wang K, Du Y, Zhang Z, He K, Cheng Z, Yin L, Dong D, Li C, Li W, Hu Z (2023) Fluorescence image-guided tumour surgery. Nat Rev Bioeng 1:161\u2013179. https:\/\/doi.org\/10.1038\/s44222-022-00017-1","journal-title":"Nat Rev Bioeng"},{"key":"2060_CR6","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.ejso.2021.10.005","volume":"48","author":"HA Galema","year":"2022","unstructured":"Galema HA, Meijer RPJ, Lauwerends LJ, Verhoef C, Burggraaf J, Vahrmeijer AL, Hutteman M, Keereweer S, Hilling DE (2022) Fluorescence-guided surgery in colorectal cancer; a review on clinical results and future perspectives. Eur J Surg Oncol 48:810\u2013821. https:\/\/doi.org\/10.1016\/j.ejso.2021.10.005","journal-title":"Eur J Surg Oncol"},{"key":"2060_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.cbpa.2009.09.029","volume":"14","author":"SA Hilderbrand","year":"2010","unstructured":"Hilderbrand SA, Weissleder R (2010) Near-infrared fluorescence: application to in vivo molecular imaging. Curr Opin Chem Biol 14:71\u201379. https:\/\/doi.org\/10.1016\/j.cbpa.2009.09.029","journal-title":"Curr Opin Chem Biol"},{"key":"2060_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00314","volume":"7","author":"T Nagaya","year":"2017","unstructured":"Nagaya T, Nakamura YA, Choyke PL, Kobayashi H (2017) Fluorescence-guided surgery. Front Oncol 7:314. https:\/\/doi.org\/10.3389\/fonc.2017.00314","journal-title":"Front Oncol"},{"key":"2060_CR9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1152\/physrev.00019.2012","volume":"93","author":"D G\u00fcnzel","year":"2013","unstructured":"G\u00fcnzel D, Yu ASL (2013) Claudins and the modulation of tight junction permeability. Physiol Rev 93:525\u2013569. https:\/\/doi.org\/10.1152\/physrev.00019.2012","journal-title":"Physiol Rev"},{"key":"2060_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1320766","volume":"14","author":"B Vonniessen","year":"2024","unstructured":"Vonniessen B, Tabari\u00e8s S, Siegel PM (2024) Antibody-mediated targeting of Claudins in cancer. Front Oncol 14:1320766. https:\/\/doi.org\/10.3389\/fonc.2024.1320766","journal-title":"Front Oncol"},{"key":"2060_CR11","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abj4221","volume":"14","author":"N Roehlen","year":"2022","unstructured":"Roehlen N, Saviano A, El Saghire H, Crouchet E, Nehme Z, Del Zompo F, J\u00fchling F, Oudot MA, Durand SC, Duong FHT et al (2022) A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity. Sci Transl Med 14:eabj4221. https:\/\/doi.org\/10.1126\/scitranslmed.abj4221","journal-title":"Sci Transl Med"},{"key":"2060_CR12","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/s41571-024-00874-2","volume":"21","author":"I Nakayama","year":"2024","unstructured":"Nakayama I, Qi C, Chen Y, Nakamura Y, Shen L, Shitara K (2024) Claudin 18.2 as a novel therapeutic target. Nat Rev Clin Oncol 21:354\u2013369. https:\/\/doi.org\/10.1038\/s41571-024-00874-2","journal-title":"Nat Rev Clin Oncol"},{"key":"2060_CR13","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s10585-022-10146-x","volume":"39","author":"M Primeaux","year":"2022","unstructured":"Primeaux M, Gowrikumar S, Dhawan P (2022) Role of CD44 isoforms in epithelial-mesenchymal plasticity and metastasis. Clin Exp Metastasis 39:391\u2013406. https:\/\/doi.org\/10.1007\/s10585-022-10146-x","journal-title":"Clin Exp Metastasis"},{"key":"2060_CR14","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1136\/gutjnl-2018-316906","volume":"68","author":"MB Zeisel","year":"2019","unstructured":"Zeisel MB, Dhawan P, Baumert TF (2019) Tight junction proteins in gastrointestinal and liver disease. Gut 68:547\u2013561. https:\/\/doi.org\/10.1136\/gutjnl-2018-316906","journal-title":"Gut"},{"key":"2060_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216479","volume":"579","author":"M Primeaux","year":"2023","unstructured":"Primeaux M, Liu X, Gowrikumar S, Fatima I, Fisher KW, Bastola D, Vecchio AJ, Singh AB, Dhawan P (2023) Claudin-1 interacts with EPHA2 to promote cancer stemness and chemoresistance in colorectal cancer. Cancer Lett 579:216479. https:\/\/doi.org\/10.1016\/j.canlet.2023.216479","journal-title":"Cancer