{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T21:17:44Z","timestamp":1783372664726,"version":"3.54.6"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007660","name":"Universiteit Antwerpen","doi-asserted-by":"publisher","award":["BOF (KP)"],"award-info":[{"award-number":["BOF (KP)"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s11307-026-02102-y","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T15:14:58Z","timestamp":1776698098000},"page":"490-501","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Accurate Reference Region Calculation in Mouse Brain [18F]fallypride Studies"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5381-015X","authenticated-orcid":false,"given":"Alan","family":"Miranda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9790-3369","authenticated-orcid":false,"given":"Filipe","family":"Elvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Staelens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"2102_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev-psych-010418-103337","volume":"71","author":"RA Wise","year":"2020","unstructured":"Wise RA, Robble MA (2020) Dopamine and addiction. Annu Rev Psychol 71:79\u2013106","journal-title":"Annu Rev Psychol"},{"key":"2102_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040735","author":"L Speranza","year":"2021","unstructured":"Speranza L, di Porzio U, Viggiano D, de Donato A, Volpicelli F (2021) Dopamine: the neuromodulator of long-term synaptic plasticity, reward and movement control. Cells. https:\/\/doi.org\/10.3390\/cells10040735","journal-title":"Cells"},{"key":"2102_CR3","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s12264-020-00582-8","volume":"36","author":"T Glaser","year":"2020","unstructured":"Glaser T, Andrejew R, Oliveira-Giacomelli A et al (2020) Purinergic receptors in basal ganglia diseases: shared molecular mechanisms between Huntington\u2019s and Parkinson\u2019s disease. Neurosci Bull 36:1299\u20131314","journal-title":"Neurosci Bull"},{"key":"2102_CR4","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1002\/syn.20785","volume":"64","author":"A Rominger","year":"2010","unstructured":"Rominger A, Mille E, Boning G et al (2010) alpha2-adrenergic drugs modulate the binding of [18F]fallypride to dopamine D2\/3 receptors in striatum of living mouse. Synapse 64:654\u2013657","journal-title":"Synapse"},{"key":"2102_CR5","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1016\/j.neuroimage.2012.05.075","volume":"62","author":"P Millet","year":"2012","unstructured":"Millet P, Moulin-Sallanon M, Tournier BB et al (2012) Quantification of dopamine D(2\/3) receptors in rat brain using factor analysis corrected [18F]fallypride images. Neuroimage 62:1455\u20131468","journal-title":"Neuroimage"},{"key":"2102_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2310\/7290.2014.00028","volume":"13","author":"S Tsartsalis","year":"2014","unstructured":"Tsartsalis S, Moulin-Sallanon M, Dumas N, Tournier BB, Ginovart N, Millet P (2014) A modified simplified reference tissue model for the quantification of dopamine D2\/3 receptors with [18F]fallypride images. Mol Imaging 13:1\u201314","journal-title":"Mol Imaging"},{"key":"2102_CR7","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/jcbfm.2014.202","volume":"35","author":"CA Salinas","year":"2015","unstructured":"Salinas CA, Searle GE, Gunn RN (2015) The simplified reference tissue model: model assumption violations and their impact on binding potential. J Cereb Blood Flow Metab 35:304\u2013311","journal-title":"J Cereb Blood Flow Metab"},{"key":"2102_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s40658-023-00599-8","volume":"10","author":"A Miranda","year":"2023","unstructured":"Miranda A, Bertoglio D, Staelens S, Verhaeghe J (2023) Accurate image derived input function in [(18)F]SynVesT-1 mouse studies using isoflurane and ketamine\/xylazine anesthesia. EJNMMI Phys 10:78","journal-title":"EJNMMI Phys"},{"key":"2102_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s41060-022-00370-9","author":"SF Hafshejani","year":"2022","unstructured":"Hafshejani SF, Moaberfard Z (2022) Initialization for non-negative matrix factorization: a comprehensive review. Int J Data Sci Anal. https:\/\/doi.org\/10.1007\/s41060-022-00370-9","journal-title":"Int J Data Sci Anal"},{"key":"2102_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-19872-4","volume":"12","author":"L Presotto","year":"2022","unstructured":"Presotto L, Bettinardi V, Mercatelli D et al (2022) Development of a new toolbox for mouse PET-CT brain image analysis fully based on CT images and validation in a PD mouse model. Sci Rep 12:15822","journal-title":"Sci Rep"},{"key":"2102_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081390","volume":"8","author":"J Dutta","year":"2013","unstructured":"Dutta J, Leahy RM, Li Q (2013) Non-local means denoising of dynamic PET images. PLoS One 8:e81390","journal-title":"PLoS One"},{"key":"2102_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0010-4825(93)90108-D","volume":"23","author":"DG Feng","year":"1993","unstructured":"Feng DG, Wang XM (1993) A computer-simulation study on the effects of input function measurement noise in tracer kinetic modeling with positron emission tomography (Pet). Comput Biol Med 23:57\u201368","journal-title":"Comput Biol Med"},{"key":"2102_CR13","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S0306-4522(97)00565-4","volume":"84","author":"A Gobert","year":"1998","unstructured":"Gobert A, Rivet JM, Audinot V, Newman-Tancredi A, Cistarelli L, Millan MJ (1998) Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release. Neuroscience 84:413\u2013429","journal-title":"Neuroscience"},{"key":"2102_CR14","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1365-2680.1999.tb00003.x","volume":"19","author":"AL Hudson","year":"1999","unstructured":"Hudson AL, Robinson ES, Lalies MD, Tyacke RJ, Jackson HC, Nutt DJ (1999) In vitro and in vivo approaches to the characterization of the alpha2-adrenoceptor. J Auton Pharmacol 19:311\u2013320","journal-title":"J Auton Pharmacol"},{"key":"2102_CR15","doi-asserted-by":"publisher","DOI":"10.1088\/2057-1976\/ab8c13","volume":"6","author":"A Miranda","year":"2020","unstructured":"Miranda A, Bertoglio D, Glorie D, Stroobants S, Staelens S, Verhaeghe J (2020) Validation of a spatially variant resolution model for small animal brain PET studies. Biomed Phys Eng Express 6:045001","journal-title":"Biomed Phys Eng Express"},{"key":"2102_CR16","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1006\/nimg.1996.0066","volume":"4","author":"AA Lammertsma","year":"1996","unstructured":"Lammertsma AA, Hume SP (1996) Simplified reference tissue model for PET receptor studies. Neuroimage 4:153\u2013158","journal-title":"Neuroimage"},{"key":"2102_CR17","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1097\/00004647-199609000-00008","volume":"16","author":"J Logan","year":"1996","unstructured":"Logan J, Fowler JS, Volkow ND, Wang GJ, Ding YS, Alexoff DL (1996) Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab 16:834\u2013840","journal-title":"J Cereb Blood Flow Metab"},{"key":"2102_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF03033993","volume":"21","author":"Y Kimura","year":"2007","unstructured":"Kimura Y, Naganawa M, Shidahara M, Ikoma Y, Watabe H (2007) PET kinetic analysis \u2013pitfalls and a solution for the Logan plot. Ann Nucl Med 21:1\u20138","journal-title":"Ann Nucl Med"},{"key":"2102_CR19","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.nucmedbio.2009.06.007","volume":"36","author":"MN Tantawy","year":"2009","unstructured":"Tantawy MN, Jones CK, Baldwin RM et al (2009) (18)F]fallypride dopamine D2 receptor studies using delayed microPET scans and a modified Logan plot. Nucl Med Biol 36:931\u2013940","journal-title":"Nucl Med Biol"},{"key":"2102_CR20","doi-asserted-by":"crossref","unstructured":"Ding C, Li T, Peng W, Park H (2006) Orthogonal nonnegative matrix t-factorizations for clustering. In Proceedings of the 12th ACM SIGKDD international conference on knowledge discovery and data mining. Association for Computing Machinery,\u00a0Philadelphia, PA, USA, pp 126\u2013135","DOI":"10.1145\/1150402.1150420"},{"key":"2102_CR21","doi-asserted-by":"publisher","first-page":"4843","DOI":"10.1109\/JSTARS.2019.2925098","volume":"12","author":"AMS Ang","year":"2019","unstructured":"Ang AMS, Gillis N (2019) Algorithms and comparisons of nonnegative matrix factorizations with volume regularization for hyperspectral unmixing. IEEE J Sel Top Appl Earth Obs Remote Sens 12:4843\u20134853","journal-title":"IEEE J Sel Top Appl Earth Obs Remote Sens"},{"key":"2102_CR22","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.2967\/jnumed.110.078451","volume":"51","author":"A Rominger","year":"2010","unstructured":"Rominger A, Mille E, Zhang S et al (2010) Validation of the octamouse for simultaneous 18F-fallypride small-animal PET recordings from 8 mice. J Nucl Med 51:1576\u20131583","journal-title":"J Nucl Med"},{"key":"2102_CR23","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/syn.20730","volume":"64","author":"A Rominger","year":"2010","unstructured":"Rominger A, Wagner E, Mille E et al (2010) Endogenous competition against binding of [(18)F]DMFP and [(18)F]fallypride to dopamine D(2\/3) receptors in brain of living mouse. Synapse 64:313\u2013322","journal-title":"Synapse"},{"key":"2102_CR24","doi-asserted-by":"crossref","unstructured":"Price JC, Mason NS, Lopresti B, et al. (1998) PET measurement of endogenous neurotransmitter activity using high and low affinity radiotracers.\u00a0In: Carson RE, Daube-Witherspoon ME, Herscovitch P (eds) Quantitative functional brain imaging with positron emission tomography. Academic Press. pp. 441\u2013448","DOI":"10.1016\/B978-012161340-2\/50068-8"},{"key":"2102_CR25","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.nucmedbio.2013.06.003","volume":"40","author":"MA Peyronneau","year":"2013","unstructured":"Peyronneau MA, Saba W, Goutal S et al (2013) [(18)F]Fallypride: metabolism studies and quantification of the radiotracer and its radiometabolites in plasma using a simple and rapid solid-phase extraction method. Nucl Med Biol 40:887\u2013895","journal-title":"Nucl Med Biol"},{"key":"2102_CR26","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/syn.10128","volume":"46","author":"J Mukherjee","year":"2002","unstructured":"Mukherjee J, Christian BT, Dunigan KA et al (2002) Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2\/D-3 receptors. Synapse 46:170\u2013188","journal-title":"Synapse"},{"key":"2102_CR27","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.2967\/jnumed.107.048330","volume":"49","author":"OG Rousset","year":"2008","unstructured":"Rousset OG, Collins DL, Rahmim A, Wong DF (2008) Design and implementation of an automated partial volume correction in PET: application to dopamine receptor quantification in the normal human striatum. J Nucl Med 49:1097\u20131106","journal-title":"J Nucl Med"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-026-02102-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11307-026-02102-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-026-02102-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T21:09:49Z","timestamp":1783372189000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11307-026-02102-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["2102"],"URL":"https:\/\/doi.org\/10.1007\/s11307-026-02102-y","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"assertion":[{"value":"1 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments followed the European Ethics Committee recommendations (decree 86\/609\/CEE) and were approved by the Animal Experimental Ethical Committee of the University of Antwerp, Antwerp, Belgium (ECD 2023-75).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}}]}}