{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:53:13Z","timestamp":1772833993903,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s11325-021-02400-5","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T22:02:33Z","timestamp":1621116153000},"page":"287-295","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["7,8-Dihydroxyflavone protects retinal ganglion cells against chronic intermittent hypoxia-induced oxidative stress damage via activation of the BDNF\/TrkB signaling pathway"],"prefix":"10.1007","volume":"26","author":[{"given":"Yuan-yuan","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huo-jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-hao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9722-833X","authenticated-orcid":false,"given":"Hui-guo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"issue":"7","key":"2400_CR1","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1111\/resp.13838","volume":"25","author":"MM Lyons","year":"2020","unstructured":"Lyons MM, Bhatt NY, Pack AI et al (2020) Global burden of sleep-disordered breathing and its implications. Respirology (Carlton, Vic) 25(7):690\u2013702. https:\/\/doi.org\/10.1111\/resp.13838","journal-title":"Respirology (Carlton, Vic)"},{"key":"2400_CR2","doi-asserted-by":"publisher","unstructured":"Light M, McCowen K, Malhotra A et al. (2018) Sleep apnea, metabolic disease, and the cutting edge of therapy. Metabol: Clin Exper 84:94\u201398. https:\/\/doi.org\/10.1016\/j.metabol.2017.09.004","DOI":"10.1016\/j.metabol.2017.09.004"},{"issue":"8","key":"2400_CR3","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1136\/bjophthalmol-2018-312910","volume":"103","author":"HK Yang","year":"2019","unstructured":"Yang HK, Park SJ, Byun SJ et al (2019) Obstructive sleep apnoea and increased risk of non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol 103(8):1123\u20131128. https:\/\/doi.org\/10.1136\/bjophthalmol-2018-312910","journal-title":"Br J Ophthalmol"},{"issue":"9","key":"2400_CR4","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1038\/s41433-019-0430-2","volume":"33","author":"YY Fan","year":"2019","unstructured":"Fan YY, Su WW, Liu CH et al (2019) Correlation between structural progression in glaucoma and obstructive sleep apnea. Eye (Lond) 33(9):1459\u20131465. https:\/\/doi.org\/10.1038\/s41433-019-0430-2","journal-title":"Eye (Lond)"},{"issue":"4","key":"2400_CR5","doi-asserted-by":"publisher","first-page":"399","DOI":"10.5664\/jcsm.1202","volume":"7","author":"S Javaheri","year":"2011","unstructured":"Javaheri S, Qureshi Z, Golnik K (2011) Resolution of papilledema associated with OSA treatment. J Clin Sleep Med 7(4):399\u2013400. https:\/\/doi.org\/10.5664\/jcsm.1202","journal-title":"J Clin Sleep Med"},{"issue":"8","key":"2400_CR6","doi-asserted-by":"publisher","first-page":"e919","DOI":"10.1111\/aos.13798","volume":"96","author":"E Agard","year":"2018","unstructured":"Agard E, El Chehab H, Vie AL et al (2018) Retinal vein occlusion and obstructive sleep apnea: a series of 114 patients. Acta Ophthalmol 96(8):e919\u2013e925. https:\/\/doi.org\/10.1111\/aos.13798","journal-title":"Acta Ophthalmol"},{"issue":"12","key":"2400_CR7","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.3390\/ijms20122937","volume":"20","author":"YC Chen","year":"2019","unstructured":"Chen YC, Hsu PY, Hsiao CC et al (2019) Epigenetics: a potential mechanism involved in the pathogenesis of various adverse consequences of obstructive sleep apnea. Int J Mol Sci 20(12):2937. https:\/\/doi.org\/10.3390\/ijms20122937","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2400_CR8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/aps.2011.184","volume":"33","author":"H Xie","year":"2012","unstructured":"Xie H, Yung WH (2012) Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor. Acta Pharmacol Sin 33(1):5\u201310. https:\/\/doi.org\/10.1038\/aps.2011.184","journal-title":"Acta Pharmacol Sin"},{"issue":"9","key":"2400_CR9","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.3390\/ijms17091584","volume":"17","author":"A Kimura","year":"2016","unstructured":"Kimura A, Namekata K, Guo X et al (2016) Neuroprotection, growth factors and BDNF-TrkB signalling in retinal degeneration. Int J Mol Sci 17(9):1584. https:\/\/doi.org\/10.3390\/ijms17091584","journal-title":"Int J Mol Sci"},{"key":"2400_CR10","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40035-015-0048-7","volume":"5","author":"C Liu","year":"2016","unstructured":"Liu C, Chan CB, Ye K (2016) 7,8-Dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders. Translat Neurodegen 5:2. https:\/\/doi.org\/10.1186\/s40035-015-0048-7","journal-title":"Translat Neurodegen"},{"key":"2400_CR11","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.freeradbiomed.2018.11.024","volume":"130","author":"J Zhao","year":"2019","unstructured":"Zhao J, Du J, Pan Y et al (2019) Activation of cardiac TrkB receptor by its small molecular agonist 7,8-dihydroxyflavone inhibits doxorubicin-induced cardiotoxicity via enhancing mitochondrial oxidative phosphorylation. Free Radical Biol Med 130:557\u2013567. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.11.024","journal-title":"Free Radical Biol Med"},{"key":"2400_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ejphar.2018.02.045","volume":"828","author":"N Aytan","year":"2018","unstructured":"Aytan N, Choi JK, Carreras I et al (2018) Protective effects of 7,8-dihydroxyflavone on neuropathological and neurochemical changes in a mouse model of Alzheimer\u2019s disease. Eur J Pharmacol 828:9\u201317. https:\/\/doi.org\/10.1016\/j.ejphar.2018.02.045","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"2400_CR13","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.bbrc.2015.06.149","volume":"464","author":"S Xie","year":"2015","unstructured":"Xie S, Deng Y, Pan YY et al (2015) Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5\u2032 adenosine monophosphate-activated protein kinase pathway. Biochem Biophys Res Commun 464(4):975\u2013981. https:\/\/doi.org\/10.1016\/j.bbrc.2015.06.149","journal-title":"Biochem Biophys Res Commun"},{"issue":"3\u20134","key":"2400_CR14","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/dneu.22741","volume":"80","author":"GR Musada","year":"2020","unstructured":"Musada GR, Dvoriantchikova G, Myer C et al (2020) The effect of extrinsic Wnt\/\u03b2-catenin signaling in Muller glia on retinal ganglion cell neurite growth. Dev Neurobiol 80(3\u20134):98\u2013110. https:\/\/doi.org\/10.1002\/dneu.22741","journal-title":"Dev Neurobiol"},{"issue":"3","key":"2400_CR15","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s11596-018-1893-2","volume":"38","author":"J Ren","year":"2018","unstructured":"Ren J, Liu W, Li GC et al (2018) Atorvastatin attenuates myocardial hypertrophy induced by chronic intermittent hypoxia in vitro partly through miR-31\/PKC\u03b5 pathway. Curr Med Sci 38(3):405\u2013412. https:\/\/doi.org\/10.1007\/s11596-018-1893-2","journal-title":"Curr Med Sci"},{"key":"2400_CR16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.smrv.2017.05.003","volume":"38","author":"M Mentek","year":"2018","unstructured":"Mentek M, Aptel F, Godin-Ribuot D et al (2018) Diseases of the retina and the optic nerve associated with obstructive sleep apnea. Sleep Med Rev 38:113\u2013130. https:\/\/doi.org\/10.1016\/j.smrv.2017.05.003","journal-title":"Sleep Med Rev"},{"issue":"6","key":"2400_CR17","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.ajo.2014.01.028","volume":"157","author":"T Shiba","year":"2014","unstructured":"Shiba T, Takahashi M, Sato Y et al (2014) Relationship between severity of obstructive sleep apnea syndrome and retinal nerve fiber layer thickness. Am J Ophthalmol 157(6):1202\u20131208. https:\/\/doi.org\/10.1016\/j.ajo.2014.01.028","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"2400_CR18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.sleep.2012.07.004","volume":"14","author":"S Moghimi","year":"2013","unstructured":"Moghimi S, Ahmadraji A, Sotoodeh H et al (2013) Retinal nerve fiber thickness is reduced in sleep apnea syndrome. Sleep Med 14(1):53\u201357. https:\/\/doi.org\/10.1016\/j.sleep.2012.07.004","journal-title":"Sleep Med"},{"issue":"12","key":"2400_CR19","doi-asserted-by":"publisher","first-page":"5256","DOI":"10.1167\/iovs.18-25151","volume":"59","author":"M Mentek","year":"2018","unstructured":"Mentek M, Morand J, Baldazza M et al (2018) Chronic intermittent hypoxia alters rat ophthalmic artery reactivity through oxidative stress, endothelin and endothelium-derived hyperpolarizing pathways. Invest Ophthalmol Vis Sci 59(12):5256\u20135265. https:\/\/doi.org\/10.1167\/iovs.18-25151","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"2400_CR20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.optom.2017.06.002","volume":"11","author":"C McMonnies","year":"2018","unstructured":"McMonnies C (2018) Reactive oxygen species, oxidative stress, glaucoma and hyperbaric oxygen therapy. J Optometry 11(1):3\u20139. https:\/\/doi.org\/10.1016\/j.optom.2017.06.002","journal-title":"J Optometry"},{"issue":"1","key":"2400_CR21","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.nbd.2010.05.020","volume":"40","author":"H Xie","year":"2010","unstructured":"Xie H, Leung KL, Chen L et al (2010) Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity. Neurobiol Dis 40(1):155\u2013162. https:\/\/doi.org\/10.1016\/j.nbd.2010.05.020","journal-title":"Neurobiol Dis"},{"key":"2400_CR22","doi-asserted-by":"publisher","first-page":"117573","DOI":"10.1016\/j.lfs.2020.117573","volume":"250","author":"JR An","year":"2020","unstructured":"An JR, Zhao YS, Luo LF et al (2020) Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia. Life Sci 250:117573. https:\/\/doi.org\/10.1016\/j.lfs.2020.117573","journal-title":"Life Sci"},{"issue":"9","key":"2400_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11427-019-1567-0","volume":"63","author":"R Du","year":"2020","unstructured":"Du R, Wang X, He S (2020) BDNF improves axon transportation and rescues visual function in a rodent model of acute elevation of intraocular pressure. Sci China Life Sci 63(9):1\u201310. https:\/\/doi.org\/10.1007\/s11427-019-1567-0","journal-title":"Sci China Life Sci"},{"issue":"6","key":"2400_CR24","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.1073\/pnas.0913572107","volume":"107","author":"SW Jang","year":"2010","unstructured":"Jang SW, Liu X, Yepes M et al (2010) A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci USA 107(6):2687\u20132692. https:\/\/doi.org\/10.1073\/pnas.0913572107","journal-title":"Proc Natl Acad Sci USA"},{"issue":"23","key":"2400_CR25","doi-asserted-by":"publisher","first-page":"8274","DOI":"10.1021\/jm101206p","volume":"53","author":"X Liu","year":"2010","unstructured":"Liu X, Chan CB, Jang SW et al (2010) A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. J Med Chem 53(23):8274\u20138286. https:\/\/doi.org\/10.1021\/jm101206p","journal-title":"J Med Chem"},{"issue":"2","key":"2400_CR26","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1176\/appi.ajp.2010.10030326","volume":"168","author":"R Andero","year":"2011","unstructured":"Andero R, Heldt SA, Ye K et al (2011) Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. Am J Psychiatry 168(2):163\u2013172. https:\/\/doi.org\/10.1176\/appi.ajp.2010.10030326","journal-title":"Am J Psychiatry"},{"issue":"16","key":"2400_CR27","doi-asserted-by":"publisher","first-page":"3144","DOI":"10.1093\/hmg\/ddx198","volume":"26","author":"G Garc\u00eda-D\u00edaz Barriga","year":"2017","unstructured":"Garc\u00eda-D\u00edaz Barriga G, Giralt A, Anglada-Huguet M et al (2017) 7,8-Dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington\u2019s disease mouse model through specific activation of the PLC\u03b31 pathway. Hum Mol Genet 26(16):3144\u20133160. https:\/\/doi.org\/10.1093\/hmg\/ddx198","journal-title":"Hum Mol Genet"},{"issue":"1","key":"2400_CR28","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.bbrc.2017.11.007","volume":"495","author":"X Yu","year":"2018","unstructured":"Yu X, Liu Q, Wang X et al (2018) 7,8-Dihydroxyflavone ameliorates high-glucose induced diabetic apoptosis in human retinal pigment epithelial cells by activating TrkB. Biochem Biophys Res Commun 495(1):922\u2013927. https:\/\/doi.org\/10.1016\/j.bbrc.2017.11.007","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"2400_CR29","doi-asserted-by":"publisher","first-page":"3124","DOI":"10.1167\/iovs.18-23792","volume":"59","author":"HM Huang","year":"2018","unstructured":"Huang HM, Huang CC, Tsai MH et al (2018) Systemic 7,8-dihydroxyflavone treatment protects immature retinas against hypoxic-ischemic injury via M\u00fcller glia regeneration and MAPK\/ERK activation. Invest Ophthalmol Vis Sci 59(7):3124\u20133135. https:\/\/doi.org\/10.1167\/iovs.18-23792","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2400_CR30","doi-asserted-by":"publisher","unstructured":"Emili M, Guidi S, Uguagliati B et al. (2020) Treatment with the flavonoid 7,8-dihydroxyflavone: a promising strategy for a constellation of body and brain disorders. Critic Rev Food Sci Nutri:1\u201338. https:\/\/doi.org\/10.1080\/10408398.2020.1810625","DOI":"10.1080\/10408398.2020.1810625"},{"key":"2400_CR31","doi-asserted-by":"publisher","first-page":"5029797","DOI":"10.1155\/2016\/5029797","volume":"2016","author":"R