{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T19:59:44Z","timestamp":1785095984794,"version":"3.55.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["G085620N"],"award-info":[{"award-number":["G085620N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["S000922N"],"award-info":[{"award-number":["S000922N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Strategic Research Fund Vrije Universiteit Brussel","award":["SRP95"],"award-info":[{"award-number":["SRP95"]}]},{"name":"Innovation Research Fund Vrije Universiteit Brussel","award":["IOF3030"],"award-info":[{"award-number":["IOF3030"]}]},{"name":"Intramural Research Program of the National Institutes of Health","award":["ZIABC011506"],"award-info":[{"award-number":["ZIABC011506"]}]},{"name":"Intramural Research Program of the National Institutes of Health","award":["ZIABC011564"],"award-info":[{"award-number":["ZIABC011564"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"DOI":"10.1007\/s11307-026-02120-w","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:14:13Z","timestamp":1784816053000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In vivo Fluorescent Molecular Imaging Using Nanobodies Labeled with Next-Generation FNIR-Tag-Dyes"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-5302","authenticated-orcid":false,"given":"Dora M.","family":"Chigoho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7331-7135","authenticated-orcid":false,"given":"Marcus C. M.","family":"Stroet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6968-5835","authenticated-orcid":false,"given":"Jelena","family":"Sali\u00ebn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3642-0539","authenticated-orcid":false,"given":"Sofie","family":"Pollenus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2556-1624","authenticated-orcid":false,"given":"Dong-Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0503-0116","authenticated-orcid":false,"given":"Martin","family":"Schnermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8739-6137","authenticated-orcid":false,"given":"Sophie","family":"Hernot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"issue":"6428","key":"2120_CR1","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/363446a0","volume":"363","author":"C Hamers-Casterman","year":"1993","unstructured":"Hamers-Casterman C et al (1993) Naturally occurring antibodies devoid of light chains. Nature 363(6428):446\u2013448","journal-title":"Nature"},{"issue":"3","key":"2120_CR2","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1039\/D1CB00023C","volume":"2","author":"TJ Harmand","year":"2021","unstructured":"Harmand TJ et al (2021) Nanobodies as in vivo, non-invasive, imaging agents. RSC Chem Biol 2(3):685\u2013701","journal-title":"RSC Chem Biol"},{"issue":"17","key":"2120_CR3","doi-asserted-by":"publisher","first-page":"13229","DOI":"10.3390\/ijms241713229","volume":"24","author":"S Kunz","year":"2026","unstructured":"Kunz S et al (2026) Nanobody\u00ae\u00a0molecule, a giga medical tool in nanodimensions. Int J Mol Sci 24(17):13229","journal-title":"Int J Mol Sci"},{"key":"2120_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/antib8010012","author":"P Debie","year":"2019","unstructured":"Debie P, Devoogdt N, Hernot S (2019) Targeted nanobody-based molecular tracers for nuclear imaging and image-guided surgery. Antibodies. https:\/\/doi.org\/10.3390\/antib8010012","journal-title":"Antibodies"},{"issue":"1","key":"2120_CR5","doi-asserted-by":"publisher","first-page":"ltae006","DOI":"10.1093\/immadv\/ltae006","volume":"4","author":"K Zeven","year":"2024","unstructured":"Zeven K et al (2024) Advancements in nuclear imaging using radiolabeled nanobody tracers to support cancer immunotherapy. Immunother Adv 4(1):ltae006","journal-title":"Immunother Adv"},{"key":"2120_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2025.104524","author":"L Blank","year":"2025","unstructured":"Blank L et al (2025) Exploiting the unique properties of nanobodies: enhancing therapeutics, drug delivery, and targeted diagnostics. Drug Discov