{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T13:29:56Z","timestamp":1780752596288,"version":"3.54.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["2018YFC1002106"],"award-info":[{"award-number":["2018YFC1002106"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Clinical Research Project of Peking University Third Hospital","award":["BYBY2018016"],"award-info":[{"award-number":["BYBY2018016"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s11325-021-02376-2","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T07:25:16Z","timestamp":1621495516000},"page":"497-503","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Analysis of the proportion and clinical characteristics of obstructive sleep apnea in women with polycystic ovary syndrome"],"prefix":"10.1007","volume":"26","author":[{"given":"Rui","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguo","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"2376_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/humrep\/der396","volume":"910","author":"Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group","year":"2012","unstructured":"Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group (2012) Consensus on women\u2019s health aspects of polycystic ovary syndrome (PCOS). Hum Reprod 910:14\u201324. https:\/\/doi.org\/10.1093\/humrep\/der396","journal-title":"Hum Reprod"},{"issue":"9","key":"2376_CR2","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1093\/humrep\/det262","volume":"28","author":"R Li","year":"2013","unstructured":"Li R, Zhang Q, Yang D, Li S, Lu S, Wu X, Wei Z, Song X, Wang X, Fu S, Lin J, Zhu Y, Jiang Y, Feng H, Qiao J (2013) Prevalence of polycystic ovary syndrome in women in China: a large community-based study. Hum Reprod 28(9):2562\u20132569. https:\/\/doi.org\/10.1093\/humrep\/det262","journal-title":"Hum Reprod"},{"key":"2376_CR3","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1210\/jcem.84.1.5393","volume":"84","author":"RS Legro","year":"1999","unstructured":"Legro RS, Kunselman AR, Dodson WC, Dunaif A (1999) Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 84:165\u2013169. https:\/\/doi.org\/10.1210\/jcem.84.1.5393","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2376_CR4","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s11325-019-01835-1","volume":"24","author":"H Kahal","year":"2020","unstructured":"Kahal H, Kyrou I, Uthman OA, Brown A, Johnson S, Wall PDH, Metcalfe A, Parr DG, Tahrani AA, Randeva HS (2020) The prevalence of obstructive sleep apnoea in women with polycystic ovary syndrome: a systematic review and meta-analysis. Sleep Breath 24(1):339\u2013350","journal-title":"Sleep Breath"},{"key":"2376_CR5","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1056\/NEJM199304293281704","volume":"328","author":"T Young","year":"1993","unstructured":"Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230\u20131235. https:\/\/doi.org\/10.1056\/NEJM199304293281704","journal-title":"N Engl J Med"},{"key":"2376_CR6","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1513\/pats.200709-155MG","volume":"5","author":"NM Punjabi","year":"2008","unstructured":"Punjabi NM (2008) The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 5:136\u2013143. https:\/\/doi.org\/10.1513\/pats.200709-155MG","journal-title":"Proc Am Thorac Soc"},{"key":"2376_CR7","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/cen.13392","volume":"87","author":"H Kahal","year":"2017","unstructured":"Kahal H, Kyrou I, Tahrani A, Randeva H (2017) Obstructive sleep apnoea and polycystic ovary syndrome: a comprehensive review of clinical interactions and underlying pathophysiology. Clin Endocrinol 87:313\u2013319. https:\/\/doi.org\/10.1111\/cen.13392","journal-title":"Clin