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Dr. Lal is a consultant for Jazz pharmaceuticals and Cipla pharmaceuticals. Dr. Charlie Strange has current, past, or pending grants in COPD from the Alpha-1 Foundation, Adverum, BTG, CSL Behring, Grifols, NIH, MatRx, Novartis, Pulmonx, Shire, and Vertex. He consults for AstraZeneca, Boehringer-Ingelheim, CSL Behring, Grifols, and Uptake Medical on COPD.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any study with human subjects or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This study did not qualify as research on human subjects as determined by the Medical University of South Carolina\u2019s Institutional Review Board (IRB), and hence IRB approval was not needed. 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