{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:16:49Z","timestamp":1792617409682,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,11,30]],"date-time":"2019-11-30T00:00:00Z","timestamp":1575072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,30]],"date-time":"2019-11-30T00:00:00Z","timestamp":1575072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s11325-019-01970-9","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T12:33:15Z","timestamp":1575289995000},"page":"637-651","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Sleep spindles, K-complexes, limb movements and sleep stage proportions may be biomarkers for amnestic mild cognitive impairment and Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"24","author":[{"given":"Shunjie","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5345-3359","authenticated-orcid":false,"given":"Zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,30]]},"reference":[{"issue":"s1","key":"1970_CR1","doi-asserted-by":"crossref","first-page":"S329","DOI":"10.3233\/JAD-179914","volume":"64","author":"A Gutierrez","year":"2018","unstructured":"Gutierrez A, Vitorica J (2018) Toward a new concept of Alzheimer's disease models: a perspective from neuroinflammation. J Alzheimers Dis 64(s1):S329\u2013S338","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"1970_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2012.11.006","volume":"9","author":"A Wimo","year":"2013","unstructured":"Wimo A, Jonsson L, Bond J, Prince M, Winblad B (2013) The worldwide economic impact of dementia 2010. Alzheimers Dement 9(1):1\u201311","journal-title":"Alzheimers Dement"},{"issue":"2","key":"1970_CR3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/0891988713509135","volume":"27","author":"DG Gunn","year":"2014","unstructured":"Gunn DG, Naismith SL, Terpening Z, Lewis SJ (2014) The relationships between poor sleep efficiency and mild cognitive impairment in Parkinson disease. J Geriatr Psychiatry Neurol 27(2):77\u201384","journal-title":"J Geriatr Psychiatry Neurol"},{"issue":"2","key":"1970_CR4","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/13803395.2018.1513453","volume":"41","author":"C Malone","year":"2018","unstructured":"Malone C, Deason RG, Palumbo R, Heyworth N, Tat M, Budson AE (2018) False memories in patients with mild cognitive impairment and mild Alzheimer's disease dementia: can cognitive strategies help? J Clin Exp Neuropsychol 41(2):204\u2013218","journal-title":"J Clin Exp Neuropsychol"},{"issue":"2","key":"1970_CR5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bjpt.2017.03.010","volume":"21","author":"JH Ansai","year":"2017","unstructured":"Ansai JH, Andrade LP, Rossi PG, Takahashi ACM, Vale FAC, Rebelatto JR (2017) Gait, dual task and history of falls in elderly with preserved cognition, mild cognitive impairment, and mild Alzheimer's disease. Braz J Phys Ther 21(2):144\u2013151","journal-title":"Braz J Phys Ther"},{"issue":"1","key":"1970_CR6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuron.2017.02.004","volume":"94","author":"BA Mander","year":"2017","unstructured":"Mander BA, Winer JR, Walker MP (2017) Sleep and human aging. Neuron 94(1):19\u201336","journal-title":"Neuron"},{"issue":"8","key":"1970_CR7","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s10072-017-2975-9","volume":"38","author":"M Hu","year":"2017","unstructured":"Hu M, Zhang P, Li C, Tan Y, Li G, Xu D, Chen L (2017) Sleep disturbance in mild cognitive impairment: a systematic review of objective measures. Neurol Sci 38(8):1363\u20131371","journal-title":"Neurol Sci"},{"issue":"8","key":"1970_CR8","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.tins.2016.05.002","volume":"39","author":"BA Mander","year":"2016","unstructured":"Mander BA, Winer JR, Jagust WJ, Walker MP (2016) Sleep: a novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer's disease? Trends Neurosci 