Lett"},{"key":"2060_CR16","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1172\/jci24543","volume":"115","author":"P Dhawan","year":"2005","unstructured":"Dhawan P, Singh AB, Deane NG, No Y, Shiou SR, Schmidt C, Neff J, Washington MK, Beauchamp RD (2005) Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest 115:1765\u20131776. https:\/\/doi.org\/10.1172\/jci24543","journal-title":"J Clin Invest"},{"key":"2060_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/biom14030272","author":"KE Cox","year":"2024","unstructured":"Cox KE, Liu S, Hoffman RM, Batra SK, Dhawan P, Bouvet M (2024) The expression of the claudin family of proteins in colorectal cancer. Biomolecules. https:\/\/doi.org\/10.3390\/biom14030272","journal-title":"Biomolecules"},{"key":"2060_CR18","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.jss.2019.04.048","volume":"242","author":"HM Hollandsworth","year":"2019","unstructured":"Hollandsworth HM, Lwin TM, Amirfakhri S, Filemoni F, Batra SK, Hoffman RM, Dhawan P, Bouvet M (2019) Anti-Claudin-1 conjugated to a near-infrared fluorophore targets colon cancer in PDOX mouse models. J Surg Res 242:145\u2013150. https:\/\/doi.org\/10.1016\/j.jss.2019.04.048","journal-title":"J Surg Res"},{"key":"2060_CR19","doi-asserted-by":"publisher","first-page":"3586","DOI":"10.1021\/acs.molpharmaceut.2c00203","volume":"19","author":"MT Olson","year":"2022","unstructured":"Olson MT, Aguilar EN, Brooks CL, Isder CC, Muilenburg KM, Talmon GA, Ly QP, Carlson MA, Hollingsworth MA, Mohs AM (2022) Preclinical evaluation of a humanized, near-infrared fluorescent antibody for fluorescence-guided surgery of MUC16-expressing pancreatic cancer. Mol Pharm 19:3586\u20133599. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.2c00203","journal-title":"Mol Pharm"},{"key":"2060_CR20","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1158\/1535-7163.Mct-20-0033","volume":"19","author":"MT Olson","year":"2020","unstructured":"Olson MT, Wojtynek NE, Talmon GA, Caffrey TC, Radhakrishnan P, Ly QP, Hollingsworth MA, Mohs AM (2020) Development of a MUC16-targeted near-infrared fluorescent antibody conjugate for intraoperative imaging of pancreatic cancer. Mol Cancer Ther 19:1670\u20131681. https:\/\/doi.org\/10.1158\/1535-7163.Mct-20-0033","journal-title":"Mol Cancer Ther"},{"key":"2060_CR21","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.cd-12-0095","volume":"2","author":"E Cerami","year":"2012","unstructured":"Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E et al (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2:401\u2013404. https:\/\/doi.org\/10.1158\/2159-8290.cd-12-0095","journal-title":"Cancer Discov"},{"key":"2060_CR22","doi-asserted-by":"publisher","unstructured":"Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E\u00a0(2013) Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 6:l1. https:\/\/doi.org\/10.1126\/scisignal.2004088","DOI":"10.1126\/scisignal.2004088"},{"key":"2060_CR23","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.97279","volume":"13","author":"JH Shin","year":"2024","unstructured":"Shin JH, Park J, Lim J, Jeong J, Dinesh RK, Maher SE, Kim J, Park S, Hong JY, Wysolmerski J et al (2024) Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties. Elife 13:RP97279. https:\/\/doi.org\/10.7554\/eLife.97279","journal-title":"Elife"},{"key":"2060_CR24","doi-asserted-by":"publisher","first-page":"456","DOI":"10.2144\/btn-2020-0172","volume":"71","author":"R Ahmad","year":"2021","unstructured":"Ahmad R, Kumar B, Tamang RL, Xu W, Talmon GA, Mohs AM, Dhawan P, Singh AB (2021) Colonoscopy-based intramucosal transplantation of cancer cells for mouse modeling of colon cancer and lung metastasis. Biotechniques 71:456\u2013464. https:\/\/doi.org\/10.2144\/btn-2020-0172","journal-title":"Biotechniques"},{"key":"2060_CR25","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nprot.2017.136","volume":"13","author":"J Roper","year":"2018","unstructured":"Roper J, Tammela T, Akkad A, Almeqdadi M, Santos SB, Jacks T, Yilmaz \u00d6H (2018) Colonoscopy-based colorectal cancer modeling in mice with CRISPR\u2013Cas9 genome editing and organoid transplantation. Nat Protoc 13:217\u2013234. https:\/\/doi.org\/10.1038\/nprot.2017.136","journal-title":"Nat