{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:17:52Z","timestamp":1789615072218,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Basic Research Program of China","award":["2014CB542401"],"award-info":[{"award-number":["2014CB542401"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470462"],"award-info":[{"award-number":["81470462"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670297"],"award-info":[{"award-number":["81670297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heilongjiang Province Outstanding Youth Foundation","award":["JC201208"],"award-info":[{"award-number":["JC201208"]}]},{"name":"the Technology Research and Development Program of Heilongjiang Province","award":["GA14C101"],"award-info":[{"award-number":["GA14C101"]}]},{"name":"Chang Jiang Scholar Candidates Programme for Provincial Universities in Heilongjiang","award":["2013CJHB001"],"award-info":[{"award-number":["2013CJHB001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s11325-018-1688-5","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T08:11:59Z","timestamp":1530087119000},"page":"227-233","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Metoprolol has a similar therapeutic effect as amlodipine on BP lowering in hypertensive patients with obstructive sleep apnea"],"prefix":"10.1007","volume":"23","author":[{"given":"Jing","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijiao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danghui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wennan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7727-905X","authenticated-orcid":false,"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"issue":"2","key":"1688_CR1","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1513\/pats.200709-155MG","volume":"5","author":"NM Punjabi","year":"2008","unstructured":"Punjabi NM (2008) The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 5(2):136\u2013143","journal-title":"Proc Am Thorac Soc"},{"issue":"2","key":"1688_CR2","doi-asserted-by":"publisher","first-page":"277","DOI":"10.5507\/bp.2014.063","volume":"159","author":"M Sova","year":"2015","unstructured":"Sova M, Sovova E, Hobzova M, Zapletalova J, Kamasova M, Kolek V (2015) The effect of continuous positive airway pressure therapy on the prevalence of masked hypertension in obstructive sleep apnea patients. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 159(2):277\u2013282","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"1688_CR3","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s11906-013-0411-y","volume":"16","author":"JA Marcus","year":"2014","unstructured":"Marcus JA, Pothineni A, Marcus CZ, Bisognano JD (2014) The role of obesity and obstructive sleep apnea in the pathogenesis and treatment of resistant hypertension. Curr Hypertens Rep 16:411","journal-title":"Curr Hypertens Rep"},{"issue":"5","key":"1688_CR4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S1474-4422(10)70066-1","volume":"9","author":"PM Rothwell","year":"2010","unstructured":"Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahl\u00f6f B, Poulter NR, Sever PS, ASCOT-BPLA and MRC Trial Investigators (2010) Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke. Lancet Neurol 9(5):469\u2013480","journal-title":"Lancet Neurol"},{"issue":"6","key":"1688_CR5","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/hr.2014.33","volume":"37","author":"N Levi-Marpillat","year":"2014","unstructured":"Levi-Marpillat N, Macquin-Mavier I, Tropeano AI, Parati G, Maison P (2014) Antihypertensive drug classes have different effects on short-term blood pressure variability in essential hypertension. Hypertens Res 37(6):585\u2013590","journal-title":"Hypertens Res"},{"issue":"9718","key":"1688_CR6","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/S0140-6736(10)60235-8","volume":"375","author":"AJ Webb","year":"2010","unstructured":"Webb AJ, Fischer U, Mehta Z, Rothwell PM (2010) Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis. Lancet 