{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:37:57Z","timestamp":1770435477105,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T00:00:00Z","timestamp":1294185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1007\/s11325-010-0472-y","type":"journal-article","created":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T06:32:40Z","timestamp":1294122760000},"page":"181-186","source":"Crossref","is-referenced-by-count":43,"title":["Sleepiness as a marker of glucose deregulation in obstructive sleep apnea"],"prefix":"10.1007","volume":"16","author":[{"given":"Evangelia","family":"Nena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paschalis","family":"Steiropoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Papanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venetia","family":"Tsara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Fitili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marios E.","family":"Froudarakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstratios","family":"Maltezos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demosthenes","family":"Bouros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,1,5]]},"reference":[{"key":"472_CR1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1513\/pats.200709-155MG","volume":"5","author":"NM Punjabi","year":"2008","unstructured":"Punjabi NM (2008) The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 5:136\u2013143","journal-title":"Proc Am Thorac Soc"},{"key":"472_CR2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1183\/09031936.00027406","volume":"29","author":"WT McNicholas","year":"2007","unstructured":"McNicholas WT, Bonsigore MR (2007) Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities. Eur Respir J 29:156\u2013178","journal-title":"Eur Respir J"},{"key":"472_CR3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1183\/09031936.00166808","volume":"34","author":"P L\u00e9vy","year":"2009","unstructured":"L\u00e9vy P, Bonsignore MR, Eckel J (2009) Sleep, sleep-disordered breathing and metabolic consequences. Eur Respir J 34:243\u2013260","journal-title":"Eur Respir J"},{"key":"472_CR4","doi-asserted-by":"crossref","first-page":"675320","DOI":"10.1155\/2010\/675320","volume":"2010","author":"P Steiropoulos","year":"2010","unstructured":"Steiropoulos P, Papanas N, Nena E, Antoniadou M, Serasli E, Papoti S, Hatzizisi O, Kyriazis G, Tzouvelekis A, Maltezos E, Tsara V, Bouros D (2010) Inflammatory markers in middle-aged obese subjects: does obstructive sleep apnea syndrome play a role? Mediat Inflamm 2010:675320","journal-title":"Mediat Inflamm"},{"key":"472_CR5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2174\/157339910791162943","volume":"6","author":"P Steiropoulos","year":"2010","unstructured":"Steiropoulos P, Papanas N, Nena E, Maltezos E, Bouros D (2010) Continuous positive airway pressure treatment in patients with sleep apnoea: does it really improve glucose metabolism? Curr Diabetes Rev 6:156\u2013166","journal-title":"Curr Diabetes Rev"},{"key":"472_CR6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1183\/09031936.00009506","volume":"30","author":"O Mediano","year":"2007","unstructured":"Mediano O, Barcel\u00f3 A, de la Pe\u00f1a M, Gozal D, Agust\u00ed A, Barb\u00e9 F (2007) Daytime sleepiness and polysomnographic variables in sleep apnoea patients. Eur Respir J 30:110\u2013113","journal-title":"Eur Respir J"},{"key":"472_CR7","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1210\/jc.2005-0035","volume":"90","author":"EO Bixler","year":"2005","unstructured":"Bixler EO, Vgontzas AN, Lin HM, Calhoun SL, Vela-Bueno A, Kales A (2005) Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression. J Clin Endocrinol Metab 90:4510\u20134515","journal-title":"J Clin Endocrinol Metab"},{"key":"472_CR8","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.rmed.2006.10.015","volume":"101","author":"E Lindberg","year":"2007","unstructured":"Lindberg E, Berne C, Franklin KA, Svensson M, Janson C (2007) Snoring and daytime sleepiness as risk factors for hypertension and diabetes in women\u2014a population-based study. Respir Med 101:1283\u20131290","journal-title":"Respir Med"},{"key":"472_CR9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1164\/rccm.200606-795PP","volume":"176","author":"JM Montserrat","year":"2007","unstructured":"Montserrat JM, Garcia-Rio F, Barbe F (2007) Diagnostic and therapeutic