{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:55:48Z","timestamp":1781538948619,"version":"3.54.5"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Excessive daytime sleepiness (EDS) is a main symptom in patients with obstructive sleep apnea (OSA); however, patients with OSA\u00a0have significant variability in their reported EDS which cannot be fully explained by the apnea-hypopnea index (AHI). The purpose of this study was to investigate gender differences regarding the sleep test variables contributing to excessive daytime sleepiness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of 578 men and 270 women with suspected OSA who underwent home overnight sleep test. We assessed the correlation between sleep test variables and EDS, using the Epworth Sleepiness Scale (ESS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the group\u00a0of men, correlation was found between ESS to BMI (<jats:italic>r<\/jats:italic>\u2009=\u2009.107,<jats:italic>p<\/jats:italic>\u2009=\u2009.010), AHI (<jats:italic>r<\/jats:italic>\u2009=\u2009.158,<jats:italic>p\u00a0<\/jats:italic>&lt;\u2009.001), number of apneas (<jats:italic>r<\/jats:italic>\u2009=\u2009.129,<jats:italic>p<\/jats:italic>\u2009=\u2009.002), number of hypopneas (<jats:italic>r<\/jats:italic>\u2009=\u2009.115,<jats:italic>p<\/jats:italic>\u2009=\u2009.006), number of blood oxygen desaturations (<jats:italic>r<\/jats:italic>\u2009=\u2009.145,<jats:italic>p\u00a0<\/jats:italic>\u2009&lt;\u2009.001), and percent of time the blood oxygen saturation was under 90% (<jats:italic>r<\/jats:italic>\u2009=\u2009.130,<jats:italic>p<\/jats:italic>\u2009=\u2009.002). However, among the group\u00a0of women, no significant correlation was found between any of the sleep test parameters or BMI to ESS. Among the group\u00a0of women, a negative correlation was found between age and EDS (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u2009.208,<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Men showed correlations between sleep test variables and EDS, while women did not show such correlations. The results suggest that men\u2019s sleepiness is more influenced by OSA and sleep variables compared to women. To our knowledge, this is the first study which shows difference between genders in the influence of sleep variables and OSA on EDS.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s11325-020-02276-x","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T09:02:51Z","timestamp":1611046971000},"page":"1837-1842","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Gender differences in the sleep variables contributing to excessive daytime sleepiness among patients with obstructive sleep apnea"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2977-4785","authenticated-orcid":false,"given":"Eliya","family":"Honig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Dagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"issue":"1","key":"2276_CR1","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1093\/sleep\/24.1.96","volume":"24","author":"CM Baldwin","year":"2001","unstructured":"Baldwin CM, Griffith KA, Nieto FJ, O\u2019Connor GT, Walsleben JA, Redline S (2001) The association of sleep-disordered breathing and sleep symptoms with quality of life in the sleep heart health study. Sleep 24(1):96\u2013105","journal-title":"Sleep"},{"issue":"2","key":"2276_CR2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1093\/sleep\/27.2.305","volume":"27","author":"CM Baldwin","year":"2004","unstructured":"Baldwin CM, Kapur VK, Holberg CJ, Rosen C, Nieto FJ (2004) Associations between gender and measures of daytime somnolence in the Sleep Heart Health Study. Sleep 27(2):305\u2013311","journal-title":"Sleep"},{"issue":"9","key":"2276_CR3","first-page":"E298","volume":"7","author":"RC Stansbury","year":"2015","unstructured":"Stansbury RC, Strollo PJ (2015) Clinical manifestations of sleep apnea. J Thorac Dis 7(9):E298\u2013E310","journal-title":"J Thorac