Protoc"},{"key":"2060_CR26","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1152\/physrev.00019.2012","volume":"93","author":"D G\u00fcnzel","year":"2013","unstructured":"G\u00fcnzel D, Yu AS (2013) Claudins and the modulation of tight junction permeability. Physiol Rev 93:525\u2013569. https:\/\/doi.org\/10.1152\/physrev.00019.2012","journal-title":"Physiol Rev"},{"key":"2060_CR27","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1001\/jamasurg.2015.1525","volume":"150","author":"R Amri","year":"2015","unstructured":"Amri R, Bordeianou LG, Sylla P, Berger DL (2015) Association of radial margin positivity with colon cancer. JAMA Surg 150:890\u2013898. https:\/\/doi.org\/10.1001\/jamasurg.2015.1525","journal-title":"JAMA Surg"},{"key":"2060_CR28","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/j.surg.2016.05.028","volume":"160","author":"QD Chu","year":"2016","unstructured":"Chu QD, Zhou M, Medeiros K, Peddi P (2016) Positive surgical margins contribute to the survival paradox between patients with stage IIB\/C (T4N0) and stage IIIA (T1\u20132N1, T1N2a) colon cancer. Surgery 160:1333\u20131343. https:\/\/doi.org\/10.1016\/j.surg.2016.05.028","journal-title":"Surgery"},{"key":"2060_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/cells11020249","author":"TM Lwin","year":"2022","unstructured":"Lwin TM, Turner MA, Amirfakhri S, Nishino H, Hoffman RM, Bouvet M (2022) Fluorescence molecular targeting of colon cancer to visualize the invisible. Cells. https:\/\/doi.org\/10.3390\/cells11020249","journal-title":"Cells"},{"key":"2060_CR30","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1021\/bc100070g","volume":"21","author":"H Maeda","year":"2010","unstructured":"Maeda H (2010) Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects. Bioconjug Chem 21:797\u2013802. https:\/\/doi.org\/10.1021\/bc100070g","journal-title":"Bioconjug Chem"},{"key":"2060_CR31","first-page":"6387","volume":"46","author":"Y Matsumura","year":"1986","unstructured":"Matsumura Y, Maeda H (1986) A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 46:6387\u20136392","journal-title":"Cancer Res"},{"key":"2060_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2025.115550","volume":"219","author":"IB Belyaev","year":"2025","unstructured":"Belyaev IB, Griaznova OY, Yaremenko AV, Deyev SM, Zelepukin IV (2025) Beyond the EPR effect: intravital microscopy analysis of nanoparticle drug delivery to tumors. Adv Drug Deliv Rev 219:115550. https:\/\/doi.org\/10.1016\/j.addr.2025.115550","journal-title":"Adv Drug Deliv Rev"},{"key":"2060_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13030580","author":"JI Traylor","year":"2021","unstructured":"Traylor JI, Pernik MN, Sternisha AC, McBrayer SK, Abdullah KG (2021) Molecular and metabolic mechanisms underlying selective 5-aminolevulinic acid-induced fluorescence in gliomas. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers13030580","journal-title":"Cancers (Basel)"},{"key":"2060_CR34","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1097\/00000658-199409000-00015","volume":"220","author":"AE Giuliano","year":"1994","unstructured":"Giuliano AE, Kirgan DM, Guenther JM, Morton DL (1994) Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Ann Surg 220:391\u2013398. https:\/\/doi.org\/10.1097\/00000658-199409000-00015","journal-title":"Ann Surg"},{"key":"2060_CR35","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-4021","volume":"9","author":"Y Cao","year":"2021","unstructured":"Cao Y, Wang P, Wang Z, Zhang W, Lu Q, Butch CJ, Guissi NEI, You Q, Cai H, Ding Y, Wang Y (2021) A pilot study of near-infrared fluorescence guided surgery for primary tumor localization and lymph node mapping in colorectal cancer. Ann Transl Med 9:1342. https:\/\/doi.org\/10.21037\/atm-21-4021","journal-title":"Ann Transl Med"},{"key":"2060_CR36","doi-asserted-by":"publisher","first-page":"3350","DOI":"10.1245\/s10434-018-6655-7","volume":"25","author":"CES Hoogstins","year":"2018","unstructured":"Hoogstins CES, Boogerd LSF, Sibinga Mulder BG, Mieog JSD, Swijnenburg RJ, van de Velde CJH, Farina Sarasqueta A, Bonsing BA, Framery B, P\u00e8legrin A et al (2018) Image-guided surgery