39(8):552\u2013566","journal-title":"Trends Neurosci"},{"issue":"03","key":"1970_CR9","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1017\/S135561771200001X","volume":"18","author":"CE Westerberg","year":"2012","unstructured":"Westerberg CE, Mander BA, Florczak SM, Weintraub S, Mesulam MM, Zee PC, Paller KA (2012) Concurrent impairments in sleep and memory in amnestic mild cognitive impairment. J Int Neuropsychol Soc 18(03):490\u2013500","journal-title":"J Int Neuropsychol Soc"},{"issue":"48","key":"1970_CR10","doi-asserted-by":"crossref","first-page":"11675","DOI":"10.1523\/JNEUROSCI.3033-16.2017","volume":"37","author":"BA Mander","year":"2017","unstructured":"Mander BA, Zhu AH, Lindquist JR, Villeneuve S, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP (2017) White matter structure in older adults moderates the benefit of sleep spindles on motor memory consolidation. J Neurosci 37(48):11675\u201311687","journal-title":"J Neurosci"},{"issue":"8","key":"1970_CR11","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1093\/brain\/awx148","volume":"140","author":"YS Ju","year":"2017","unstructured":"Ju YS, Ooms SJ, Sutphen C, Macauley SL, Zangrilli MA, Jerome G, Fagan AM, Mignot E, Zempel JM, Claassen JAHR, Holtzman DM (2017) Slow wave sleep disruption increases cerebrospinal fluid amyloid-\u03b2 levels. Brain 140(8):2104\u20132111","journal-title":"Brain"},{"issue":"7","key":"1970_CR12","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nn.4035","volume":"18","author":"BA Mander","year":"2015","unstructured":"Mander BA, Marks SM, Vogel JW, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP (2015) \u03b2-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation. Nat Neurosci 18(7):1051\u20131057","journal-title":"Nat Neurosci"},{"issue":"5","key":"1970_CR13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1053\/smrv.2002.0252","volume":"7","author":"L De Gennaro","year":"2003","unstructured":"De Gennaro L, Ferrara M (2003) Sleep spindles: an overview. Sleep Med Rev 7(5):423\u2013440","journal-title":"Sleep Med Rev"},{"issue":"2","key":"1970_CR14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1046\/j.1365-2869.2002.00293.x","volume":"11","author":"K Crowley","year":"2002","unstructured":"Crowley K, Trinder J, Colrain IM (2002) An examination of evoked K-complex amplitude and frequency of occurrence in the elderly. J Sleep Res 11(2):129\u2013140","journal-title":"J Sleep Res"},{"issue":"6","key":"1970_CR15","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.cub.2018.01.087","volume":"28","author":"SA Cairney","year":"2018","unstructured":"Cairney SA, Guttesen A\u00c1V, El Marj N, Staresina BP (2018) Memory consolidation is linked to spindle-mediated information processing during sleep. Curr Biol 28(6):948\u2013954","journal-title":"Curr Biol"},{"key":"1970_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/8376108","volume":"2016","author":"M Gorgoni","year":"2016","unstructured":"Gorgoni M, Lauri G, Truglia I, Cordone S, Sarasso S, Scarpelli S, Mangiaruga A, Atri DA et al (2016) Parietal fast sleep spindle density decrease in Alzheimer\u2019s disease and amnesic mild cognitive impairmenT. Neural Plast 2016:1\u201310","journal-title":"Neural Plast"},{"issue":"12","key":"1970_CR17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/brainsci7050051","volume":"7","author":"F Reda","year":"2017","unstructured":"Reda F, Gorgoni M, Lauri G, Truglia I, Cordone S, Scarpelli S, Mangiaruga A, D'Atri A et al (2017) In Search of sleep biomarkers of Alzheimer\u2019s disease: K-complexes do not discriminate between patients with mild cognitive impairment and healthy controls. Brain Sci 7(12):51","journal-title":"Brain Sci"},{"issue":"1","key":"1970_CR18","doi-asserted-by":"crossref","first-page":"39688","DOI":"10.1038\/srep39688","volume":"7","author":"L De Gennaro","year":"2017","unstructured":"De Gennaro L, Gorgoni M, Reda F, Lauri G, Truglia