Endocrinol"},{"key":"2376_CR8","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1097\/MCP.0b013e3283659da5","volume":"19","author":"AA Tahrani","year":"2013","unstructured":"Tahrani AA, Ali A, Stevens MJ (2013) Obstructive sleep apnoea and diabetes: an update. Curr Opin Pulm Med 19:631\u2013638. https:\/\/doi.org\/10.1097\/MCP.0b013e3283659da5","journal-title":"Curr Opin Pulm Med"},{"issue":"2","key":"2376_CR9","doi-asserted-by":"publisher","first-page":"81","DOI":"10.17925\/EE.2015.11.02.81","volume":"11","author":"AA Tahrani","year":"2015","unstructured":"Tahrani AA (2015) Obstructive sleep apnoea and vascular disease in patients with type 2 diabetes. Eur Endocrinol 11(2):81\u201389. https:\/\/doi.org\/10.17925\/EE.2015.11.02.81","journal-title":"Eur Endocrinol"},{"issue":"6","key":"2376_CR10","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/oby.2010.344","volume":"19","author":"AO Hammoud","year":"2011","unstructured":"Hammoud AO, Walker JM, Gibson M, Cloward TV, Hunt SC, Kolotkin RL, Adams TD, Meikle AW (2011) Sleep apnea, reproductive hormones and quality of sexual life in severely obese men. Obesity (Silver Spring) 19(6):1118\u20131123. https:\/\/doi.org\/10.1038\/oby.2010.344","journal-title":"Obesity (Silver Spring)"},{"issue":"1","key":"2376_CR11","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/aja.2011.64","volume":"14","author":"AO Hammoud","year":"2012","unstructured":"Hammoud AO, Carrell DT, Gibson M, Peterson CM, Meikle AW (2012) Updates on the relation of weight excess and reproductive function in men: sleep apnea as a new area of interest. Asian J Androl 14(1):77\u201381. https:\/\/doi.org\/10.1038\/aja.2011.64","journal-title":"Asian J Androl"},{"issue":"1","key":"2376_CR12","first-page":"53","volume":"70","author":"CA Nigro","year":"2010","unstructured":"Nigro CA, Serrano F, Aimaretti S, Gonz\u00e1lez S, Codinardo C, Rhodius E (2010) Utility of ApneaLink for the diagnosis of sleep apnea-hypopnea syndrome. Medicina (B Aires) 70(1):53\u201359","journal-title":"Medicina (B Aires)"},{"issue":"6","key":"2376_CR13","first-page":"916","volume":"73","author":"E Ito","year":"2015","unstructured":"Ito E, Inoue Y (2015) The International Classification of Sleep Disorders, third edition. American Academy of Sleep Medicine. Includes bibliographies and index. Nihon Rinsho 73(6):916\u2013923","journal-title":"Nihon Rinsho"},{"issue":"3","key":"2376_CR14","first-page":"156","volume":"12","author":"Metabolic syndrome research collaboration group from Chinese Diabetes Society","year":"2004","unstructured":"Metabolic syndrome research collaboration group from Chinese Diabetes Society (2004) Suggestions on metabolic syndrome from Chinese Diabetes Society. Chin J Diabetes 12(3):156\u2013161","journal-title":"Chin J Diabetes"},{"issue":"7","key":"2376_CR15","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1530\/EC-17-0129","volume":"6","author":"N Helvaci","year":"2017","unstructured":"Helvaci N, Karabulut E, Demir AU, Yildiz BO (2017) Polycystic ovary syndrome and the risk of obstructive sleep apnea: a meta-analysis and review of the literature. Endocr Connect 6(7):437\u2013445. https:\/\/doi.org\/10.1530\/EC-17-0129","journal-title":"Endocr Connect"},{"issue":"4","key":"2376_CR16","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s11325-007-0120-3","volume":"11","author":"S Subramanian","year":"2007","unstructured":"Subramanian S, Desai A, Joshipura M, Surani S (2007) Practice patterns of screening for sleep apnea in physicians treating PCOS patients. Sleep Breath 11(4):233\u2013237. https:\/\/doi.org\/10.1007\/s11325-007-0120-3","journal-title":"Sleep Breath"},{"key":"2376_CR17","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.sleep.2016.12.029","volume":"36","author":"TY Lin","year":"2017","unstructured":"Lin TY, Lin PY, Su TP, Li CT, Lin WC, Chang WH, Chen