{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:17:42Z","timestamp":1778779062621,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-16067714"],"award-info":[{"award-number":["RS-2025-16067714"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008130","name":"Pusan National University Hospital","doi-asserted-by":"publisher","award":["Clinical research grant 2025"],"award-info":[{"award-number":["Clinical research grant 2025"]}],"id":[{"id":"10.13039\/501100008130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"DOI":"10.1007\/s11307-026-02108-6","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:44:09Z","timestamp":1778773449000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain Amyloid Deposition Is Negatively Associated with Cardiac Amyloid Retention in Apo E4 Carriers: A Pilot Study"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-1894","authenticated-orcid":false,"given":"Kyoungjune","family":"Pak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keunyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungwon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunji","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwagyu","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunsoo","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Dae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je-Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hyun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"2108_CR1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.4161\/pri.2.3.7488","volume":"2","author":"RN Rambaran","year":"2008","unstructured":"Rambaran RN, Serpell LC (2008) Amyloid fibrils: abnormal protein assembly. Prion 2:112\u2013117","journal-title":"Prion"},{"key":"2108_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2174\/156720510790274473","volume":"7","author":"F Angelucci","year":"2010","unstructured":"Angelucci F, Spalletta G, di Iulio F et al (2010) Alzheimer\u2019s disease (AD) and mild cognitive impairment (MCI) patients are characterized by increased BDNF serum levels. Curr Alzheimer Res 7:15\u201320","journal-title":"Curr Alzheimer Res"},{"key":"2108_CR3","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","volume":"396","author":"G Livingston","year":"2020","unstructured":"Livingston G, Huntley J, Sommerlad A et al (2020) Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet 396:413\u2013446","journal-title":"Lancet"},{"key":"2108_CR4","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s13139-024-00861-6","volume":"58","author":"SK Kang","year":"2024","unstructured":"Kang SK, Heo M, Chung JY et al (2024) Clinical performance evaluation of an artificial intelligence-powered amyloid brain PET quantification method. Nucl Med Mol Imaging 58:246\u2013254","journal-title":"Nucl Med Mol Imaging"},{"key":"2108_CR5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s13139-024-00848-3","volume":"58","author":"KW Park","year":"2024","unstructured":"Park KW (2024) Anti-amyloid antibody therapies for Alzheimer\u2019s disease. Nucl Med Mol Imaging 58:227\u2013236","journal-title":"Nucl Med Mol Imaging"},{"key":"2108_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14338","volume":"21","author":"GD Rabinovici","year":"2025","unstructured":"Rabinovici GD, Knopman DS, Arbizu J et al (2025) Updated appropriate use criteria for amyloid and tau PET: a report from the Alzheimer\u2019s Association and Society for Nuclear Medicine and Molecular Imaging Workgroup. Alzheimers Dement 21:e14338","journal-title":"Alzheimers Dement"},{"key":"2108_CR7","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.tcm.2017.07.004","volume":"28","author":"OK Siddiqi","year":"2018","unstructured":"Siddiqi OK, Ruberg FL (2018) Cardiac amyloidosis: an update on pathophysiology, diagnosis, and treatment. Trends Cardiovasc Med 28:10\u201321","journal-title":"Trends Cardiovasc Med"},{"key":"2108_CR8","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jcmg.2020.05.031","volume":"14","author":"D Genovesi","year":"2021","unstructured":"Genovesi D, Vergaro G, Giorgetti A et al (2021) [18F]-Florbetaben PET\/CT for differential diagnosis among cardiac immunoglobulin light chain, transthyretin amyloidosis, and