I, Cordone S, Scarpelli S, Mangiaruga A et al (2017) The fall of sleep K-complex in Alzheimer disease. Sci Rep 7(1):39688","journal-title":"Sci Rep"},{"key":"1970_CR19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3389\/fneur.2019.00197","volume":"10","author":"J Taillard","year":"2019","unstructured":"Taillard J, Sagaspe P, Berthomier C, Brandewinder M, Amieva H, Dartigues J, Rainfray M, Harston S et al (2019) Non-REM sleep characteristics predict early cognitive impairment in an aging population. Front Neurol 10:197","journal-title":"Front Neurol"},{"issue":"3","key":"1970_CR20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00406-016-0725-2","volume":"267","author":"C Schilling","year":"2017","unstructured":"Schilling C, Schlipf M, Spietzack S, Rausch F, Eisenacher S, Englisch S, Reinhard I, Haller L, Grimm O, Deuschle M, Tost H, Zink M, Meyer-Lindenberg A, Schredl M (2017) Fast sleep spindle reduction in schizophrenia and healthy first-degree relatives: association with impaired cognitive function and potential intermediate phenotype. Eur Arch Psychiatry Clin Neurosci 267(3):213\u2013224","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"1970_CR21","doi-asserted-by":"crossref","unstructured":"Gorgoni M, Reda F, D'Atri A, Scarpelli S, Ferrara M, De Gennaro L (2019) The heritability of the human K-complex: a twin study. Sleep 42(6)","DOI":"10.1093\/sleep\/zsz053"},{"issue":"2","key":"1970_CR22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4103\/0022-3859.65284","volume":"56","author":"R Natarajan","year":"2010","unstructured":"Natarajan R (2010) Review of periodic limb movement and restless leg syndrome. J Postgrad Med 56(2):157\u2013162","journal-title":"J Postgrad Med"},{"issue":"4","key":"1970_CR23","first-page":"e195473","volume":"13","author":"M Wu","year":"2018","unstructured":"Wu M, Tseng P, Chen T, Chen Y, Liou L, Lin P, Hsu C (2018) The efficacy and tolerability of rotigotine on patients with periodic limb movement in sleep: a systematic review and meta-analysis. PLoS One 13(4):e195473","journal-title":"PLoS One"},{"issue":"5","key":"1970_CR24","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/mds.26929","volume":"32","author":"B H\u00f6gl","year":"2017","unstructured":"H\u00f6gl B, Stefani A (2017) Restless legs syndrome and periodic leg movements in patients with movement disorders: specific considerations. Mov Disord 32(5):669\u2013681","journal-title":"Mov Disord"},{"issue":"3-4","key":"1970_CR25","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000439252","volume":"16","author":"L Chwiszczuk","year":"2016","unstructured":"Chwiszczuk L, Breitve M, Hynninen M, Gjerstad MD, Aarsland D, Rongve A (2016) Higher frequency and complexity of sleep disturbances in dementia with Lewy bodies as compared to Alzheimer's disease. Neurodegener Dis 16(3-4):152\u2013160","journal-title":"Neurodegener Dis"},{"key":"1970_CR26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.sleep.2017.03.026","volume":"35","author":"JA Albers","year":"2017","unstructured":"Albers JA, Chand P, Anch AM (2017) Multifactorial sleep disturbance in Parkinson's disease. Sleep Med 35:41\u201348","journal-title":"Sleep Med"},{"issue":"3","key":"1970_CR27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","volume":"256","author":"RC Petersen","year":"2004","unstructured":"Petersen RC (2004) Mild cognitive impairment as a diagnostic entity. J Intern Med 256(3):183\u2013194","journal-title":"J Intern Med"},{"key":"1970_CR28","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders","author":"Association AP","year":"2013","unstructured":"Association AP (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Washington","edition":"5"},{"issue":"3","key":"1970_CR29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CJ, Kawas CH, Klunk WE, Koroshetz WJ et al (2011) The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7(3):263\u2013269","journal-title":"Alzheimers