375(9718):906\u2013915","journal-title":"Lancet"},{"issue":"5","key":"1688_CR7","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00395-014-0427-8","volume":"109","author":"J Zhao","year":"2014","unstructured":"Zhao J, Xu W, Yun F, Zhao H, Li W, Gong Y, Yuan Y, Yan S, Zhang S, Ding X, Wang D, Zhang C, Dong D, Xiu C, Yang N, Liu L, Xue J, Li Y (2014) Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. Basic Res Cardiol 109(5):427","journal-title":"Basic Res Cardiol"},{"issue":"36","key":"1688_CR8","doi-asserted-by":"publisher","first-page":"57545","DOI":"10.18632\/oncotarget.11296","volume":"7","author":"X Ding","year":"2016","unstructured":"Ding X, Yu C, Liu Y, Yan S, Li W, Wang D, Sun L, Han Y, Li M, Zhang S, Yun F, Zhao H, Li Y (2016) Chronic obstructive sleep apnea accelerates pulmonary remodeling via TGF-\u03b2\/miR-185\/CoLA1 signaling in a canine model. Oncotarget 7(36):57545\u201357555","journal-title":"Oncotarget"},{"issue":"23","key":"1688_CR9","doi-asserted-by":"publisher","first-page":"37705","DOI":"10.18632\/oncotarget.17144","volume":"8","author":"C Yu","year":"2017","unstructured":"Yu C, Liu Y, Sun L, Wang D, Wang Y, Zhao S, Dai H, Zhao J, Zhang S, Li M, Han Y, Lu S, Dong X, Liu G, Yu S, Li Y (2017) Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145\/Smad3 signaling pathway. Oncotarget 8(23):37705\u201337716","journal-title":"Oncotarget"},{"issue":"3","key":"1688_CR10","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1159\/000430284","volume":"36","author":"W Li","year":"2015","unstructured":"Li W, Yan S, Zhao J, Ding X, Zhang S, Wang D, Liu L, Peng W, Li H, Wang D, Liu Z, Li Y (2015) Metoprolol inhibits cardiac apoptosis and fibrosis in a canine model of chronic obstructive sleep apnea. Cell Physiol Biochem 36(3):1131\u20131141","journal-title":"Cell Physiol Biochem"},{"key":"1688_CR11","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1161\/01.HYP.0000158306.87582.43","volume":"45","author":"NA Zakopoulos","year":"2005","unstructured":"Zakopoulos NA, Tsivgoulis G, Barlas G, Papamichael C, Spengos K, Manios E, Ikonomidis I, Kotsis V, Spiliopoulou I, Vemmos K, Mavrikakis M, Moulopoulos SD (2005) Time rate of blood pressure variation is associated with increased common carotid artery intima-media thickness. Hypertension 45:505\u2013512","journal-title":"Hypertension"},{"key":"1688_CR12","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1093\/eurheartj\/eht151","volume":"34","author":"G Mancia","year":"2013","unstructured":"Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, B\u00f6hm M, Christiaens T, Cifkova R, de Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M, Waeber B, Zannad F, Redon J, Dominiczak A, Narkiewicz K, Nilsson PM, Burnier M, Viigimaa M, Ambrosioni E, Caufield M, Coca A, Olsen MH, Schmieder RE, Tsioufis C, van de Borne P, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Clement DL, Coca A, Gillebert TC, Tendera M, Rosei EA, Ambrosioni E, Anker SD, Bauersachs J, Hitij JB, Caulfield M, de Buyzere M, de Geest S, Derumeaux GA, Erdine S, Farsang C, Funck-Brentano C, Gerc V, Germano G, Gielen S, Haller H, Hoes AW, Jordan J, Kahan T, Komajda M, Lovic D, Mahrholdt H, Olsen MH, Ostergren J, Parati G, Perk J, Polonia J, Popescu BA, Reiner Z, Ryd\u00e9n L, Sirenko Y, Stanton A, Struijker-Boudier H, Tsioufis C, van de Borne P, Vlachopoulos C, Volpe M, Wood DA (2013) 2013 ESH\/ESC guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 34:2159\u20132219","journal-title":"Eur Heart J"},{"key":"1688_CR13","doi-asserted-by":"crossref","unstructured":"Xiong H, Wu D, Tian X, Lin WH, Li C, Zhang H, Cai Y, Zhang YT. The relationship between the 24\u2009h blood pressure variability and carotid intima-media thickness: a compared study. Comput Math Methods Med 2014;2014:303159, 1, 9","DOI":"10.1155\/2014\/303159"},{"issue":"4","key":"1688_CR14","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1097\/MBP.0000000000000259","volume":"22","author":"J Shi","year":"2017","unstructured":"Shi J, Piao J, Liu B, Pan Y, Gong Y, Deng X, Sun W, Lu S, Li Y (2017) Obstructive sleep apnea increases systolic and diastolic