Today. https:\/\/doi.org\/10.1016\/j.drudis.2025.104524","journal-title":"Drug Discov Today"},{"issue":"6","key":"2120_CR7","doi-asserted-by":"publisher","first-page":"885","DOI":"10.2967\/jnumed.117.199901","volume":"59","author":"A Krasniqi","year":"2018","unstructured":"Krasniqi A et al (2018) Same-day imaging using small proteins: clinical experience and translational prospects in oncology. J Nucl Med 59(6):885\u2013891","journal-title":"J Nucl Med"},{"issue":"2","key":"2120_CR8","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3390\/biom11020311","volume":"11","author":"TM Lwin","year":"2021","unstructured":"Lwin TM, Hoffman RM, Bouvet M (2021) Unique benefits of tumor-specific nanobodies for fluorescence guided surgery. Biomolecules 11(2):311","journal-title":"Biomolecules"},{"issue":"3","key":"2120_CR9","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s11307-017-1134-2","volume":"20","author":"P Debie","year":"2018","unstructured":"Debie P et al (2018) Improved debulking of peritoneal tumor implants by near-infrared fluorescent nanobody image guidance in an experimental mouse model. Mol Imaging Biol 20(3):361\u2013367","journal-title":"Mol Imaging Biol"},{"issue":"1","key":"2120_CR10","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.surg.2020.02.020","volume":"168","author":"TM Lwin","year":"2020","unstructured":"Lwin TM et al (2020) Tumor-specific near-infrared nanobody probe rapidly labels tumors in an orthotopic mouse model of pancreatic cancer. Surgery 168(1):85\u201391","journal-title":"Surgery"},{"issue":"7","key":"2120_CR11","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1002\/jso.26623","volume":"124","author":"TM Lwin","year":"2021","unstructured":"Lwin TM et al (2021) Rapid tumor-labeling kinetics with a site-specific near-infrared anti-CEA nanobody in a patient-derived orthotopic xenograft mouse model of colon cancer. J Surg Oncol 124(7):1121\u20131127","journal-title":"J Surg Oncol"},{"issue":"30","key":"2120_CR12","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400700","volume":"11","author":"L Mateusiak","year":"2024","unstructured":"Mateusiak L et al (2024) Generation and characterization of novel pan-cancer anti-uPAR fluorescent nanobodies as tools for image-guided surgery. Adv Sci (Weinh) 11(30):e2400700","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"2120_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2024.109537","volume":"51","author":"L Mateusiak","year":"2024","unstructured":"Mateusiak L et al (2024) Fluorescent nanobodies for enhanced guidance in digestive tumors and liver metastasis surgery. Eur J Surg Oncol 51(3):109537","journal-title":"Eur J Surg Oncol"},{"key":"2120_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1266288","volume":"14","author":"NCH do Valle","year":"2023","unstructured":"do Valle NCH et al (2023) Safety assessment of fluorescently labeled anti-EGFR nanobodies in healthy dogs. Front Pharmacol 14:1266288","journal-title":"Front Pharmacol"},{"issue":"4","key":"2120_CR15","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1021\/acs.molpharmaceut.6b01053","volume":"14","author":"P Debie","year":"2017","unstructured":"Debie P et al (2017) Effect of dye and conjugation chemistry on the biodistribution profile of near-infrared-labeled nanobodies as tracers for image-guided surgery. Mol Pharm 14(4):1145\u20131153","journal-title":"Mol Pharm"},{"issue":"6","key":"2120_CR16","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1021\/acsptsci.5c00024","volume":"8","author":"L Mateusiak","year":"2025","unstructured":"Mateusiak L et al (2025) Molecular tuning of cyanine 5 dyes to improve the pharmacokinetic profile of nanobody-based fluorescent tracers. ACS Pharmacol Transl Sci 8(6):1659\u20131668","journal-title":"ACS Pharmacol Transl Sci"},{"issue":"21","key":"2120_CR17","doi-asserted-by":"publisher","first-page":"23472","DOI":"10.1021\/acs.jmedchem.5c02376","volume":"68","author":"NB Declerck","year":"2025","unstructured":"Declerck NB et al (2025) A comparative study on the effect of near-infrared fluorescent dyes on the pharmacokinetic behavior of nanobody-based tracers