{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:31:30Z","timestamp":1788481890841,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T00:00:00Z","timestamp":1576886400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T00:00:00Z","timestamp":1576886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Sichuan Medical Association Youth Foundation Project","award":["Q18034"],"award-info":[{"award-number":["Q18034"]}]},{"name":"Sichuan Ministry of Health Foundation Project","award":["19PJ059"],"award-info":[{"award-number":["19PJ059"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s11325-019-02001-3","type":"journal-article","created":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T23:02:11Z","timestamp":1576969331000},"page":"653-659","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Effect-size seed-based d mapping of resting-state fMRI for persistent insomnia disorder"],"prefix":"10.1007","volume":"24","author":[{"given":"Binghu","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,21]]},"reference":[{"key":"2001_CR1","unstructured":"Association AP. Diagnostic and statistical manual of mental disorders (DSM-5). Washington, DC. London, England; 2013"},{"key":"2001_CR2","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/S1474-4422(15)00021-6","volume":"14","author":"D Riemann","year":"2015","unstructured":"Riemann D, Nissen C, Palagini L, Otte A, Perlis ML, Spiegelhalder K (2015) The neurobiology, investigation, and treatment of chronic insomnia. Lancet Neurol 14:547\u2013558","journal-title":"Lancet Neurol"},{"key":"2001_CR3","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1146\/annurev-psych-010213-115205","volume":"66","author":"MR Irwin","year":"2015","unstructured":"Irwin MR (2015) Why sleep is important for health: a psychoneuroimmunology perspective. Annu Rev Psychol 66:143\u2013172","journal-title":"Annu Rev Psychol"},{"key":"2001_CR4","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.sleep.2014.10.018","volume":"16","author":"KF Chung","year":"2015","unstructured":"Chung KF, Yeung WF, Ho FY, Yung KP, Yu YM, Kwok CW (2015) Cross-cultural and comparative epidemiology of insomnia: the diagnostic and statistical manual (DSM), international classification of diseases (ICD) and international classification of sleep disorders (ICSD). Sleep Med 16:477\u2013482","journal-title":"Sleep Med"},{"key":"2001_CR5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s11910-015-0527-3","volume":"15","author":"K Spiegelhalder","year":"2015","unstructured":"Spiegelhalder K, Regen W, Baglioni C et al (2015) Neuroimaging insights into insomnia. Curr Neurol Neurosci Rep 15:9","journal-title":"Curr Neurol Neurosci Rep"},{"key":"2001_CR6","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.patbio.2014.05.013","volume":"62","author":"JN O\u2019Byrne","year":"2014","unstructured":"O\u2019Byrne JN, Berman Rosa M, Gouin JP, Dang-Vu TT (2014) Neuroimaging findings in primary insomnia. Pathol Biol (Paris) 62:262\u2013269","journal-title":"Pathol Biol (Paris)"},{"key":"2001_CR7","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.3174\/ajnr.A5452","volume":"39","author":"H Lv","year":"2018","unstructured":"Lv H, Wang Z, Tong E, Williams LM, Zaharchuk G, Zeineh M, Goldstein-Piekarski AN, Ball TM, Liao C, Wintermark M (2018) Resting-state functional MRI: everything that nonexperts have always wanted to know. AJNR Am J Neuroradiol 39:1390\u20131399","journal-title":"AJNR Am J Neuroradiol"},{"key":"2001_CR8","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1038\/s41467-019-08934-3","volume":"10","author":"ABA Stevner","year":"2019","unstructured":"Stevner ABA, Vidaurre D, Cabral J et al (2019) Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep. Nat Commun 10:1035","journal-title":"Nat Commun"},{"key":"2001_CR9","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.smrv.2018.07.004","volume":"42","author":"M Tahmasian","year":"2018","unstructured":"Tahmasian M, Noori K, Samea F, Zarei M, Spiegelhalder K, Eickhoff SB, van Someren E, Khazaie H, Eickhoff CR (2018) A lack of consistent brain alterations in insomnia disorder: an activation likelihood estimation meta-analysis. Sleep Med Rev 42:111\u2013118","journal-title":"Sleep Med Rev"},{"key":"2001_CR10","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.neubiorev.2016.03.026","volume":"65","author":"M Tahmasian","year":"2016","unstructured":"Tahmasian M, Rosenzweig I, Eickhoff SB et al (2016) Structural and functional neural adaptations in obstructive sleep apnea: an activation likelihood estimation meta-analysis. Neurosci Biobehav Rev 65:142\u2013156","journal-title":"Neurosci Biobehav