TJ, Bai YM, Chen MH (2017) Risk of developing obstructive sleep apnea among women with polycystic ovarian syndrome: a nationwide longitudinal follow-up study. Sleep Med 36:165\u2013169. https:\/\/doi.org\/10.1016\/j.sleep.2016.12.029","journal-title":"Sleep Med"},{"key":"2376_CR18","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/s1389-9457(02)00033-3","volume":"3","author":"M Gopal","year":"2002","unstructured":"Gopal M, Duntley S, Uhles M, Attarian H (2002) The role of obesity in the increased prevalence of obstructive sleep apnea syndrome in patients with polycystic ovarian syndrome. Sleep Med 3:401\u2013404. https:\/\/doi.org\/10.1016\/s1389-9457(02)00033-3","journal-title":"Sleep Med"},{"key":"2376_CR19","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ijgo.2009.02.004","volume":"105","author":"HP Yang","year":"2009","unstructured":"Yang HP, KangJH SuHY, Tzeng CR, Liu WM, Huang SY (2009) Apnea-hypopnea index in nonobese women with polycystic ovary syndrome. Int J Gynecol Obstet 105:226\u20139. https:\/\/doi.org\/10.1016\/j.ijgo.2009.02.004","journal-title":"Int J Gynecol Obstet"},{"issue":"10","key":"2376_CR20","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.7661\/j.cjim.20180730.248","volume":"38","author":"MM Liu","year":"2018","unstructured":"Liu MM, Yu S, Wang M et al (2018) The influence factors of sleep quality in patients with polycystic ovarian syndrome. Chin J Integr Trad West Med 38(10):1185\u20139. https:\/\/doi.org\/10.7661\/j.cjim.20180730.248","journal-title":"Chin J Integr Trad West Med"},{"key":"2376_CR21","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1210\/jcem.86.2.7185","volume":"86","author":"AN Vgontzas","year":"2001","unstructured":"Vgontzas AN, Legro RS, Bixler EO, Grayev A, Kales A, Chrousos GP (2001) Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance. J Clin Endocrinol Metab 86:517\u2013520. https:\/\/doi.org\/10.1210\/jcem.86.2.7185","journal-title":"J Clin Endocrinol Metab"},{"key":"2376_CR22","doi-asserted-by":"publisher","first-page":"28.e25","DOI":"10.1016\/j.fertnstert.2011.09.024","volume":"97","author":"BC Fauser","year":"2012","unstructured":"Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R et al (2012) Consensus on women\u2019s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril 97:28.e25-38.e25. https:\/\/doi.org\/10.1016\/j.fertnstert.2011.09.024","journal-title":"Fertil Steril"},{"key":"2376_CR23","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.fertnstert.2011.12.024","volume":"97","author":"B Mokhlesi","year":"2012","unstructured":"Mokhlesi B, Scoccia B, Mazzone T, Susan S (2012) Risk of obstructive sleep apnea in obese and nonobese women with polycystic ovary syndrome and healthy reproductively normal women. Fertil Steril 97:786\u2013791. https:\/\/doi.org\/10.1016\/j.fertnstert.2011.12.024","journal-title":"Fertil Steril"},{"issue":"9","key":"2376_CR24","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1093\/humrep\/dey256","volume":"33","author":"HJ Teede","year":"2018","unstructured":"Teede HJ, Misso ML, Costello MF, Anuja D, Laven J, Moran L, Piltonen T, Norman RJ, International PCOS Network (2018) Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Hum Reprod 33(9):1602\u20131618. https:\/\/doi.org\/10.1093\/humrep\/dey256","journal-title":"Hum Reprod"},{"key":"2376_CR25","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1210\/jc.2013-2350","volume":"98","author":"RS Legro","year":"2013","unstructured":"Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, Welt CK, Endocrine Society (2013) Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 98:4565\u20134592. https:\/\/doi.org\/10.1210\/jc.2013-2350","journal-title":"J Clin Endocrinol Metab"},{"key":"2376_CR26","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s11325-010-0469-6","volume":"16","author":"G