for in vivo imaging. J Med Chem 68(21):23472\u201384","journal-title":"J Med Chem"},{"issue":"1","key":"2120_CR18","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s44303-025-00109-8","volume":"3","author":"V Edupuganti","year":"2025","unstructured":"Edupuganti V, Escorcia FE, Schnermann MJ (2025) Through every lens: assessing the impact of chemical modifications on antibody-conjugates using in vivo imaging. NPJ Imaging 3(1):56","journal-title":"NPJ Imaging"},{"key":"2120_CR19","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.cbpa.2021.01.009","volume":"63","author":"SM Usama","year":"2021","unstructured":"Usama SM et al (2021) Not so innocent: impact of fluorophore chemistry on the in vivo properties of bioconjugates. Curr Opin Chem Biol 63:38\u201345","journal-title":"Curr Opin Chem Biol"},{"issue":"5","key":"2120_CR20","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1021\/acschembio.9b00122","volume":"14","author":"MP Luciano","year":"2019","unstructured":"Luciano MP et al (2019) A nonaggregating heptamethine cyanine for building brighter labeled biomolecules. ACS Chem Biol 14(5):934\u2013940","journal-title":"ACS Chem Biol"},{"issue":"27","key":"2120_CR21","doi-asserted-by":"publisher","first-page":"14647","DOI":"10.1021\/jacs.3c01765","volume":"145","author":"SM Usama","year":"2023","unstructured":"Usama SM et al (2023) Method to diversify cyanine chromophore functionality enables improved biomolecule tracking and intracellular imaging. J Am Chem Soc 145(27):14647\u201314659","journal-title":"J Am Chem Soc"},{"key":"2120_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-025-02076-3","author":"K Cox","year":"2026","unstructured":"Cox K et al (2026) Enhanced fluorescence of near-infrared anti-CEA antibodies for visualizing colorectal cancers using modified heptamethine cyanines. Mol Imaging Biol. https:\/\/doi.org\/10.1007\/s11307-025-02076-3","journal-title":"Mol Imaging Biol"},{"issue":"8","key":"2120_CR23","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1002\/ijc.26145","volume":"129","author":"RC Roovers","year":"2011","unstructured":"Roovers RC et al (2011) A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth. Int J Cancer 129(8):2013\u20132024","journal-title":"Int J Cancer"},{"issue":"7","key":"2120_CR24","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1161\/CIRCRESAHA.112.265140","volume":"110","author":"A Broisat","year":"2012","unstructured":"Broisat A et al (2012) Nanobodies targeting mouse\/human VCAM1 for the nuclear imaging of atherosclerotic lesions. Circ Res 110(7):927\u2013937","journal-title":"Circ Res"},{"issue":"5","key":"2120_CR25","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1002\/cmmi.1637","volume":"10","author":"P Bannas","year":"2015","unstructured":"Bannas P et al (2015) Molecular imaging of tumors with nanobodies and antibodies: timing and dosage are crucial factors for improved in vivo detection. Contrast Media Mol Imaging 10(5):367\u2013378","journal-title":"Contrast Media Mol Imaging"},{"issue":"1","key":"2120_CR26","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2310\/7290.2011.00025","volume":"11","author":"S Oliveira","year":"2012","unstructured":"Oliveira S et al (2012) Rapid visualization of human tumor xenografts through optical imaging with a near-infrared fluorescent anti-epidermal growth factor receptor nanobody. Mol Imaging 11(1):33\u201346","journal-title":"Mol Imaging"},{"issue":"29","key":"2120_CR27","doi-asserted-by":"publisher","first-page":"12154","DOI":"10.1002\/anie.202004449","volume":"59","author":"DH Li","year":"2020","unstructured":"Li DH, Schreiber CL, Smith BD (2020) Sterically shielded heptamethine cyanine dyes for bioconjugation and high performance near-infrared fluorescence imaging. Angew Chem Int Ed Engl 59(29):12154\u201312161","journal-title":"Angew Chem Int Ed Engl"},{"issue":"8","key":"2120_CR28","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1080\/17425247.2016.1178235","volume":"13","author":"S Massa","year":"2016","unstructured":"Massa S et al (2016) Emerging site-specific bioconjugation strategies for