Dis"},{"issue":"7","key":"2276_CR4","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1093\/sleep\/19.7.583","volume":"19","author":"B Briones","year":"1996","unstructured":"Briones B, Adams N, Strauss M, Rosenberg C, Whalen C, Carskadon M, Roebuck T, Winters M, Redline S (1996) Relationship between sleepiness and general health status. Sleep 19(7):583\u2013588","journal-title":"Sleep"},{"issue":"3 I","key":"2276_CR5","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1164\/ajrccm.163.3.2005065","volume":"163","author":"J Dur\u00e1n","year":"2001","unstructured":"Dur\u00e1n J, Esnaola S, Rubio R, Iztueta \u00c1 (2001) Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. Am J Respir Crit Care Med 163(3 I):685\u2013689","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"2276_CR6","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1378\/chest.125.6.2091","volume":"125","author":"MA Gon\u00e7alves","year":"2004","unstructured":"Gon\u00e7alves MA, Paiva T, Ramos E, Guilleminault C (2004) Obstructive sleep apnea syndrome, sleepiness, and quality of life. Chest 125(6):2091\u20132096","journal-title":"Chest"},{"issue":"1","key":"2276_CR7","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1378\/chest.94.1.32","volume":"94","author":"C Guilleminault","year":"1998","unstructured":"Guilleminault C, Partinen M, Quera-Salva MA, Hayes B, Dement WC, Nino-Murcia G (1998) Determinants of daytime sleepiness in obstructive sleep apnea. Chest 94(1):32\u201337","journal-title":"Chest"},{"key":"2276_CR8","unstructured":"John R. Giudicessi, BA Michael, J. Ackerman. 2013. \u57fa\u56e0\u7684\u6539\u53d8NIH Public Access. Bone [Internet]. 2008;23(1):1\u20137. Available from:\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3624763\/pdf\/nihms412728.pdf. Accessed 2013"},{"issue":"8","key":"2276_CR9","doi-asserted-by":"publisher","first-page":"4510","DOI":"10.1210\/jc.2005-0035","volume":"90","author":"EO Bixler","year":"2005","unstructured":"Bixler EO, Vgontzas AN, Lin HM, Calhoun SL, Vela-Bueno A, Kales A (2005) Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression. J Clin Endocrinol Metab 90(8):4510\u20134515","journal-title":"J Clin Endocrinol Metab"},{"issue":"suppl_8","key":"2276_CR10","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1093\/sleep\/16.suppl_8.S1","volume":"16","author":"T Young","year":"1993","unstructured":"Young T (1993) Analytic epidemiology studies of sleep disordered breathing\u2014what explains the gender difference in sleep disordered breathing? Sleep 16(suppl_8):S1\u2013S2","journal-title":"Sleep"},{"issue":"10","key":"2276_CR11","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.rmed.2004.03.002","volume":"98","author":"E Quintana-Gallego","year":"2004","unstructured":"Quintana-Gallego E, Carmona-Bernal C, Capote F, S\u00e1nchez-Armengol \u00c1, Botebol-Benhamou G, Polo-Padillo J, Castillo-G\u00f3mez J (2004) Gender differences in obstructive sleep apnea syndrome: a clinical study of 1166 patients. Respir Med 98(10):984\u2013989","journal-title":"Respir Med"},{"issue":"6","key":"2276_CR12","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1111\/j.1445-5994.1991.tb01408.x","volume":"21","author":"A Ambrogetti","year":"1991","unstructured":"Ambrogetti A, Olson LG, Saunders NA (1991) Differences in the symptoms of men and women with obstructive sleep apnoea. Aust NZ J Med 21(6):863\u2013866","journal-title":"Aust NZ J Med"},{"issue":"2","key":"2276_CR13","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.ccm.2004.01.002","volume":"25","author":"NA Collop","year":"2004","unstructured":"Collop NA, Adkins D, Phillips BA (2004) Gender differences in sleep and sleep-disordered breathing. Clin Chest Med 25(2):257\u2013268","journal-title":"Clin Chest Med"},{"issue":"3","key":"2276_CR14","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1093\/sleep\/30.3.312","volume":"30","author":"A Valipour","year":"2007","unstructured":"Valipour A, Lothaller H, Rauscher H, Zwick H, Burghuber OC, Lavie P (2007) Gender-related differences in symptoms of patients with suspected breathing disorders in sleep: a