{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:03:55Z","timestamp":1789916635020,"version":"4.0.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["2016-2021"],"award-info":[{"award-number":["2016-2021"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["12H4516N"],"award-info":[{"award-number":["12H4516N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s11325-018-1752-1","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T18:57:10Z","timestamp":1542221830000},"page":"879-883","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Successful upper airway stimulation therapy in an adult Down syndrome patient with severe obstructive sleep apnea"],"prefix":"10.1007","volume":"23","author":[{"given":"Eli","family":"Van de Perck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolien","family":"Beyers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke","family":"Dieltjens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Op de Beeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Verbraecken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Van de Heyning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Boudewyns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4088-4213","authenticated-orcid":false,"given":"Olivier M.","family":"Vanderveken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,14]]},"reference":[{"issue":"12","key":"1752_CR1","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1002\/bdra.20735","volume":"88","author":"SE Parker","year":"2010","unstructured":"Parker SE, Mai CT, Canfield MA, Rickard R, Wang Y, Meyer RE, Anderson P, Mason CA, Collins JS, Kirby RS, Correa A, N National Birth Defects Prevention (2010) Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006. Birth Defects Res A Clin Mol Teratol 88(12):1008\u20131016. https:\/\/doi.org\/10.1002\/bdra.20735","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"3","key":"1752_CR2","doi-asserted-by":"publisher","first-page":"699","DOI":"10.5665\/sleep.5554","volume":"39","author":"M Maris","year":"2016","unstructured":"Maris M, Verhulst S, Wojciechowski M, Van de Heyning P, Boudewyns A (2016) Prevalence of obstructive sleep apnea in children with Down syndrome. Sleep 39(3):699\u2013704. https:\/\/doi.org\/10.5665\/sleep.5554","journal-title":"Sleep"},{"issue":"4","key":"1752_CR3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5664\/jcsm.27541","volume":"5","author":"MS Trois","year":"2009","unstructured":"Trois MS, Capone GT, Lutz JA, Melendres MC, Schwartz AR, Collop NA, Marcus CL (2009) Obstructive sleep apnea in adults with Down syndrome. J Clin Sleep Med 5(4):317\u2013323","journal-title":"J Clin Sleep Med"},{"issue":"6","key":"1752_CR4","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/S1474-4422(10)70112-5","volume":"9","author":"IT Lott","year":"2010","unstructured":"Lott IT, Dierssen M (2010) Cognitive deficits and associated neurological complications in individuals with Down\u2019s syndrome. Lancet Neurol 9(6):623\u2013633. https:\/\/doi.org\/10.1016\/S1474-4422(10)70112-5","journal-title":"Lancet Neurol"},{"issue":"2","key":"1752_CR5","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1378\/chest.14-0266","volume":"147","author":"C Lal","year":"2015","unstructured":"Lal C, White DR, Joseph JE, van Bakergem K, LaRosa A (2015) Sleep-disordered breathing in Down syndrome. Chest 147(2):570\u2013579. https:\/\/doi.org\/10.1378\/chest.14-0266","journal-title":"Chest"},{"issue":"3","key":"1752_CR6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5664\/jcsm.27497","volume":"5","author":"LJ Epstein","year":"2009","unstructured":"Epstein LJ, Kristo D, Strollo PJ Jr, Friedman N, Malhotra A, Patil SP, Ramar K, Rogers R, Schwab RJ, Weaver EM, Weinstein MD, M Adult Obstructive Sleep Apnea Task Force of the American Academy of Sleep (2009) Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 5(3):263\u2013276","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"1752_CR7","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/S0022-3913(99)70248-9","volume":"81","author":"K Yoshida","year":"1999","unstructured":"Yoshida K (1999) Elastic retracted oral appliance to treat sleep apnea in mentally impaired patients and patients with neuromuscular disabilities. J Prosthet Dent 81(2):196\u2013201","journal-title":"J Prosthet Dent"},{"issue":"2","key":"1752_CR8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1056\/NEJMoa1308659","volume":"370","author":"PJ Strollo Jr","year":"2014","unstructured":"Strollo PJ Jr, Soose RJ, Maurer JT, de Vries N, Cornelius J, Froymovich O, Hanson RD, Padhya TA, Steward DL, Gillespie MB, Woodson BT, Van de Heyning PH, Goetting MG, Vanderveken OM, Feldman N, Knaack L, Strohl KP, ST Group (2014) Upper-airway stimulation for obstructive sleep apnea. N Engl J Med 370(2):139\u2013149. https:\/\/doi.org\/10.1056\/NEJMoa1308659","journal-title":"N Engl J Med"},{"issue":"1","key":"1752_CR9","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1183\/09031936.00059414","volume":"45","author":"F Safiruddin","year":"2015","unstructured":"Safiruddin F, Vanderveken OM, de Vries N, Maurer JT, Lee K, Ni Q, Strohl KP (2015) Effect of upper-airway stimulation for obstructive sleep apnoea on airway dimensions. Eur Respir J 45(1):129\u2013138. https:\/\/doi.org\/10.1183\/09031936.00059414","journal-title":"Eur Respir J"},{"issue":"7","key":"1752_CR10","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1002\/lary.23301","volume":"122","author":"PH Heyning Van de","year":"2012","unstructured":"Van de Heyning PH, Badr MS, Baskin JZ, Cramer Bornemann MA, De Backer WA, Dotan Y, Hohenhorst W, Knaack L, Lin HS, Maurer JT, Netzer A, Odland RM, Oliven A, Strohl KP, Vanderveken OM, Verbraecken J, Woodson BT (2012) Implanted upper airway stimulation device for obstructive sleep apnea. Laryngoscope 122(7):1626\u20131633. https:\/\/doi.org\/10.1002\/lary.23301","journal-title":"Laryngoscope"},{"issue":"5","key":"1752_CR11","doi-asserted-by":"publisher","first-page":"e20153663","DOI":"10.1542\/peds.2015-3663","volume":"137","author":"GR Diercks","year":"2016","unstructured":"Diercks GR, Keamy D, Kinane TB, Skotko B, Schwartz A, Grealish E, Dobrowski J, Soose R, Hartnick CJ (2016) Hypoglossal nerve stimulator implantation in an adolescent with Down syndrome and sleep apnea. Pediatrics 137(5):e20153663. https:\/\/doi.org\/10.1542\/peds.2015-3663","journal-title":"Pediatrics"},{"key":"1752_CR12","doi-asserted-by":"publisher","unstructured":"Diercks GR, Wentland C, Keamy D, Kinane TB, Skotko B, de Guzman V, Grealish E, Dobrowski J, Soose R, Hartnick CJ (2017) Hypoglossal nerve stimulation in adolescents with Down syndrome and obstructive sleep apnea. JAMA Otolaryngol Head Neck Surg. https:\/\/doi.org\/10.1001\/jamaoto.2017.1871","DOI":"10.1001\/jamaoto.2017.1871"},{"key":"1752_CR13","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1002\/lary.26808","volume":"128","author":"SN Bowe","year":"2017","unstructured":"Bowe SN, Diercks GR, Hartnick CJ (2017) Modified surgical approach to hypoglossal nerve stimulator implantation in the pediatric population. Laryngoscope 128:1490\u20131492. https:\/\/doi.org\/10.1002\/lary.26808","journal-title":"Laryngoscope"},{"issue":"2","key":"1752_CR14","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s11325-012-0764-5","volume":"17","author":"JP Maanen van","year":"2013","unstructured":"van Maanen JP, Meester KA, Dun LN, Koutsourelakis I, Witte BI, Laman DM, Hilgevoord AA, de Vries N (2013) The sleep position trainer: a new treatment for positional obstructive sleep apnoea. Sleep Breath 17(2):771\u2013779. https:\/\/doi.org\/10.1007\/s11325-012-0764-5","journal-title":"Sleep Breath"},{"key":"1752_CR15","doi-asserted-by":"publisher","first-page":"575","DOI":"10.5664\/jcsm.7048","volume":"14","author":"J Beyers","year":"2018","unstructured":"Beyers J, Dieltjens M, Kastoer C, Opdebeeck L, Boudewyns AN, De Volder I, Van Gastel A, Verbraecken JA, De Backer WA, Braem MJ, Van de Heyning PH, Vanderveken OM (2018) Evaluation of a trial period with a sleep position trainer in patients with positional sleep apnea. J Clin Sleep Med 14:575\u2013583","journal-title":"J Clin Sleep Med"},{"issue":"3","key":"1752_CR16","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s11325-014-0989-6","volume":"18","author":"A Vito De","year":"2014","unstructured":"De Vito A, Carrasco Llatas M, Vanni A, Bosi M, Braghiroli A, Campanini A, de Vries N, Hamans E, Hohenhorst W, Kotecha BT, Maurer J, Montevecchi F, Piccin O, Sorrenti G, Vanderveken OM, Vicini C (2014) European position paper on drug-induced sedation endoscopy (DISE). Sleep Breath 18(3):453\u2013465. https:\/\/doi.org\/10.1007\/s11325-014-0989-6","journal-title":"Sleep Breath"},{"key":"1752_CR17","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1002\/lary.26158","volume":"126","author":"C Heiser","year":"2016","unstructured":"Heiser C, Thaler