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However, the gold standard for its diagnosis, polysomnography (PSG), is expensive resulting in inadequate diagnosis of this disease in primary clinics. Therefore, a simple and rapid method for initial screening for OSA\u00a0is needed. Acoustic pharyngometry (APh) is an FDA-approved noninvasive method that is gradually being\u00a0applied to screening\u00a0for OSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials And Methods<\/jats:title><jats:p>In this study, we applied\u00a0analysis with receiver operating characteristic (ROC) curves to explore how APh may play a greater role in the screening of subjects with suspected\u00a0OSA. Patients admitted into the departments of otolaryngology at our hospital from March 2017 to May 2019 were recruited into the study. All subjects underwent PSG monitor and were\u00a0separated into two groups according to the apnea-hypopnea index (AHI) from\u00a0the PSG results: OSA group (AHI \u2265 5) and control group (AHI &lt; 5). APh measurements and other indicators of the subjects, including age, height, and weight; Epworth Sleepiness Scale (ESS) score; and the pharynx examination, including the degree of tonsil enlargement and tongue hypertrophy, were also be recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The<jats:italic>t<\/jats:italic>-test results showed that almost all indicators except age and height have significant differences between the OSA group and control group. Subjects with OSA\u00a0had greater weight, BMI, ESS, higher degree of tonsil enlargement, and tongue hypertrophy, while they had smaller minimal cross-sectional area (mCSA) and pharyngeal volume than the subjects in control group. The correlation analysis revealed that pharyngeal volume and mCSA were two helpful indicators to screen for OSA. Furthermore, we established the ROC curve and calculated the combining predictors (combining predictors = pharyngeal volume + mCSA * (\u2212 2.347)\/(\u2212 0.225)). The area under the ROC curve (AUC) of combining predictors was 0.917 (95% CI 0.842\u20130.991,<jats:italic>P<\/jats:italic>&lt; 0.001), which was higher than combinations of\u00a0other two independent indicators. The cutoff point of combining predictors was found to be 59.84 (AUC = 0.917, sensitivity = 0.80, 1-specificity = 0.06,<jats:italic>P<\/jats:italic>&lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that APh is a simple, rapid, and economical detection method which may be useful in screening for OSA, especially in communities and primary clinics where PSG cannot be performed.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s11325-021-02358-4","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T18:02:42Z","timestamp":1620496962000},"page":"243-250","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Combined application of pharyngeal volume and minimal cross-sectional area may be helpful in screening persons suspected of obstructive sleep apnea (OSA)"],"prefix":"10.1007","volume":"26","author":[{"given":"Yuliang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,8]]},"reference":[{"key":"2358_CR1","doi-asserted-by":"crossref","unstructured":"West SD, Turnbull C (2018) Obstructive sleep apnoea. 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Based on the study design, after the review of the Ethics Committee, the health, right, and privacy of subjects are fully protected; potential risk and harm to the subjects are controllable to minimal. This study was approved by Research Ethics Committee of the second hospital of Hebei Medical University. The approval number is 2018-R251.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All presentations of data have consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}