{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T21:17:44Z","timestamp":1783372664711,"version":"3.54.6"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL135103"],"award-info":[{"award-number":["R01 HL135103"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL173102"],"award-info":[{"award-number":["R01 HL173102"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      A standard imaging strategy for quantifying skeletal muscle perfusion in peripheral artery disease (PAD) does not exist, and the widespread use of PET imaging for this purpose has traditionally been limited by the need for onsite production of short half-life perfusion radioisotopes. Therefore, this study investigated the feasibility of multiparametric PET imaging with commercially available fluorine-18 (\n                      <jats:sup>18<\/jats:sup>\n                      F)-fluorodeoxyglucose (FDG) for the quantification of skeletal muscle perfusion and metabolism in a porcine model of PAD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eight Yorkshire pigs underwent 60-min dynamic\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET imaging under resting conditions immediately following unilateral surgical ligation of the femoral artery and 2\u00a0weeks after arterial occlusion. Calf muscle perfusion was computed using 1-compartment modeling of the first 2.5\u00a0min of PET data acquisition, and the metabolic rate of glucose (MRGlu) was computed using 3-compartment modeling of the entire 60-min dataset. Two weeks after arterial occlusion, the gastrocnemius muscle was harvested to compare microvascular density between ischemic and control hindlimbs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Calf perfusion and MRGlu were significantly reduced following peripheral artery occlusion and recovered to control levels 2\u00a0weeks later. Recovery of perfusion and metabolism in calf skeletal muscle coincided with a significant increase in calf muscle capillary density 2\u00a0weeks after arterial occlusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study demonstrates the novel use of dynamic, multiparametric\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET\/CT imaging for quantifying ischemia-induced alterations in skeletal muscle perfusion and metabolism, providing a unique comprehensive approach for evaluating PAD pathophysiology and creating opportunities for monitoring treatment responses to emerging therapeutics.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11307-026-02106-8","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:10:26Z","timestamp":1777648226000},"page":"449-456","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual Quantification of Skeletal Muscle Perfusion and Metabolism in a Porcine Model of Peripheral Artery Disease Using Multiparametric 18F-FDG PET Imaging"],"prefix":"10.1007","volume":"28","author":[{"given":"Ting-Heng","family":"Chou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboubeh","family":"Nabavinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor T.","family":"Rimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrin","family":"Mansfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumudha Narayana","family":"Musini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen K.","family":"Tram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8423-1011","authenticated-orcid":false,"given":"Mitchel R.","family":"Stacy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"2106_CR1","doi-asserted-by":"publisher","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","volume":"145","author":"CW Tsao","year":"2022","unstructured":"Tsao CW, Aday AW, Almarzooq ZI et al (2022) Heart disease and stroke statistics-2022 update: a report from the American Heart Association. 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All procedures followed the National Institutes of Health Guide for the Care and Use of Laboratory Animals. The ARRIVE guidelines and regulations were followed for reporting of animal use and study results.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Drs. Stacy and Chou have a pending patent (US patent application # 18\/800,902). All other authors have no relevant conflicts of interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}