E, Boon M, Soose RJ, Woodson BT (2016) Updates of operative techniques for upper airway stimulation. Laryngoscope 126:S12\u2013S16. https:\/\/doi.org\/10.1002\/lary.26158","journal-title":"Laryngoscope"},{"key":"1752_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00523","volume":"11","author":"OM Vanderveken","year":"2017","unstructured":"Vanderveken OM, Beyers J, Op de Beeck S, Dieltjens M, Willemen M, Verbraecken JA, De Backer WA, Van de Heyning PH (2017) Development of a clinical pathway and technical aspects of upper airway stimulation therapy for obstructive sleep apnea. Front Neurosci 11:523. https:\/\/doi.org\/10.3389\/fnins.2017.00523","journal-title":"Front Neurosci"},{"key":"1752_CR19","doi-asserted-by":"publisher","unstructured":"Maris M, Verhulst S, Saldien V, Van de Heyning P, Wojciechowski M, Boudewyns A (2016) Drug-induced sedation endoscopy in surgically naive children with Down syndrome and obstructive sleep apnea. Sleep Med 24:63\u201370. https:\/\/doi.org\/10.1016\/j.sleep.2016.06.018","DOI":"10.1016\/j.sleep.2016.06.018"},{"issue":"5","key":"1752_CR20","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1152\/japplphysiol.00203.2003","volume":"95","author":"A Oliven","year":"2003","unstructured":"Oliven A, O'Hearn DJ, Boudewyns A, Odeh M, De Backer W, van de Heyning P, Smith PL, Eisele DW, Allan L, Schneider H, Testerman R, Schwartz AR (2003) Upper airway response to electrical stimulation of the genioglossus in obstructive sleep apnea. J Appl Physiol 95(5):2023\u20132029. https:\/\/doi.org\/10.1152\/japplphysiol.00203.2003","journal-title":"J Appl Physiol"},{"key":"1752_CR21","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1177\/0194599818762383","volume":"194599818762383","author":"BT Woodson","year":"2018","unstructured":"Woodson BT, Strohl KP, Soose RJ, Gillespie MB, Maurer JT, de Vries N, Padhya TA, Badr MS, Lin HS, Vanderveken OM, Mickelson S, Strollo PJ Jr (2018) Upper airway stimulation for obstructive sleep apnea: 5-year outcomes. Otolaryngol Head Neck Surg 194599818762383:194\u2013202. https:\/\/doi.org\/10.1177\/0194599818762383","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"1752_CR22","doi-asserted-by":"publisher","first-page":"433","DOI":"10.5664\/jcsm.2658","volume":"9","author":"OM Vanderveken","year":"2013","unstructured":"Vanderveken OM, Maurer JT, Hohenhorst W, Hamans E, Lin HS, Vroegop AV, Anders C, de Vries N, Van de Heyning PH (2013) Evaluation of drug-induced sleep endoscopy as a patient selection tool for implanted upper airway stimulation for obstructive sleep apnea. J Clin Sleep Med 9(5):433\u2013438. https:\/\/doi.org\/10.5664\/jcsm.2658","journal-title":"J Clin Sleep Med"},{"key":"1752_CR23","unstructured":"Beyers J, Dieltjens M, Vonk PE, Ravesloot MJ, Willemen M, Verbraecken JA, Van de Heyning PH, de Vries N, Vanderveken OM (2018) Prevalence and clinical significance of positional obstructive sleep apnea in patients treated with upper airway stimulation therapy. Sleep Breath. abstract International Sleep Surgery Society Meeting, Munich, Germany, April 5-7, 2018"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-018-1752-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11325-018-1752-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-018-1752-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T07:22:29Z","timestamp":1605424949000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11325-018-1752-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,14]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["1752"],"URL":"https:\/\/doi.org\/10.1007\/s11325-018-1752-1","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"value":"1520-9512","type":"print"},{"value":"1522-1709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,14]]},"assertion":[{"value":"7 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Olivier Vanderveken has the following potential conflicts of interest: research support and lecture fees from Inspire Medical Systems, research grant from and consultancy for Philips Respironics, research grant and lecture fees from Somnomed, consultancy for Nyxoah, consultancy for Galvani, research support from ReVent, research support from Nightbalance. The other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The patient guardian has consented to the submission of the paper for submission to the journal.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent statement"}}]}}