radioimmunotracer development. Expert Opin Drug Deliv 13(8):1149\u20131163","journal-title":"Expert Opin Drug Deliv"},{"key":"2120_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2026.102665","volume":"92","author":"L Wei","year":"2026","unstructured":"Wei L et al (2026) Recent advances in protein modification-enabled potential therapeutics. Curr Opin Chem Biol 92:102665","journal-title":"Curr Opin Chem Biol"},{"key":"2120_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2024.102471","volume":"81","author":"J Sebastiano","year":"2024","unstructured":"Sebastiano J et al (2024) Site-specific bioconjugation and nuclear imaging. Curr Opin Chem Biol 81:102471","journal-title":"Curr Opin Chem Biol"},{"issue":"5","key":"2120_CR31","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/cmmi.1696","volume":"11","author":"S Massa","year":"2016","unstructured":"Massa S et al (2016) Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities. Contrast Media Mol Imaging 11(5):328\u2013339","journal-title":"Contrast Media Mol Imaging"},{"issue":"Pt 2","key":"2120_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114361","volume":"388","author":"S Declercq","year":"2025","unstructured":"Declercq S et al (2025) VyPAL2 peptide asparaginyl ligase enables versatile workflows for radiolabeling single-domain antibody-based theranostics. J Control Release 388(Pt 2):114361","journal-title":"J Control Release"},{"issue":"10","key":"2120_CR33","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1021\/acs.bioconjchem.3c00423","volume":"34","author":"S Zhou","year":"2023","unstructured":"Zhou S et al (2023) Site-specific modification of single domain antibodies by enzyme-immobilized magnetic beads. Bioconjug Chem 34(10):1914\u20131922","journal-title":"Bioconjug Chem"},{"issue":"44","key":"2120_CR34","doi-asserted-by":"publisher","first-page":"30130","DOI":"10.1021\/acsomega.1c04991","volume":"6","author":"RS Gamage","year":"2021","unstructured":"Gamage RS et al (2021) Comparison of cRGDfK peptide probes with appended shielded heptamethine cyanine dye (s775z) for near infrared fluorescence imaging of cancer. ACS Omega 6(44):30130\u201330139","journal-title":"ACS Omega"},{"issue":"3","key":"2120_CR35","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1021\/acs.bioconjchem.2c00049","volume":"33","author":"P Adumeau","year":"2022","unstructured":"Adumeau P et al (2022) Site-specific, platform-based conjugation strategy for the synthesis of dual-labeled immunoconjugates for bimodal PET\/NIRF imaging of HER2-positive tumors. Bioconjug Chem 33(3):530\u2013540","journal-title":"Bioconjug Chem"},{"issue":"2","key":"2120_CR36","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1002\/mp.16849","volume":"51","author":"BW Pogue","year":"2024","unstructured":"Pogue BW et al (2024) AAPM task group report 311: guidance for performance evaluation of fluorescence-guided surgery systems. Med Phys 51(2):740\u2013771","journal-title":"Med Phys"},{"issue":"1","key":"2120_CR37","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11307-018-1220-0","volume":"21","author":"C Hoogstins","year":"2019","unstructured":"Hoogstins C et al (2019) Setting standards for reporting and quantification in fluorescence-guided surgery. Mol Imaging Biol 21(1):11\u201318","journal-title":"Mol Imaging Biol"},{"issue":"1","key":"2120_CR38","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s44303-025-00125-8","volume":"3","author":"B Keizers","year":"2025","unstructured":"Keizers B et al (2025) Reflect: reporting guidelines for preclinical, translational and clinical fluorescence molecular imaging studies. NPJ Imaging 3(1):62","journal-title":"NPJ Imaging"},{"issue":"2","key":"2120_CR39","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1200\/JCO.22.00291","volume":"41","author":"JL Tanyi","year":"2023","unstructured":"Tanyi JL et al (2023) A phase III study of pafolacianine injection (OTL38) for intraoperative imaging of folate receptor-positive ovarian cancer (study 006). J Clin Oncol 41(2):276\u2013284","journal-title":"J Clin