clinical population study using the Sleep Disorders Questionnaire. Sleep 30(3):312\u2013319","journal-title":"Sleep"},{"issue":"4","key":"2276_CR15","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s11325-008-0184-8","volume":"12","author":"H Alotair","year":"2008","unstructured":"Alotair H, BaHammam A (2008) Gender differences in Saudi patients with obstructive sleep apnea. Sleep Breath 12(4):323\u2013329","journal-title":"Sleep Breath"},{"key":"2276_CR16","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1007\/s11325-019-01943-y","volume":"24","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Cheng J, Yang W, Zou H, Su C, Miao J (2019) Gender differences in clinical manifestations and polysomnographic findings in Chinese patients with obstructive sleep apnea. Sleep Breath 24:1019\u20131026","journal-title":"Sleep Breath"},{"issue":"2","key":"2276_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/sleep\/zsx199","volume":"41","author":"B Prasad","year":"2018","unstructured":"Prasad B, Steffen AD, Van Dongen HPA, Pack FM, Strakovsky I, Staley B et al (2018) Determinants of sleepiness in obstructive sleep apnea. Sleep 41(2):1\u20139","journal-title":"Sleep"},{"issue":"17","key":"2276_CR18","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.3760\/cma.j.issn.0366-6999.20130690","volume":"126","author":"SJ Cai","year":"2013","unstructured":"Cai SJ, Chen R, Zhang YL, Xiong KP, Lian YX, Li J, Shen JC, Liu CF (2013) Correlation of Epworth Sleepiness Scale with multiple sleep latency test and its diagnostic accuracy in assessing excessive daytime sleepiness in patients with obstructive sleep apnea hypopnea syndrome. Chin Med J 126(17):3245\u20133250","journal-title":"Chin Med J"},{"issue":"6","key":"2276_CR19","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","volume":"14","author":"MW Johns","year":"1991","unstructured":"Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14(6):540\u2013545","journal-title":"Sleep"},{"issue":"7","key":"2276_CR20","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.sleep.2008.02.006","volume":"9","author":"N Roure","year":"2008","unstructured":"Roure N, Gomez S, Mediano O, Duran J, de la Pe\u00f1a M, Capote F et al (2008) Daytime sleepiness and polysomnography in obstructive sleep apnea patients. Sleep Med 9(7):727\u2013731","journal-title":"Sleep Med"},{"issue":"1","key":"2276_CR21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.5336\/medsci.2013-36830","volume":"34","author":"B Eri\u015f G\u00fclbay","year":"2014","unstructured":"Eri\u015f G\u00fclbay B, Acican T, \u00c7ift\u00e7i F, Erdemir I\u015fik M, \u00d6nen ZP (2014) Comparison of polysomnography variables in obstructive sleep apnea patients with or without excessive daytime sleepiness. Turkiye Klin J Med Sci 34(1):87\u201392","journal-title":"Turkiye Klin J Med Sci"},{"issue":"9","key":"2276_CR22","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1164\/rccm.200209-1055OC","volume":"167","author":"T Young","year":"2003","unstructured":"Young T, Finn L, Austin D, Peterson A (2003) Menopausal status and sleep-disordered breathing in the Wisconsin Sleep Cohort Study. Am J Respir Crit Care Med 167(9):1181\u20131185","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-020-02276-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11325-020-02276-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-020-02276-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T16:54:43Z","timestamp":1724345683000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11325-020-02276-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,19]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2276"],"URL":"https:\/\/doi.org\/10.1007\/s11325-020-02276-x","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"value":"1520-9512","type":"print"},{"value":"1522-1709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,19]]},"assertion":[{"value":"18 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.Study number: ASMC 0076-18.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}