Dement"},{"issue":"6","key":"1970_CR30","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2044-8260.1967.tb00530.x","volume":"4","author":"M Hamilton","year":"1967","unstructured":"Hamilton M (1967) Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 4(6):278\u2013296","journal-title":"Br J Soc Clin Psychol"},{"key":"1970_CR31","first-page":"3","volume":"52","author":"GH Klem","year":"1999","unstructured":"Klem GH, Luders HO, Jasper HH, Elger C (1999) The ten-twenty electrode system of the International Federation. The International Federation of Clinical Neurophysiology. Electroencephalogr Clin Neurophysiol Suppl 52:3\u20136","journal-title":"Electroencephalogr Clin Neurophysiol Suppl"},{"key":"1970_CR32","volume-title":"for the American Academyof Sleep Medicine. The AASM manual for the scoring of sleep and associated events; rules, terminology and technical specifcations","author":"C Iber","year":"2007","unstructured":"Iber C, Ancoli-Israel S, Chesson A, Quan S (2007) for the American Academyof Sleep Medicine. The AASM manual for the scoring of sleep and associated events; rules, terminology and technical specifcations, 1st edn. American Academy of Sleep Medicine, Westchester","edition":"1"},{"issue":"24","key":"1970_CR33","doi-asserted-by":"crossref","first-page":"10941","DOI":"10.1523\/JNEUROSCI.22-24-10941.2002","volume":"22","author":"M Molle","year":"2002","unstructured":"Molle M, Marshall L, Gais S, Born J (2002) Grouping of spindle activity during slow oscillations in human non-rapid eye movement sleep. J Neurosci 22(24):10941\u201310947","journal-title":"J Neurosci"},{"issue":"2","key":"1970_CR34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jpsychores.2009.01.014","volume":"67","author":"CH Bastien","year":"2009","unstructured":"Bastien CH, St-Jean G, Turcotte I, Morin CM, Lavallee M, Carrier J, Forget D (2009) Spontaneous K-complexes in chronic psychophysiological insomnia. J Psychosom Res 67(2):117\u2013125","journal-title":"J Psychosom Res"},{"issue":"10","key":"1970_CR35","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/S1388-2457(02)00237-7","volume":"113","author":"K Crowley","year":"2002","unstructured":"Crowley K, Trinder J, Kim Y, Carrington M, Colrain IM (2002) The effects of normal aging on sleep spindle and K-complex production. Clin Neurophysiol 113(10):1615\u20131622","journal-title":"Clin Neurophysiol"},{"key":"1970_CR36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroimage.2019.01.012","volume":"189","author":"NS Hashemi","year":"2019","unstructured":"Hashemi NS, Dehnavi F, Moghimi S, Ghorbani M (2019) Slow spindles are associated with cortical high frequency activity. Neuroimage 189:71\u201384","journal-title":"Neuroimage"},{"issue":"10","key":"1970_CR37","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.5665\/SLEEP.1290","volume":"34","author":"M Molle","year":"2011","unstructured":"Molle M, Bergmann TO, Marshall L, Born J (2011) Fast and slow spindles during the sleep slow oscillation: disparate coalescence and engagement in memory processing. Sleep 34(10):1411\u20131421","journal-title":"Sleep"},{"key":"1970_CR38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fnagi.2017.00171","volume":"9","author":"S Guo","year":"2017","unstructured":"Guo S, Huang J, Jiang H, Han C, Li J, Xu X, Zhang G, Lin Z et al (2017) Restless legs syndrome: from pathophysiology to clinical diagnosis and management. Front Aging Neurosci 9:171","journal-title":"Front Aging Neurosci"},{"key":"1970_CR39","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.phrs.2018.01.016","volume":"130","author":"DM Amelio","year":"2018","unstructured":"Amelio DM, Puglisi-Allegra S, Mercuri N (2018) The role of dopaminergic midbrain in Alzheimer\u2019s disease: translating basic science into clinical practice. Pharmacol Res 130:414\u2013419","journal-title":"Pharmacol