{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:28:41Z","timestamp":1793143721492,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,5,4]],"date-time":"2019-05-04T00:00:00Z","timestamp":1556928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008309","name":"Hengityssairauksien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008309","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008493","name":"V\u00e4in\u00f6 ja Laina Kiven S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008493","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008368","name":"Suomen Tuberkuloosin Vastustamisyhdistyksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s11325-019-01846-y","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T14:07:58Z","timestamp":1557151678000},"page":"191-199","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Gender-specific change in leptin concentrations during long-term CPAP therapy"],"prefix":"10.1007","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3072-9164","authenticated-orcid":false,"given":"Miia","family":"Aro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Anttalainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samu","family":"Kurki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerttu","family":"Irjala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Polo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Saaresranta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,4]]},"reference":[{"key":"1846_CR1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0140-6736(02)09464-3","volume":"360","author":"A Malhotra","year":"2002","unstructured":"Malhotra A, White DP (2002) Obstructive sleep apnoea. Lancet 360:237\u2013245. \nhttps:\/\/doi.org\/10.1016\/S0140-6736(02)09464-3","journal-title":"Lancet"},{"key":"1846_CR2","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1093\/aje\/kws342","volume":"177","author":"PE Peppard","year":"2013","unstructured":"Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM (2013) Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 177:1006\u20131014. \nhttps:\/\/doi.org\/10.1093\/aje\/kws342","journal-title":"Am J Epidemiol"},{"key":"1846_CR3","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/S0140-6736(81)92140-1","volume":"1","author":"CE Sullivan","year":"1981","unstructured":"Sullivan CE, Issa FG, Berthon-Jones M, Eves L (1981) Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares. Lancet 1:862\u2013865","journal-title":"Lancet"},{"key":"1846_CR4","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1053\/smrv.2001.0245","volume":"7","author":"MH Bonnet","year":"2003","unstructured":"Bonnet MH, Arand DL (2003) Clinical effects of sleep fragmentation versus sleep deprivation. Sleep Med Rev 7:297\u2013310","journal-title":"Sleep Med Rev"},{"key":"1846_CR5","doi-asserted-by":"publisher","first-page":"519","DOI":"10.5664\/jcsm.5680","volume":"12","author":"M Myllyl\u00e4","year":"2016","unstructured":"Myllyl\u00e4 M, Kurki S, Anttalainen U, Saaresranta T, Laitinen T (2016) High adherence to CPAP treatment does not prevent the continuation of weight gain among severely obese OSAS patients. J Clin Sleep Med 12:519\u2013528 10.5664\/jcsm.5680","journal-title":"J Clin Sleep Med"},{"key":"1846_CR6","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1136\/thoraxjnl-2014-205361","volume":"70","author":"LF Drager","year":"2015","unstructured":"Drager LF, Brunoni AR, Jenner R, Lorenzi-Filho G, Bensenor IM, Lotufo PA (2015) Effects of CPAP on body weight in patients with obstructive sleep apnoea: a meta-analysis of randomised trials. Thorax 70:258\u2013264. \nhttps:\/\/doi.org\/10.1136\/thoraxjnl-2014-205361","journal-title":"Thorax"},{"key":"1846_CR7","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/S0140-6736(97)06348-4","volume":"351","author":"J Auwerx","year":"1998","unstructured":"Auwerx J, Staels B (1998) Leptin. Lancet 351:737\u2013742. \nhttps:\/\/doi.org\/10.1016\/S0140-6736(97)06348-4","journal-title":"Lancet"},{"key":"1846_CR8","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1159\/000184187","volume":"42","author":"LE Underwood","year":"1994","unstructured":"Underwood LE, Thissen JP, Lemozy S, Ketelslegers JM, Clemmons DR (1994) Hormonal and nutritional regulation of IGF-I and its binding proteins. Horm Res 42:145\u2013151. \nhttps:\/\/doi.org\/10.1159\/000184187","journal-title":"Horm Res"},{"key":"1846_CR9","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1177\/0194599814562719","volume":"152","author":"X Chen","year":"2015","unstructured":"Chen X, Xun N, Kong W (2015) Effect of continuous positive airway pressure on leptin levels in patients with obstructive sleep