Rev"},{"key":"2001_CR11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fpsyt.2014.00013","volume":"5","author":"J Radua","year":"2014","unstructured":"Radua J, Rubia K, Canales-Rodriguez EJ et al (2014) Anisotropic kernels for coordinate-based meta-analyses of neuroimaging studies. Front Psychiatry 5:13","journal-title":"Front Psychiatry"},{"key":"2001_CR12","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.neubiorev.2017.11.012","volume":"84","author":"VI Muller","year":"2018","unstructured":"Muller VI, Cieslik EC, Laird AR et al (2018) Ten simple rules for neuroimaging meta-analysis. Neurosci Biobehav Rev 84:151\u2013161","journal-title":"Neurosci Biobehav Rev"},{"key":"2001_CR13","unstructured":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. at http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp)"},{"key":"2001_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.529","volume":"6","author":"F Zhou","year":"2016","unstructured":"Zhou F, Huang S, Gao L et al (2016) Temporal regularity of intrinsic cerebral activity in patients with chronic primary insomnia: a brain entropy study using resting-state fMRI. Brain Behav 6:e00529","journal-title":"Brain Behav"},{"key":"2001_CR15","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.2147\/NDT.S137292","volume":"13","author":"S Huang","year":"2017","unstructured":"Huang S, Zhou F, Jiang J, Huang M, Zeng X, Ding S, Gong H (2017) Regional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia. Neuropsychiatr Dis Treat 13:1449\u20131462","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2001_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.876","volume":"8","author":"X Dong","year":"2018","unstructured":"Dong X, Qin H, Wu T et al (2018) Rest but busy: aberrant resting-state functional connectivity of triple network model in insomnia. Brain Behav 8:e00876","journal-title":"Brain Behav"},{"key":"2001_CR17","doi-asserted-by":"publisher","first-page":"856","DOI":"10.3389\/fneur.2018.00856","volume":"9","author":"CQ Yan","year":"2018","unstructured":"Yan CQ, Wang X, Huo JW et al (2018) Abnormal global brain functional connectivity in primary insomnia patients: a resting-state functional MRI study. Front Neurol 9:856","journal-title":"Front Neurol"},{"key":"2001_CR18","doi-asserted-by":"publisher","first-page":"5891","DOI":"10.1038\/s41598-018-23699-3","volume":"8","author":"X Liu","year":"2018","unstructured":"Liu X, Zheng J, Liu BX et al (2018) Altered connection properties of important network hubs may be neural risk factors for individuals with primary insomnia. Sci Rep 8:5891","journal-title":"Sci Rep"},{"key":"2001_CR19","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3389\/fpsyt.2018.00046","volume":"9","author":"X Ma","year":"2018","unstructured":"Ma X, Jiang G, Fu S et al (2018) Enhanced network efficiency of functional brain networks in primary insomnia patients. Front Psychiatry 9:46","journal-title":"Front Psychiatry"},{"key":"2001_CR20","doi-asserted-by":"publisher","first-page":"3678534","DOI":"10.1155\/2018\/3678534","volume":"2018","author":"E Santarnecchi","year":"2018","unstructured":"Santarnecchi E, Del Bianco C, Sicilia I et al (2018) Age of insomnia onset correlates with a reversal of default mode network and supplementary motor cortex connectivity. Neural Plast 2018:3678534","journal-title":"Neural Plast"},{"key":"2001_CR21","doi-asserted-by":"publisher","first-page":"917","DOI":"10.3389\/fnins.2018.00917","volume":"12","author":"L Wang","year":"2018","unstructured":"Wang L, Wang K, Liu JH et al (2018) Altered default mode and sensorimotor network connectivity with striatal subregions in primary insomnia: a resting-state multi-band fMRI study. Front Neurosci 12:917","journal-title":"Front Neurosci"},{"key":"2001_CR22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.jpsychires.2018.05.013","volume":"103","author":"S Yu","year":"2018","unstructured":"Yu S, Guo B, Shen Z, Wang Z, Kui Y, Hu Y, Feng F (2018) The imbalanced anterior and posterior default mode network in the primary insomnia. J Psychiatr Res 103:97\u2013103","journal-title":"J Psychiatr Res"},{"key":"2001_CR23","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3389\/fneur.2018.00317","volume":"9","author":"C Li","year":"2018","unstructured":"Li C, Dong M, Yin Y et al (2018) Aberrant effective connectivity of the right anterior insula in primary insomnia. Front Neurol 9:317","journal-title":"Front Neurol"},{"key":"2001_CR24","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.2147\/NDT.S111298","volume":"12","author":"C Li","year":"2016","unstructured":"Li C, Ma X, Dong M, Yin Y, Hua K, Li M, Li C, Zhan W, Li C, Jiang G (2016) Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study. Neuropsychiatr Dis Treat 12:1371\u20131378","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2001_CR25","doi-asserted-by":"publisher","first-page":"363","DOI":"10.5664\/jcsm.5586","volume":"12","author":"XJ Dai","year":"2016","unstructured":"Dai XJ, Nie X, Liu X, Pei L, Jiang J, Peng DC, Gong HH, Zeng XJ, W\u00e1ng YX, Zhan Y (2016) Gender differences in regional brain activity in patients with chronic primary insomnia: evidence from a resting-state fMRI study. J Clin Sleep Med 12:363\u2013374","journal-title":"J Clin Sleep Med"},{"key":"2001_CR26","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.nicl.2016.05.011","volume":"15","author":"F Zhou","year":"2017","unstructured":"Zhou F, Huang S, Zhuang Y, Gao L, Gong H (2017) Frequency-dependent changes in local intrinsic oscillations in chronic primary insomnia: a study of the amplitude of low-frequency fluctuations in the resting state. Neuroimage Clin 15:458\u2013465","journal-title":"Neuroimage Clin"},{"key":"2001_CR27","doi-asserted-by":"publisher","first-page":"84877","DOI":"10.18632\/oncotarget.17921","volume":"8","author":"Q Ran","year":"2017","unstructured":"Ran Q, Chen J, Li C, Wen L, Yue F, Shu T, Mi J, Wang G, Zhang L, Gao D, Zhang D (2017) Abnormal amplitude of low-frequency fluctuations associated with rapid-eye movement in chronic primary insomnia patients. Oncotarget 8:84877\u201384888","journal-title":"Oncotarget"},{"key":"2001_CR28","doi-asserted-by":"publisher","first-page":"12528","DOI":"10.1038\/s41598-017-13065-0","volume":"7","author":"SJ Kim","year":"2017","unstructured":"Kim SJ, Lee YJ, Kim N et al (2017) Exploration of changes in the brain response to sleep-related pictures after cognitive-behavioral therapy for psychophysiological insomnia. Sci Rep 7:12528","journal-title":"Sci Rep"},{"key":"2001_CR29","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.2147\/NDT.S69681","volume":"10","author":"XJ Dai","year":"2014","unstructured":"Dai XJ, Peng DC, Gong HH, Wan AL, Nie X, Li HJ, Wang YX (2014) Altered intrinsic regional brain spontaneous activity and subjective sleep quality in patients with chronic primary insomnia: a resting-state fMRI study. Neuropsychiatr Dis Treat 10:2163\u20132175","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2001_CR30","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1007\/s00330-015-3960-4","volume":"26","author":"T Wang","year":"2016","unstructured":"Wang T, Li S, Jiang G, Lin C, Li M, Ma X, Zhan W, Fang J, Li L, Li C, Tian J (2016) Regional homogeneity changes in patients with primary insomnia. Eur Radiol 26:1292\u20131300","journal-title":"Eur Radiol"},{"key":"2001_CR31","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s41105-017-0096-8","volume":"15","author":"DR Marques","year":"2017","unstructured":"Marques DR, Gomes AA, Clemente V et al (2017) Unbalanced resting-state networks activity in psychophysiological insomnia. Sleep Biol Rhythms 15:167\u2013177","journal-title":"Sleep Biol Rhythms"},{"key":"2001_CR32","first-page":"7","volume":"4","author":"S Zeng","year":"2015","unstructured":"Zeng S, Li C, Jiang G et al (2015) An investigation on the functional changes in the local brain areas of the primary insomnia patients using resting state functional MRI. Funct Mol Med Imaging 4:7\u201312","journal-title":"Funct Mol Med Imaging"},{"key":"2001_CR33","first-page":"10","volume":"33","author":"M Liang","year":"2014","unstructured":"Liang M, Zhou Q, Yang X et al (2014) The study of resting state fMRI changes in primary insomnia patients based on regional homogeneity. J Clin Radiol 33:10\u201314","journal-title":"J Clin Radiol"},{"key":"2001_CR34","first-page":"390","volume":"38","author":"X Ma","year":"2017","unstructured":"Ma X, Zeng S, Fang J (2017) Change of whole brain degree in primary insomnia. Journal of Sunyat-Sen University 38:390\u2013394","journal-title":"Journal of Sunyat-Sen University"},{"key":"2001_CR35","first-page":"701","volume":"16","author":"X Ma","year":"2017","unstructured":"Ma X, Wu Y, Zeng S et al (2017) Change of fractional amplitude of low frequency fluctuation in untreated primary insomnia patients: a resting state functional magnetic resonance imaging. Chin J Neuromed 16:701\u2013705","journal-title":"Chin J Neuromed"},{"key":"2001_CR36","first-page":"204","volume":"32","author":"X Nie","year":"2016","unstructured":"Nie X, Peng D, Li H et al (2016) Frequency-dependent alterations in amplitude of low-frequency fluctuations in primary insomnia: resting-state fMRI study. Chin J Med Imaging Technol 32:204\u2013208","journal-title":"Chin J Med Imaging Technol"},{"key":"2001_CR37","first-page":"15","volume":"35","author":"Y