blood pressure variability in hypertensive patients. Blood Press Monit 22(4):208\u2013212","journal-title":"Blood Press Monit"},{"issue":"2","key":"1688_CR15","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1161\/HYPERTENSIONAHA.110.162255","volume":"57","author":"P Muntner","year":"2011","unstructured":"Muntner P, Shimbo D, Tonelli M, Reynolds K, Arnett DK, Oparil S (2011) The relationship between visit-to-visit variability in systolic blood pressure and all-cause mortality in the general population: findings from NHANES III, 1988 to 1994. Hypertension 57(2):160\u2013166","journal-title":"Hypertension"},{"key":"1688_CR16","doi-asserted-by":"publisher","first-page":"e107581","DOI":"10.1371\/journal.pone.0107581","volume":"9","author":"S Camargo","year":"2014","unstructured":"Camargo S, Riedl M, Anteneodo C, Kurths J, Penzel T, Wessel N (2014) Sleep apnea-hypopnea quantification by cardiovascular data analysis. PLoS One 9:e107581","journal-title":"PLoS One"},{"issue":"4","key":"1688_CR17","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.amjcard.2017.05.042","volume":"120","author":"AS Abuzaid","year":"2017","unstructured":"Abuzaid AS, Al Ashry HS, Elbadawi A, Ld H, Saad M, Elgendy IY et al (2017) Meta-analysis of cardiovascular outcomes with continuous positive airway pressure therapy in patients with obstructive sleep apnea. Am J Cardiol 120(4):693\u2013699","journal-title":"Am J Cardiol"},{"issue":"8","key":"1688_CR18","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1253\/circj.CJ-16-0302","volume":"80","author":"K Shiina","year":"2016","unstructured":"Shiina K, Tomiyama H, Takata Y, Matsumoto C, Odaira M, Kato K, Yamaguchi T, Usui Y, Yamashina A (2016) Obstructive sleep apnea as possible causal factor for visit-to-visit blood pressure variability. Circ J 80(8):1787\u20131794","journal-title":"Circ J"},{"issue":"11","key":"1688_CR19","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1111\/jch.12845","volume":"18","author":"MF Pengo","year":"2016","unstructured":"Pengo MF, Ratneswaran C, Berry M, Kent BD, Kohler M, Rossi GP, Steier J (2016) Effect of continuous positive airway pressure on blood pressure variability in patients with obstructive sleep apnea. J Clin Hypertens (Greenwich) 18(11):1180\u20131184","journal-title":"J Clin Hypertens (Greenwich)"},{"issue":"1","key":"1688_CR20","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00380-009-1164-z","volume":"25","author":"H Abe","year":"2010","unstructured":"Abe H, Takahashi M, Yaegashi H, Eda S, Tsunemoto H, Kamikozawa M, Koyama J, Yamazaki K, Ikeda U (2010) Efficacy of continuous positive airway pressure on arrhythmias in obstructive sleep apnea patients. Heart Vessel 25(1):63\u201369","journal-title":"Heart Vessel"},{"issue":"9","key":"1688_CR21","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1097\/HJH.0000000000000250","volume":"32","author":"AS Schein","year":"2014","unstructured":"Schein AS, Kerkhoff AC, Coronel CC, Plentz RD, Sbruzzi G (2014) Continuous positive airway pressure reduces blood pressure in patients with obstructive sleep apnea; a systematic review and meta-analysis with 1000 patients. J Hypertens 32(9):1762\u20131773","journal-title":"J Hypertens"},{"issue":"4","key":"1688_CR22","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1161\/HYPERTENSIONAHA.114.04852","volume":"65","author":"ES Muxfeldt","year":"2015","unstructured":"Muxfeldt ES, Margallo V, Costa LM, Guimar\u00e3es G, Cavalcante AH, Azevedo JC, de Souza F, Cardoso CR, Salles GF (2015) Effects of continuous positive airway pressure treatment on clinic and ambulatory blood pressures in patients with obstructive sleep apnea and resistant hypertension: a randomized controlled trial. Hypertension 65(4):736\u2013742","journal-title":"Hypertension"},{"issue":"2","key":"1688_CR23","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1513\/pats.200708-119MG","volume":"5","author":"TE Weaver","year":"2008","unstructured":"Weaver TE, Grunstein RR (2008) Adherence to continuous positive airway pressure therapy: the challenge to