in patients with pancreatic cancer: first results of a clinical trial using SGM-101, a novel carcinoembryonic antigen-targeting, near-infrared fluorescent agent. Ann Surg Oncol 25:3350\u20133357. https:\/\/doi.org\/10.1245\/s10434-018-6655-7","journal-title":"Ann Surg Oncol"},{"key":"2060_CR37","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.suronc.2017.03.002","volume":"26","author":"M Gutowski","year":"2017","unstructured":"Gutowski M, Framery B, Boonstra MC, Garambois V, Quenet F, Dumas K, Scherninski F, Cailler F, Vahrmeijer AL, P\u00e8legrin A (2017) SGM-101: an innovative near-infrared dye-antibody conjugate that targets CEA for fluorescence-guided surgery. Surg Oncol 26:153\u2013162. https:\/\/doi.org\/10.1016\/j.suronc.2017.03.002","journal-title":"Surg Oncol"},{"key":"2060_CR38","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1158\/1078-0432.Ccr-19-4156","volume":"26","author":"KS de Valk","year":"2020","unstructured":"de Valk KS, Deken MM, Handgraaf HJM, Bhairosingh SS, Bijlstra OD, van Esdonk MJ, Terwisscha van Scheltinga AGT, Valentijn A, March TL, Vuijk J et al (2020) First-in-human assessment of cRGD-ZW800-1, a zwitterionic, integrin-targeted, near-infrared fluorescent peptide in colon carcinoma. Clin Cancer Res 26:3990\u20133998. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-19-4156","journal-title":"Clin Cancer Res"},{"key":"2060_CR39","doi-asserted-by":"publisher","first-page":"655","DOI":"10.2967\/jnumed.119.232355","volume":"61","author":"SJ de Jongh","year":"2020","unstructured":"de Jongh SJ, Tjalma JJJ, Koller M, Linssen MD, Vonk J, Dobosz M, Jorritsma-Smit A, Kleibeuker JH, Hospers GAP, Havenga K et al (2020) Back-table fluorescence-guided imaging for circumferential resection margin evaluation using Bevacizumab-800CW in patients with locally advanced rectal cancer. J Nucl Med 61:655\u2013661. https:\/\/doi.org\/10.2967\/jnumed.119.232355","journal-title":"J Nucl Med"},{"key":"2060_CR40","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1136\/gutjnl-2019-319755","volume":"69","author":"JJJ Tjalma","year":"2020","unstructured":"Tjalma JJJ, Koller M, Linssen MD, Hartmans E, de Jongh SJ, Jorritsma-Smit A, Karrenbeld A, de Vries EG, Kleibeuker JH, Pennings JP et al (2020) Quantitative fluorescence endoscopy: an innovative endoscopy approach to evaluate neoadjuvant treatment response in locally advanced rectal cancer. Gut 69:406\u2013410. https:\/\/doi.org\/10.1136\/gutjnl-2019-319755","journal-title":"Gut"},{"key":"2060_CR41","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.cllc.2024.11.004","volume":"26","author":"IS Sarkaria","year":"2025","unstructured":"Sarkaria IS, Biro TG, Singhal S, Reddy RM, Martin LW, Rice DC, Lopez AS, Stevens G, Barret T, Murthy SC (2025) Intraoperative molecular imaging with pafolacianine: histologic characteristics of identified nodules. Clin Lung Cancer 26:104\u2013115. https:\/\/doi.org\/10.1016\/j.cllc.2024.11.004","journal-title":"Clin Lung Cancer"},{"key":"2060_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16814-4","volume":"11","author":"FJ Voskuil","year":"2020","unstructured":"Voskuil FJ, Steinkamp PJ, Zhao T, van der Vegt B, Koller M, Doff JJ, Jayalakshmi Y, Hartung JP, Gao J, Sumer BD et al (2020) Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery. Nat Commun 11:3257. https:\/\/doi.org\/10.1038\/s41467-020-16814-4","journal-title":"Nat Commun"},{"key":"2060_CR43","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1101\/gad.293449.116","volume":"31","author":"AT Boutin","year":"2017","unstructured":"Boutin AT, Liao WT, Wang M, Hwang SS, Karpinets TV, Cheung H, Chu GC, Jiang S, Hu J, Chang K et al (2017) Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. Genes Dev 31:370\u2013382. https:\/\/doi.org\/10.1101\/gad.293449.116","journal-title":"Genes Dev"},{"key":"2060_CR44","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.trecan.2023.09.011","volume":"10","author":"A Aiderus","year":"2024","unstructured":"Aiderus A, Barker N, Tergaonkar V (2024) Serrated colorectal cancer: preclinical models and molecular pathways. Trends Cancer 10:76\u201391. https:\/\/doi.org\/10.1016\/j.trecan.2023.09.011","journal-title":"Trends