mimicking conditions. JACC Cardiovasc Imaging 14:246\u2013255","journal-title":"JACC Cardiovasc Imaging"},{"key":"2108_CR9","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.2967\/jnumed.115.169870","volume":"57","author":"WP Law","year":"2016","unstructured":"Law WP, Wang WY, Moore PT, Mollee PN, Ng AC (2016) Cardiac amyloid imaging with 18F-Florbetaben PET: a pilot study. J Nucl Med 57:1733\u20131739","journal-title":"J Nucl Med"},{"key":"2108_CR10","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1007\/s00259-019-04290-y","volume":"46","author":"M Kircher","year":"2019","unstructured":"Kircher M, Ihne S, Brumberg J et al (2019) Detection of cardiac amyloidosis with (18)F-Florbetaben-PET\/CT in comparison to echocardiography, cardiac MRI and DPD-scintigraphy. Eur J Nucl Med Mol Imaging 46:1407\u20131416","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2108_CR11","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2967\/jnumed.111.102053","volume":"54","author":"G Antoni","year":"2013","unstructured":"Antoni G, Lubberink M, Estrada S et al (2013) In vivo visualization of amyloid deposits in the heart with 11C-PIB and PET. J Nucl Med 54:213\u2013220","journal-title":"J Nucl Med"},{"key":"2108_CR12","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/j.jcmg.2023.08.009","volume":"16","author":"JS Wall","year":"2023","unstructured":"Wall JS, Martin EB, Lands R et al (2023) Cardiac amyloid detection by PET\/CT imaging of iodine ((124)I) Evuzamitide ((124)I-p5+14): a Phase 1\/2 study. JACC Cardiovasc Imaging 16:1433\u20131448","journal-title":"JACC Cardiovasc Imaging"},{"key":"2108_CR13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.124.017807","volume":"18","author":"A Kurian","year":"2025","unstructured":"Kurian A, de Moraes A, Clerc OF et al (2025) (124)I-Evuzamitide PET\/CT diagnosis of wild-type Transthyretin Amyloid Cardiomyopathy in a woman with negative diagnostic evaluation. Circ Cardiovasc Imaging 18:e017807","journal-title":"Circ Cardiovasc Imaging"},{"issue":"Pt A","key":"2108_CR14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.nbd.2014.08.025","volume":"72","author":"Y Huang","year":"2014","unstructured":"Huang Y, Mahley RW (2014) Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer\u2019s diseases. Neurobiol Dis 72(Pt A):3\u201312","journal-title":"Neurobiol Dis"},{"key":"2108_CR15","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","volume":"278","author":"LA Farrer","year":"1997","unstructured":"Farrer LA, Cupples LA, Haines JL et al (1997) Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 278:1349\u20131356","journal-title":"JAMA"},{"key":"2108_CR16","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030780","volume":"12","author":"A Saeed","year":"2023","unstructured":"Saeed A, Lopez O, Cohen A, Reis SE (2023) Cardiovascular disease and Alzheimer\u2019s disease: the heart-brain axis. J Am Heart Assoc 12:e030780","journal-title":"J Am Heart Assoc"},{"key":"2108_CR17","first-page":"20150181","volume":"374","author":"A Silvani","year":"2016","unstructured":"Silvani A, Calandra-Buonaura G, Dampney RA, Cortelli P (2016) Brain-heart interactions: physiology and clinical implications. Philos Trans A Math Phys Eng Sci 374:20150181","journal-title":"Philos Trans A Math Phys Eng Sci"},{"key":"2108_CR18","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.70043","volume":"46","author":"S Shin","year":"2026","unstructured":"Shin S, Pak K (2026) Association between heart rate variability and brain glucose metabolism in healthy middle-aged men. Clin Physiol Funct Imaging 46:e70043","journal-title":"Clin Physiol Funct Imaging"},{"key":"2108_CR19","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","volume":"256","author":"RC Petersen","year":"2004","unstructured":"Petersen RC (2004) Mild cognitive impairment as a diagnostic entity. J Intern Med 256:183\u2013194","journal-title":"J Intern Med"},{"key":"2108_CR20","first-page":"206","volume":"8","author":"HM Ku","year":"2004","unstructured":"Ku HM, Kim JH, Lee HS, Ko HJ, Kwon EJ, Jo S, Kim DK (2004) A study on the reliability and validity of Seoul-Activities of Daily Living(S-ADL). J Korean Geriatr Soc 8:206\u2013214","journal-title":"J Korean