approach to nonsleepy apnea. Am J Respir Crit Care Med 176:6\u20139","journal-title":"Am J Respir Crit Care Med"},{"key":"472_CR10","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.7326\/0003-4819-134-11-200106050-00007","volume":"134","author":"F Barb\u00e9","year":"2001","unstructured":"Barb\u00e9 F, Mayoralas LR, Masa DJ, JF MA, Montserrat JM, Monasterio C, Bosch M, Ladaria A, Rubio M, Rubio R, Medinas M, Hernandez L, Vidal S, Douglas NJ, Agust\u00ed AG (2001) Treatment with continuous positive airway pressure is not effective in patients with sleep apnea but no daytime sleepiness, a randomized, controlled trial. Ann Intern Med 134:1015\u20131023","journal-title":"Ann Intern Med"},{"key":"472_CR11","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1136\/thx.2007.088096","volume":"63","author":"GV Robinson","year":"2008","unstructured":"Robinson GV, Langford BA, Smith DM, Stradling JR (2008) Predictors of blood pressure fall with continuous positive airway pressure (CPAP) treatment of obstructive sleep apnoea (OSA). Thorax 63:855\u2013859","journal-title":"Thorax"},{"key":"472_CR12","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1136\/thx.2007.093740","volume":"63","author":"A Barcel\u00f3","year":"2008","unstructured":"Barcel\u00f3 A, Barb\u00e9 F, de la Pe\u00f1a M, Martinez P, Soriano JB, Pi\u00e9rola J, Agust\u00ed AG (2008) Insulin resistance and daytime sleepiness in patients with sleep apnoea. Thorax 63:946\u2013950","journal-title":"Thorax"},{"key":"472_CR13","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/JOM.0b013e3181e12b05","volume":"52","author":"E Nena","year":"2010","unstructured":"Nena E, Steiropoulos P, Constantinidis TC, Perantoni E, Tsara V (2010) Work productivity in obstructive sleep apnea patients. J Occup Environ Med 52:622\u2013625","journal-title":"J Occup Environ Med"},{"key":"472_CR14","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2337\/diacare.20.7.1183","volume":"20","author":"Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","year":"1997","unstructured":"Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Diab Care 20:1183\u20131197","journal-title":"Diab Care"},{"key":"472_CR15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1055\/s-2004-829632","volume":"8","author":"V Tsara","year":"2004","unstructured":"Tsara V, Serasli E, Amfilochiou A, Constantinidis T, Christaki P (2004) Greek version of the Epworth Sleepiness Scale. Sleep Breath 8:91\u201395","journal-title":"Sleep Breath"},{"key":"472_CR16","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412\u2013419","journal-title":"Diabetologia"},{"key":"472_CR17","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.rmed.2004.11.017","volume":"99","author":"T Saaresranta","year":"2005","unstructured":"Saaresranta T, Irjala K, Aittokallio T, Polo O (2005) Sleep quality, daytime sleepiness and fasting insulin levels in women with chronic obstructive pulmonary disease. Respir Med 99:856\u2013863","journal-title":"Respir Med"},{"key":"472_CR18","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1136\/thx.2009.115105","volume":"64","author":"PE Ronksley","year":"2009","unstructured":"Ronksley PE, Hemmelgarn BR, Heitman SJ, Hanly PJ, Faris PD, Quan H, Tsai WH (2009) Obstructive sleep apnoea is associated with diabetes in sleepy subjects. Thorax 64:834\u2013839","journal-title":"Thorax"},{"key":"472_CR19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.sleep.2005.06.006","volume":"7","author":"VY Polotsky","year":"2006","unstructured":"Polotsky VY, Rubin AE, Balbir A, Dean T, Smith PL, Schwartz AR, O'Donnell CP (2006) Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL\/6J mouse. Sleep Med 7:7\u201316","journal-title":"Sleep Med"},{"key":"472_CR20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/sleep\/27.2.194","volume":"27","author":"SC Veasey","year":"2004","unstructured":"Veasey SC, Davis CW, Fenik P, Zhan G, Hsu YJ, Pratico D, Gow A (2004) Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep\u2013wake brain regions. Sleep 27:194\u2013201","journal-title":"Sleep"},{"key":"472_CR21","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1164\/ajrccm.165.5.2103001","volume":"165","author":"MS Ip","year":"2002","unstructured":"Ip MS, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS (2002) Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 165:670\u2013676","journal-title":"Am J Respir Crit Care