Cancer"},{"key":"2060_CR45","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000089","volume":"11","author":"F Wang","year":"2020","unstructured":"Wang F, Duan X, Chen J, Gao Z, Zhou J, Wu X, Chang TS, Lee M, Li G, Nusrat A et al (2020) Integrated imaging methodology detects Claudin-1 expression in premalignant nonpolypoid and polypoid colonic epithelium in mice. Clin Transl Gastroenterol 11:e00089. https:\/\/doi.org\/10.14309\/ctg.0000000000000089","journal-title":"Clin Transl Gastroenterol"},{"issue":"2","key":"2060_CR46","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.jcmgh.2015.12.001","volume":"2","author":"EF Rabinsky","year":"2016","unstructured":"Rabinsky EF, Joshi BP, Pant A, Zhou J, Duan X, Smith A, Kuick R, Fan S, Nusrat A, Owens SR et al (2016) Overexpressed claudin-1 can be visualized endoscopically in colonic adenomas in vivo. Cell Mol Gastroenterol Hepatol 2(2):222\u2013237. https:\/\/doi.org\/10.1016\/j.jcmgh.2015.12.001","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2060_CR47","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/j.1572-0241.2006.00390.x","volume":"101","author":"JC van Rijn","year":"2006","unstructured":"van Rijn JC, Reitsma JB, Stoker J, Bossuyt PM, van Deventer SJ, Dekker E (2006) Polyp miss rate determined by tandem colonoscopy: a systematic review. Am J Gastroenterol 101:343\u2013350. https:\/\/doi.org\/10.1111\/j.1572-0241.2006.00390.x","journal-title":"Am J Gastroenterol"},{"key":"2060_CR48","doi-asserted-by":"publisher","first-page":"747","DOI":"10.5009\/gnl16523","volume":"11","author":"MX Ma","year":"2017","unstructured":"Ma MX, Bourke MJ (2017) Sessile serrated adenomas: how to detect, characterize and resect. Gut Liver 11:747\u2013760. https:\/\/doi.org\/10.5009\/gnl16523","journal-title":"Gut Liver"},{"key":"2060_CR49","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.tranon.2014.05.009","volume":"7","author":"M Caruso","year":"2014","unstructured":"Caruso M, Fung KY, Moore J, Brierley GV, Cosgrove LJ, Thomas M, Cheetham G, Brook E, Fraser LM, Tin T et al (2014) Claudin-1 expression is elevated in colorectal cancer precursor lesions harboring the BRAF V600E mutation. Transl Oncol 7:456\u2013463. https:\/\/doi.org\/10.1016\/j.tranon.2014.05.009","journal-title":"Transl Oncol"},{"key":"2060_CR50","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1158\/0008-5472.Can-16-3217","volume":"77","author":"WS Tummers","year":"2017","unstructured":"Tummers WS, Warram JM, Tipirneni KE, Fengler J, Jacobs P, Shankar L, Henderson L, Ballard B, Pfefer TJ, Pogue BW et al (2017) Regulatory aspects of optical methods and exogenous targets for cancer detection. Cancer Res 77:2197\u20132206. https:\/\/doi.org\/10.1158\/0008-5472.Can-16-3217","journal-title":"Cancer Res"},{"key":"2060_CR51","doi-asserted-by":"publisher","first-page":"3658","DOI":"10.1158\/1078-0432.Ccr-14-3284","volume":"21","author":"EL Rosenthal","year":"2015","unstructured":"Rosenthal EL, Warram JM, de Boer E, Chung TK, Korb ML, Brandwein-Gensler M, Strong TV, Schmalbach CE, Morlandt AB, Agarwal G et al (2015) Safety and tumor specificity of Cetuximab-IRDye800 for surgical navigation in head and neck cancer. Clin Cancer Res 21:3658\u20133666. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-14-3284","journal-title":"Clin Cancer Res"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-025-02060-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11307-025-02060-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-025-02060-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:16:04Z","timestamp":1772817364000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11307-025-02060-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["2060"],"URL":"https:\/\/doi.org\/10.1007\/s11307-025-02060-x","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"5 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study followed all applicable institutional and\/or national guidelines for the care and use of animals under IACUC # 16\u2013058-08-FC.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare that they have no conflict of interest with regard to this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}