effective treatment. Proc Am Thorac Soc 5(2):173\u2013178","journal-title":"Proc Am Thorac Soc"},{"issue":"3","key":"1688_CR24","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0002-9343(82)90716-1","volume":"73","author":"WP Miller","year":"1982","unstructured":"Miller WP (1982) Cardiac arrhythmias and conduction disturbances in the sleep apnea syndrome. Prevalence and significance. Am J Med 73(3):317\u2013321","journal-title":"Am J Med"},{"issue":"5","key":"1688_CR25","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/0002-9149(83)90013-9","volume":"52","author":"C Guilleminault","year":"1983","unstructured":"Guilleminault C, Connolly SJ, Winkle RA (1983) Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol 52(5):490\u2013494","journal-title":"Am J Cardiol"},{"issue":"8","key":"1688_CR26","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1164\/rccm.200509-1442OC","volume":"173","author":"R Mehra","year":"2006","unstructured":"Mehra R, Benjamin EJ, Shahar E, Gottlieb DJ, Nawabit R, Kirchner HL, Sahadevan J, Redline S, Sleep Heart Health Study (2006) Association of nocturnal arrhythmias with sleep-disordered breathing: the Sleep Heart Health Study. Am J Respir Crit Care Med 173(8):910\u2013916","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"1688_CR27","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.arbres.2015.03.008","volume":"52","author":"N Grau","year":"2016","unstructured":"Grau N, Bazan V, Kallouchi M, Rodriguez D, Estirado C, Corral MI, Valls MT, Ramos P, Sanjuas C, Felez M, Valles E, Benito B, Gea J, Bruguera-Cortada J, Mart\u00ed-Almor J (2016) Long-term impact of continuous positive airway pressure therapy on arrhythmia and heart rate variability in patients with sleep apnea. Arch Bronconeumol 52(1):17\u201323","journal-title":"Arch Bronconeumol"},{"key":"1688_CR28","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ijcard.2015.08.139","volume":"202","author":"J Wolf","year":"2016","unstructured":"Wolf J, Drozdowski J, Czechowicz K, Winklewski PJ, Jassem E, Kara T, Somers VK, Narkiewicz K (2016) Effect of beta-blocker therapy on heart rate response in patients with hypertension and newly diagnosed untreated obstructive sleep apnea syndrome. Int J Cardiol 202:67\u201372","journal-title":"Int J Cardiol"},{"issue":"4","key":"1688_CR29","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1007\/BF01856511","volume":"4","author":"R Fogari","year":"1990","unstructured":"Fogari R, Zoppi A, Tettamanti F, Poletti L, Rizzardi G, Fiocchi G (1990) Comparative effects of celiprolol, propranolol, oxprenolol, and atenolol on respiratory function in hypertensive patients with chronic obstructive lung disease. Cardiovasc Drugs Ther 4(4):1145\u20131149","journal-title":"Cardiovasc Drugs Ther"},{"issue":"4","key":"1688_CR30","first-page":"190","volume":"57","author":"L Tivenius","year":"1976","unstructured":"Tivenius L (1976) Effects of multiple doses of metoprolol and propranolol on ventilatory function in patients with chronic obstructive lung disease. Scand J Respir Dis 57(4):190\u2013196","journal-title":"Scand J Respir Dis"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-018-1688-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11325-018-1688-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-018-1688-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T17:45:56Z","timestamp":1569001556000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11325-018-1688-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,27]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["1688"],"URL":"https:\/\/doi.org\/10.1007\/s11325-018-1688-5","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"value":"1520-9512","type":"print"},{"value":"1522-1709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,27]]},"assertion":[{"value":"16 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the Ethics Committee of the First Affiliated Hospital of Harbin Medical University (\n            \n            identifier: NCT02408172)","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}