Geriatr Soc"},{"key":"2108_CR21","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H et al (2011) The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement 7:263\u2013269","journal-title":"Alzheimers Dement"},{"key":"2108_CR22","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3346\/jkms.2005.20.3.361","volume":"20","author":"MH Shin","year":"2005","unstructured":"Shin MH, Kim HN, Cui LH et al (2005) The effect of apolipoprotein E polymorphism on lipid levels in Korean adults. J Korean Med Sci 20:361\u2013366","journal-title":"J Korean Med Sci"},{"key":"2108_CR23","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0022-2275(20)43176-1","volume":"31","author":"JE Hixson","year":"1990","unstructured":"Hixson JE, Vernier DT (1990) Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res 31:545\u2013548","journal-title":"J Lipid Res"},{"key":"2108_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","volume":"28","author":"RM Lang","year":"2015","unstructured":"Lang RM, Badano LP, Mor-Avi V et al (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 28:1-39 e14","journal-title":"J Am Soc Echocardiogr"},{"key":"2108_CR25","doi-asserted-by":"publisher","first-page":"A31","DOI":"10.1016\/j.echo.2022.06.006","volume":"35","author":"SAM Cuddy","year":"2022","unstructured":"Cuddy SAM, Chetrit M, Jankowski M et al (2022) Practical points for echocardiography in cardiac amyloidosis. J Am Soc Echocardiogr 35:A31\u2013A40","journal-title":"J Am Soc Echocardiogr"},{"key":"2108_CR26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fninf.2020.00003","volume":"14","author":"T Karjalainen","year":"2020","unstructured":"Karjalainen T, Tuisku J, Santavirta S et al (2020) Magia: robust automated image processing and kinetic modeling toolbox for PET neuroinformatics. Front Neuroinform 14:3","journal-title":"Front Neuroinform"},{"key":"2108_CR27","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/j.jalz.2015.02.004","volume":"11","author":"O Sabri","year":"2015","unstructured":"Sabri O, Sabbagh MN, Seibyl J et al (2015) Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer\u2019s disease: phase 3 study. Alzheimers Dement 11:964\u2013974","journal-title":"Alzheimers Dement"},{"key":"2108_CR28","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1016\/S0022-2275(20)39197-5","volume":"36","author":"J Deng","year":"1995","unstructured":"Deng J, Rudick V, Dory L (1995) Lysosomal degradation and sorting of apolipoprotein E in macrophages. J Lipid Res 36:2129\u20132140","journal-title":"J Lipid Res"},{"key":"2108_CR29","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1007\/s00018-003-3018-7","volume":"60","author":"FW Pfrieger","year":"2003","unstructured":"Pfrieger FW (2003) Cholesterol homeostasis and function in neurons of the central nervous system. Cell Mol Life Sci 60:1158\u20131171","journal-title":"Cell Mol Life Sci"},{"key":"2108_CR30","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1126\/science.8346443","volume":"261","author":"EH Corder","year":"1993","unstructured":"Corder EH, Saunders AM, Strittmatter WJ et al (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families. Science 261:921\u2013923","journal-title":"Science"},{"key":"2108_CR31","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev-pathmechdis-030421-112756","volume":"17","author":"N Koutsodendris","year":"2022","unstructured":"Koutsodendris N, Nelson MR, Rao A, Huang Y (2022) Apolipoprotein E and Alzheimer\u2019s disease: findings, hypotheses, and potential mechanisms. Annu Rev Pathol 17:73\u201399","journal-title":"Annu Rev Pathol"},{"key":"2108_CR32","doi-asserted-by":"publisher","first-page":"7293","DOI":"10.1523\/JNEUROSCI.5198-13.2014","volume":"34","author":"A Boehm-Cagan","year":"2014","unstructured":"Boehm-Cagan A, Michaelson DM (2014) Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene. J Neurosci 34:7293\u20137301","journal-title":"J Neurosci"},{"key":"2108_CR33","doi-asserted-by":"publisher","first-page":"18700","DOI":"10.1073\/pnas.0508693102","volume":"102","author":"S Ye","year":"2005","unstructured":"Ye S, Huang Y, Mullendorff K et al (2005) Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci U S A 