de Sousa","year":"2012","unstructured":"de Sousa G, Schl\u00fcter B, Buschatz D, Menke T, Trowitzsch E, Andler W, Reinehr T (2012) The impact of insulin resistance and hyperandrogenemia on polysomnographic variables in obese adolescents with polycystic ovarian syndrome. Sleep Breath 16:169\u2013175. https:\/\/doi.org\/10.1007\/s11325-010-0469-6","journal-title":"Sleep Breath"},{"key":"2376_CR27","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.jpeds.2011.04.027","volume":"159","author":"K Nandalike","year":"2011","unstructured":"Nandalike K, Strauss T, Agarwal C, Coupey SM, Sin S, Rajpathak S, Cohen HW, Arens R (2011) Screening for sleep-disordered breathing and excessive daytime sleepiness in adolescent girls with polycystic ovarian syndrome. J Pediatr 159:591\u2013596. https:\/\/doi.org\/10.1016\/j.jpeds.2011.04.027","journal-title":"J Pediatr"},{"key":"2376_CR28","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.smrv.2014.10.005","volume":"22","author":"JD Kloss","year":"2015","unstructured":"Kloss JD, Perlis ML, Zamzow JA, Culnan EJ, Gracia CR (2015) Sleep, sleep disturbance, and fertility in women. Sleep Med Rev 22:78\u201387. https:\/\/doi.org\/10.1016\/j.smrv.2014.10.005","journal-title":"Sleep Med Rev"},{"issue":"5","key":"2376_CR29","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.beem.2010.08.001","volume":"24","author":"K Nitsche","year":"2010","unstructured":"Nitsche K, Ehrmann DA (2010) Obstructive sleep apnea and metabolic dysfunction in polycystic ovary syndrome. Best Pract Res Clin Endocrinol Metab 24(5):717\u2013730. https:\/\/doi.org\/10.1016\/j.beem.2010.08.001","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"6","key":"2376_CR30","first-page":"1064","volume":"3","author":"S Jehan","year":"2016","unstructured":"Jehan S, Auguste E, Zizi F, Pandi-Perumal SR, Gupta R, Attarian H, Jean-Louis G, Mcfarlane S (2016) Obstructive sleep apnea: women\u2019s perspective. J Sleep Med Disord 3(6):1064","journal-title":"J Sleep Med Disord"},{"issue":"1","key":"2376_CR31","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1093\/humrep\/dei284","volume":"21","author":"D Polat","year":"2006","unstructured":"Polat D, Demirta\u015fEzgi Ahmet B, Yarali H (2006) Decreased serum paraoxonase 1 (PON1) activity: an additional risk factor for atherosclerotic heart disease in patients with PCOS? Hum Reprod 21(1):104\u2013108. https:\/\/doi.org\/10.1093\/humrep\/dei284","journal-title":"Hum Reprod"},{"key":"2376_CR32","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1111\/j.1464-5491.2011.03459.x","volume":"28","author":"E Van Cauter","year":"2011","unstructured":"Van Cauter E (2011) Sleep disturbances and insulin resistance. Diabet Med 28:1455\u20131462. https:\/\/doi.org\/10.1111\/j.1464-5491.2011.03459.x","journal-title":"Diabet Med"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-021-02376-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11325-021-02376-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-021-02376-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T00:35:52Z","timestamp":1645230952000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11325-021-02376-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,19]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["2376"],"URL":"https:\/\/doi.org\/10.1007\/s11325-021-02376-2","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"value":"1520-9512","type":"print"},{"value":"1522-1709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,19]]},"assertion":[{"value":"6 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards and the study was approved by the Ethical Committee of Peking University Third Hospital (Beijing, China). (IRB00006761-M2020391).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}