Res"},{"issue":"12","key":"1970_CR40","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.jpsychires.2012.07.007","volume":"46","author":"S Hibi","year":"2012","unstructured":"Hibi S, Yamaguchi Y, Umeda-Kameyama Y, Yamamoto H, Iijima K, Momose T, Akishita M, Ouchi Y (2012) The high frequency of periodic limb movements in patients with Lewy body dementia. J Psychiatr Res 46(12):1590\u20131594","journal-title":"J Psychiatr Res"},{"issue":"11","key":"1970_CR41","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.neurobiolaging.2008.10.018","volume":"31","author":"RO Roberts","year":"2010","unstructured":"Roberts RO, Knopman DS, Geda YE, Cha RH, Roger VL, Petersen RC (2010) Coronary heart disease is associated with non-amnestic mild cognitive impairment. Neurobiol Aging 31(11):1894\u20131902","journal-title":"Neurobiol Aging"},{"key":"1970_CR42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.psychres.2018.07.026","volume":"268","author":"J Oltra-Cucarella","year":"2018","unstructured":"Oltra-Cucarella J, Delgado S, Duque P, P\u00e9rez-Vicente JA, Cabello-Rodr\u00edguez L (2018) Encoding deficits in low-educated individuals with non-amnestic mild cognitive impairment. Analysis of memory processes using the Item Specific Deficit Approach. Psychiatry Res 268:211\u2013216","journal-title":"Psychiatry Res"},{"key":"1970_CR43","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.conb.2017.05.001","volume":"44","author":"R Boyce","year":"2017","unstructured":"Boyce R, Williams S, Adamantidis A (2017) REM sleep and memory. Curr Opin Neurobiol 44:167\u2013177","journal-title":"Curr Opin Neurobiol"},{"key":"1970_CR44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.nlm.2018.04.004","volume":"160","author":"I Skelin","year":"2019","unstructured":"Skelin I, Kilianski S, McNaughton BL (2019) Hippocampal coupling with cortical and subcortical structures in the context of memory consolidation. Neurobiol Learn Mem 160:21\u201331","journal-title":"Neurobiol Learn Mem"},{"issue":"11","key":"1970_CR45","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1021\/acschemneuro.8b00198","volume":"9","author":"M Paraskevaidi","year":"2018","unstructured":"Paraskevaidi M, Morais C, Halliwell DE, Mann D, Allsop D, Martin-Hirsch PL, Martin FL (2018) Raman spectroscopy to diagnose Alzheimer's disease and dementia with Lewy bodies in blood. ACS Chem Neurosci 9(11):2786\u20132794","journal-title":"ACS Chem Neurosci"},{"issue":"2","key":"1970_CR46","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.clinph.2003.10.014","volume":"115","author":"K Crowley","year":"2004","unstructured":"Crowley K (2004) Evoked K-complex generation: the impact of sleep spindles and age. Clin Neurophysiol 115(2):471\u2013476","journal-title":"Clin Neurophysiol"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-019-01970-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11325-019-01970-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-019-01970-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T00:35:17Z","timestamp":1606610117000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11325-019-01970-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,30]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["1970"],"URL":"https:\/\/doi.org\/10.1007\/s11325-019-01970-9","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"value":"1520-9512","type":"print"},{"value":"1522-1709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,30]]},"assertion":[{"value":"21 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors have approved the final manuscript for submission.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The ethical committee of The Sixth Affiliated Hospital of Sun Yat-Sen University approved this study, and the study was carried out in accordance with the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All subjects gave their written informed consent to participate in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}