Med"},{"key":"472_CR22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/aje\/kwh261","volume":"160","author":"NM Punjabi","year":"2004","unstructured":"Punjabi NM, Shahar E, Redline S, Gottlieb DJ, Givelber R, Resnick HE, Sleep Heart Health Study Investigators (2004) Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am J Epidemiol 160:521\u2013530","journal-title":"Am J Epidemiol"},{"key":"472_CR23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1113\/jphysiol.2003.048173","volume":"552","author":"VY Polotsky","year":"2003","unstructured":"Polotsky VY, Li J, Punjabi NM, Rubin AE, Smith PL, Schwartz AR, O'Donnell CP (2003) Intermittent hypoxia increases insulin resistance in genetically obese mice. J Physiol 552:253\u2013264","journal-title":"J Physiol"},{"key":"472_CR24","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1164\/rccm.200610-1527OC","volume":"175","author":"N Liyori","year":"2007","unstructured":"Liyori N, Alonso LC, Li J, Sanders MH, Garcia-Ocana A, O'Doherty RM, Polotsky VY, O'Donnell CP (2007) Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am J Respir Crit Care Med 175:851\u2013857","journal-title":"Am J Respir Crit Care Med"},{"key":"472_CR25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1196\/annals.1367.023","volume":"1083","author":"AN Vgontzas","year":"2006","unstructured":"Vgontzas AN, Bixler EO, Chrousos GP (2006) Obesity-related sleepiness and fatigue: the role of the stress system and cytokines. Ann NY Acad Sci 1083:329\u2013344","journal-title":"Ann NY Acad Sci"},{"key":"472_CR26","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1136\/thx.2008.099689","volume":"63","author":"MS Ip","year":"2008","unstructured":"Ip MS (2008) Obstructive sleep apnoea, insulin resistance and sleepiness. Thorax 63:939\u2013940","journal-title":"Thorax"},{"issue":"5","key":"472_CR27","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s001250051341","volume":"43","author":"K Nonogaki","year":"2000","unstructured":"Nonogaki K (2000) New insights into sympathetic regulation of glucose and fat metabolism. Diabetologia 43(5):533\u2013549","journal-title":"Diabetologia"},{"key":"472_CR28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1378\/chest.09-0791","volume":"137","author":"KA Stamatakis","year":"2010","unstructured":"Stamatakis KA, Punjabi NM (2010) Effects of sleep fragmentation on glucose metabolism in normal subjects. Chest 137:95\u2013101","journal-title":"Chest"},{"key":"472_CR29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1365-2869.2000.00177.x","volume":"29","author":"MW Johns","year":"2000","unstructured":"Johns MW (2000) Sensitivity and specificity of the multiple sleep latency test (MSLT), the maintenance of wakefulness test and the Epworth sleepiness scale: failure of the MSLT as a gold standard. J Sleep Res 29:5\u201311","journal-title":"J Sleep Res"},{"key":"472_CR30","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1378\/chest.08-0812","volume":"134","author":"BV Vaughn","year":"2008","unstructured":"Vaughn BV, Giallanza P (2008) Technical review of polysomnography. Chest 134:1310\u20131319","journal-title":"Chest"},{"key":"472_CR31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.diabres.2009.11.006","volume":"87","author":"N Unwin","year":"2010","unstructured":"Unwin N, Gan D, Whiting D (2010) The IDF Diabetes Atlas: providing evidence, raising awareness and promoting action. Diabetes Res Clin Pract 87:2\u20133","journal-title":"Diabetes Res Clin Pract"},{"key":"472_CR32","first-page":"217","volume":"137","author":"R Thurnheer","year":"2007","unstructured":"Thurnheer R (2007) Obstructive sleep apnea and cardiovascular disease\u2014time to act! Swiss Med Wkly 137:217\u2013222","journal-title":"Swiss Med Wkly"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-010-0472-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11325-010-0472-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-010-0472-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T09:44:09Z","timestamp":1559382249000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11325-010-0472-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,5]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["472"],"URL":"https:\/\/doi.org\/10.1007\/s11325-010-0472-y","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"value":"1520-9512","type":"print"},{"value":"1522-1709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,5]]}}}