Ma","year":"2016","unstructured":"Ma R, Zhang J, Liu X et al (2016) 7,8-DHF treatment induces Cyr61 expression to suppress hypoxia induced ER stress in HK-2 cells. Biomed Res Int 2016:5029797. https:\/\/doi.org\/10.1155\/2016\/5029797","journal-title":"Biomed Res Int"},{"issue":"4","key":"2400_CR32","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.3892\/ijmm.2014.1652","volume":"33","author":"HY Park","year":"2014","unstructured":"Park HY, Park C, Hwang HJ et al (2014) 7,8-Dihydroxyflavone attenuates the release of pro-inflammatory mediators and cytokines in lipopolysaccharide-stimulated BV2 microglial cells through the suppression of the NF-\u03baB and MAPK signaling pathways. Int J Mol Med 33(4):1027\u20131034. https:\/\/doi.org\/10.3892\/ijmm.2014.1652","journal-title":"Int J Mol Med"},{"issue":"1\u20132","key":"2400_CR33","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/s0304-3835(98)00141-4","volume":"130","author":"JC Le Bail","year":"1998","unstructured":"Le Bail JC, Varnat F, Nicolas JC et al (1998) Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids. Cancer Lett 130(1\u20132):209\u2013216. https:\/\/doi.org\/10.1016\/s0304-3835(98)00141-4","journal-title":"Cancer Lett"},{"issue":"1","key":"2400_CR34","doi-asserted-by":"publisher","first-page":"528","DOI":"10.3892\/or.2016.4825","volume":"36","author":"DY Sim","year":"2016","unstructured":"Sim DY, Sohng JK, Jung HJ (2016) Anticancer activity of 7,8-dihydroxyflavone in melanoma cells via downregulation of \u03b1-MSH\/cAMP\/MITF pathway. Oncol Rep 36(1):528\u2013534. https:\/\/doi.org\/10.3892\/or.2016.4825","journal-title":"Oncol Rep"},{"key":"2400_CR35","doi-asserted-by":"publisher","first-page":"107957","DOI":"10.1016\/j.exer.2020.107957","volume":"193","author":"LA Mesentier-Louro","year":"2020","unstructured":"Mesentier-Louro LA, Shariati MA, Dalal R et al (2020) Systemic hypoxia led to little retinal neuronal loss and dramatic optic nerve glial response. Exp Eye Res 193:107957. https:\/\/doi.org\/10.1016\/j.exer.2020.107957","journal-title":"Exp Eye Res"},{"issue":"2","key":"2400_CR36","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/path.2858","volume":"224","author":"V Sivakumar","year":"2011","unstructured":"Sivakumar V, Foulds WS, Luu CD et al (2011) Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina. J Pathol 224(2):245\u2013260. https:\/\/doi.org\/10.1002\/path.2858","journal-title":"J Pathol"},{"key":"2400_CR37","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.sleep.2019.10.019","volume":"67","author":"PW Lin","year":"2020","unstructured":"Lin PW, Lin HC, Friedman M et al (2020) Effects of CPAP for patients with OSA on visual sensitivity and retinal thickness. Sleep Med 67:156\u2013163. https:\/\/doi.org\/10.1016\/j.sleep.2019.10.019","journal-title":"Sleep Med"},{"issue":"8","key":"2400_CR38","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1038\/s41433-018-0088-1","volume":"32","author":"MH Sun","year":"2018","unstructured":"Sun MH, Liao YJ, Lin CC et al (2018) Association between obstructive sleep apnea and optic neuropathy: a Taiwanese population-based cohort study. Eye (Lond) 32(8):1353\u20131358. https:\/\/doi.org\/10.1038\/s41433-018-0088-1","journal-title":"Eye (Lond)"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-021-02400-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11325-021-02400-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-021-02400-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T00:34:54Z","timestamp":1645230894000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11325-021-02400-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,15]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["2400"],"URL":"https:\/\/doi.org\/10.1007\/s11325-021-02400-5","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"value":"1520-9512","type":"print"},{"value":"1522-1709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,15]]},"assertion":[{"value":"11 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures described in the present study were approved by the Institutional Animal Care and Use Committee of Tongji Medical College at Huazhong University of Science and Technology (TJH-201901002) and were performed in accordance with the ARVO statement for the Use of Animals in Ophthalmic and Vision Research and NIH guidelines for the care and use of animals in research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}