apnea a meta-analysis. Otolaryngol Neck Surg 152:610\u2013618","journal-title":"Otolaryngol Neck Surg"},{"key":"1846_CR10","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1056\/nejm199602013340503","volume":"334","author":"RV Considine","year":"1996","unstructured":"Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF (1996) Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292\u2013295. \nhttps:\/\/doi.org\/10.1056\/nejm199602013340503","journal-title":"N Engl J Med"},{"key":"1846_CR11","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1001\/archinte.158.12.1333","volume":"158","author":"N Vgontzas a","year":"1998","unstructured":"Vgontzas a N, Bixler EO, Tan TL et al (1998) Obesity without sleep apnea is associated with daytime sleepiness. Arch Intern Med 158:1333\u20131337. \nhttps:\/\/doi.org\/10.1001\/archinte.158.12.1333","journal-title":"Arch Intern Med"},{"key":"1846_CR12","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1164\/rccm.200405-579OC","volume":"171","author":"A Barcelo","year":"2005","unstructured":"Barcelo A, Barbe F, Llompart E et al (2005) Neuropeptide Y and leptin in patients with obstructive sleep apnea syndrome: role of obesity. Am J Respir Crit Care Med 171:183\u2013187. \nhttps:\/\/doi.org\/10.1164\/rccm.200405-579OC","journal-title":"Am J Respir Crit Care Med"},{"key":"1846_CR13","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.physbeh.2006.05.038","volume":"88","author":"Y Zhang","year":"2006","unstructured":"Zhang Y, Scarpace PJ (2006) The role of leptin in leptin resistance and obesity. Physiol Behav 88:249\u2013256. \nhttps:\/\/doi.org\/10.1016\/j.physbeh.2006.05.038","journal-title":"Physiol Behav"},{"key":"1846_CR14","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1155\/2018\/5137947","volume":"70","author":"S Berger","year":"2015","unstructured":"Berger S, Polotsky VY (2015) Leptin and leptin resistance in the pathogenesis of obstructive sleep apnea: a possible link to oxidative stress and cardiovascular complications. Thorax 70:258\u2013264. \nhttps:\/\/doi.org\/10.1155\/2018\/5137947","journal-title":"Thorax"},{"key":"1846_CR15","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1183\/09031936.04.00067804","volume":"23","author":"BM Sanner","year":"2004","unstructured":"Sanner BM, Kollhosser P, Buechner N, Zidek W, Tepel M (2004) Influence of treatment on leptin levels in patients with obstructive sleep apnoea. Eur Respir J 23:601\u2013604. \nhttps:\/\/doi.org\/10.1183\/09031936.04.00067804","journal-title":"Eur Respir J"},{"key":"1846_CR16","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.sleep.2007.08.004","volume":"14","author":"MW Johns","year":"1991","unstructured":"Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep J Sleep Res Sleep Med 14:540\u2013545. \nhttps:\/\/doi.org\/10.1016\/j.sleep.2007.08.004","journal-title":"Sleep J Sleep Res Sleep Med"},{"key":"1846_CR17","unstructured":"Iber C, Ancoli-Israel S, Chesson A, Quan S, American Academy of Sleep Medicine (2007) The AASM Manual for the scoring of sleep and associated events: rules, terminology and technical specifications, 1st edn. American Academy of Sleep Medicine, Westchester"},{"key":"1846_CR18","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1016\/j.physbeh.2016.10.011","volume":"48","author":"A Shechter","year":"2016","unstructured":"Shechter A (2016) Effects of continuous positive airway pressure on energy balance regulation: a systematic review. Eur Respir J 48:1640\u20131657. \nhttps:\/\/doi.org\/10.1016\/j.physbeh.2016.10.011","journal-title":"Eur Respir J"},{"key":"1846_CR19","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.smrv.2013.07.003","volume":"18","author":"W Pan","year":"2014","unstructured":"Pan W, Kastin AJ (2014) Leptin: A biomarker for sleep disorders? Sleep Med Rev 18:283\u2013290. \nhttps:\/\/doi.org\/10.1016\/j.smrv.2013.07.003","journal-title":"Sleep Med Rev"},{"key":"1846_CR20","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1471-2466-8-21","volume":"8","author":"M Drummond","year":"2008","unstructured":"Drummond M, Winck JC, Guimar\u00e3es JT, Santos AC, Almeida J, Marques JA (2008) Autoadjusting-CPAP effect on serum leptin concentrations in obstructive sleep apnoea patients. BMC Pulm Med 8:21. \nhttps:\/\/doi.org\/10.1186\/1471-2466-8-21","journal-title":"BMC Pulm Med"},{"key":"1846_CR21","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/1465-9921-12-80","volume":"12","author":"JM Garcia","year":"2011","unstructured":"Garcia JM, Sharafkhaneh H, Hirshkowitz M, Elkhatib R, Sharafkhaneh A (2011) Weight and metabolic effects of CPAP in obstructive sleep apnea patients with obesity. Respir Res 