Shen","year":"2019","unstructured":"Shen Y, Li Z, Wu X et al (2019) Resting-state fMRI observation on functional connectivity of insula in patients with chronic insomnia based on Chinese brain template. Chin J Med Imaging Technol 35:15\u201319","journal-title":"Chin J Med Imaging Technol"},{"key":"2001_CR38","first-page":"608","volume":"38","author":"X Shi","year":"2017","unstructured":"Shi X, Liu M, Li C (2017) Abnormal functional connectivity of insular in primary insomnia based on resting-state fMRI study. Journal of Sun Yat-Sen University (Medical Sciences) 38:608\u2013613","journal-title":"Journal of Sun Yat-Sen University (Medical Sciences)"},{"key":"2001_CR39","first-page":"1976","volume":"22","author":"Y Wang","year":"2018","unstructured":"Wang Y, Li T, Mang J et al (2018) Resting-state fMRI in primary insomnia patients and healthy population. Chin J Lab Diagn 22:1976\u20131980","journal-title":"Chin J Lab Diagn"},{"key":"2001_CR40","first-page":"1251","volume":"15","author":"X Xu","year":"2016","unstructured":"Xu X, Wang S, Ge T et al (2016) Neuromechanism of acupuncture therapy in primary insomnia patients. Chin J Neuro Med 15:1251\u20131254","journal-title":"Chin J Neuro Med"},{"key":"2001_CR41","first-page":"5","volume":"24","author":"M Zheng","year":"2014","unstructured":"Zheng M, Zheng G, He F et al (2014) A study of resting-state fMRI on primary insomnia. Journal of Fujian University of TCM 24:5\u20139","journal-title":"Journal of Fujian University of TCM"},{"key":"2001_CR42","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.smrv.2009.04.002","volume":"14","author":"D Riemann","year":"2010","unstructured":"Riemann D, Spiegelhalder K, Feige B, Voderholzer U, Berger M, Perlis M, Nissen C (2010) The hyperarousal model of insomnia: a review of the concept and its evidence. Sleep Med Rev 14:19\u201331","journal-title":"Sleep Med Rev"},{"key":"2001_CR43","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1007\/s00330-017-5012-8","volume":"28","author":"S Li","year":"2018","unstructured":"Li S, Tian J, Li M, Wang T, Lin C, Yin Y, Zeng L, Li C, Jiang G (2018) Altered resting state connectivity in right side frontoparietal network in primary insomnia patients. Eur Radiol 28:664\u2013672","journal-title":"Eur Radiol"},{"key":"2001_CR44","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1126\/science.272.5261.545","volume":"272","author":"JH Gao","year":"1996","unstructured":"Gao JH, Parsons LM, Bower JM, Xiong J, Li J, Fox PT (1996) Cerebellum implicated in sensory acquisition and discrimination rather than motor control. Science 272:545\u2013547","journal-title":"Science"},{"key":"2001_CR45","doi-asserted-by":"publisher","first-page":"731","DOI":"10.5665\/sleep.2638","volume":"36","author":"K Spiegelhalder","year":"2013","unstructured":"Spiegelhalder K, Regen W, Baglioni C, Kl\u00f6ppel S, Abdulkadir A, Hennig J, Nissen C, Riemann D, Feige B (2013) Insomnia does not appear to be associated with substantial structural brain changes. Sleep 36:731\u2013737","journal-title":"Sleep"},{"key":"2001_CR46","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s12013-013-9529-4","volume":"67","author":"CG Jiang","year":"2013","unstructured":"Jiang CG, Zhang T, Yue FG, Yi ML, Gao D (2013) Efficacy of repetitive transcranial magnetic stimulation in the treatment of patients with chronic primary insomnia. Cell Biochem Biophys 67:169\u2013173","journal-title":"Cell Biochem Biophys"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-019-02001-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11325-019-02001-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-019-02001-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T00:22:16Z","timestamp":1608423736000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11325-019-02001-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,21]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["2001"],"URL":"https:\/\/doi.org\/10.1007\/s11325-019-02001-3","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"value":"1520-9512","type":"print"},{"value":"1522-1709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,21]]},"assertion":[{"value":"9 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Author Binghu Jiang has received research grants from Sichuan Medical Association Youth Foundation Project (Grant No.: Q18034) and Sichuan Ministry of Health Foundation Project (Grant No.: 19PJ059). Author Dongmei He declares that she has no conflict of interest. Author Zhiwei Guo declares that he has no conflict of interest. Author Zhanhui Gao declares that he has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}