Oncol"},{"issue":"11","key":"2120_CR40","doi-asserted-by":"publisher","first-page":"6227","DOI":"10.1007\/s00464-024-11236-5","volume":"38","author":"A Preziosi","year":"2024","unstructured":"Preziosi A et al (2024) State of the art medical devices for fluorescence-guided surgery (FGS): technical review and future developments. Surg Endosc 38(11):6227\u20136236","journal-title":"Surg Endosc"},{"issue":"7","key":"2120_CR41","doi-asserted-by":"publisher","first-page":"e354","DOI":"10.1016\/S1470-2045(19)30317-1","volume":"20","author":"S Hernot","year":"2019","unstructured":"Hernot S et al (2019) Latest developments in molecular tracers for fluorescence image-guided cancer surgery. Lancet Oncol 20(7):e354\u2013e367","journal-title":"Lancet Oncol"},{"issue":"3","key":"2120_CR42","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1364\/BOE.504878","volume":"15","author":"Y Feng","year":"2024","unstructured":"Feng Y et al (2024) Quantitative pharmacokinetic and biodistribution studies for fluorescent imaging agents. Biomed Opt Express 15(3):1861\u20131877","journal-title":"Biomed Opt Express"},{"issue":"2","key":"2120_CR43","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/cmmi.408","volume":"6","author":"LO Gainkam","year":"2011","unstructured":"Gainkam LO et al (2011) Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice. Contrast Media Mol Imaging 6(2):85\u201392","journal-title":"Contrast Media Mol Imaging"},{"issue":"12","key":"2120_CR44","doi-asserted-by":"publisher","first-page":"4090","DOI":"10.1021\/acs.bioconjchem.8b00699","volume":"29","author":"Z Zhou","year":"2018","unstructured":"Zhou Z et al (2018) An efficient method for labeling single domain antibody fragments with (18)F using tetrazine- trans-cyclooctene ligation and a renal brush border enzyme-cleavable linker. Bioconjug Chem 29(12):4090\u20134103","journal-title":"Bioconjug Chem"},{"issue":"11","key":"2120_CR45","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.2967\/jnumed.120.261446","volume":"62","author":"Z Zhou","year":"2021","unstructured":"Zhou Z et al (2021) Site-specific and residualizing linker for (18)F labeling with enhanced renal clearance: application to an anti-HER2 single-domain antibody fragment. J Nucl Med 62(11):1624\u20131630","journal-title":"J Nucl Med"},{"issue":"5","key":"2120_CR46","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1021\/acs.molpharmaceut.5c00041","volume":"22","author":"T Peng","year":"2025","unstructured":"Peng T et al (2025) (68)Ga-NOTA-m-SNA006: a next-generation CD8-targeting nanobody probe to enhance renal and hepatic clearance in noninvasive ImmunoPET imaging. Mol Pharm 22(5):2639\u20132649","journal-title":"Mol Pharm"},{"issue":"10","key":"2120_CR47","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.2967\/jnumed.124.267624","volume":"65","author":"S Poty","year":"2024","unstructured":"Poty S et al (2024) Optimizing the therapeutic index of sdAb-based radiopharmaceuticals using pretargeting. J Nucl Med 65(10):1564\u20131570","journal-title":"J Nucl Med"},{"key":"2120_CR48","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.cbpa.2021.06.008","volume":"63","author":"DM Chigoho","year":"2021","unstructured":"Chigoho DM, Bridoux J, Hernot S (2021) Reducing the renal retention of low- to moderate-molecular-weight radiopharmaceuticals. Curr Opin Chem Biol 63:219\u2013228","journal-title":"Curr Opin Chem Biol"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-026-02120-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11307-026-02120-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-026-02120-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T19:01:55Z","timestamp":1785092515000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11307-026-02120-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":48,"alternative-id":["2120"],"URL":"https:\/\/doi.org\/10.1007\/s11307-026-02120-w","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"18 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"SH holds a patent on the FNIR-Tag labeling of Nanobodies (PCT\/EP2022\/077690). The other authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}