12:80. \nhttps:\/\/doi.org\/10.1186\/1465-9921-12-80","journal-title":"Respir Res"},{"key":"1846_CR22","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1183\/09031936.00126712","volume":"43","author":"I Kritikou","year":"2014","unstructured":"Kritikou I, Basta M, Vgontzas AN, Pejovic S, Liao D, Tsaoussoglou M, Bixler EO, Stefanakis Z, Chrousos GP (2014) Sleep apnoea, sleepiness, inflammation and insulin resistance in middle-aged males and females. Eur Respir J 43:145\u2013155","journal-title":"Eur Respir J"},{"key":"1846_CR23","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1136\/thoraxjnl-2011-201420","volume":"67","author":"CM Hoyos","year":"2012","unstructured":"Hoyos CM, Killick R, Yee BJ, Phillips CL, Grunstein RR, Liu PY (2012) Cardiometabolic changes after continuous positive airway pressure for obstructive sleep apnoea: a randomised sham-controlled study. Thorax 67:1081\u20131089. \nhttps:\/\/doi.org\/10.1136\/thoraxjnl-2011-201420","journal-title":"Thorax"},{"key":"1846_CR24","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1053\/meta.2000.9519","volume":"49","author":"T Thomas","year":"2000","unstructured":"Thomas T, Burguera B, Melton Iii LJ et al (2000) Relationship of serum leptin levels with body composition and sex steroid and insulin levels in men and women. Metab Clin Exp 49:1278\u20131284. \nhttps:\/\/doi.org\/10.1053\/meta.2000.9519","journal-title":"Metab Clin Exp"},{"key":"1846_CR25","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/echo.12392","volume":"31","author":"H Akilli","year":"2014","unstructured":"Akilli H, Kayrak M, Bekci TT, Erdogan H\u0130, Aribas A, Yildirim O, Taner A, Erer M, Unlu A (2014) Gender-related changes of the epicardial fat thickness and leptin in obstructive sleep apnea. Echocardiography 31:411\u2013419. \nhttps:\/\/doi.org\/10.1111\/echo.12392","journal-title":"Echocardiography"},{"key":"1846_CR26","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1371\/journal.pmed.0010062","volume":"1","author":"S Taheri","year":"2004","unstructured":"Taheri S, Lin L, Austin D, Young T, Mignot E (2004) Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med 1:210\u2013217. \nhttps:\/\/doi.org\/10.1371\/journal.pmed.0010062","journal-title":"PLoS Med"},{"key":"1846_CR27","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1172\/JCI119717","volume":"100","author":"DA Schoeller","year":"1997","unstructured":"Schoeller DA, Cella LK, Sinha MK, Caro JF (1997) Entrainment of the diurnal rhythm of plasma leptin to meal timing. J Clin Invest 100:1882\u20131887. \nhttps:\/\/doi.org\/10.1172\/JCI119717","journal-title":"J Clin Invest"},{"key":"1846_CR28","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s11684-013-0263-5","volume":"7","author":"Y Zhou","year":"2014","unstructured":"Zhou Y, Rui L (2014) Leptin signaling and leptin resistance. Front Med 7:207\u2013222. \nhttps:\/\/doi.org\/10.1007\/s11684-013-0263-5","journal-title":"Front Med"},{"key":"1846_CR29","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1530\/EJE-09-0919","volume":"162","author":"T M\u00fcnzer","year":"2010","unstructured":"M\u00fcnzer T, Hegglin A, Stannek T, Schoch OD, Korte W, B\u00fcche D, Schmid C, H\u00fcrny C (2010) Effects of long-term continuous positive airway pressure on body composition and IGF1. Eur J Endocrinol 162:695\u2013704. \nhttps:\/\/doi.org\/10.1530\/EJE-09-0919","journal-title":"Eur J Endocrinol"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-019-01846-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11325-019-01846-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-019-01846-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T23:27:36Z","timestamp":1588462056000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11325-019-01846-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,4]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["1846"],"URL":"https:\/\/doi.org\/10.1007\/s11325-019-01846-y","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"value":"1520-9512","type":"print"},{"value":"1522-1709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,4]]},"assertion":[{"value":"30 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"MA: personal fees from Astra Zeneca, outside the submitted work; UA: personal fees from ResMed Finland, grants from Boehringer-Ingelheim, outside the submitted work; and Member of the Task Force for the National Current Care Guidelines for Obstructive Sleep Apnoea; TS: personal fees from ResMed Finland, personal fees from Boehringer Ingelheim, outside the submitted work; and President of the Task Force for the National Current Care Guidelines for Obstructive Sleep Apnoea.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}