102:18700\u201318705","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2108_CR34","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1093\/brain\/awy103","volume":"141","author":"S Mishra","year":"2018","unstructured":"Mishra S, Blazey TM, Holtzman DM et al (2018) Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE epsilon4 genotype. Brain 141:1828\u20131839","journal-title":"Brain"},{"key":"2108_CR35","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","volume":"9","author":"CC Liu","year":"2013","unstructured":"Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G (2013) Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol 9:106\u2013118","journal-title":"Nat Rev Neurol"},{"key":"2108_CR36","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3233\/JAD-181282","volume":"69","author":"JB Toledo","year":"2019","unstructured":"Toledo JB, Habes M, Sotiras A et al (2019) APOE effect on Amyloid-beta PET spatial distribution, deposition rate, and cut-points. J Alzheimers Dis 69:783\u2013793","journal-title":"J Alzheimers Dis"},{"key":"2108_CR37","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.pharmthera.2017.06.011","volume":"180","author":"KM Alexander","year":"2017","unstructured":"Alexander KM, Singh A, Falk RH (2017) Novel pharmacotherapies for cardiac amyloidosis. Pharmacol Ther 180:129\u2013138","journal-title":"Pharmacol Ther"},{"key":"2108_CR38","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1136\/heartjnl-2012-302353","volume":"98","author":"D Phelan","year":"2012","unstructured":"Phelan D, Collier P, Thavendiranathan P et al (2012) Relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis. Heart 98:1442\u20131448","journal-title":"Heart"},{"key":"2108_CR39","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jcmg.2009.09.023","volume":"3","author":"IS Syed","year":"2010","unstructured":"Syed IS, Glockner JF, Feng D et al (2010) Role of cardiac magnetic resonance imaging in the detection of cardiac amyloidosis. JACC Cardiovasc Imaging 3:155\u2013164","journal-title":"JACC Cardiovasc Imaging"},{"key":"2108_CR40","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.221082","volume":"306","author":"YM Khor","year":"2023","unstructured":"Khor YM, Cuddy SAM, Singh V, Falk RH, Di Carli MF, Dorbala S (2023) (99m)Tc bone-avid tracer cardiac scintigraphy: role in noninvasive diagnosis of transthyretin cardiac amyloidosis. Radiology 306:e221082","journal-title":"Radiology"},{"key":"2108_CR41","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1016\/j.jacc.2016.08.073","volume":"68","author":"L Troncone","year":"2016","unstructured":"Troncone L, Luciani M, Coggins M et al (2016) Abeta amyloid pathology affects the hearts of patients with Alzheimer\u2019s disease: mind the heart. J Am Coll Cardiol 68:2395\u20132407","journal-title":"J Am Coll Cardiol"},{"key":"2108_CR42","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.1007\/s12035-024-04442-8","volume":"62","author":"C Corino","year":"2025","unstructured":"Corino C, Aimo A, Luigetti M et al (2025) Tetrameric transthyretin as a protective factor against Alzheimer\u2019s disease. Mol Neurobiol 62:2945\u20132954","journal-title":"Mol Neurobiol"},{"key":"2108_CR43","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0014-5793(98)00234-8","volume":"425","author":"A Merched","year":"1998","unstructured":"Merched A, Serot JM, Visvikis S, Aguillon D, Faure G, Siest G (1998) Apolipoprotein E, transthyretin and actin in the CSF of Alzheimer\u2019s patients: relation with the senile plaques and cytoskeleton biochemistry. FEBS Lett 425:225\u2013228","journal-title":"FEBS Lett"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-026-02108-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11307-026-02108-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-026-02108-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:02:40Z","timestamp":1778778160000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11307-026-02108-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":43,"alternative-id":["2108"],"URL":"https:\/\/doi.org\/10.1007\/s11307-026-02108-6","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]},"assertion":[{"value":"26 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}